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Che-Pei Kung et al.
Molecular cancer research : MCR, 13(2), 250-262 (2014-09-27)
The tumor-suppressor protein p53, encoded by TP53, inhibits tumorigenesis by inducing cell-cycle arrest, senescence, and apoptosis. Several genetic polymorphisms exist in TP53, including a proline to arginine variant at amino acid 72 (P72 and R72, respectively); this polymorphism alters p53
Renfeng Zhang et al.
Cancer letters, 357(1), 141-151 (2014-12-03)
To achieve a better understanding of mechanisms that underlie carcinogenesis and to identify novel target molecules for diagnosis and therapy of carcinoma, we previously identified 24 distinct gene clones by immunoscreening of a cDNA library derived from an ovarian cancer
S López-Estévez et al.
Gene therapy, 21(7), 673-681 (2014-05-09)
Suicide gene therapy (SGT) is a promising strategy for treating cancer. In this work, we show that thymidine phosphorylase (TP) deficiency, the underlying genetic defect in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), presents an opportunity to apply SGT using capecitabine, a commonly
Timothy R Donahue et al.
Journal of surgical oncology, 110(8), 952-959 (2014-08-19)
MicroRNA-21 (miR-21) is upregulated and inversely associated with survival in many cancer types, including pancreatic ductal adenocarcinoma (PDAC). We studied the predictive value of miR-21 levels for gemcitabine or 5-fluorouracil (5-FU) response in tumor cells (TCs) or cancer associated fibroblasts
Brian P Weiser et al.
Scientific reports, 5, 9695-9695 (2015-04-09)
We used a photoactive general anesthetic called meta-azi-propofol (AziPm) to test the selectivity and specificity of alkylphenol anesthetic binding in mammalian brain. Photolabeling of rat brain sections with [(3)H]AziPm revealed widespread but heterogeneous ligand distribution, with [(3)H]AziPm preferentially binding to
Tania Diaz et al.
Journal of surgical oncology, 109(7), 676-683 (2014-02-11)
Surgery is the standard treatment for colorectal cancer (CRC), and adjuvant chemotherapy has been shown to be effective in stage III but less so in stage II. We have analyzed the expression of the miR-200 family in tissue samples from
Lin Wang et al.
Diseases of the colon and rectum, 58(2), 186-192 (2015-01-15)
We previously conducted a prospective phase II clinical trial studying a unique 22-fraction neoadjuvant intensity-modulated radiotherapy with concurrent capecitabine treatment followed by total mesorectal excision for locally advanced rectal cancer. The objective of this study was to retrospectively review the
Jiujiao Gao et al.
PloS one, 9(7), e102590-e102590 (2014-07-16)
Resistance to fluoropyrimidine-based chemotherapy is the main reason for the failure of cancer treatment, and drug resistance is associated with an inability of tumor cells to undergo apoptosis in response to treatment. Alterations in the expression of epithelial cell adhesion
The wide gulf between stage III and stage IV colon cancer.
David T Ting et al.
The Lancet. Oncology, 15(8), 785-786 (2014-06-15)
Ganji Purnachandra Nagaraju et al.
Oncotarget, 5(20), 9980-9991 (2014-10-10)
Cell cycle progression and DNA synthesis are essential steps in cancer cell growth. Thymidylate synthase (TS) is a therapeutic target for 5FU. We tested the hypothesis that HSP90 transcriptional and functional inhibition can inhibit cell cycle progression, downregulate TS levels
Tullayakorn Plengsuriyakarn et al.
Clinical and experimental pharmacology & physiology, 42(3), 293-304 (2014-12-30)
Cholangiocarcinoma (CCA) is an important public health problem in several parts of South East Asia, particularly in Thailand. The limited availability of effective diagnostic tools for early stage CCA, including chemotherapeutic options, constitutes a major problem for treatment and control
Umesh Das et al.
Journal of cancer research and clinical oncology, 140(10), 1777-1782 (2014-06-05)
Preoperative or neoadjuvant chemotherapy is an option in patients with large operable breast cancer to facilitate the breast conservation and to downstage the disease to make inoperable breast cancer to operable one. It is also called the window of opportunity;
Junsong Chen et al.
Journal of bioscience and bioengineering, 118(2), 214-222 (2014-04-02)
Cancer cells behave differently in a three-dimensional (3D) cell culture compared with in the conventional two-dimensional (2D) one. Accumulated evidences indicate that the characteristics of cancer stem cells (CSCs) are different from common cancer cells due to their ability to
Jian Chen et al.
Oncotarget, 6(1), 355-367 (2014-11-27)
p21-Activated kinase 6 (PAK6) has been implicated in radiotherapy and docetaxel resistance. We have further evaluated PAK6 as a predictor of 5-fluorouracil (5-FU) treatment response in colon cancer. Here we report that in colon cancer PAK6 promotes tumor progression and
Xiao-Dong Liang et al.
PloS one, 9(6), e97739-e97739 (2014-06-07)
The mitotic spindle checkpoint (SAC) genes have been considered targets of anticancer therapies. Here, we sought to identify the attractive mitotic spindle checkpoint genes appropriate for human hepatocellular carcinoma (HCC) therapies. Through expression profile analysis of 137 selected mitotic spindle
P-H Chiang et al.
