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Showing 1-30 of 51 results for "05-338" within Papers
M Czystowska et al.
Cell death and differentiation, 16(5), 708-718 (2009-01-31)
IRX-2 is a cytokine-based biologic agent that has the potential to enhance antitumor immune responses. We investigated whether IRX-2 can protect T cells from tumor-induced apoptosis. Tumor-derived microvesicles (MV) expressing FasL were purified from supernatants of tumor cells and incubated
Bin Zhang et al.
The Journal of biological chemistry, 278(31), 28443-28454 (2003-05-09)
Phagocytosis of complement-opsonized targets is a primary function of neutrophils at sites of inflammation, and the clearance of neutrophils that have phagocytosed microbes is important for the resolution of inflammation. Our previous work suggests that phagocytosis leads to rapid neutrophil
Networked T cell death following macrophage infection by Mycobacterium tuberculosis.
Macdonald, SH; Woodward, E; Coleman, MM; Dorris, ER; Nadarajan, P; Chew, WM; McLaughlin et al.
Testing null
Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis
Boirivant, M., et al
The Journal of Clinical Investigation, 98, 2616-2622 (1996)
Nassir M Mansour et al.
Cancer research, 75(10), 2039-2048 (2015-03-27)
Temozolomide is used widely to treat malignant glioma, but the overall response to this agent is generally poor. Resistance to DNA-damaging drugs such as temozolomide has been related to the induction of antiapoptotic proteins. Specifically, the transcription factor NF-κB has
Sang Hyeok Woo et al.
International journal of cancer, 112(4), 596-606 (2004-09-24)
CD95/Fas is a cell surface protein that belongs to the tumor necrosis factor receptor family. Signals through CD95/Fas are able to induce apoptosis in sensitive cells. Therefore, modalities to regulate the CD95/Fas expression level in tumor cells are called for.
Yan Ge et al.
Cellular microbiology, 8(9), 1406-1416 (2006-08-23)
Anaplasma phagocytophilum infects human neutrophils and inhibits the intrinsic pathway of spontaneous neutrophil apoptosis by protecting mitochondrial membrane integrity. In the present study, we investigated the molecular signalling of the extrinsic pathway and the interaction between the intrinsic and extrinsic
Lin-Sen Shi et al.
Molecular medicine reports, 10(6), 2898-2904 (2014-10-02)
Gastrokine‑2 is a putative gastric cancer‑specific tumor suppressor gene, the loss of which is known to be involved in the development and progression of gastric cancer, and restoration of gastrokine‑2 expression inhibits growth of gastric cancer cells in vitro. However
Adnana Paunel-Görgülü et al.
Critical care (London, England), 15(1), R20-R20 (2011-01-15)
Deregulated apoptosis and overshooting neutrophil functions contribute to immune and organ dysfunction in sepsis and multiple organ failure (MOF). In the present study, we determined the role of soluble Fas (sFas) in the regulation of posttraumatic neutrophil extrinsic apoptosis and
Irene Mavroudi et al.
Journal of leukocyte biology, 89(5), 771-783 (2011-03-04)
CD40 is a member of the TNFR family and upon interaction with its cognate ligand (CD40L), induces diverse biologic responses related to cell survival/growth. As altered CD40/CD40L interactions have been associated with neutropenia, we investigated the role of CD40/CD40L on
E Lacana et al.
Nature medicine, 5(5), 542-547 (1999-05-06)
Programmed cell death is a process required for the normal development of an organism. One of the best understood apoptotic pathways occurs in T lymphocytes and is mediated by Fas/Fas ligand (FasL) interaction. During studies of apoptosis induced by T
Ornela Sulejmani et al.
Cancers, 13(21) (2021-11-14)
Chimeric antigen receptor (CAR) T cell therapy has emerged as a promising treatment strategy, however, therapeutic success against solid tumors such as neuroblastoma remains modest. Recurrence of antigen-poor tumor variants often ultimately results in treatment failure. Using antigen-independent killing mechanisms
Dongjin Jeong et al.
eLife, 10 (2021-07-06)
To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulated via interaction with Fas in vivo. We found that FasL interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as death receptor (DR)5. Autoantibody-induced
M T Cencioni et al.
Cell death & disease, 6, e1741-e1741 (2015-05-08)
Functionally distinct T-helper (Th) subsets orchestrate immune responses. Maintenance of homeostasis through the tight control of inflammatory Th cells is crucial to avoid autoimmune inflammation. Activation-Induced Cell Death (AICD) regulates homeostasis of T cells, and it has never been investigated
B Liu et al.
Oncogene, 20(28), 3726-3734 (2001-07-06)
We previously reported that the anti-epidermal growth factor (EGF) receptor monoclonal antibody (mAb) 225 induces DiFi colon cancer cells to undergo apoptosis, and this apoptosis was accompanied by activation of the two apoptosis initiation caspases, caspase-8 and caspase-9. In the
Secreted Fas Decoys Enhance the Antitumor Activity of Engineered and Bystander T Cells in Fas Ligand-Expressing Solid Tumors.
