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05-1050-m

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Regulation of estrogen rapid signaling through arginine methylation by PRMT1.

Muriel Le Romancer et al.

Molecular cell, 31(2), 212-221 (2008-07-29)

Evidence is emerging that estrogen receptor alpha (ERalpha) is central to the rapid transduction of estrogen signaling to the downstream kinase cascades; however, the mechanisms underlying this nongenomic function are not fully understood. Here we report a paradigm of ERalpha

Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.

T Papagiannakopoulos et al.

Oncogene, 31(15), 1884-1895 (2011-08-30)

MicroRNAs (miRNAs) carry out post-transcriptional control of a multitude of cellular processes. Aberrant expression of miRNA can lead to diseases, including cancer. Gliomas are aggressive brain tumors that are thought to arise from transformed glioma-initiating neural stem cells (giNSCs). With

Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBP? expression and contributes to transformation of breast tumor cells.

Sarkar, TR; Sharan, S; Wang, J; Pawar, SA; Cantwell, CA; Johnson, PF; Morrison, DK; Wang et al.

Molecular and cellular biology null

LRP4 serves as a coreceptor of agrin.

Bin Zhang et al.

Neuron, 60(2), 285-297 (2008-10-30)

Neuromuscular junction (NMJ) formation requires agrin, a factor released from motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by agrin. However, how signal is transduced from agrin to MuSK remains unclear. We report that LRP4, a low-density lipoprotein

The metastasis gene NEDD9 product acts through integrin β3 and Src to promote mesenchymal motility and inhibit amoeboid motility.

Jessica Ahn et al.

Journal of cell science, 125(Pt 7), 1814-1826 (2012-02-14)

Neural precursor expressed, developmentally down-regulated 9 (NEDD9), a member of the Cas family of signal transduction molecules, is amplified at the genetic level in melanoma, and elevated expression levels have been shown to correlate with melanoma progression and metastasis. NEDD9

Prolactin-induced activation of phagocyte NADPH oxidase in the teleost fish gilthead seabream involves the phosphorylation of p47phox by protein kinase C.

Víctor H Olavarría et al.

Developmental and comparative immunology, 36(1), 216-221 (2011-09-03)

The pituitary hormone prolactin (PRL) is a multifunctional polypeptide which act as a key component of the neuroendocrine-immune loop and as a local regulator of the macrophage response. The involvement of PRL in regulating monocyte/macrophage functions is suggested by the

Themis sets the signal threshold for positive and negative selection in T-cell development.

Fu, G; Casas, J; Rigaud, S; Rybakin, V; Lambolez, F; Brzostek, J; Hoerter, JA; Paster et al.

Nature null

Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.

Natalie S Poulter et al.

Nature communications, 6, 7254-7254 (2015-06-02)

The actin nodule is a novel F-actin structure present in platelets during early spreading. However, only limited detail is known regarding nodule organization and function. Here we use electron microscopy, SIM and dSTORM super-resolution, and live-cell TIRF microscopy to characterize

SILAC-based quantitative proteomic analysis of human lung cell response to copper oxide nanoparticles.

Mariola J Edelmann et al.

PloS one, 9(12), e114390-e114390 (2014-12-04)

Copper (II) oxide (CuO) nanoparticles (NP) are widely used in industry and medicine. In our study we evaluated the response of BEAS-2B human lung cells to CuO NP, using Stable isotope labeling by amino acids in cell culture (SILAC)-based proteomics

Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-κB activation.

Gabrielle Carvalho et al.

PloS one, 6(3), e18159-e18159 (2011-04-12)

Beside their established function in shaping cell architecture, some cell polarity proteins were proposed to participate to lymphocyte migration, homing, scanning, as well as activation following antigen receptor stimulation. Although PALS1 is a central component of the cell polarity network

Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa.

Vigodner, M; Shrivastava, V; Gutstein, LE; Schneider, J; Nieves, E; Goldstein et al.

Human Reproduction null

Digital microfluidic assay for protein detection.

Mok, J; Mindrinos, MN; Davis, RW; Javanmard, M

Proceedings of the National Academy of Sciences of the USA null

Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-γ1 phosphorylation.

Gregory Driessens et al.

Journal of immunology (Baltimore, Md. : 1950), 186(2), 784-790 (2010-12-15)

Despite the defined function of the β-catenin pathway in thymocytes, its functional role in peripheral T cells is poorly understood. We report that in a mouse model, β-catenin protein is constitutively degraded in peripheral T cells. Introduction of stabilized β-catenin

Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade.

Huang, J; Bae, JO; Tsai, JP; Kadenhe-Chiweshe, A; Papa, J; Lee, A; Zeng, S; Kornfeld et al.

International journal of oncology null

Cytoskeletal polarity mediates localized induction of the heart progenitor lineage.

James Cooley et al.

