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Mazin A Zamzami et al.
Bioelectrochemistry (Amsterdam, Netherlands), 143, 107982-107982 (2021-10-30)
The large-scale diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is important for traceability and treatment during pandemic outbreaks. We developed a fast (2-3 min), easy-to-use, low-cost, and quantitative electrochemical biosensor based on carbon nanotube field-effect transistor (CNT-FET) that allows
Yimu Li et al.
Journal of microencapsulation, 31(8), 805-814 (2014-08-05)
The aim of the present study is to construct a type of polyion complex micelles made of PF127-PEI copolymer and cholic acid (CA) and to evaluate the potential of this type of micelles as a targeted drug delivery system for
Kunihiko Seno et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 24(4), 505-508 (2008-04-12)
1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCl) is a very useful agent to form amide bonds (peptide bonds) in an aqueous medium. A simple and fast detection system was developed using the reaction with pyridine and ethylenediamine in acidic aqueous solution and spectrophotometric flow
Yu Tao et al.
Biomaterials, 35(37), 9963-9971 (2014-09-17)
Graphene oxide (GO) has attracted tremendous research interest due to its excellent electrical, thermal, and mechanical properties. Here, we apply the polyethylene glycol (PEG) and polyethylenimine (PEI) dual-polymer-functionalized GO (GO-PEG-PEI) as the carrier for efficient CpG delivery. GO-PEG-PEI can significantly
Ahu Arslan Yildiz et al.
Analytical biochemistry, 423(1), 39-45 (2012-02-07)
The analysis of membrane proteins is notoriously difficult because isolation and detergent-mediated reconstitution often results in compromising the protein structure and function. We introduce a novel strategy of combining a cell-free expression method for synthesis of a protein species coping
Cailuan Lu et al.
PloS one, 9(7), e101898-e101898 (2014-07-08)
Molecular magnetic resonance imaging (mMRI) has been paid more and more attention for early diagnosis of cancer. A sensitive and specific mMRI probe plays the most important role in this technique. In this study, superparamagnetic iron oxide (SPIO) nanoparticles and
Ju Du et al.
AAPS PharmSciTech, 15(6), 1535-1544 (2014-08-01)
Incorporation of drug-loaded nanoparticles into swellable and respirable microparticles is a promising strategy to avoid rapid clearance from the lung and achieve sustained drug release. In this investigation, a copolymer of polyethylene glycol grafted onto phthaloyl chitosan (PEG-g-PHCs) was synthesized
Understanding bacterial uptake by protozoa: A versatile technique for surface modification of bacteria
Siegmund L and Wostemeyer J
Endocytobiosis and cell research, 27, 17-21 (2016)
Aki Stubb et al.
Nano letters, 20(4), 2230-2245 (2020-03-07)
Cellular mechanics play a crucial role in tissue homeostasis and are often misregulated in disease. Traction force microscopy is one of the key methods that has enabled researchers to study fundamental aspects of mechanobiology; however, traction force microscopy is limited
Natalie L Leong et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(2), 229-236 (2014-11-05)
Anterior cruciate ligament (ACL) rupture is a common injury often necessitating surgical treatment with graft reconstruction. Due to limitations associated with current graft options, there is interest in a tissue-engineered substitute for use in ACL regeneration. While they represent an
Chunfeng Zhao et al.
Clinical orthopaedics and related research, 472(9), 2569-2578 (2014-06-08)
Adhesions and poor healing are complications of flexor tendon repair. The purpose of this study was to investigate a tissue engineering approach to improve functional outcomes after flexor tendon repair in a canine model. Flexor digitorum profundus tendons were lacerated
Amit K Jha et al.
PloS one, 9(6), e98640-e98640 (2014-06-18)
Osteogenic differentiation of human mesenchymal stem cells (hMSCs) is guided by various physical and biochemical factors. Among these factors, modulus (i.e., rigidiy) of the ECM has gained significant attention as a physical osteoinductive signal that can contribute to endochondral ossification
Rouhollah Khodadust et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(8), 979-987 (2014-12-03)
The objective of this study was to develop and evaluate the anticancer activity and the safety of a combinational drug delivery system using polyamidoamine (PAMAM) dendrimer-coated iron oxide nanoparticles for doxorubicin and poly I:C delivery in vitro. Dendrimer-coated magnetic nanoparticles
Erman Karakuş et al.
Analytica chimica acta, 1182, 338939-338939 (2021-10-05)
Since emerging in China in December 2019, COVID-19 has spread globally, wreaked havoc for public health and economies worldwide and, given the high infectivity and unexpectedly rapid spread of the virus responsible-that is, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-urged
Ioanna Sandvig et al.
Journal of biomedical materials research. Part A, 103(3), 896-906 (2014-05-16)
One of the main challenges in tissue engineering and regenerative medicine is the ability to maintain optimal cell function and survival post-transplantation. Biomaterials such as alginates are commonly used for immunoisolation, while they may also provide structural support to the
Ahmed Gomaa et al.
Food chemistry, 175, 585-592 (2015-01-13)
Food allergy is a public health concern and an important food safety issue. Food allergies affect up to 6% of infants and children and 4% of adults. The objective of this work was to determine differences in the detection of
Nathan A Hotaling et al.
