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Jérémy Carlier et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 70-77 (2014-12-23)
Hypoglycin A (HGA) is the toxic principle in ackee (Blighia sapida Koenig), a nutritious and readily available fruit which is a staple of the Jamaican working-class and rural population. The aril of the unripe fruit has high concentrations of HGA
Antonis Myridakis et al.
Analytical and bioanalytical chemistry, 407(9), 2509-2518 (2015-02-04)
Phthalates, bisphenol A (BPA) and parabens (PBs), organic chemicals widely used in everyday products, are considered to be endocrine disruptors. We propose a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of seven phthalate metabolites, six PBs and BPA
Giovanni Licari et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 3-9 (2014-07-23)
1. Perhexiline, a chiral anti-anginal agent, may be useful to develop new cardiovascular therapies, despite its potential hepatotoxicity. 2. This study compared Dark Agouti (DA) and Sprague-Dawley (SD) rats, as models of perhexiline's metabolism and hepatotoxicity in humans. Rats (n
Phenylisothiocyanate and dansyl chloride precolumn derivatizations for the high-performance liquid chromatography analysis of the antitumoral agent ES-285 in dog plasma.
Maraschiello, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 791(1-2), 1-11 (2003)
M Lisa Manier et al.
Journal of mass spectrometry : JMS, 49(8), 665-673 (2014-07-22)
Imaging mass spectrometry (IMS) studies increasingly focus on endogenous small molecular weight metabolites and consequently bring special analytical challenges. Since analytical tissue blanks do not exist for endogenous metabolites, careful consideration must be given to confirm molecular identity. Here, we
DeQing Cao et al.
Drug and chemical toxicology, 38(1), 44-49 (2014-03-22)
A Type II pyrethroid pesticide β-cypermethrin is widely used in agriculture and domestic applications for pest control. However, the effect of β-cypermethrin on the glutamate neurotransmitter has not been well-documented. In the current study, mice were treated with 20, 40
Miguel López-Gómez et al.
Phytochemistry, 107, 32-41 (2014-09-16)
Polyamines (PAs) are low molecular weight aliphatic compounds that have been shown to be an important part of plant responses to salt stress. For that reason in this work we have investigated the involvement of PAs in the response to
Maria T Hultman et al.
Aquatic toxicology (Amsterdam, Netherlands), 159, 233-244 (2015-01-07)
Vitellogenin (Vtg) induction in primary fish hepatocytes has been proposed as an in vitro screening assay for ER agonists and antagonists, but has not yet been used extensively as a high-throughput screening tool due to poor reproducibility, sensitivity and overall
Tomofumi Santa
Biomedical chromatography : BMC, 25(1-2), 1-10 (2010-11-09)
Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) is one of the most prominent analytical techniques owing to its inherent selectivity and sensitivity. In LC/ESI-MS/MS, chemical derivatization is often used to enhance the detection sensitivity. Derivatization improves the chromatographic separation, and
Trace analysis of icariin in human serum with dansyl chloride derivatization after oral administration of Epimedium decoction by liquid chromatography tandem mass spectrometry.
Gong, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 860(2), 166-172 (2007)
Determination of the xenoestrogens 4-nonylphenol and bisphenol A by high-performance liquid chromatography and fluorescence detection after derivatisation with dansyl chloride.
Naassner, et al.
Journal of Chromatography A, 945(1-2), 133-138 (2002)
Barbara J Fuhrman et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 23(12), 2649-2657 (2014-12-05)
Interindividual differences in estrogen metabolism may partially account for differences in risks of estrogen-responsive cancers. We conducted a proof-of-performance study to assess the reproducibility of a LC/MS-MS method for measurement of 15 serum estrogens and metabolites (all 15 termed EM)
V Vijayabhaskar et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 27-36 (2015-03-24)
A rapid selective and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed for the quantitative determination of derivatised cytochrome P450-2C19 oxidation product (dansyl-4-OH mephenytoin) and its underivatised form (4-OH mephenytoin). Samples were anaysed on C18 column (Waters Xbridge, 50
Kristel Kodar et al.
Chembiochem : a European journal of chemical biology, 16(4), 683-693 (2015-02-04)
Trehalose glycolipids play an important role in the pathogenesis of Mycobacterium tuberculosis and are used as adjuvants for vaccines; however, much still remains unanswered about the mechanisms through which these glycolipids exert their immunomodulatory potential. Recently, the macrophage-inducible C-type lectin
Omar Abdel-Aziz et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 140, 229-240 (2015-01-24)
Simple, selective and reproducible spectrofluorimetric and spectrophotometric methods have been developed for the determination of vildagliptin and saxagliptin in bulk and their pharmaceutical dosage forms. The first proposed spectrofluorimetric method is based on the dansylation reaction of the amino group
Chen Chen et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 71, 74-80 (2014-06-10)
This study was conducted to determine the occurrence of the natural steroid hormones estrone (E1), 17α-estradiol (αE2), 17β-estradiol (βE2) and estriol (E3) in 38 commercial milk samples obtained from markets in Beijing, China. Liquid Chromatography coupled with tandem mass spectrometry
Gilles Provencher et al.
Journal of chromatography. A, 1348, 97-104 (2014-05-20)
Bisphenol A (BPA) and triclosan (TCS) are ubiquitous environmental phenols exhibiting endocrine disrupting activities that may be involved in various health disorders in humans. There is a need to measure separately free forms and conjugated metabolites because only the former
Christine N Habib et al.
Life sciences, 121, 10-15 (2014-11-30)
The present study was designed to investigate the effect of leptin on estrogen metabolism in prostatic cells. Malignant (PC-3) and benign (BPH-1) human prostate cells were treated with 17-β-hydroxyestradiol (1 μM) alone or in combination with leptin (0.4, 4, 40
Yu Zhu et al.
Molecular pharmaceutics, 12(2), 332-341 (2014-08-26)
Polycations are explored as carriers to deliver therapeutic nucleic acids. Polycations are conventionally pharmacological inert with the sole function of delivering therapeutic cargo. This study reports synthesis of a self-immolative polycation (DSS-BEN) based on a polyamine analogue drug N(1),N(11)-bisethylnorspermine (BENSpm).
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