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Behnusch Athenstädt et al.
Rapid communications in mass spectrometry : RCM, 26(16), 1810-1816 (2012-07-11)
Plastics are increasingly used as packaging materials for pharmaceuticals. However, diffusion of compounds in plastic into drugs may endanger patients' health. Regulatory authorities therefore demand detailed information about leachable compounds in plastics. Here we identify migrating components of a sterilization-resistant
Wenshou Wang et al.
Nature communications, 5, 5459-5459 (2014-12-03)
The invention of paper as writing materials has greatly contributed to the development and spread of civilization. However, its large-scale production and usage have also brought significant environment and sustainability problems to modern society. To reduce paper production and consumption
Ze-Jian Wang et al.
Journal of photochemistry and photobiology. B, Biology, 115, 16-24 (2012-07-17)
Photodynamic therapy (PDT) has recently been proposed as a possible indication in the conservative treatment of hereditary retinoblastoma. In order to create photosensitizers with enhanced targeting ability toward retinoblastoma cells, meso-tetraphenylporphyrins bearing one glycodendrimeric moiety have been synthesized. The binding
Asuman C Kucuk et al.
Langmuir : the ACS journal of surfaces and colloids, 27(10), 6381-6388 (2011-04-16)
"Core-corona" type amphiphiles, which comprise double-decker-shaped POSSs (DDSQs) as the core and two or four di(ethylene glycol) (DEG) units as the coronae, have recently been reported to form a stable monolayer at the air-water interface. In this paper, another core-corona
Parisa Sadatmousavi et al.
Acta biomaterialia, 8(9), 3241-3250 (2012-05-30)
Self-assembling peptide nanofibers have emerged as important nanobiomaterials, with such applications as delivery of therapeutic agents and vaccines, nanofabrication and biomineralization, tissue engineering and regenerative medicine. Recently a new class of self-assembling peptides has been introduced, which takes into consideration
Two centuries of assessing drug risks.
Jerry Avorn
The New England journal of medicine, 367(3), 193-197 (2012-07-20)
Nestor R Sosa et al.
Annals of emergency medicine, 64(1), 38-47 (2014-01-21)
Diethylene glycol is a toxic industrial solvent responsible for more than 13 mass poisonings since 1937. Little is known about the clinical spectrum, progression, and neurotoxic potential of diethylene glycol-associated disease because of its high mortality and the absence of
Hsiao-yin Yang et al.
Pharmaceutical research, 32(2), 680-690 (2014-08-29)
To develop a bio-assay for measuring long-term bioactivity of released anti-inflammatory compounds and to test the bioactivity of celecoxib (CXB) and triamcinolone acetonide (TA) released from a new PLGA-based microsphere platform. Human osteoarthritic chondrocytes were plated according to standardized procedures
Joshua G Schier et al.
Journal of public health policy, 30(2), 127-143 (2009-07-15)
Diethylene glycol (DEG), an extremely toxic chemical, has been implicated as the etiologic agent in at least 12 medication-associated mass poisonings over the last 70 years. Why DEG mass poisonings occur remains unclear. Most reports do not contain detailed reports
J A Prince et al.
Scientific reports, 4, 6555-6555 (2014-10-10)
Bio-fouling is a serious problem in many membrane-based separation processes for water and wastewater treatment. Current state of the art methods to overcome this are to modify the membranes with either hydrophilic additives or with an antibacterial compound. In this
Julian Schubert et al.
Nature genetics, 46(12), 1327-1332 (2014-11-05)
Febrile seizures affect 2-4% of all children and have a strong genetic component. Recurrent mutations in three main genes (SCN1A, SCN1B and GABRG2) have been identified that cause febrile seizures with or without epilepsy. Here we report the identification of
Leo J Schep et al.
Clinical toxicology (Philadelphia, Pa.), 47(6), 525-535 (2009-07-10)
Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. In addition to its use in a wide range of industrial products, it has also been involved in a number of prominent mass poisonings
Tao Zhou et al.
Journal of separation science, 30(16), 2620-2627 (2007-09-21)
A simple and reliable HPLC method was developed for the simultaneous quantitative analysis of diethylene glycol (DEG) and propylene glycol (PG) in pharmaceutical products by precolumn derivatization. The derivatization reagent p-toluenesulfonyl isocyanate (TSIC, 10 microL, 20% in ACN v/v) was
Laurent Imbert et al.
Journal of analytical toxicology, 38(9), 676-680 (2014-09-05)
A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters
Evgeni Eltzov et al.
Analytical chemistry, 87(7), 3655-3661 (2015-03-17)
Indoor air pollution became a recent concern found to be oftentimes worse than outdoor air quality. We developed a tool that is cheap and simple and enables continuous monitoring of air toxicity. It is a biosensor with both a nondisposable
Formation of diethylene glycol as a side reaction during production of polyethylene terephthalate.
