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Showing 1-30 of 288 results for "06-942" within Papers
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression.
Mehta, DS; Wurster, AL; Weinmann, AS; Grusby, MJ
Proceedings of the National Academy of Sciences of the USA null
Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes.
Miao, F; Chen, Z; Zhang, L; Liu, Z; Wu, X; Yuan, YC; Natarajan, R
The Journal of Biological Chemistry null
Soizik Berlivet et al.
Human genetics, 131(7), 1161-1171 (2012-01-25)
Phenotypic variation results from variation in gene expression, which is modulated by genetic and/or epigenetic factors. To understand the molecular basis of human disease, interaction between genetic and epigenetic factors needs to be taken into account. The asthma-associated region 17q12-q21
Sara Vicente-Muñoz et al.
FEBS open bio, 4, 996-1006 (2014-12-05)
Histone acetylation affects several aspects of gene regulation, from chromatin remodelling to gene expression, by modulating the interplay between chromatin and key transcriptional regulators. The exact molecular mechanism underlying acetylation patterns and crosstalk with other epigenetic modifications requires further investigation.
A B Ruiz-García et al.
FEBS letters, 403(2), 186-190 (1997-02-17)
Enzymatic extracts from a gcn5 mutant and wild-type strains of Saccharomyces cerevisiae were chromatographically fractionated and the histone acetyltransferase activities compared. When free histones were used as substrate, extracts from wild-type cells showed two peaks of activity on histone H3
Matthew S Yan et al.
The Journal of biological chemistry, 293(12), 4381-4402 (2018-02-08)
Although the functional role of chromatin marks at promoters in mediating cell-restricted gene expression has been well characterized, the role of intragenic chromatin marks is not well understood, especially in endothelial cell (EC) gene expression. Here, we characterized the histone
Clint J Winkler et al.
PloS one, 5(4), e10166-e10166 (2010-04-21)
Groucho (Gro) is a Drosophila melanogaster transcriptional corepressor that directly interacts with the histone deacetylase Rpd3. Although previous studies suggest that this interaction is required for repression of Gro-responsive reporters in cultured cells, the in vivo significance of this interaction
Thomas A Milne et al.
Methods in molecular biology (Clifton, N.J.), 538, 409-423 (2009-03-12)
Disruption of epigenetic regulators of transcription is a central mechanism of oncogenesis. Many of the advances in the understanding of these mechanisms are attributable to the successful development of chromatin immunoprecipitation (ChIP) for in vivo detection of histone modifications as
Kristin M Kohler et al.
Journal of immunology (Baltimore, Md. : 1950), 189(11), 5314-5326 (2012-10-23)
Somatic hypermutation (SHM) diversifies the V region of Ig genes and underlies the process of affinity maturation, in which B lymphocytes producing high-affinity Abs are generated and selected. SHM is triggered in activated B cells by deamination of deoxycytosine residues
Jun Miao et al.
PLoS pathogens, 17(8), e1009351-e1009351 (2021-08-18)
The histone acetyltransferase GCN5-associated SAGA complex is evolutionarily conserved from yeast to human and functions as a general transcription co-activator in global gene regulation. In this study, we identified a divergent GCN5 complex in Plasmodium falciparum, which contains two plant
Jae Duk Choi et al.
Nucleic acids research, 40(22), 11321-11338 (2012-10-18)
Heterochromatin protein 1γ (HP1γ) is a chromatin protein involved in gene silencing. Herein, we show that HP1γ interacts with breast cancer type 1 susceptibility protein (BRCA1) and regulates BRCA1-mediated transcription via modulation of promoter occupancy and histone modification. We used
Xiao Chen et al.
Bone research, 6, 34-34 (2018-12-05)
RANKL signaling is essential for osteoclastogenesis. Its role in osteoblastic differentiation and bone formation is unknown. Here we demonstrate that RANK is expressed at an early stage of bone marrow mesenchymal stem cells (BMSCs) during osteogenic differentiation in both mice
Dynamic chromatin boundaries delineate a latency control region of Epstein-Barr virus.
Chau, CM; Lieberman, PM
Journal of virology null
Mohamad Omar Ashi et al.
Cellular & molecular immunology, 16(10), 810-819 (2018-08-22)
The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We recently demonstrated that aberrant Ig chains lacking variable (V) domains can be produced after nonsense-associated altered splicing (NAS) events. Remarkably, the expression of these truncated Ig
Michelle L T Nguyen et al.
European journal of immunology, 46(2), 307-318 (2015-11-01)
Numerous studies have focused on the molecular regulation of perforin (PFP) and granzyme B (GZMB) expression by activated cytotoxic T lymphocytes (CTLs), but little is known about the molecular factors that underpin granzyme A (GZMA) expression. In vitro activation of
Mark B Meyer et al.
