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Mai Akada et al.
Cellular signalling, 26(12), 2879-2884 (2014-09-23)
Anoikis is a specific type of apoptosis induced by detachment of epithelial cells from extracellular matrix, and acquiring resistance to anoikis is an important step that enables cancer cells to metastasize. EphA2, which is overexpressed in a variety of human
Hui-Ying Liu et al.
World journal of gastroenterology, 21(10), 2918-2925 (2015-03-18)
To improve an asialoglycoprotein receptor (ASGPR)-based enrichment method for detection of circulating tumor cells (CTCs) of hepatocellular carcinoma (HCC). Peripheral blood samples were collected from healthy subjects, patients with HCC or various other cancers, and patients with hepatic lesions or
Omesha Perera et al.
Cancer letters, 361(1), 104-111 (2015-03-10)
Trefoil factor 3 (TFF3) is a secreted protein which functions in mucosal repair of the gastrointestinal tract. This is achieved through the combined stimulation of cell migration and prevention of apoptosis and anoikis, thus facilitating repair. Deregulated TFF3 expression at
Jianlin Wang et al.
Biochimica et biophysica acta, 1852(3), 395-405 (2014-12-09)
Drug resistance is the major cause of failure of cancer chemotherapy in ovarian cancer. However, the molecular mechanisms on the regulation of drug resistance are not fully understood. Here we showed that Trx1 and FOXO1 were involved in paclitaxel (PTX)-induced
Ewa Kilar et al.
Cancer biomarkers : section A of Disease markers, 15(1), 99-102 (2014-12-20)
Complement information about the share the role of antipapain activity in serum people with breast cancer. We measured the activity of cysteine peptidase inhibitors in the sera of 150 patients with breast cancer. Patients were divided into four groups depending
Xiao Lin Peng et al.
PloS one, 9(11), e113716-e113716 (2014-11-25)
Vascular endothelial hyperpermeability is one of the manifestations of endothelial dysfunction. Resveratrol (Res) is considered to be beneficial in protecting endothelial function. However, currently, the exact protective effect and involved mechanisms of Res on endothelial dysfunction-hyperpermeability have not been completely
Jun Liu et al.
Molecular medicine reports, 11(3), 1708-1714 (2014-11-08)
The aim of the present study was to explore the effect of hypoxia on ovarian cancer. A total of 6 samples were analyzed: SKOV3‑IP cells (ovarian cancer cell line); SKOV3‑IP and regulatory T (Treg) cells; SKOV3‑IP and cytotoxic T lymphocytes
Ryan G Spurrier et al.
The Journal of surgical research, 190(2), 399-406 (2014-05-27)
Short bowel syndrome causes significant morbidity and mortality. Tissue-engineered intestine may serve as a viable replacement. Tissue-engineered small intestine (TESI) has previously been generated in the mouse model from donor cells that were harvested and immediately reimplanted; however, this technique
Daniele Moretti et al.
PloS one, 10(2), e0117258-e0117258 (2015-02-07)
Calpain-3 is an intracellular cysteine protease, belonging to Calpain superfamily and predominantly expressed in skeletal muscle. In human melanoma cell lines and biopsies, we previously identified two novel splicing variants (hMp78 and hMp84) of Calpain-3 gene (CAPN3), which have a
Yuichi Ohnishi et al.
Oncology reports, 32(2), 780-786 (2014-06-14)
Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognized, the underlying mechanisms remain unclear. In the present study, we characterized cetuximab-resistant oral squamous cell carcinoma
Anu Jain et al.
The Journal of antimicrobial chemotherapy, 69(7), 1777-1784 (2014-04-29)
Gram-negative bacteria with diverse carbapenemases, including New Delhi metallo-β-lactamase (NDM) enzymes, have been increasingly recorded in the UK since 2007. We analysed patient data for NDM-positive isolates confirmed by the national reference laboratory from UK laboratories from February 2008 to
Jérôme Gouge et al.
The EMBO journal, 34(8), 1126-1142 (2015-03-13)
Eukaryotic DNA polymerase mu of the PolX family can promote the association of the two 3'-protruding ends of a DNA double-strand break (DSB) being repaired (DNA synapsis) even in the absence of the core non-homologous end-joining (NHEJ) machinery. Here, we
Petter Holland et al.
Traffic (Copenhagen, Denmark), 15(12), 1390-1405 (2014-09-13)
Mutations in the large BEACH domain-containing protein LYST causes Chediak-Higashi syndrome. The diagnostic hallmark is enlarged lysosomes and lysosome-related organelles in various cell types. Dysfunctional secretion of enlarged lysosome-related organelles has been observed in cells with mutations in LYST, but
EunByeol Han et al.
Archives of dermatological research, 307(1), 57-72 (2014-07-27)
Melanin is major factor that determines skin color as well as one of the defense systems that prevent the UV-induced damage. In case of abnormal concentration of melanin, skin diseases or problems occur such as albinism, leukoplakia, melasma, freckles, moles
Sushma Singh et al.
Rheumatology international, 34(10), 1395-1400 (2014-04-11)
MicroRNAs (miRNAs) are non-coding RNA that modulate the expression of multiple target genes at the post-transcriptional level. Single-nucleotide polymorphisms (SNPs) in pre-miRNAs can alter miRNA expression, and polymorphism in target molecules can affect binding to target mRNA. Studies have shown
A D Christensen et al.
