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Hong-Bo Zhu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(9), 1386-1389 (2013-08-16)
To study the chemical constituents of Camellia sinensis var. assamica. The compounds were isolated by NKA Macroporous resin silica gel, Sephadex LH-20, RP-C18 column chromatographies and semi-preparative HPLC,and their structures were elucidated by physicochemical properties and spectral analysis. Thirteen compounds
Anna Vogiatzoglou et al.
The British journal of nutrition, 111(8), 1463-1473 (2013-12-18)
Dietary interventions with flavan-3-ols have shown beneficial effects on vascular function. The translation of these findings into the context of the health of the general public requires detailed information on habitual dietary intake. However, only limited data are currently available
Absorption, metabolism, and excretion of (-)-epicatechin in humans: an evaluation of recent findings.
Alan Crozier
The American journal of clinical nutrition, 98(4), 861-862 (2013-08-30)
Aleksander Salwiński et al.
Rapid communications in mass spectrometry : RCM, 28(18), 1957-1963 (2014-08-19)
Tyrosinase-coupled magnetic particles (EMPs) were used to demonstrate that resorcinol-containing tyrosinase inhibitors are oxidised by tyrosinase only in the presence of the enzyme's classic substrate. This shows the potential for the application of EMPs as a non-organic matrix for monitoring
Chee W How et al.
Biochimica et biophysica acta, 1838(5), 1215-1224 (2014-02-13)
Catechin flavonoids are the main components of green tea extracts which present broad potential physiological activities. Several of their biological activities seem to affect membrane-dependent cellular processes and it is known that some catechins interact with phospholipid membranes. In this
M Sałaga et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(11), 1069-1078 (2014-08-01)
Oenothera paradoxa (EP) preparations are commonly used in folk medicine to treat skin diseases, neuralgia, and gastrointestinal (GI) disorders. Several reports suggested that EP preparations exhibit potent anti-inflammatory and antioxidant activities both in vitro and in vivo. Here, we aimed
Juan Mielgo-Ayuso et al.
The British journal of nutrition, 111(7), 1263-1271 (2013-12-05)
The aim of the present study was to examine the effects of green tea epigallocatechin-3-gallate (EGCG) on changes in body composition, energy and substrate metabolism, cardiometabolic risk factors and liver function enzymes after an energy-restricted diet intervention in obese women.
Jehan S Al-Amri et al.
Indian journal of experimental biology, 51(5), 357-362 (2013-07-05)
Degeneration of dopamine (DA)-containing neurons in the substantia nigra of the midbrain causes Parkinson's disease (PD). Although neuroinflammatory response of the brain has long been speculated to play a role in the pathogenesis of this neurological disorder, the mechanism is
A Rinaldi et al.
Food chemistry, 164, 142-149 (2014-07-06)
The flavan-3-ol and proanthocyanidin composition of Aglianico seeds and skins were for the first time determined by HPLC-MS in comparison with the international grapes Merlot and Cabernet Sauvignon. Monomers [(+)-catechin C, (-)-epicatechin EC, (-)-epicatechin-3-O-gallate, ECG] and oligomers [B1, B2, B3
Chun-Mao Yuan et al.
Journal of Asian natural products research, 15(6), 638-643 (2013-05-15)
Two new compounds, khayseneganin I (1) and 2α,3α,16β-trihydroxy-20-acetoxy-20(R)-pregnane (2), along with six known compounds, 2α,3α,20-trihydroxy-16β-acetoxy-20(R)-pregnane (3), 2α,3β-dihydroxypregnan-16-one-2β,19-hemiketal (4), (+)-catechin (5), ivorenolide A (6), luteolin-7-O-α-l-rhamnoside (7), and ( - )-5'-methoxy-isolariciresinol-2a-O-β-d-xylopyranoside (8), were isolated from the leaves and twigs of Khaya senegalensis. The structures
Panpan Ye et al.
Molekuliarnaia biologiia, 47(2), 251-257 (2013-07-03)
(-)-Epigallocatechin gallate (EGCG), the most abundant component in green tea, has a potent anti-apoptotic activity. The purpose of this study was to investigate the protective effects of EGCG and their molecular mechanisms on high glucose-induced apoptosis of human lens epithelial
Burcu Bekdeşer et al.
Journal of agricultural and food chemistry, 62(46), 11109-11115 (2014-11-05)
Hypochlorous acid (HOCl) is an important reactive oxygen species (ROS) and non-radical and is taking part in physiological processes concerned with the defense of the organism, but there has been limited information regarding its scavenging by polyphenols. This study was
V N Pavlov et al.
Urologiia (Moscow, Russia : 1999), (2)(2), 42-44 (2013-06-26)
The article presents a method of conservative treatment of men with I-II stage prostatic adenoma using a combination of doxazosin and indigal, which has antioxidant, antiproliferative and anti-inflammatory properties, that allowed improving urodynamic parameters and reducing the progression prostate adenoma
Hyun-Ju Jang et al.
American journal of physiology. Endocrinology and metabolism, 305(12), E1444-E1451 (2013-10-24)
Insulin resistance, a hallmark of metabolic disorders, is a risk factor for diabetes and cardiovascular disease. Impairment of insulin responsiveness in vascular endothelium contributes to insulin resistance. The reciprocal relationship between insulin resistance and endothelial dysfunction augments the pathophysiology of
Paolo Cocci et al.
