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Showing 1-30 of 38 results for "05-212" within Papers
Laurent Calvier et al.
Arteriosclerosis, thrombosis, and vascular biology, 41(4), 1309-1318 (2021-02-26)
[Figure: see text].
Colin M Segovis et al.
Journal of immunology (Baltimore, Md. : 1950), 182(11), 6933-6942 (2009-05-21)
The NK cell-activating receptor NKG2D plays a critical role in the destruction of malignant cells, but many of the cell-signaling mechanisms governing NKG2D-mediated cellular cytotoxicity are unknown. We have identified an NKG2D-mediated signaling pathway that governs both conjugate formation and
P Lebrun et al.
The Journal of biological chemistry, 273(48), 32244-32253 (1998-11-21)
Insulin receptor substrate-1 (IRS-1) is a major substrate of insulin and insulin-like growth factor-I receptors, which upon phosphorylation on tyrosine docks several signaling molecules. Recently, IRS-1 was found to interact with alphav beta3 integrins upon insulin stimulation. Integrins are transmembrane
Ana Ruiz-Saenz et al.
Cancer research, 78(13), 3645-3658 (2018-05-16)
Current evidence suggests that HER2-driven tumorigenesis requires HER3. This is likely due to the unique ability of HER3 to activate PI3K/Akt pathway signaling, which is not directly accessible to HER2. By genetic elimination of HER3 or shRNA knockdown of HER3
Lauren M Thorpe et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(27), 7095-7100 (2017-06-21)
Mutation or loss of the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3K) is emerging as a transforming factor in cancer, but the mechanism of transformation has been controversial. Here we find that hemizygous deletion of the PIK3R1 gene encoding p85α
Unlocking the mystery of oral cancer: HSDM student researcher finds link in chain of oral carcinogenesis.
Scott P Edwards
Harvard dental bulletin null
Jun Chen et al.
Neuroscience letters, 723, 134861-134861 (2020-02-28)
Ototoxic drugs may induce auditory sensory hair cell loss and permanent deafness; however, there is still no effective treatments or prevention strategies for this side effect. A recent study found that microRNA182 (miR-182) protected cochlear hair cells from ototoxic drug-induced
Profiling the HER3/PI3K pathway in breast tumors using proximity-directed assays identifies correlations between protein complexes and phosphoproteins.
Mukherjee, A; Badal, Y; Nguyen, XT; Miller, J; Chenna, A; Tahir, H; Newton, A; Parry, G; Williams, S
Testing null
Jonathan A Deane et al.
Journal of immunology (Baltimore, Md. : 1950), 172(11), 6615-6625 (2004-05-22)
Phosphoinositide 3-kinase activation is important for lymphocyte proliferation and survival. Disrupting the gene that encodes the major phosphoinositide 3-kinase regulatory isoform p85alpha impairs B cell development and proliferation. However, T cell functions are intact in the absence of p85alpha. In
Kendal G Cooper et al.
PloS one, 6(7), e22260-e22260 (2011-07-23)
Salmonella enterica uses effector proteins translocated by a Type III Secretion System to invade epithelial cells. One of the invasion-associated effectors, SopB, is an inositol phosphatase that mediates sustained activation of the pro-survival kinase Akt in infected cells. Canonical activation
Identification and characterization of an interleukin-3 receptor-associated 110-kDa serine/threonine kinase
Liu, L., et al
The Journal of Biological Chemistry, 270, 22422-22427 (1995)
Kyung-Min Lee et al.
Nature communications, 11(1), 5488-5488 (2020-11-01)
The 17q23 amplicon is associated with poor outcome in ER+ breast cancers, but the causal genes to endocrine resistance in this amplicon are unclear. Here, we interrogate transcriptome data from primary breast tumors and find that among genes in 17q23
Kohjiro Ueki et al.
Molecular and cellular biology, 22(3), 965-977 (2002-01-11)
Class Ia phosphoinositide (PI) 3-kinase is a central component in growth factor signaling and is comprised of a p110 catalytic subunit and a regulatory subunit, the most common family of which is derived from the p85alpha gene (Pik3r1). Optimal signaling
Victoria A Elliott et al.
PloS one, 9(5), e97432-e97432 (2014-05-16)
Liver metastasis is the most common cause of death in patients with colorectal cancer. Despite extensive research into the biology of cancer progression, the molecular mechanisms that drive colorectal cancer metastasis are not well characterized. HT29 LM1, HT29 LM2, HT29
Differential activation of phospholipase C-gamma 1 and mitogen-activated protein kinase in naive and antigen-primed CD4 T cells by the peptide/MHC ligand
Ericsson, P. O., et al
Journal of immunology (Baltimore, Md. : 1950), 156, 2045-2053 (1996)
Coralie Poulard et al.