Clinical and experimental immunology, 179(3), 485-499 (2014-10-11)
Regulatory T cells (Tregs ) are known to play an immunosuppressive role in the response of contact hypersensitivity (CHS), but neither the dynamics of Tregs during the CHS response nor the exaggerated inflammatory response after depletion of Tregs has been
Cecilia Augustsson et al.
Thrombosis research, 134(1), 132-137 (2014-05-03)
Tissue factor pathway inhibitor (TFPI) is present in plasma as full-length free TFPI (TFPIα) and as C-terminally degraded forms mainly associated with low-density lipoprotein particles (LDL-TFPI). Addition of TFPIα to plasma induces a prolongation of the clotting time when tested
Jeffrey R Bishop et al.
Psychopharmacology, 232(1), 145-154 (2014-08-07)
Type-3 metabotropic glutamate receptor gene (GRM3) single nucleotide polymorphisms (SNPs) have been associated with cognitive performance and prefrontal cortex brain activity in chronically treated schizophrenia patients. Whether these SNPs are associated with cognitive and symptom response to antipsychotic therapy has
ZhaoHui Luo et al.
BMC medical genomics, 8, 13-13 (2015-04-19)
A novel class of transcripts, long non-coding RNAs (lncRNAs), has recently emerged as a key player in several biological processes, and important roles for these molecules have been reported in a number of complex human diseases, such as autoimmune diseases
Ana Beatriz DePaula-Silva et al.
Virology, 477, 10-17 (2015-01-27)
Vpr and Vpx are a group of highly related accessory proteins from primate lentiviruses. Despite the high degree of amino acid homology within this group, these proteins can be highly divergent in their functions. In this work, we constructed chimeric
Jonathan M Locke et al.
Diabetologia, 58(4), 745-748 (2015-01-31)
Intronic single nucleotide polymorphisms (SNPs) in the CDKAL1 gene are associated with risk of developing type 2 diabetes. A strong correlation between risk alleles and lower levels of the non-coding RNA, CDKAL1-v1, has recently been reported in whole blood extracted
Florian Lelchat et al.
Applied microbiology and biotechnology, 99(6), 2637-2647 (2014-10-17)
Alteromonas macleodii subsp. fijiensis biovar deepsane is a deep-sea ecotype exopolysaccharide-producing bacteria isolated from the polychaete annelid Alvinella pompejana. The high molecular weight biopolymer HYD657 produced by this strain, is the first marine exopolysaccharide (EPS) to be commercialized for cosmetic
Carla L Ellis et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(6), 875-886 (2013-12-07)
Xp11 translocation renal cell carcinomas harbor chromosome translocations involving the Xp11 breakpoint, resulting in gene fusions involving the TFE3 gene. The most common subtypes are the ASPSCR1-TFE3 renal cell carcinomas resulting from t(X;17)(p11;q25) translocation, and the PRCC-TFE3 renal cell carcinomas
Katsuki Naitoh et al.
Journal of immunological methods, 418, 52-60 (2015-02-07)
Soluble Glycoprotein VI (GPVI) is an attractive marker for disorders marked by platelet activation, such as thrombotic microangiopathy, myocardial infarction, and stroke. Several groups have already developed an immunoassay for soluble GPVI; however, there are several discrepancies between the groups'
Maryam Monajemzadeh et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(9), 734-741 (2013-12-11)
Neuroblastoma is the most common extracranial solid tumor of children, accounting for an estimated 15% cancer-related deaths in this period. It has been hypothesized that drug resistance of cancer stem cells may be responsible for chemotherapy failure, sustained tumor growth
Mohannad Nassar et al.
Journal of endodontics, 41(2), 242-247 (2014-12-03)
The objectives of this study were to investigate the effect of phytic acid, inositol hexakisphosphate (IP6), as a final rinse on the surface of instrumented root canals and smear-layered flat dentin surfaces treated with sodium hypochlorite (NaOCl) and to evaluate
Yibo Zhuang et al.
The Journal of biological chemistry, 289(36), 25101-25111 (2014-07-26)
Proteinuria serves as a direct causative factor of renal tubular cell injury and is highly associated with the progression of chronic kidney disease via uncertain mechanisms. Recently, evidence demonstrated that both NLRP3 inflammasome and mitochondria are involved in the chronic
Andrew Fulton et al.
Journal of chromatography. A, 1389, 128-132 (2015-03-10)
Monoclonal antibodies (mAbs) are one of the fastest growing drug molecules targeting the treatment of diseases ranging from arthritis, immune disorders, and infectious diseases to cancer. Due to its unique application principle, antibodies are commonly produced in large quantities. Plants
Saif Ahmad et al.
Journal of neuroimmunology, 277(1-2), 96-104 (2014-12-03)
Traumatic optic neuropathy (TON) is associated with apoptosis of retinal ganglion cells. Local productions of reactive oxygen species and inflammatory mediators from activated microglial cells have been hypothesized to underlie apoptotic processes. We previously demonstrated that the anti-inflammatory effect of
Alireza Mehdizadeh et al.
Lasers in medical science, 29(3), 939-948 (2013-09-10)
The use of lasers has emerged to be highly promising for cancer therapy modalities, most commonly, the photothermal therapy method. Unfortunately, the most common disadvantage of laser therapy is its nonselectivity and requirement of high power density. The use of
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