Gene, 545(2), 220-225 (2014-05-20)
Epigallocatechin gallate (EGCG), the major active component of the green tea, has recently been found to inhibit 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCoAR) activity in vitro and to modulate lipogenesis in vivo. In this study we have evaluated the effects of short-term in
Vondina R Moseley et al.
Anticancer research, 33(12), 5325-5333 (2013-12-11)
Colon cancer is still the second leading cause of cancer deaths in the United States. Epigenetic gene silencing involving DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) plays an important role in the progression of colon cancer. In the present study
S Misaka et al.
Clinical pharmacology and therapeutics, 95(4), 432-438 (2014-01-15)
This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β-blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green
Seyung S Chung et al.
Anticancer research, 35(1), 39-46 (2015-01-01)
The cancer stem cell (CSC) model postulates the existence of a small proportion of cancer cells capable of sustaining tumor formation, self-renewal and differentiation. Signal Transducer and Activator of Transcription 3 (STAT3) signaling is known to be selectively activated in
Akiko Takagaki et al.
Archives of microbiology, 196(10), 681-695 (2014-06-21)
Two intestinal bacterial strains MT4s-5 and MT42 involved in the degradation of (-)-epigallocatechin (EGC) were isolated from rat feces. Strain MT4s-5 was tentatively identified as Adlercreutzia equolifaciens. This strain converted EGC into not only 1-(3, 4, 5-trihydroxyphenyl)-3-(2, 4, 6-trihydroxyphenyl)propan-2-ol (1)
Sumit Bansal et al.
Natural product reports, 30(11), 1438-1454 (2013-09-24)
Extensive research on tea catechins, mainly (-)-epigallocatechin gallate, has shown numerous health promoting effects. However, various clinical studies demonstrated several issues associated with tea catechins which account for their poor systemic bioavailability. In order to improve pharmacological activity and bioavailability
Mi Ran Byun et al.
The Journal of biological chemistry, 289(14), 9926-9935 (2014-02-12)
Osteoporosis is a degenerative bone disease characterized by low bone mass and is caused by an imbalance between osteoblastic bone formation and osteoclastic bone resorption. It is known that the bioactive compounds present in green tea increase osteogenic activity and
Haixia Yang et al.
Biochemical pharmacology, 92(4), 599-606 (2014-12-03)
Procyanidins are the flavanols from polyphenols commonly found in fruits and red wine. Recent studies have shown that procyanidins possess potential anti-inflammatory activities. However, underlying mechanisms remain to be understood. Inflammasomes are multi-protein complexes composed of pro-caspase and pattern recognition
Heike J Wobst et al.
FEBS letters, 589(1), 77-83 (2014-12-02)
The accumulation of amyloid-beta (Aβ) and tau aggregates is a pathological hallmark of Alzheimer's disease. Both polypeptides form fibrillar deposits, but several lines of evidence indicate that Aβ and tau form toxic oligomeric aggregation intermediates. Depleting such structures could thus
Sarah-Ann Aelvoet et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16518-16532 (2014-12-05)
Alpha-synuclein (αSYN) aggregation plays a pivotal role in the pathogenesis of Parkinson's disease and other synucleinopathies. In this multistep process, oligomerization of αSYN monomers is the first step in the formation of fibrils and intracytoplasmic inclusions. Although αSYN oligomers are
Julia K Keppler et al.
Biochimica et biophysica acta, 1844(6), 1083-1093 (2014-03-05)
The structure of β-lactoglobulin (β-LG) is well characterized, but the exact location of binding sites for retinol and (-)-epigallocatechingallate (EGCG) is still a subject of controversy. Here we report that the genetic β-LG variants A, B and C have different
Lucie Trnková et al.
Biochimica et biophysica acta, 1830(3), 2671-2682 (2013-05-15)
Green tea is a rich source of polyphenols, mainly catechins (flavanols), which significantly contribute to the beneficial health effects of green tea in the prevention and treatment of various diseases. In this study the effects of four green tea catechins
Milan S Geybels et al.
American journal of epidemiology, 177(12), 1388-1398 (2013-06-01)
Flavonoids are natural antioxidants found in various foods, and a major source is black tea. Some experimental evidence indicates that flavonoids could prevent prostate cancer. We investigated the associations between flavonoid intake, black tea consumption, and prostate cancer risk in
Long-Ze Lin et al.
Journal of agricultural and food chemistry, 62(39), 9387-9400 (2014-07-18)
Oligomeric proanthocyanidins were successfully identified by UHPLC-PDA-HRMS(n) in a selection of plant-derived materials (jujube fruit, Fuji apple, fruit pericarps of litchi and mangosteen, dark chocolate, and grape seed and cranberry extracts). The identities of 247 proanthocyanidins were theoretically predicted by
C L Keen
Journal of the American College of Nutrition, 20(5 Suppl), 436S-439S (2001-10-18)
Cocoa and chocolate products have been delicacies for hundreds of years. Only recently have they been recognized as significant sources of phytochemicals with healthful effects. These foods are among the most concentrated sources of the procyanidin flavonoids, catechin and epicatechin.
Marie-Claude Denis et al.
Clinical science (London, England : 1979), 128(3), 197-212 (2014-07-30)
Cranberry fruit has been reported to have high antioxidant effectiveness that is potentially linked to its richness in diversified polyphenolic content. The aim of the present study was to determine the role of cranberry polyphenolic fractions in oxidative stress (OxS)
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