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Patrice K Nicholas et al.
The Journal of the Association of Nurses in AIDS Care : JANAC, 25(4), 318-329 (2014-04-05)
Peripheral neuropathy is a common and vexing symptom for people living with HIV infection (PLWH). Neuropathy occurs in several different syndromes and is identified in the literature as distal sensory polyneuropathy or distal sensory peripheral neuropathy. More recently, the HIV...
Juliana C Perry et al.
Journal of sleep research, 23(2), 168-175 (2013-11-29)
Chronic short sleep duration has been linked to sympathoexcitation and increased risk of cardiovascular disease. The central nervous system plays an important role in the regulation of sympathetic activity. Thus, the present study evaluates the pre-autonomic neurones in the paraventricular...
Stephanie C Licata et al.
Psychiatry research, 224(1), 28-33 (2014-08-02)
Individuals with major depressive disorder (MDD) often use hypnotics like zolpidem (Ambien(®)) to improve sleep in addition to their selective serotonin reuptake inhibitor (SSRI) regimen. SSRIs act in part to restore disrupted GABAergic activity, but benzodiazepines and related drugs have...
Melissa A Farmer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(17), 5747-5753 (2014-04-25)
Chronic pain is often associated with sexual dysfunction, suggesting that pain can reduce libido. We find that inflammatory pain reduces sexual motivation, measured via mounting behavior and/or proximity in a paced mating paradigm, in female but not male laboratory mice....
Qiong Lin et al.
Gene, 554(1), 64-74 (2014-12-03)
Ponkan (Citrus reticulata Blanco cv. Ponkan) is an important mandarin citrus in China. However, the low ratio of sugars to organic acids makes it less acceptable for consumers. In this work, three stages (S120, early development stage; S195, commercial harvest...
Reihane Seifi Moroudi et al.
Molecular biology reports, 41(12), 8019-8030 (2014-09-07)
One of the important behaviors of dogs is trainability which is affected by learning and memory genes. These kinds of the genes have not yet been identified in dogs. In the current research, these genes were found in animal models...
Qinghua Tang et al.
The Analyst, 139(24), 6406-6413 (2014-10-18)
In this study, we developed a novel biomimetic electrochemical sensor sensitized with a Fe3O4@carboxyl-functionalized multiwalled carbon nanotube/chitosan nanocomposite layer using a molecularly imprinted film as a recognition element for the rapid detection of acephate and trichlorfon. The performance of the...
James M Kelley et al.
Journal of neuroinflammation, 5, 1-1 (2008-01-04)
Recent studies have demonstrated a role for spinal p38 MAP kinase (MAPK) in the development of chronic inflammation and peripheral arthritis and a role for GABA in the inhibition of p38 MAPK mediated effects. Integrating these data suggests that GABA...
Simone N Vigod et al.
Archives of women's mental health, 17(2), 87-95 (2014-01-15)
Deficiencies in the inhibitory functioning of gamma-aminobutyric acid (GABA) have been implicated in the pathophysiology of depressive disorders. Reproductive life cycle events, including menstruation, pregnancy, and menopause, are consistently associated with increased psychopathology, in particular mood disorders. Given that GABA-inhibitory...
Indri Purwana et al.
Diabetes, 63(12), 4197-4205 (2014-07-11)
γ-Aminobutyric acid (GABA) exerts protective and regenerative effects on mouse islet β-cells. However, in humans it is unknown whether it can increase β-cell mass and improve glucose homeostasis. To address this question, we transplanted a suboptimal mass of human islets...
Exercise modulates chloride homeostasis after spinal cord injury.
Cote MP, Gandhi S, Zambrotta M, et al.
The Journal of Neuroscience, 34(27), 8976-8987 (2014)
Barbara Strommer et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 234-242 (2014-08-28)
23-O-Acetylshengmanol 3-O-β-D-xylopyranoside (Ac-SM) isolated from Actaea racemosa L.-an herbal remedy for the treatment of mild menopausal disorders-has been recently identified as a novel efficacious modulator of GABAA receptors composed of α1-, β2-, and γ2S-subunits. In the present study, we analyzed...
Amanda Peltier et al.
BMJ (Clinical research ed.), 348, g1799-g1799 (2014-05-08)
Diabetes is a worldwide epidemic, and associated neuropathy is its most costly and disabling complication. Given the rising prevalence of painful diabetic neuropathy, it is increasingly important that we understand the best ways to diagnose and treat this condition. Diagnostic...
Isabella Premoli et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(16), 5603-5612 (2014-04-18)
Combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) constitutes a powerful tool to directly assess human cortical excitability and connectivity. TMS of the primary motor cortex elicits a sequence of TMS-evoked EEG potentials (TEPs). It is thought that inhibitory neurotransmission...
M Sidoryk-Wegrzynowicz et al.
Journal of internal medicine, 273(5), 466-477 (2013-01-31)
Manganese (Mn) is an essential trace element that is required for maintaining proper function and regulation of numerous biochemical and cellular reactions. Despite its essentiality, at excessive levels Mn is toxic to the central nervous system (CNS). Increased accumulation of...
Jae-Kwang Shim et al.