Bajgain, et al.
Cancer immunology research, 10, 1370-1385 (2023)
Eva U Wieckowski et al.
Journal of immunology (Baltimore, Md. : 1950), 183(6), 3720-3730 (2009-08-21)
Sera of patients with cancer contain membraneous microvesicles (MV) able to induce apoptosis of activated T cells by activating the Fas/Fas ligand pathway. However, the cellular origin of MV found in cancer patients' sera varies as do their molecular and
Joshua D Greenlee et al.
eLife, 10 (2021-08-04)
Colorectal cancer (CRC) remains a leading cause of cancer death, and its mortality is associated with metastasis and chemoresistance. We demonstrate that oxaliplatin-resistant CRC cells are sensitized to TRAIL-mediated apoptosis. Oxaliplatin-resistant cells exhibited transcriptional downregulation of caspase-10, but this had
Yuhong Chen et al.
Journal of immunology (Baltimore, Md. : 1950), 196(4), 1678-1685 (2016-01-17)
The three major Ras members, Kras, Hras, and Nras, are highly homologous and individual Ras genes can have distinct biological functions. Embryonic lethality of Kras-deficient mice precludes study of the biological functions of this Ras family member. In this study
Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis.
M S Iordanov, O P Ryabinina, J Wong, T H Dinh, D L Newton, S M Rybak, B E Magun
Cancer Research null
Kai Zhang et al.
Cell, 169(7), 1303-1314 (2017-06-13)
Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of long-distance processive movement along microtubules. However, it is unclear why dynein-1 moves poorly on its own or how it is activated by dynactin. Here, we
Eun-Young Ahn et al.
The American journal of pathology, 163(5), 2053-2063 (2003-10-28)
Calmodulin (CaM) antagonists have been shown to inhibit tumor cell invasion and metastasis and to induce apoptosis in various tumor models, but the molecular mechanism of CaM antagonist-mediated apoptosis is poorly understood. Here, we demonstrate that interferon (IFN)-gamma induces susceptibility
Min Zhang et al.
Pathobiology : journal of immunopathology, molecular and cellular biology, 84(5), 229-236 (2017-09-13)
Asbestos is harmful to human health. However, the pathogenicity of chrysotile is a controversial matter. This study aimed to investigate the apoptosis of a human bronchial epithelial cell line (BEAS-2B) exposed to chrysotile that may function in part through the
Tejeshwar C Rao et al.
The Journal of biological chemistry, 298(4), 101726-101726 (2022-02-15)
Heterogeneity within the glycocalyx influences cell adhesion mechanics and signaling. However, the role of specific glycosylation subtypes in influencing cell mechanics via alterations of receptor function remains unexplored. It has been shown that the addition of sialic acid to terminal
Paola Matarrese et al.
The Biochemical journal, 413(3), 467-478 (2008-04-30)
Participation of diverse organelles in the intracellular signalling that follows CD95/Fas receptor ligation encompasses a series of subcellular changes that are mandatory for, or even bolster, the apoptotic cascade. In the present study, we analysed the role of endocytosis in
Haishan Li et al.
Blood, 118(22), 5824-5831 (2011-09-20)
HIV infects and replicates in CD4+ T cells but effects on host immunity and disease also involve depletion, hyper-activation, and modification of CD4-negative cell populations. In particular, the depletion of CD4-negative γδ T cells is common to all HIV+ individuals.
Dong-Seok Kim et al.
Biological & pharmaceutical bulletin, 29(8), 1625-1629 (2006-08-02)
Recently, we showed that a combination of indole-3-acetic acid (IAA) and horseradish peroxidase (HRP) produces hydrogen peroxide (H2O2), and that this leads to the apoptosis of G361 human melanoma cells. In the present study, flow cytometric analysis confirmed that H2O2
Ming-Hsien Chien et al.
Molecular cancer therapeutics, 16(6), 1102-1113 (2017-03-16)
Altered expression of the Fas ligand (FasL)/Fas ratio exhibits a direct impact on the prognosis of cancer patients, and its impairment in cancer cells may lead to apoptosis resistance. Thus, the development of effective therapies targeting the FasL/Fas system may
Kirstin Veugelers et al.
Blood, 103(10), 3845-3853 (2004-01-24)
Cytotoxic T lymphocytes and natural killer cells destroy target cells via the directed exocytosis of lytic effector molecules such as perforin and granzymes. The mechanism by which these proteins enter targets is uncertain. There is ongoing debate over whether the
Nandita Saxena et al.
Toxicological sciences : an official journal of the Society of Toxicology, 135(1), 103-118 (2013-06-22)
Abrin is a plant glycoprotein toxin from the seeds of Abrus precatorius, sharing similarity in structure and properties with ricin. Abrin is highly toxic, with an estimated human fatal dose of 0.1-1 µg/kg, causing death after accidental or intentional poisoning.
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