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05002

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Ottmar Golf et al.
Journal of the American Society for Mass Spectrometry, 26(1), 44-54 (2014-11-09)
Here we present a proof of concept cross-platform normalization approach to convert raw mass spectra acquired by distinct desorption ionization methods and/or instrumental setups to cross-platform normalized analyte profiles. The initial step of the workflow is database driven peak annotation...
Vinod Vellora Thekkae Padil et al.
Carbohydrate polymers, 121, 468-476 (2015-02-11)
Electrospun nanofibre membranes from blend solutions of deacetylated gum kondagogu and polyvinyl alcohol of various weight proportions were prepared. The electrospun membrane was cross linked by heating at 150°C for 6h and later modified by methane plasma treatment. Membranes were...
Gozde Unsoy et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(5), 641-648 (2014-06-02)
The use of nanotechnology in cancer treatment offers exciting opportunities, including the possibility of destroying tumors with minimal damage to healthy tissue by novel targeted drug delivery systems. pH differences between healthy and tumor microenvironment provide pH responsive release of...
Florencia Harari et al.
Thyroid : official journal of the American Thyroid Association, 25(11), 1199-1208 (2015-09-04)
Impaired thyroid function is a common side effect of lithium medication. Recent data indicate that lithium exposure through drinking water, although providing much lower doses than the medication, may also affect thyroid hormone levels. However, the effects in susceptible groups...
Iain M McIntyre et al.
Journal of analytical toxicology, 39(2), 152-155 (2014-12-18)
A 24-year-old man whose medical history was significant for alcohol abuse and depression was found unresponsive in bed. He had several prior suicide attempts with 'pills' and had also been hospitalized for an accidental overdose on a previous occasion. Autopsy...
Judith Grothe et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(4), 1437-1453 (2015-03-21)
Liver impairment, ranging from steatosis to cirrhosis, is frequent in cystic fibrosis (CF) patients and is becoming increasingly significant due to their improved life expectancy. One aspect of hepatic alterations is caused by increased fecal loss of the essential nutrient...
Neelesh Kumar Mehra et al.
Molecular pharmaceutics, 12(2), 630-643 (2014-12-18)
Our main aim in the present investigation was to assess and compare the in vitro and in vivo cancer targeting propensity of doxorubicin (DOX) loaded folic acid (FA) and estrone (ES) anchored PEGylated multiwalled carbon nanotubes (MWCNTs) employing tumor bearing...
Yaxi Hu et al.
Food chemistry, 176, 123-129 (2015-01-28)
A novel biosensor combining molecularly imprinted polymers and surface-enhanced Raman spectroscopy (MIPs-SERS) determines melamine in whole milk. MIPs were synthesized by bulk polymerization of melamine (template), methacrylic acid (functional monomer), ethylene glycol dimethacrylate (cross-linking agent) and 2,2'-azobisisobutyronitrile (initiator). Static and...
Dae-Hee Lee et al.
PloS one, 10(3), e0117224-e0117224 (2015-03-03)
The characteristics of anterior cruciate ligament (ACL)-derived mesenchymal stem cells (MSCs), such as proportion and multilineage potential, can be affected by donor age. However, the qualitative and quantitative features of ACL MSCs isolated from younger and older individuals have not...
Yothin Teethaisong et al.
Journal of biomedical science, 21, 90-90 (2014-09-12)
Ampicillin-resistant S. aureus (ARSA) now poses a serious problem for hospitalized patients, and their care providers. Plant-derived antibacterial that can reverse the resistance to well-tried agents which have lost their original effectiveness are the research objectives of far reaching importance....
Ana R Ribeiro et al.
Journal of chromatography. A, 1418, 140-149 (2015-10-04)
The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directive 2013/39/EU), substances of...
Ana Rita Ribeiro et al.
Journal of chromatography. A, 1363, 226-235 (2014-07-23)
The interest for environmental fate assessment of chiral pharmaceuticals is increasing and enantioselective analytical methods are mandatory. This study presents an enantioselective analytical method for the quantification of seven pairs of enantiomers of pharmaceuticals and a pair of a metabolite....
Hussein Rasool Abid et al.
Nanoscale, 4(10), 3089-3094 (2012-04-26)
Several zirconium-based metal-organic frameworks (Zr-MOFs) have been synthesized using ammonium hydroxide as an additive in the synthesis process. Their physicochemical properties have been characterized by N(2) adsorption/desorption, XRD, SEM, FTIR, and TGA, and their application in CO(2) adsorption was evaluated....
Saroj Kumar Das et al.
BMC neuroscience, 16, 2-2 (2015-04-17)
Although there have been several reports on social isolation induced mood alterations, the independent contribution of monotonous environment in mediating mood alterations has been less studied. In view of the above, the present study is aimed at investigating the relative...
Marzieh Enteshari Najafabadi et al.
