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Hyeok Hee Kwon et al.
Experimental neurobiology, 28(4), 529-536 (2019-09-09)
Stress can induce a serious epileptic encephalopathy that occurs during early infancy. Recent studies have revealed that prenatal stress exposure is a risk factor for the development of infantile spasms. Our previous work demonstrates that prenatal stress with betamethasone-induced alterations...
Michele Malaguarnera et al.
Frontiers in pharmacology, 10, 132-132 (2019-03-13)
Patients with liver cirrhosis may develop minimal hepatic encephalopathy (MHE) with mild cognitive impairment. Hyperammonemia is a main contributor to cognitive impairment in MHE, which is mediated by neuroinflammation. GABAergic neurotransmission is altered in hyperammonemic rats. We hypothesized that, in...
Simonetta Pazzaglia et al.
International journal of molecular sciences, 22(8) (2021-05-01)
The brain undergoes ionizing radiation exposure in many clinical situations, particularly during radiotherapy for brain tumors. The critical role of the hippocampus in the pathogenesis of radiation-induced neurocognitive dysfunction is well recognized. The goal of this study is to test...
Jae-Hwan Jang et al.
Frontiers in neuroscience, 13, 995-995 (2019-10-17)
Growing evidence indicates that neuropathic pain is frequently accompanied by cognitive impairments, which aggravate the quality of life of chronic pain patients. Here, we investigated whether acupuncture treatments can improve cognitive dysfunction as well as allodynia induced by neuropathic pain...
Catherine Fenster et al.
Brain research bulletin, 87(1), 21-29 (2011-11-03)
Neuregulin-1 (NRG1) is a trophic and differentiation factor that signals through ErbB receptor tyrosine kinases to regulate nervous system development. Previous studies have demonstrated that NRG1 affects plasticity at glutamatergic synapses in principal glutamatergic neurons of the hippocampus and frontal...
Wei Wang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(26), 5939-5948 (2018-06-02)
Microdeletion of the human 16p11.2 gene locus has been linked to autism spectrum disorder (ASD) and intellectual disability and confers risk for a number of other neurodevelopmental deficits. Transgenic mice carrying 16p11.2 deletion (16p11+/-) display phenotypes reminiscent of those in...
Jing Fan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(35), 10928-10938 (2009-09-04)
Evidence suggests that NMDA-type glutamate receptors contribute to degeneration of striatal medium-sized spiny neurons (MSNs) in Huntington's disease (HD). Previously, we demonstrated that NMDA receptor (NMDAR)-mediated current and/or toxicity is increased in MSNs from the yeast artificial chromosome (YAC) transgenic...
Elizabeth B Glennon et al.
Brain communications, 2(1) (2020-06-06)
Polymorphisms associated with BIN1 confer the second greatest risk for developing late onset Alzheimer's disease. The biological consequences of this genetic variation are not fully understood, however BIN1 is a binding partner for tau. Tau is normally a highly soluble...
Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity.
Ma, et al.
Proceedings of the National Academy of Sciences of the USA, 114, E8760-E8769 (2018)
Preethy S Sridharan et al.
Channels (Austin, Tex.), 14(1), 287-293 (2020-08-18)
CACNA1 C, which codes for the Cav1.2 isoform of L-type Ca2+ channels (LTCCs), is a prominent risk gene in neuropsychiatric and neurodegenerative conditions. A role forLTCCs, and Cav1.2 in particular, in transcription-dependent late long-term potentiation (LTP) has long been known. Here...
Duncan Sinclair et al.
Journal of neurodevelopmental disorders, 8, 14-14 (2016-05-03)
Neurodevelopmental disorders such as autism spectrum disorders and schizophrenia differentially impact males and females and are highly heritable. The ways in which sex and genetic vulnerability influence the pathogenesis of these disorders are not clearly understood. The n-methyl-d-aspartate (NMDA) receptor...
Therése Abrahamsson et al.
Neuron, 96(4), 839-855 (2017-10-17)
Presynaptic NMDA receptors (preNMDARs) control synaptic release, but it is not well understood how. Rab3-interacting molecules (RIMs) provide scaffolding at presynaptic active zones and are involved in vesicle priming. Moreover, c-Jun N-terminal kinase (JNK) has been implicated in regulation of...
Charlotte C Bavley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(11), 2780-2795 (2018-02-21)
A homozygous nonsense mutation in the cereblon (CRBN) gene results in autosomal recessive, nonsyndromic intellectual disability that is devoid of other phenotypic features, suggesting a critical role of CRBN in mediating learning and memory. In this study, we demonstrate that...
Dab1 is required for synaptic plasticity and associative learning.