The Journal of thoracic and cardiovascular surgery, 148(1), 298-303 (2014-04-05)
Activation of presynaptic voltage-gated calcium channels and release of glutamate play a central role in neuronal necrosis after cardiopulmonary bypass with deep hypothermic circulatory arrest. Pregabalin binds to the α2-δ subunit of voltage-gated calcium channels resulting in reduced glutamate release....
Emerging perspectives in perioperative use of gabapentinoids.
Veena Kachhwah et al.
Anesthesiology, 121(2), 424-424 (2014-07-23)
Ruiqian Wan et al.
Journal of neurochemistry, 129(4), 573-580 (2014-01-31)
Autonomic control of heart rate is mediated by cardioinhibitory parasympathetic cholinergic neurons located in the brainstem and stimulatory sympathetic noradrenergic neurons. During embryonic development the survival and cholinergic phenotype of brainstem autonomic neurons is promoted by brain-derived neurotrophic factor (BDNF)....
Christopher J Earley
The Journal of clinical psychiatry, 75(4), e08-e08 (2014-05-13)
Restless legs syndrome (RLS) is a common disorder that can have a considerable impact on a patient's functioning and quality of life. The pharmacologic armamentarium for RLS contains dopamine agonists, a-2d ligands, and opioids, among other agents. Each of these...
Antoni Kowalski et al.
Postepy biochemii, 53(4), 356-360 (2008-11-26)
Gamma-aminobutyric acid is a major inhibitory neurotransmitter in the central nervous system. GABA metabolism is dependent on the activity of three enzymes: glutamic acid decarboxylase, GABA-transaminase and succinic semialdehyde dehydrogenase. Decreased activity of these enzymes may cause many neurological syndromes...
Haixing Li et al.
Amino acids, 39(5), 1107-1116 (2010-04-07)
Gamma-aminobutyric acid is a non-protein amino acid that is widely present in organisms. Several important physiological functions of gamma-aminobutyric acid have been characterized, such as neurotransmission, induction of hypotension, diuretic effects, and tranquilizer effects. Many microorganisms can produce gamma-aminobutyric acid...
Barna Dudok et al.
Nature neuroscience, 18(1), 75-86 (2014-12-09)
A major challenge in neuroscience is to determine the nanoscale position and quantity of signaling molecules in a cell type- and subcellular compartment-specific manner. We developed a new approach to this problem by combining cell-specific physiological and anatomical characterization with...
Elke Hattingen et al.
Epilepsia, 55(7), 1030-1037 (2014-06-07)
Juvenile myoclonic epilepsy (JME) has been considered to be a frontal variant of thalamocortical network dysfunction in epilepsy. Changes of γ-aminobutyric acid (GABA)ergic neurotransmission may play a key role in this dysfunction. Magnetic resonance spectroscopy (MRS) is the only noninvasive...
Rossana Coda et al.
International journal of food microbiology, 193, 34-42 (2014-12-03)
The effects of air classification and lactic acid bacteria fermentation on the reduction of anti-nutritional factors (vicine and convicine, trypsin inhibitor activity, condensed tannins and phytic acid) and in vitro protein and starch digestibility of faba bean flour were studied....
Hussein A N Al-Wadei et al.
Molecular nutrition & food research, 55(12), 1745-1758 (2011-08-02)
GABA is a bioactive constituent of fruits, vegetables, cereals and is believed to play a role in defense against stress in plants. In animals, it acts as an inhibitory neurotransmitter in brain while also expressed in non-neuronal cells. Studies have...
Jesse Jackson et al.
Nature neuroscience, 17(10), 1362-1370 (2014-09-01)
Activity flow through the hippocampus is thought to arise exclusively from unidirectional excitatory synaptic signaling from CA3 to CA1 to the subiculum. Theta rhythms are important for hippocampal synchronization during episodic memory processing; thus, it is assumed that theta rhythms...
Abdolreza Najafi Anaraki et al.
Archives of gynecology and obstetrics, 290(1), 47-52 (2014-02-13)
Pain after cesarean delivery is a leading cause of chronic pain and there are many attempts to reduce it without total success. Gabapentin is effective in reducing acute and chronic pain with little experience in parturient. The purpose of this...
Richard A DeFazio et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16296-16308 (2014-12-05)
Gonadotropin-releasing hormone (GnRH) secretion is regulated by estradiol feedback. This feedback switches from negative to positive in females; this switch depends on time of day in many species. Estradiol feedback is likely conveyed via afferents. Kisspeptin neurons of the arcuate...
Na-Hyun Kim et al.
Biochemical and biophysical research communications, 447(1), 205-209 (2014-04-08)
Major pelvic ganglia (MPG) are relay centers for autonomic reflexes such as micturition and penile erection. MPG innervate the urogenital system, including bladder. γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system, and may also...
Maram Hilwi et al.
The Journal of biological chemistry, 289(49), 34258-34266 (2014-10-24)
The sodium- and chloride-coupled GABA transporter GAT-1 is a member of the neurotransmitter:sodium:symporters, which are crucial for synaptic transmission. Structural work on the bacterial homologue LeuT suggests that extracellular loop 4 closes the extracellular solvent pathway when the transporter becomes...
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