Journal of pharmaceutical and biomedical analysis, 107, 244-250 (2015-01-28)
Magnetic nanoparticles (MNPs) conjugated with aptamer was developed for the selective extraction of adenosine in urine samples followed by electrospray ionization-ion mobility spectrometry (ESI-IMS). The ion mobility spectrum of adenosine showed two peaks at low concentrations and two more peaks...
Camilla Benevides Freitas et al.
Talanta, 147, 335-341 (2015-11-26)
This report describes the development of an analytical methodology on microchip electrophoresis (ME) devices coupled with capacitively coupled contactless conductivity detection (C(4)D) to monitor inorganic anions in environmental samples. The buffer composition as well as detection operating parameters were optimized...
Kayla N Ellefsen et al.
Analytical and bioanalytical chemistry, 406(25), 6213-6223 (2014-08-19)
Breath has been investigated as an alternative matrix for detecting recent cocaine intake; however, there are no controlled cocaine administration studies that investigated the drug's disposition into breath. Breath was collected from 10 healthy adult cocaine users by asking them...
Dong Wei et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 971, 133-140 (2014-10-08)
Dexpramipexole (DEX) was being investigated in clinical studies for the treatment of amyotrophic lateral sclerosis (ALS). To monitor the potential chiral interconversion of dexpramipexole to pramipexole (PPX) in vivo, a highly sensitive and selective chiral LC-MS/MS assay was developed and...
Amy E Clipperton-Allen et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 54(6), 718-730 (2015-12-04)
Few studies have evaluated the long-term effects of providing environmental resources to mice. This consideration is important given that mice are often maintained in vivaria for months. We evaluated the effects of providing simple cage resources (wood wool, cotton nesting...
Sébastien Sart et al.
Tissue engineering. Part A, 20(1-2), 54-66 (2013-07-16)
Embryonic stem cells (ESCs) emerge as a promising tool for tissue engineering and regenerative medicines due to their extensive self-renewal ability and the capacity to give rise to cells from all three-germ layers. ESCs also secrete a large amount of...
Joost Westerhout et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 11-24 (2014-01-28)
Children and adults with malignant diseases have a high risk of prevalence of the tumor in the central nervous system (CNS). As prophylaxis treatment methotrexate is often given. In order to monitor methotrexate exposure in the CNS, cerebrospinal fluid (CSF)...
Elena Sánchez-López et al.
Journal of chromatography. A, 1363, 356-362 (2014-08-03)
Two chiral methodologies were developed by capillary electrophoresis (CE) with UV and mass spectrometry (MS) detection to ensure the quality control of the drug duloxetine, commercialized as a pure enantiomer. Both methods were optimized to achieve a high baseline enantioresolution...
Kurt G Pike et al.
Journal of medicinal chemistry, 58(5), 2326-2349 (2015-02-03)
High throughput screening followed by a lead generation campaign uncovered a novel series of urea containing morpholinopyrimidine compounds which act as potent and selective dual inhibitors of mTORC1 and mTORC2. We describe the continued compound optimization campaign for this series...
Paula Paíga et al.
Journal of pharmaceutical and biomedical analysis, 106, 61-70 (2014-07-09)
An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass...
Fang Zhang et al.
ChemSusChem, 8(6), 1043-1048 (2015-02-17)
A thermally regenerative ammonia battery (TRAB) is a new approach for converting low-grade thermal energy into electricity by using an ammonia electrolyte and copper electrodes. TRAB operation at 72 °C produced a power density of 236 ± 8 Wm(-2), with a...
Ming-Chuan Wang et al.
Analytical and bioanalytical chemistry, 407(5), 1343-1356 (2014-12-10)
Tyrosine phosphorylation is an important regulator of signaling in cellular pathways, and dysregulated tyrosine phosphorylation causes several diseases. Mass spectrometry has revealed the importance of global phosphoproteomic characterization. Analysis of tyrosine phosphorylation by studying the mass-spectrometry (MS)-determined phosphoproteome remains difficult...
Avijit Paul et al.
Nanoscale research letters, 10, 140-140 (2015-04-09)
With advancements in nanotechnology, silver has been engineered into a nanometre size and has attracted great research interest for use in the treatment of wounds. Silver nanoparticles (AgNPs) have emerged as a potential alternative to conventional antibiotics because of their...
Shahid Ullah et al.
Analytical chemistry, 87(22), 11553-11560 (2015-10-28)
An analytical method based on high-performance liquid chromatography coupled to quadrupole tandem mass spectrometry was developed for the quantitative determination of four phosphatidylcholines (PCs) in human exhaled breath particles. Analytes were conveniently collected on an electrostatic polymer filter and extracted...
Rui Liang et al.
Scientific reports, 5, 8078-8078 (2015-01-30)
Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK, MAP3K) family member that plays an important role in oxidative stress-induced cell apoptosis. In this...
Yi Min et al.
Journal of chromatography. A, 1356, 148-156 (2014-07-08)
In this work, 1.9 μm reversed-phase packing materials with superficially porous structure were prepared to achieve the rapid and high efficient separation of peptides and proteins. The silica particles were synthesized via three steps, nonporous silica particle preparation by a...
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