Nature cell biology, 13(8), 952-957 (2011-07-26)

Cells must make appropriate fate decisions within a complex and dynamic environment. In vitro studies indicate that the cytoskeleton acts as an integrative platform for this environmental input. External signals regulate cytoskeletal dynamics and the cytoskeleton reciprocally modulates signal transduction.

Mechanoinduction of lymph vessel expansion.

Lara Planas-Paz et al.

The EMBO journal, 31(4), 788-804 (2011-12-14)

In the mammalian embryo, few mechanical signals have been identified to influence organ development and function. Here, we report that an increase in the volume of interstitial or extracellular fluid mechanically induces growth of an organ system, that is, the

Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration.

Meyer, R; D'Alessandro, LA; Kar, S; Kramer, B; She, B; Kaschek, D; Hahn, B; Wrangborg et al.

Frontiers in Physiology null

Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis.

Chengyong Shen et al.

The Journal of clinical investigation, 123(12), 5190-5202 (2013-11-10)

Myasthenia gravis (MG) is the most common disorder affecting the neuromuscular junction (NMJ). MG is frequently caused by autoantibodies against acetylcholine receptor (AChR) and a kinase critical for NMJ formation, MuSK; however, a proportion of MG patients are double-negative for

An adaptor role for cytoplasmic Sam68 in modulating Src activity during cell polarization.

Marc-Etienne Huot et al.

Molecular and cellular biology, 29(7), 1933-1943 (2009-01-14)

The Src-associated substrate during mitosis with a molecular mass of 68 kDa (Sam68) is predominantly nuclear and is known to associate with proteins containing the Src homology 3 (SH3) and SH2 domains. Although Sam68 is a Src substrate, little is

Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy.

Zhang, S; Chen, L; Luo, Y; Gunawan, A; Lawrence, DS; Zhang, ZY

Journal of the American Chemical Society null

Angiotensin II induces membrane trafficking of natively expressed transient receptor potential vanilloid type 4 channels in hypothalamic 4B cells.

Ashwini Saxena et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 307(8), R945-R955 (2014-08-01)

Transient receptor potential vanilloid family type 4 (TRPV4) channels are expressed in central neuroendocrine neurons and have been shown to be polymodal in other systems. We previously reported that in the rodent, a model of dilutional hyponatremia associated with hepatic

A pathobiological role of the insulin receptor in chronic lymphocytic leukemia.

Kamlai Saiya-Cork et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 17(9), 2679-2692 (2011-02-11)

The chromosomal deletion 11q affects biology and clinical outcome in chronic lymphocytic leukemia (CLL) but del11q-deregulated genes remain incompletely characterized. We have employed integrated genomic profiling approaches on CLL cases with and without del11q to identify 11q-relevant genes. We have

Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues.

Veronique M Neumeister et al.

Journal of the National Cancer Institute, 104(23), 1815-1824 (2012-10-24)

Companion diagnostic tests can depend on accurate measurement of protein expression in tissues. Preanalytic variables, especially cold ischemic time (time from tissue removal to fixation in formalin) can affect the measurement and may cause false-negative results. We examined 23 proteins

Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells.

Lakshmi Reddy Bollu et al.

Cell cycle (Georgetown, Tex.), 13(15), 2415-2430 (2014-12-09)

Increased expressions of fatty acid synthase (FASN) and epidermal growth factor receptor (EGFR) are common in cancer cells. De novo synthesis of palmitate by FASN is critical for the survival of cancer cells via mechanisms independent of its role as

Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer.

Linger, RM; Cohen, RA; Cummings, CT; Sather, S; Migdall-Wilson, J; Middleton, DH; Lu et al.

Oncogene null

Wnt proteins regulate acetylcholine receptor clustering in muscle cells.

Bin Zhang et al.

Molecular brain, 5, 7-7 (2012-02-09)

The neuromuscular junction (NMJ) is a cholinergic synapse that rapidly conveys signals from motoneurons to muscle cells and exhibits a high degree of subcellular specialization characteristic of chemical synapses. NMJ formation requires agrin and its coreceptors LRP4 and MuSK. Increasing

Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance.

Zhou L, Zhang J, Fang Q, Liu M, Liu X, Jia W, Dong LQ, Liu F

Molecular Pharmacology null

Directed discovery of agents targeting the Met tyrosine kinase domain by virtual screening.

Peach, ML; Tan, N; Choyke, SJ; Giubellino, A; Athauda, G; Burke, TR; Nicklaus, MC; Bottaro, DP

Journal of medicinal chemistry null

Osmotic stress stimulates phosphorylation and cellular expression of heat shock proteins in rhesus macaque sperm.

Cole JA, Meyers SA

Journal of Andrology null

Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling.

Helmer, RA; Panchoo, M; Dertien, JS; Bhakta, SM; Hewetson, A; Chilton, BS

Molecular and cellular endocrinology null

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