Trotter, J; Lee, GH; Kazdoba, TM; Crowell, B; Domogauer, J; Mahoney, HM; Franco et al.
The Journal of Neuroscience null
Jie-Min Jia et al.
Nature neuroscience, 16(11), 1627-1636 (2013-10-15)
Dopamine D2 receptors (D2R) are G protein-coupled receptors that modulate synaptic transmission and are important for various brain functions, including learning and working memory. Abnormal D2R signaling has been implicated in psychiatric disorders such as schizophrenia. Here we report a...
Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia.
Kristiansen, LV; Beneyto, M; Haroutunian, V; Meador-Woodruff, JH
Molecular Psychiatry null
Judith R Reinhard et al.
Nature communications, 7, 11613-11613 (2016-05-20)
Hippocampal long-term potentiation (LTP) represents the cellular response of excitatory synapses to specific patterns of high neuronal activity and is required for learning and memory. Here we identify a mechanism that requires the calcium-binding protein Copine-6 to translate the initial...
Alice Shaam Al Abed et al.
Aging cell, 19(10), e13243-e13243 (2020-10-04)
GluN2B subunits of NMDA receptors have been proposed as a target for treating age-related memory decline. They are indeed considered as crucial for hippocampal synaptic plasticity and hippocampus-dependent memory formation, which are both altered in aging. Because a synaptic enrichment...
Ksenia Kurbatskaya et al.
Acta neuropathologica communications, 4, 34-34 (2016-04-03)
Alterations in calcium homeostasis are widely reported to contribute to synaptic degeneration and neuronal loss in Alzheimer's disease. Elevated cytosolic calcium concentrations lead to activation of the calcium-sensitive cysteine protease, calpain, which has a number of substrates known to be...
Wei Li et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(19), 8423-8441 (2013-05-10)
Profound synapse loss is one of the major pathological hallmarks associated with Alzheimer's disease (AD) and might underlie memory impairment. Our previous work demonstrated that the magnesium ion is a critical factor in controlling synapse density/plasticity. Here, we investigated whether...
Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.
Li, Lijun, et al.
Neurobiology of Aging, 24, 1113-1121 (2003)
Tianyun Zhao et al.
Scientific reports, 6, 26865-26865 (2016-05-27)
Ketamine is commonly used for anesthesia and as a recreational drug. In pregnant users, a potential neurotoxicity in offspring has been noted. Our previous work demonstrated that ketamine exposure of pregnant rats induces affective disorders and cognitive impairments in offspring....
A Rao et al.
Neuron, 19(4), 801-812 (1997-11-14)
We describe here a novel effect of activity on the subcellular distribution of NMDA receptors in hippocampal neurons in culture. In spontaneously active neurons, NMDA receptors were clustered at a few synaptic and nonsynaptic sites. Chronic blockade of NMDA receptor...
The Novel Antipsychotic Drug Lurasidone Enhances NMDA Receptor-Mediated Synaptic Responses.
Yuen EY, Li X, Wei J, Horiguchi M, Meltzer HY, Yan Z
Molecular Pharmacology null
Hong-Yan Geng et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(31), 7450-7464 (2017-07-02)
Medium spiny neurons (MSNs), the major GABAergic projection neurons in the striatum, are implicated in many neuropsychiatric diseases such as schizophrenia, but the underlying mechanisms remain unclear. We found that a deficiency in Erbb4, a schizophrenia risk gene, in MSNs...
Specific involvement of atypical PKC?/PKM? in spinal persistent nociceptive processing following peripheral inflammation in rat.
Marchand, F; D'Mello, R; Yip, PK; Calvo, M; Muller, E; Pezet, S; Dickenson, AH; McMahon, SB
Molecular Pain null
Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model.
Hu, XL; Cheng, X; Cai, L; Tan, GH; Xu, L; Feng, XY; Lu, TJ; Xiong, H; Fei, J; Xiong, ZQ
Cerebral Cortex (1991)
Candice E Van Skike et al.
Alcoholism, clinical and experimental research, 39(2), 262-271 (2015-02-17)
Ethanol (EtOH) dependence and tolerance in the adult are marked by increased function of NMDA receptors and decreased function of GABAA receptors, which coincide with altered receptor subunit expression in specific brain regions. Adolescents often use EtOH at levels greater...
Ling-Dan Dong et al.
Neural plasticity, 2013, 670254-670254 (2013-11-01)
DBA/2J mouse has been used as a model for spontaneous secondary glaucoma. Here, we investigated changes in expression of NMDA receptor (NMDAR) subunits and Cdk5/p35/NMDAR signaling in retinas of DBA/2J mice using Western blot technique. The protein levels of NR1...
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