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Kaitlin H Wade et al.
The American journal of clinical nutrition, 101(1), 202-209 (2014-12-21)
Observational studies showed that circulating L-ascorbic acid (vitamin C) is inversely associated with cardiometabolic traits. However, these studies were susceptible to confounding and reverse causation. We assessed the relation between L-ascorbic acid and 10 cardiometabolic traits by using a single
H Sakagami et al.
Anticancer research, 17(6D), 4451-4452 (1998-03-12)
This review summarizes our comparative study of the antitumor action of sodium 5,6-benzylidene-L-ascorbate (SBA) and sodium ascorbate. Both SBA and ascorbate produced ascorbate radicals during decomposition, elevated oxidation potential and oxidized methionine to methionine sulfoxide, in the regular culture medium.
Maria G Mason et al.
Biochimica et biophysica acta, 1837(11), 1882-1891 (2014-09-02)
We re-determined the near infrared (NIR) spectral signatures (650-980nm) of the different cytochrome c oxidase redox centres, in the process separating them into their component species. We confirm that the primary contributor to the oxidase NIR spectrum between 700 and
Dayong Wang et al.
Journal of Alzheimer's disease : JAD, 43(2), 519-534 (2014-08-13)
The stress protein heme oxygenase-1 (HO-1) is upregulated and co-localizes to pathological features, including tauopathies in the brains of individuals with Alzheimer's disease. However, the relationship between HO-1 and Alzheimer's disease remains unclear. In our previous research, the long-term overexpression
Qiong Dai et al.
ACS nano, 9(3), 2876-2885 (2015-02-26)
Engineered particles adsorb biomolecules (e.g., proteins) when introduced in a biological medium to form a layer called a "corona". Coronas, in particular the protein corona, play an important role in determining the surface properties of particles and their targeting abilities.
Carl C Awh et al.
Ophthalmology, 122(1), 162-169 (2014-09-10)
To evaluate the impact of complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk alleles on the observed response to components of the Age-Related Eye Disease Study (AREDS) formulation. Genetic and statistical subgroup analysis of a randomized, prospective
Holly R Harris et al.
European journal of cancer (Oxford, England : 1990), 50(7), 1223-1231 (2014-03-13)
The association between dietary vitamin C intake and breast cancer survival is inconsistent and few studies have specifically examined vitamin C supplement use among women with breast cancer. The purpose of this study was to summarise results from prospective studies
A Valente et al.
Food chemistry, 154, 71-77 (2014-02-13)
Reference materials are useful for the quality control of analytical procedures and to evaluate the performance of laboratories. There are few and expensive certified reference materials commercially available for vitamin C or ascorbic acid analysis in food matrices. In this
Ida R Hansen et al.
Biochimica et biophysica acta, 1841(12), 1691-1699 (2014-09-17)
Based on results from a signal sequence trap, we investigated chemerin gene expression in brown adipose tissue. Male NMRI mice were exposed to 30, 22 or 4 °C for 3 weeks, or were fed control (chow) diet, cafeteria diet or
Weimin Chen et al.
Nanotoxicology, 8 Suppl 1, 11-23 (2013-11-22)
Engineered nanoparticles are widely used in commercial products, and yet due to the paucity of safety information, there are concerns surrounding potential adverse health effects, especially from inhaled nanoparticles and their putative contribution to allergic airway disease. The objective of
Burcu Seckin Dinler et al.
Acta biologica Hungarica, 65(4), 469-480 (2014-12-06)
In the present study, the effect of ascorbic acid (5 mM) on some physiological parameters and three hormones (auxin, abscisic acid, salicylic acid) was determined under heat stress (40 °C) in maize tolerant cv. (MAY 69) and sensitive cv. SHEMAL
Ibironke O Olofin et al.
Journal of acquired immune deficiency syndromes (1999), 67 Suppl 4, S173-S178 (2014-12-02)
HIV and malaria infections occur in the same individuals, particularly in sub-Saharan Africa. We examined whether daily multivitamin supplementation (vitamins B complex, C, and E) or vitamin A supplementation altered malaria incidence in HIV-infected women of reproductive age. HIV-infected pregnant
Xiao Zhu et al.
Toxicology, 321, 62-72 (2014-04-12)
Drug-induced liver injury (DILI) is one of the most common drug-induced adverse events (AEs) leading to life-threatening conditions such as acute liver failure. It has also been recognized as the single most common cause of safety-related post-market withdrawals or warnings.
Amy R Elmore
International journal of toxicology, 24 Suppl 2, 51-111 (2005-09-13)
L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate function in cosmetic formulations primarily as antioxidants. Ascorbic Acid is commonly called Vitamin C. Ascorbic Acid is used as an antioxidant and pH adjuster in
Tomoko Ariga et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 48-53 (2015-02-07)
Iron (Fe) is an essential element for higher plants, which take it up from the soil at the root surface and transport it to shoots through the xylem. Fe(III) chelators, such as organic acids and phytosiderophores, play important roles in
Nicole A H Janssen et al.
