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Maria Chiara Monti et al.
Biochimica et biophysica acta, 1844(4), 713-721 (2014-02-18)
The proteasome, a complex multimeric structure strictly implicated in cell protein degradation, has gained the status of privileged drug target since its functional involvement in relevant pathways ruling the cell life, such as cell cycle, transcription and protein quality control...
Li Chen et al.
Chemico-biological interactions, 206(1), 76-82 (2013-09-03)
Herbal hepatotoxicity has been increasingly reported in clinical context, but the underlying mechanisms are poorly understood. Saikosaponin D (SSD) is a major component of saikosaponins isolated from Bupleurum falactum, a herb that has been linked to hepatotoxicity. Our current study...
Manu Sharma
Molecules (Basel, Switzerland), 18(3), 3442-3444 (2013-03-16)
An article by Sasidharan et al. recently published in the journal Molecules [1] claimed to show the hepatoprotective effects of lantadene A against acetaminophen-induced liver damage in mice. While reading this paper, I came across certain points that need to...
Flora Pensec et al.
Journal of agricultural and food chemistry, 62(32), 7998-8007 (2014-07-25)
Triterpenoids present in grape cuticular waxes are of interest due to their potential role in protection against biotic stresses, their impact on the mechanical toughness of the fruit surface, and the potential industrial application of these biologically active compounds from...
Claudio Baiocchi et al.
European journal of mass spectrometry (Chichester, England), 19(1), 1-15 (2013-07-12)
The many effects of the African medicinal herb Desmodium adscendens were studied in the 1980s and 1990s. In spite of this, a comprehensive analytical protocol for the quality control of its constituents (soyasaponins, alkaloids and flavonoids) has not yet been...
Pooi Yin Chung et al.
PloS one, 8(2), e56687-e56687 (2013-02-26)
Staphylococcus aureus is an important human pathogen in both hospital and the community that has demonstrated resistance to all currently available antibiotics over the last two decades. Multidrug-resistant isolates of methicillin-resistant S. aureus (MRSA) exhibiting decreased susceptibilities to glycopeptides has...
Sejeong Kim et al.
PloS one, 10(3), e0118800-e0118800 (2015-03-11)
This study investigated the antimicrobial action of oleanolic acid against Listeria monocytogenes, Enterococcus faecium, and Enterococcus faecalis. To determine the cytotoxicity of oleanolic acid, HEp-2 cells were incubated with oleanolic acid at 37°C. MICs (minimal inhibition concentrations) for L. monocytogenes...
Israel Matos et al.
Molecular immunology, 54(3-4), 482-492 (2013-03-05)
The pentacyclic triterpene α,β-amyrin has been previously reported as an effective compound in the treatment of several inflammatory conditions. Recent evidence indicates that α,β-amyrin displayed its effects through interaction with the cannabinoid pathway. We assessed the anti-inflammatory effects of the...
Duraisamy Ramasamy et al.
Natural product communications, 8(4), 433-434 (2013-06-07)
A new oleanane triterpenoid, methyl 27-caffeoyloxyoleanolate (2), together with eight known compounds viz. oleanolic acid, kaempferol, quercetin, beta-sitosterol-3-O-beta-D-glucopyranoside, kaempferol-3-O-alpha-D-rhamnopyranoside, gossypin, quercetin-3-O-beta-D-glucopyranoside and mangiferin were isolated from the ethanol extract of roots of Hibiscus vitifolius Linn. The structure of the new...
Aminu Muhammad et al.
Natural product communications, 8(10), 1435-1437 (2013-12-21)
The stem bark extracts of Bauhinia rufescens Lam. (Fabaceae) yielded 6-methoxy-7-methyl-8-hydroxydibenz[b,f]oxepin, alpha-amyrin acetate, beta-sitosterol 3-O-beta-D-xylopyranoside, 4-(2'-Hydroxyphenethyl)-5-methoxy-2-methylphenol, menisdaurin and sequoyitol. Their structures were determined using spectroscopic methods and comparisons with the literature data. For the antimicrobial assay Gram-positive and Gram-negative bacterial...
Rui-Song Huang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(5), 762-767 (2013-06-04)
To establish quality standard of Zhuang medicine Lonicera dasystyla, and provide scientific basis for the quality control of L. dasystyla. Characteristics of materia medica, microscopic features, TLC indentification, inspection, extractum and determination of chlorogenic acid, macranthoidin B, dipsacoside B were...
J Liu
Journal of ethnopharmacology, 49(2), 57-68 (1995-12-01)
Oleanolic acid and ursolic acid are triterpenoid compounds that exist widely in food, medicinal herbs and other plants. This review summarizes the pharmacological studies on these two triterpenoids. Both oleanolic acid and ursolic acid are effective in protecting against chemically...
Anupam Bishayee et al.
International journal of cancer, 133(5), 1054-1063 (2013-02-14)
Breast cancer represents one of the most frequently diagnosed cancers and predominant causes of death in women worldwide. The value of preventive therapy to limit the devastating impact of breast cancer is well established. Various plant triterpenoids and their synthetic...
Yuan-Fu Lu et al.
Molecules (Basel, Switzerland), 18(3), 3060-3071 (2013-03-09)
Oleanolic acid (OA) is a triterpenoid and a fantastic molecule with many beneficial effects. However, high-doses and long-term use can produce adverse effects. This study aimed to characterize the hepatotoxic potential of OA. Mice were given OA at doses of...
Liangfeng Fu et al.