International journal of molecular sciences, 20(11) (2019-06-15)
Endocrine therapies targeting oestrogen signalling have significantly improved breast cancer management. However, their efficacy is limited by intrinsic and acquired resistance to treatment, which remains a major challenge for oestrogen receptor α (ERα)-positive tumours. Though many studies using in vitro
Cyril Basquin et al.
Journal of cell science, 126(Pt 5), 1099-1108 (2013-01-25)
Receptor-mediated endocytosis is an essential process used by eukaryotic cells to internalise many molecules. Several clathrin-independent endocytic routes exist, but the molecular mechanism of each pathway remains to be uncovered. The present study focuses on a clathrin-independent dynamin-dependent pathway used
Hans H Bock et al.
The Journal of biological chemistry, 278(40), 38772-38779 (2003-07-29)
Reelin is a large secreted signaling protein that binds to two members of the low density lipoprotein receptor family, the apolipoprotein E receptor 2 and the very low density lipoprotein receptor, and regulates neuronal positioning during brain development. Reelin signaling
Kianoush Khaleghpour et al.
Carcinogenesis, 25(2), 241-248 (2003-10-28)
The phosphoinositide 3-kinase (PI 3-kinase) signaling pathway has been shown to play a pivotal role in intracellular signal transduction pathways involved in cell growth, cellular transformation and tumorigenesis. Analysis of several colon adenocarcinoma cell lines indicates that the PI 3-kinase
A Craxton et al.
The Journal of biological chemistry, 274(43), 30644-30650 (1999-10-16)
Activation of Akt by multiple stimuli including B cell antigen receptor (BCR) engagement requires phosphatidylinositol 3-kinase and regulates processes including cell survival, proliferation, and metabolism. BCR cross-linking activates three families of non-receptor protein tyrosine kinases (PTKs) and these are transducers
Xuan Cao et al.
Nature communications, 6, 7721-7721 (2015-07-15)
Although cell migration plays a central role in development and disease, the underlying molecular mechanism is not fully understood. Here we report that a phosphorylation-mediated molecular switch comprising deleted in liver cancer 1 (DLC1), tensin-3 (TNS3), phosphatase and tensin homologue
Jingjing Wu et al.
Molecular medicine reports, 20(4), 3233-3239 (2019-08-23)
Homoharringtonine (HHT) and imatinib have a synergistic effect in the clinical treatment of chronic myeloid leukemia (CML). The purpose of the present study was to explore the underlying mechanisms by which HHT enhanced imatinib sensitivity. K562 CML cells were treated
Jose Mercado-Matos et al.
Molecular and cellular biology, 38(14) (2018-04-25)
Although the insulin receptor substrate (IRS) proteins IRS1 and IRS2 share considerable homology and activate common signaling pathways, their contributions to breast cancer are distinct. IRS1 has been implicated in the proliferation and survival of breast tumor cells. In contrast
Michael J Fry
Methods in molecular biology (Clifton, N.J.), 462, 345-362 (2009-01-24)
The regulation of phosphoinositide (PI) 3-kinase activities has been linked to many normal and disease-related processes, including cell survival, cell growth and proliferation, cell differentiation, cell motility, and intracellular vesicle trafficking. However, as the family of enzymes has now grown
K Nishigaki et al.
Journal of virology, 74(7), 3037-3045 (2000-03-09)
The erythroleukemia-inducing Friend spleen focus-forming virus (SFFV) encodes a unique envelope glycoprotein which allows erythroid cells to proliferate and differentiate in the absence of erythropoietin (Epo). In an effort to understand how SFFV causes Epo independence, we have been examining
Jonathan D Lautz et al.
Cell reports, 37(9), 110076-110076 (2021-12-02)
A core network of widely expressed proteins within the glutamatergic post-synapse mediates activity-dependent synaptic plasticity throughout the brain, but the specific proteomic composition of synapses differs between brain regions. Here, we address the question, how does proteomic composition affect activity-dependent
Thomas Karlsson et al.
Oncotarget, 8(3), 3881-3894 (2016-12-22)
PTEN loss and constitutive activation of the class I phosphoinositide 3-kinase (PI3K) pathway are key drivers of endometrial tumorigenesis. In some cancer types, PTEN-deficient tumors are reliant on class I PI3K p110β (encoded by PIK3CB) activity but little is known
Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor.
Miura, O, et al.
The Journal of Biological Chemistry, 269, 614-620 (1994)
Structure of 85 kDa subunit of human phosphatidylinositol 3-kinase analyzed by using monoclonal antibodies
Tanaka, S., et al
Japanese Journal of Cancer Research, 84, 279-289 (1993)
Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity.
Lee J, Xu Y, Lu L, Bergman B, Leitner JW, Greyson C, Draznin B, Schwartz GG
American Journal of Physiology. Heart and Circulatory Physiology null
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