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J Selvarajah et al.
Cell death & disease, 4, e865-e865 (2013-10-19)
The DNA-damaging agent camptothecin (CPT) and its analogs demonstrate clinical utility for the treatment of advanced solid tumors, and CPT-based nanopharmaceuticals are currently in clinical trials for advanced kidney cancer; however, little is known regarding the effects of CPT on
Bo Yang et al.
Carbohydrate polymers, 92(2), 1308-1314 (2013-02-13)
A series of scutellarin-cyclodextrin conjugates (SCU-CD conjugates), in which scutellarin was covalently bound to one of the primary hydroxyl groups of β-CD, were prepared, and their structures were determined using NMR and MS. These conjugates were further characterized by XRD
Woon-Won Jung
International journal of molecular medicine, 33(5), 1327-1334 (2014-02-28)
Apigenin, a plant-derived flavonoid, was investigated to determine whether it could influence hydrogen peroxide (H2O2)-induced oxidative damage and cellular dysfunction in the MC3T3-E1 mouse osteoblastic cell line. In the present study, osteoblastic cells were treated with H2O2 in the presence
Jun Cheng et al.
Food chemistry, 168, 90-99 (2014-08-31)
The aim of this study was to investigate the applicability of artificial neural network (ANN) and multiple linear regression (MLR) models for the estimation of acrylamide reduction by flavonoids, using multiple antioxidant capacities of Maillard reaction products as variables via
Antonella Smeriglio et al.
Anti-cancer agents in medicinal chemistry, 14(10), 1386-1396 (2014-06-26)
Prostate function is critical for male fertility and its well-known oncological biomarker, namely Prostate-Specific Antigen (PSA), can be also used to monitor prostate epithelial human cells upon treatment with pharmaceutical drugs or natural bioactive compounds. The LNCaP human prostate cell
Wei Zhang et al.
PloS one, 9(10), e110429-e110429 (2014-10-21)
Flavonoids are widely distributed natural products with broad biological activities. Apigenin is a dietary flavonoid that has recently been demonstrated to interact with heterogeneous nuclear ribonucleoproteins (hnRNPs) and interferes with their RNA editing activity. We investigated whether apigenin possessed antiviral
Deendayal Patel et al.
International journal of oncology, 30(1), 233-245 (2006-12-05)
Cancer is one of the major public health burdens in the United States and in other developed countries, causing approximately 7 million deaths every year worldwide. Cancer rates vary dramatically in different regions and populations around the globe, especially between
Partha Pratim Roy et al.
Bioorganic chemistry, 56, 1-7 (2014-06-03)
The objective of the present work was tantamount to explain the antiperoxidative potential and structural requirements of twenty-eight structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation. Both experimental and computational approaches were taken to the work. The experiments were
Mrinmay Chakrabarti et al.
Experimental cell research, 319(10), 1575-1585 (2013-04-09)
Decrease in expression of the tumor suppressor microRNA-138 (miR-138) correlates well with an increase in telomerase activity in many human cancers. The ability of almost all human cancer cells to grow indefinitely is dependent on presence of telomerase activity. The
Jing Li et al.
Journal of Asian natural products research, 15(9), 969-973 (2013-10-01)
Two novel constituents, named erigeronones A (1) and B (2), together with apigenin-7-O-β-galacturonide (3), quercetin-7-O-β-glucuronide (4), quercetin-3-O-β-galacturonide (5), and eriodictyol-7-O-β-glucuronide (6), were isolated from the whole grass of Erigeron breviscapus (Vant) Hand.-Mazz (Compositae). Their structures were established on the basis
Lei Wang et al.
Toxicology and applied pharmacology, 272(1), 108-116 (2013-06-08)
Environmental exposure to arsenic is known to cause various cancers. There are some potential relationships between cell malignant transformation and C-X-C chemokine receptor type 4 (CXCR4) expressions. Metastasis, one of the major characteristics of malignantly transformed cells, contributes to the
Qing Liu et al.
Journal of natural products, 77(7), 1594-1600 (2014-06-24)
Six new diterpenoids, 4-epi-7α-O-acetylscoparic acid A (1), 7α-hydroxyscopadiol (2), 7α-O-acetyl-8,17β-epoxyscoparic acid A (3), neo-dulcinol (4), dulcinodal-13-one (5), and 4-epi-7α-hydroxydulcinodal-13-one (6), and a new flavonoid, dillenetin 3-O-(6″-O-p-coumaroyl)-β-D-glucopyranoside (10), along with 12 known compounds, were isolated from the aerial parts of Scoparia
Yan-Mei Sun et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 962, 59-67 (2014-06-08)
A fast analytical strategy of second-order calibration method based on the alternating trilinear decomposition algorithm (ATLD)-assisted high performance liquid chromatography coupled with a diode array detector (HPLC-DAD) was established for the simultaneous determination of eight flavonoids (rutin, quercetin, luteolin, kaempferol
Eugen J Verspohl et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(5), 427-431 (2013-01-30)
Gastrointestinal discomfort is frequently observed. The effects of Perilla frutescens extract and Vicenin 2 (a compound in this extract) were assayed in rat ileum with or without stimulation with acetylcholine or Ba(2+). Both had no direct spasmolytic effect, but both
Huizhen Guo et al.