Hovenkamp, S. G., and J. P. Munting.
Journal of Polymer Science. Part A-1, Polymer Chemistry, 8.3, 679-682 (1970)
Navjyoti Chakraborty et al.
PloS one, 10(2), e0117819-e0117819 (2015-02-11)
The controversy over the existence or the need for G-protein coupled receptors (GPCRs) in plant G-protein signalling has overshadowed a more fundamental quest for the role of AtGCR1, the most studied and often considered the best candidate for GPCR in
Nurhan Özlü et al.
The EMBO journal, 34(2), 251-265 (2014-12-06)
The cell surface is the cellular compartment responsible for communication with the environment. The interior of mammalian cells undergoes dramatic reorganization when cells enter mitosis. These changes are triggered by activation of the CDK1 kinase and have been studied extensively.
Rosamund Modupe Akuse et al.
Pediatric nephrology (Berlin, Germany), 27(6), 1021-1028 (2012-01-17)
In 2008, several Nigerian children developed acute kidney injury (AKI) after ingesting teething syrup contaminated with diethylene glycol (DEG). Because there are limited diagnostic facilities in resource-constrained countries, this study investigated whether AKI associated with DEG could be identified by
Christopher O Hoyte et al.
Clinical toxicology (Philadelphia, Pa.), 50(6), 525-527 (2012-06-15)
Diethylene glycol is a toxic alcohol used as an industrial solvent in various products. Human exposure to diethylene glycol has resulted in multisystem organ dysfunction and death in cases of acute intentional ingestions as well as epidemics of mass poisoning.
Qing Liu et al.
Journal of environmental sciences (China), 28, 29-36 (2015-02-11)
Pollution of antibiotics, a type of emerging contaminant, has become an issue of concern, due to their overuse in human and veterinary application, persistence in environment and great potential risk to human and animal health even at trace level. In
Validated gas chromatographic-mass spectrometric assay for determination of the antifreezes ethylene glycol and diethylene glycol in human plasma after microwave-assisted pivalylation
Maurer HH, et al.
Journal of Chromatography. B, Biomedical Applications, 754(2), 401-409 (2001)
Marcio Salazar et al.
Archives of oral biology, 60(5), 776-781 (2015-03-15)
The aim of the present study was to evaluate the effect of two different dosages of alendronate on induced orthodontic movement in an experimental model involving rats with osteoporosis following ovariectomy. Female Wistar rats (Rattus norvegicus) eight weeks of age
Sonja Klee et al.
Rapid communications in mass spectrometry : RCM, 28(14), 1591-1600 (2014-06-05)
Atmospheric pressure chemical ionization (APCI) sources operated with point to plane DC discharges ('Coronas') frequently suffer from point electrode degradation and potentially lead to oxidation and/or fragmentation of the generated analyte ions. It is postulated that these adverse effects are
S Srivastava et al.
Journal of colloid and interface science, 359(1), 104-111 (2011-04-26)
In this study, we describe the development of a facile and effective route for the synthesis of Fe(3)O(4)-based T(1) contrast agent, which can be useful for in vivo magnetic resonance (MR) imaging. Citrate-coated Fe(3)O(4) nanoparticles (6 nm) with a narrow
Jeffrey Brent
Clinical toxicology (Philadelphia, Pa.), 48(5), 401-406 (2010-07-01)
The use and clinical efficacy of the alcohol dehydrogenase inhibitor fomepizole is well established for the treatment of ethylene glycol and methanol poisonings in adults. A computerized search of the U.S. National Academy of medicine and EMBase databases was undertaken
Fast determination of toxic diethylene glycol in toothpaste by ultra-performance liquid chromatography-time of flight mass spectrometry
Hernandez F, et al.
Analytical and Bioanalytical Chemistry, 391(3), 1021-1021 (2008)
Luc Faucher et al.
Nanotechnology, 22(29), 295103-295103 (2011-06-23)
Ultra-small gadolinium oxide nanoparticles (US-Gd(2)O(3)) are used to provide 'positive' contrast effects in magnetic resonance imaging (MRI), and are being considered for molecular and cellular imaging applications. However, these nanoparticles can aggregate over time in aqueous medium, as well as
Andrea Tornambè et al.
Marine environmental research, 77, 141-149 (2012-01-17)
Diethylene glycol (DEG) is commonly used to dehydrate natural gas in off-shore extraction plants and to prevent formation of gas hydrates. It may be released into the sea accidentally or in discharged produced waters (PWs). PWs samples from off-shore gas
Nandi J Reddy et al.
Clinical toxicology (Philadelphia, Pa.), 48(10), 967-973 (2011-01-05)
Ethylene glycol, diethylene glycol and methanol are widely available chemicals and are found in a variety of common household products including antifreeze, windshield washer fluid, brake fluid and lubricants. Following ingestion of these glycols and methanol, patients frequently develop an
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