Organic letters, 15(7), 1622-1625 (2013-03-28)
Bardoxolone methyl (2-cyano-3,12-dioxooleane-1,9(11)-dien-28-oic acid methyl ester; CDDO-Me) (1), a synthetic oleanane triterpenoid with highly potent anti-inflammatory activity (levels below 1 nM), has completed a successful phase I clinical trial for the treatment of cancer and a successful phase II trial...
Adeleke Clement Adebajo et al.
Journal of diabetes, 5(3), 336-343 (2012-12-12)
The insulinotropic activity of the combined root and stem of Gongronema latifolium (Asclepiadaceae) was evaluated to justify its African ethnomedicinal use in the management of diabetes. A methanolic extract and its chromatographic fractions (A1 -A6 ) were tested for glucose-reducing...
Renata Nowak et al.
Acta poloniae pharmaceutica, 70(3), 413-418 (2013-06-14)
Spices play an important role in the chemoprevention and they can be a rich source of biologically active compounds such as triterpenes in the human diet. A method based on high performance thin-layer chromatography combined with densitometry for determination of...
Dick de Zeeuw et al.
The New England journal of medicine, 369(26), 2492-2503 (2013-11-12)
Although inhibitors of the renin-angiotensin-aldosterone system can slow the progression of diabetic kidney disease, the residual risk is high. Whether nuclear 1 factor (erythroid-derived 2)-related factor 2 activators further reduce this risk is unknown. We randomly assigned 2185 patients with...
Li-ting Tian et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 27(12), 884-886 (2003-06-05)
To summarize the pharmacological function of oleanolic acid. Based on the documents and related achievements, the pharmacological function and its mechanism including its clinical use were summed up. Oleanolic Acid is a natural chemical which has wide-ranging function and abundant...
Jin Kyeong Choi et al.
Toxicology and applied pharmacology, 269(1), 72-80 (2013-03-19)
Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are common allergic and inflammatory skin diseases caused by a combination of eczema, scratching, pruritus, and cutaneous sensitization with allergens. This paper examines whether oleanolic acid acetate (OAA) modulates AD and ACD...
Narendra Kumar Singh et al.
Pakistan journal of pharmaceutical sciences, 27(1), 187-191 (2014-01-01)
The roots of Ichnocarpus frutescens along with roots of Cissampelos pareira, Bauhinia vahlii and Ardisia solanacea are processed together and given orally to cure stomach cancer by the tribes of Chotanagpur and Santhal parganas of Bihar, India. In vitro anticancer...
Bardoxolone methyl in type 2 diabetes and advanced chronic kidney disease.
Dionysios V Chartoumpekis et al.
The New England journal of medicine, 370(18), 1767-1767 (2014-05-03)
Yun Chen et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(3), 362-365 (2013-05-15)
To determine the chemical constituents of Gentiana rhodantha. To isolate the constituents, column chromatography over silica gel, MCI, Sephadex LH-20 and C18 reverse-phased silica gel were used. Spectroscopic methods were used to elucidate the structures of the isolated compounds. Sixteen...
Dorrah Deeb et al.
Molecules (Basel, Switzerland), 18(3), 3250-3265 (2013-03-15)
Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) is a synthetic derivative of oleanolic acid, a triterpene, with apoptosis-inducing activity in a wide range of cancer cells. Induction of apoptosis by CDDO-Me is associated with the generation of reactive oxygen species (ROS) and inhibition of telomerase...
Kuo Xu et al.
Die Pharmazie, 69(7), 483-495 (2014-07-31)
The natural product oleanolic acid has been widely used for treating hepatopathy in China, whereas its clinical application was confined by poor solubility in water. Inspired by remarkable bioactivities and physical properties of triterpenoid saponins, synthesis and biological evaluation of...
Jia Liu et al.
Oncology reports, 32(2), 567-572 (2014-06-11)
Autophagy is a biological process that eliminates damaged or excessive proteins and is utilized by various types of cells to maintain cellular homeostasis. Autophagy also occurs in cancer cells and exerts anti-survival or pro-survival effects depending on stimuli, nutrient and...
Peng-Fei Yue et al.
International journal of pharmaceutics, 475(1-2), 35-48 (2014-08-27)
The freezing stress and cryoprotectants were known to be the crucial factors for solidification formability of nanosuspensions during freeze-drying. However, there has been controversy as to whether an aggressive or conservative freezing stress (freezing temperature or freezing rate) prevents from...
Wanying Zhang et al.
Cancer letters, 355(2), 273-280 (2014-10-12)
Aldo-keto reductase 1B10 (AKR1B10) has relatively specific lipid substrates including carbonyls, retinal and farnesal/geranylgeranial. Metabolizing these lipid substrates appears crucial to carcinogenesis, particularly for farnesal/geranylgeranial that involves protein prenylation. Mutant Kras is a most common active oncogene in pancreatic cancer...
Su Yeong Kim et al.
Natural product communications, 9(12), 1683-1685 (2015-01-30)
The ethanol extract of Tilia taquetii Schneider leaves was investigated for its anti-wrinkle properties and for the relevant chemical constituents. Phytochemical studies led to the identification of five known compounds, viz. phytol (1), isoquercitrin (2), oleanderolide (3), arjunolic acid (4)...
Joseph Lorent et al.
The Journal of biological chemistry, 288(20), 14000-14017 (2013-03-27)
The interactions of triterpenoid monodesmosidic saponins, α-hederin and δ-hederin, with lipid membranes are involved in their permeabilizing effect. Unfortunately, the interactions of these saponins with lipid membranes are largely unknown, as are the roles of cholesterol or the branched sugar...
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