British journal of cancer, 111(6), 1089-1094 (2014-07-25)
Limited literature on the role of intraarterial chemotherapy as first-line therapy for penile squamous cell carcinoma is available. From 2005 to 2013, a total of 12 patients with various stages of penile squamous cell carcinoma received intraarterial chemotherapy. The chemotherapeutic
Barbara Pardini et al.
Carcinogenesis, 36(1), 82-86 (2014-11-05)
Colorectal cancer (CRC) is one of the most frequently diagnosed malignancies worldwide. It is routinely cured by a 5-fluorouracil (5-FU)-based chemotherapy which improves outcomes in patients. We investigated the effect of single nucleotide polymorphisms (SNPs) in two microRNA (miRNA)-encoding genes
Kateryna Kondratska et al.
Biochimica et biophysica acta, 1843(10), 2263-2269 (2014-03-04)
The store-operated calcium channels (SOCs) represent one of the major calcium-entry pathways in non-excitable cells. SOCs and in particular their major components ORAI1 and STIM1 have been shown to be implicated in a number of physiological and pathological processes such
Michael F Sorrentino et al.
Cardiology journal, 19(5), 453-458 (2012-10-09)
5-fluorouracil (5-FU) is a key chemotherapeutic agent in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, 5-FU also possesses several undesired cardiac toxicities, including coronary vasospasm, coronary thrombosis, cardiomyopathy, and sudden cardiac death. This review addresses
Eirini Panoilia et al.
Cancer chemotherapy and pharmacology, 75(4), 791-803 (2015-02-18)
To characterize the population pharmacokinetics of bevacizumab, its binding properties to VEGF165 and the effect of demographic data and VEGF-A polymorphisms on the interplay between bevacizumab serum pharmacokinetics and VEGF165 serum concentrations in patients with colorectal cancer stage IV. Bevacizumab
Yohei Nagai et al.
Anticancer research, 34(10), 5529-5535 (2014-10-03)
We evaluated the relationship between carcinoembryonic antigen half-life (CEA-HL) in the early period of induction chemotherapy for patients with liver metastases from colorectal cancer (CRLM) and their clinicopathological response. Seventy-four patients with initially unresectable CRLM received FOLFOX with or without
Meghavi N Patel et al.
AAPS PharmSciTech, 15(6), 1498-1508 (2014-07-19)
The aim of this research was to advance solid lipid nanoparticle (SLN) preparation methodology by preparing glyceryl monostearate (GMS) nanoparticles using a temperature-modulated solidification process. The technique was reproducible and prepared nanoparticles without the need of organic solvents. An anticancer
Xin Fu Liu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(12), 12409-12414 (2014-09-05)
Thymidylate synthase (TS) is a prognostic marker in various tumors. However, the results of previous investigations in gastric cancer (GC) were controversial. The objective of this article is to investigate whether TS expression is associated with clinical outcome in advanced
Chen Yu et al.
Oncology letters, 9(2), 701-708 (2015-01-27)
Guan Chang Fu Fang (GCFF) is a natural compound, which is extracted from three medicinal plants
Matthew D Pauly et al.
Journal of virology, 89(7), 3584-3597 (2015-01-16)
Lethal mutagenesis is a broad-spectrum antiviral strategy that exploits the high mutation rate and low mutational tolerance of many RNA viruses. This approach uses mutagenic drugs to increase viral mutation rates and burden viral populations with mutations that reduce the
M Bickeböller et al.
Oncogene, 34(9), 1150-1159 (2014-03-26)
The myristoylated alanine-rich C-kinase substrate (MARCKS) acts as a tumor suppressor in a variety of human neoplasms. In colorectal cancers (CRCs), MARCKS has been shown to be a preferential target of mutational inactivation in tumors following the microsatellite instability (MSI-H)
Hans-Joachim Schmoll et al.
The Lancet. Oncology, 15(13), 1481-1492 (2014-12-03)
Oxaliplatin-based adjuvant therapy is the standard of care for stage III colon cancer. Adjuvant capecitabine with or without oxaliplatin versus leucovorin and fluorouracil with or without oxaliplatin has not been directly compared; therefore, we aimed to analyse the efficacy and
5-fluorouracil: mechanisms of action and clinical strategies
Longley DB, et al.
Nature Reviews. Cancer, 3(5), 330-338 (2003)
Xiao-Long Chen et al.
PloS one, 8(4), e60320-e60320 (2013-04-18)
Gastric carcinoma (GC) is one of the highest cancer-mortality diseases with a high incidence rate in Asia. For surgically unfit but medically fit patients, palliative chemotherapy is the main treatment. The chemotherapy regimen of docetaxel, cisplatin and 5-fluorouracil (DCF) has
Wei Gao et al.
BioMed research international, 2014, 405860-405860 (2014-07-22)
The deregulated tumorigenic long non-coding RNA (lncRNA) has been reported in several malignancies. However, there is still no comprehensive study on tongue squamous cell carcinoma (SCC). Functional reannotation for the human lncRNA was carried out by ncFANs. Real-time quantitative PCR
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