Occupational and environmental medicine, 72(1), 49-56 (2014-08-12)
We evaluated associations between three a-cellular measures of the oxidative potential (OP) of particulate matter (PM) and acute health effects. We exposed 31 volunteers for 5 h to ambient air pollution at five locations: an underground train station, two traffic sites
Tao Shang et al.
The Journal of surgical research, 188(1), 316-325 (2014-02-04)
We investigated the hypothesis that an antioxidant, Vitamin C, could attenuate abdominal aortic aneurysm (AAA) development in a rat model. An AAA model induced by intraluminal infusion was created in 36 male Sprague Dawley rats, which were randomly distributed into
Adel Tekari et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(11), 1503-1511 (2014-07-22)
For autologous chondrocyte transplantation, articular chondrocytes are harvested from cartilage tissue and expanded in vitro in monolayer culture. We aimed to characterize with a cellular resolution the synthesis of collagen type II (COL2) and collagen type I (COL1) during expansion
Srinivasan Senthilkumari et al.
Experimental eye research, 124, 24-30 (2014-05-13)
We have previously reported low concentrations of plasma ascorbate and low dietary vitamin C intake in the older Indian population and a strong inverse association of these with cataract. Little is known about ascorbate levels in aqueous humor and lens
M Leticia Castro et al.
Free radical biology & medicine, 74, 200-209 (2014-07-06)
We previously showed that 5 mM ascorbate radiosensitized early passage radioresistant glioblastoma multiforme (GBM) cells derived from one patient tumor. Here we investigate the sensitivity of a panel of cell lines to 5 mM ascorbate and 6 Gy ionizing radiation
Kyungtae Kang et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(3), E241-E248 (2015-01-08)
The posttranslational modification of neural cell-adhesion molecule (NCAM) with polysialic acid (PSA) and the spatiotemporal distribution of PSA-NCAM play an important role in the neuronal development. In this work, we developed a tissue-based strategy for metabolically incorporating an unnatural monosaccharide
Hannah E Da Silva et al.
Journal of the Academy of Nutrition and Dietetics, 114(8), 1181-1194 (2014-03-19)
Poor diet and a sedentary lifestyle can contribute to nonalcoholic fatty liver disease (NAFLD). Our aim was to compare diet and physical activity of patients with NAFLD and healthy controls with current recommendations. This was a cross-sectional study. Seventy-four patients
Anna Golunova et al.
Biomacromolecules, 16(4), 1146-1156 (2015-03-03)
The ability to tailor mechanical properties and architecture is crucial in creating macroporous hydrogel scaffolds for tissue engineering. In the present work, a technique for the modification of the pore size and stiffness of acrylamide-based cryogels is demonstrated via the
Hiroki Teraoka et al.
Aquatic toxicology (Amsterdam, Netherlands), 154, 19-26 (2014-05-27)
The cardiovascular system is one of the most characteristic and important targets for developmental toxicity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in fish larvae. However, knowledge of the mechanism of TCDD-induced edema after heterodimerization of aryl hydrocarbon receptor type 2 (AHR2) and AHR
Ana Sousa-Herves et al.
Nanoscale, 7(9), 3933-3940 (2014-12-23)
An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio. The biocompatibility of the generated
Jianqing Chen et al.
Pharmaceutical research, 31(10), 2810-2821 (2014-05-23)
To assess the application of succinimidyl iodobenzoate (SIB) iodination method in labeling biotherapeutics to study their pharmacokinetics (PK) and biodistribution. An IgG molecule (protein-01) and a 40 KDa protein (protein-02) were evaluated. Pharmacokinetics (PK) and biodistribution of the radiolabeled IgG ((125)I-protein-01)
M G Gioia et al.
Journal of pharmaceutical and biomedical analysis, 48(2), 331-339 (2008-02-26)
A reversed-phase ion pair liquid chromatographic method (RP-LC) for the determination of dehydroascorbic acid (DHA) and ascorbic acid (AA) and also acetaminophen, which is combined in pharmaceuticals, is proposed and validated. AA and acetaminophen were analyzed directly, while DHA was
G J Molderings et al.
Deutsche medizinische Wochenschrift (1946), 139(30), 1523-1534 (2014-05-08)
In the present paper clinical phenotypes, pathogenetic relationships, and diagnostic algorithms as well as therapeutic concepts of/for systemic mast cell activation disease are reviewed. The reader should be able to recognize and diagnose a systemic mast cell activation disease, as
Narayana Kilarkaje
Cancer chemotherapy and pharmacology, 74(6), 1175-1189 (2014-09-23)
To investigate the effects of therapeutically relevant dose levels of bleomycin, etoposide and cisplatin (BEP) on testicular steroidogenic enzymes, and possible protective effects of an antioxidant cocktail (AC). Adult Sprague-Dawley rats received BEP with or without the AC (α-tocopherol, L-ascorbic
Qi Xing et al.
Tissue engineering. Part C, Methods, 21(1), 77-87 (2014-05-29)
The application of cell-derived extracellular matrix (ECM) in tissue engineering has gained increasing interest because it can provide a naturally occurring, complex set of physiologically functional signals for cell growth. The ECM scaffolds produced from decellularized fibroblast cell sheets contain
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