Neurochemical research, 39(11), 2197-2210 (2014-09-12)
Ischemic stroke has been confirmed to cause neuronal injury due to its insufficient supply of glucose and oxygen to brain tissue. Previous research has shown that oxidative stress, a result of excessive accumulation of reactive oxygen species (ROS), relates to
Ming-Der Shi et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(8-9), 743-752 (2013-03-30)
Hepatocyte growth factor (HGF), and its receptor, c-Met activation has recently been shown to play important roles in cancer invasion and metastasis in a wide variety of tumor cells. We use HGF as an invasive inducer of human HepG2 cells
Li-Wei Zhu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(19), 3373-3377 (2014-01-16)
To develop a HPLC method for determination of the concentration of scutellarin and scutellarin ethyl ester and their pharmacokinetics were also compared. 104 mg kg-1of scutellarin or 114. 5 mg kg-1 scutellarin ethyl ester were given at single dose by
O Kenny et al.
Food chemistry, 161, 79-86 (2014-05-20)
Antimicrobial properties of ethanol and water extracts from eight Asteraceae species were investigated against three Gram positive (Staphylococcus aureus, MRSA and Bacillus cereus) and two Gram negative (Escherichia coli and Salmonella typhimurium) bacterial strains. Ethanol extracts from Centaurea scabiosa, Arctium
Young-Ah Suh et al.
International journal of oncology, 46(3), 1405-1411 (2014-12-30)
Ovarian cancer is the number one cause of death from gynaecological malignancy. Platinum-based and taxol-based chemotherapy has been used as a standard therapy, but intrinsic and acquired resistance to chemotherapy is a major obstacle to treat the disease. In the
Melissa A Vargo et al.
Biochemical pharmacology, 72(6), 681-692 (2006-07-18)
Apigenin, a flavone abundantly found in fruits and vegetables, exhibits antiproliferative, anti-inflammatory, and antimetastatic activities through poorly defined mechanisms. In the present study, the treatment of different cell lines with apigenin resulted in selective antiproliferative and apoptotic effect in monocytic
Cheng-Hua He et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(9), 1416-1420 (2013-08-16)
To establish an in situ single-way intestinal perfusion model, in order to study the intestinal absorption kinetics of AP. The concentration of AP in the perfusate was determined by HLPC. The results showed different AP concentrations in all intestinal segments
Paolino Ninfali et al.
Journal of the science of food and agriculture, 93(12), 3087-3093 (2013-03-26)
In the Chenopodiaceae family, the apigenin flavonoids vitexin-2-O-xyloside (VOX) and vitexin-2-O-rhamnoside (VOR) are important chemopreventive components. To investigate their bioavailability in in vivo animal studies an enzyme-linked immunosorbent assay (ELISA) method has been developed. The ELISA was based on polyclonal
Yi Zhu et al.
Molecular medicine reports, 11(2), 1004-1008 (2014-10-30)
The mortality rate associated with prostate cancer is mainly due to metastases rather than primary organ‑confined disease. Decreasing the incidence of metastasis is important in treating prostate cancer. 4',5,7‑trihydroxyflavone (apigenin) has been demonstrated to be effective in inhibiting several types
Uroš Gašić et al.
Journal of AOAC International, 97(5), 1259-1267 (2015-04-24)
Composition of phenolic compounds and the sugar content were determined as the basis for characterization of lime honey from Serbia. Particular attention was given to differences in phytochemical profiles of ripe and unripe lime honey and lime tree nectar. Melissopalynological
Buyun Ding et al.
Journal of nanoscience and nanotechnology, 13(10), 6546-6552 (2013-11-20)
In the present study, apigenin loaded lipid nanocapsules (AP-LNC) was prepared with phase inversion method and the formulation was optimized by simplex lattice design experiment with drug loading and encapsulation efficiency as the indexes. The drug loading and encapsulation efficiency
Ana Mara de Oliveira E Silva et al.
Phytotherapy research : PTR, 29(1), 125-133 (2014-10-17)
Rosmarinus officinalis L. phenolic compounds have attracted considerable attention because of their antioxidant and antimicrobial properties, including its ability to treat inflammatory disorders. In this work, we investigated the in vivo and in vitro effects of R. officinalis aqueous extract
Si Hyoung Kim et al.
Molecular and cellular endocrinology, 369(1-2), 130-139 (2013-02-05)
Apigenin promotes apoptosis in cancer cells. We studied the effect of apigenin on cell survival and c-Myc expression in FRO anaplastic thyroid carcinoma (ATC) cells. Apigenin caused apoptosis via the elevation of c-Myc levels in conjunction with the phosphorylation of
Yolanda Corbett et al.
Microbes and infection, 17(3), 184-194 (2014-12-03)
In malaria, the evidence concerning the nucleotide-binding, oligomerization domain (NOD) 2 (NOD2) receptor is fragmented and the stimuli that might activate NOD2 are not well characterized. We investigated the role of NOD2 in vitro in the response of macrophages to Plasmodium
Monika A Zielińska-Pisklak et al.
Journal of pharmaceutical and biomedical analysis, 102, 54-63 (2014-09-23)
The antioxidant activity of the crude extract (60% ethanol) from the leaves of Desmodium adscendens (Sw.) DC. (Fabaceae) was observed in DPPH, xanthine/xanthine oxidase, lipid peroxydation and neutrophils burst tests. Further activity-guided fractionation on C18 column (water, 20% methanol, 50%
Sivaprakasam Balasubramanian et al.
The Journal of biological chemistry, 281(47), 36162-36172 (2006-09-20)
Apigenin is a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent. In the present study, we examine the mechanism whereby apigenin regulates normal human keratinocyte differentiation. Expression of involucrin (hINV), a marker of keratinocyte differentiation, is
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