Biomaterials, 35(22), 5862-5874 (2014-04-22)
Carbohydrates and glycoconjugates have been shown to exert pro-inflammatory effects on the dendritic cells (DCs), supporting pathogen-induced innate immunity and antigen processing, as well as immunosuppressive effects in the tolerance to self-proteins. Additionally, the innate inflammatory response to implanted biomaterials
Na Huang et al.
Analytica chimica acta, 853, 249-257 (2014-12-04)
In this paper, a novel electro-active graphene oxide (GO) nanocomposite was firstly prepared by covalently grafted (4-ferrocenylethyne) phenylamine (Fc-NH2) onto the surface of GO. The synthesized hybridized nanocomposite of GO-Fc-NH2 coupled with HAuCl4 simultaneously electrodeposited on the glassy carbon electrodes
Yasuo Yoshimi et al.
Analytica chimica acta, 862, 77-85 (2015-02-16)
In this work, the anodic current at an electrode grafted with a molecularly imprinted polymer (MIP) crosslinked via a combination of hydrophobic ethyleneglycol dimethacrylate (EDMA) and hydrophilic methylene bisacrylamide (MBAA) was found to exhibit enantioselective sensitivity to the phenylalanine template
Fumiki Yanagawa et al.
Advanced healthcare materials, 4(2), 246-254 (2014-08-15)
Photodegradable hydrogels have emerged as powerful platforms for studying and directing cellular behavior in a spatiotemporally controlled manner. Photodegradable hydrogels have previously been formed by free radical polymerizations, Michael-type addition reactions, and orthogonal click reactions. Here, an ester-activated photocleavable crosslinker
Lokman Liv et al.
Biosensors & bioelectronics, 192, 113497-113497 (2021-07-19)
The ongoing coronavirus disease 2019 (COVID-19) pandemic continues to threaten public health systems all around the world. In controlling the viral outbreak, early diagnosis of COVID-19 is pivotal. This article describes a novel method of voltammetrically determining severe acute respiratory
Basavaraj Siddalingappa et al.
PloS one, 10(3), e0118824-e0118824 (2015-03-24)
Resveratrol is naturally occurring phytochemical with diverse biological activities such as chemoprevention, anti-inflammatory, anti-cancer, anti-oxidant. But undergoes rapid metabolism in the body (half life 0.13h). Hence Polymer conjugation utilizing different chemical linkers and polymer compositions was investigated for enhanced pharmacokinetic
Katrien Forier et al.
Journal of controlled release : official journal of the Controlled Release Society, 195, 21-28 (2014-08-16)
Encapsulation of antibiotics into nanoparticles is a potential strategy to eradicate biofilms. To allow further optimization of nanomedicines for biofilm eradication, the influence of the nanoparticle size on the penetration into dense biofilm clusters needs to be investigated. In the
Adam J McShane et al.
Journal of the American Society for Mass Spectrometry, 25(10), 1694-1704 (2014-08-06)
Direct reductive methylation of peptides is a common method for quantitative proteomics. It is an active derivatization technique; with participation of the dimethylamino group, the derivatized peptides preferentially release intense a1 ions. The advantageous generation of a1 ions for quantitative
Yan Zhang et al.
Macromolecular bioscience, 14(6), 842-852 (2014-04-18)
This work deals with the synthesis of insulin loaded nanoparticles (NPs) composed of thiolated Eudragit L100 (Eul-cys) and reduced glutathione (GSH) as potential nanocarriers for oral delivery of insulin. Perfectly spherical NPs with an average particle size of nearly 200-300 nm
Yi Liu et al.
International journal of nanomedicine, 10, 2295-2311 (2015-04-08)
7-Ethyl-10-hydroxycamptothecin (SN38), an active metabolite of irinotecan (CPT-11), is a remarkably potent antitumor agent. The clinical application of SN38 has been extremely restricted by its insolubility in water. In this study, we successfully synthesized two macromolecular prodrugs of SN38 with
Chenbo Dong et al.
Environmental science. Nano, 1(6), 95-603 (2014-12-09)
Toxicity of engineered nanomaterials is associated with their inherent properties, both physical and chemical. Recent studies have shown that exposure to multi-walled carbon nanotubes (MWCNTs) promotes tumors and tumor-associated pathologies and lead to carcinogenesis in model
In-Cheol Sun et al.
Pharmaceutical research, 31(6), 1418-1425 (2013-08-13)
The application of gold nanoparticles (AuNPs) in biomedical field was limited due to the low stability in the biological condition. Herein, to enhance stability and tumor targeting ability of AuNPs, their surface was modified with biocompatible glycol chitosan (GC) and
Heather M Powell et al.
Biomaterials, 27(34), 5821-5827 (2006-08-22)
Collagen-based scaffolds are extensively utilized as an analog for the extracellular matrix in cultured skin substitutes (CSS). To improve the mechanical properties and degradation rates of collagen scaffolds, chemical cross-linking is commonly employed. In this study, freeze-dried collagen-GAG sponges were
Sabine Hauptstein et al.
Journal of pharmaceutical sciences, 103(2), 594-601 (2014-01-03)
The objective of this study was to generate a water-soluble thiolated chitosan to enable the permeation-enhancing effect of chitosan at pH of at least 5.5 without losing the advantages of improved mucoadhesive properties. Therefore, the thiol-bearing polyoxyethylene ligand {O-(3-carboxylpropyl)-O'-[2-[3-mercaptopropionylamino)ethyl]-polyethyleneglycol} was
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