The Journal of biological chemistry, 289(23), 16016-16031 (2014-04-26)
RUNX2 is a transcription factor that is first expressed in early osteoblast-lineage cells and represents a primary determinant of osteoblastogenesis. While numerous target genes are regulated by RUNX2, little is known of sites on the genome occupied by RUNX2 or
Mark B Meyer et al.
The Journal of biological chemistry, 294(24), 9518-9535 (2019-05-06)
Vitamin D3 is terminally bioactivated in the kidney to 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) via cytochrome P450 family 27 subfamily B member 1 (CYP27B1), whose gene is regulated by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and 1,25(OH)2D3 Our recent genomic
Badi Sri Sailaja et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(52), E3687-E3695 (2012-12-14)
Stress induces long-lasting changes in neuronal gene expression and cholinergic neurotransmission, but the underlying mechanism(s) are incompletely understood. Here, we report that chromatin structure and histone modifications are causally involved in this transcriptional memory. Specifically, the AChE gene encoding the
Sabrina Chriett et al.
Scientific reports, 9(1), 742-742 (2019-01-27)
Butyrate and R-β-hydroxybutyrate are two related short chain fatty acids naturally found in mammals. Butyrate, produced by enteric butyric bacteria, is present at millimolar concentrations in the gastrointestinal tract and at lower levels in blood; R-β-hydroxybutyrate, the main ketone body
María E Pérez-Martínez et al.
Epigenetics, 15(3), 251-271 (2019-09-13)
Epigenetic information is able to interact with the cellular environment and could be especially useful for reprograming gene expression in response to a physiological perturbation. In fact the genes induced or repressed by osmotic stress undergo significant changes in terms
Xingliang Hou et al.
Nature communications, 5, 4601-4601 (2014-08-12)
Nuclear factor Y (NF-Y) is a conserved heterotrimeric transcription factor complex that binds to the CCAAT motifs within the promoter region of many genes. In plants, a large number of genes code for variants of each NF-YA, B or C
Gee Y Ching et al.
Journal of neurochemistry, 109(6), 1610-1623 (2009-05-22)
Alpha-internexin and the neurofilament triplet proteins (NF-L, NF-M, and NF-H) co-assemble into intermediate filament networks in neurons. We have found that the RE1 silencing transcription factor (REST) plays a contributory role in the neuron-specific expression of the alpha-internexin, NF-H and
Ousseynou Sarr et al.
The Journal of physiology, 594(6), 1753-1772 (2015-12-15)
Postnatal intake of an energy dense diet, the Western diet (WD), is a strong risk factor for liver fibrosis. Recently, adverse in utero conditions resulting in low birth weight (LBW) have also been associated with postnatal fibrosis development. We assessed
Leif C Lindeman et al.
Methods in molecular biology (Clifton, N.J.), 567, 75-86 (2009-07-10)
Chromatin immunoprecipitation (ChIP) is arguably the assay of choice to determine the genomic localization of DNA- or chromatin-binding proteins, including post-translationally modified histones, in cells. The increasing importance of the zebrafish, Danio rerio, as a model organism in functional genomics
Denisa Komůrková et al.
International journal of molecular sciences, 22(4) (2021-03-07)
G-quadruplexes (G4s) are four-stranded helical structures that regulate several nuclear processes, including gene expression and telomere maintenance. We observed that G4s are located in GC-rich (euchromatin) regions and outside the fibrillarin-positive compartment of nucleoli. Genomic regions around G4s were preferentially
Shivali Kapoor et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(39), 12139-12144 (2015-09-16)
Point centromeres are specified by a short consensus sequence that seeds kinetochore formation, whereas regional centromeres lack a conserved sequence and instead are epigenetically inherited. Regional centromeres are generally flanked by heterochromatin that ensures high levels of cohesin and promotes
Zhenxia Qin et al.
Amino acids, 48(2), 599-603 (2015-12-17)
Approximately 12 % of histone H2B in mammalian brain contains an unusual D-aspartate residue in its N-terminal tail. Most of this D-aspartate is linked to the C-flanking glycine via an isopeptide bond. To explore the possible significance of these modifications
Dynamic assembly of silent chromatin during thymocyte maturation.
Su, RC; Brown, KE; Saaber, S; Fisher, AG; Merkenschlager, M; Smale, ST
Nature Genetics null
Kathleen A Bishop et al.
The Journal of biological chemistry, 286(23), 20880-20891 (2011-04-14)
Receptor activator of NF-κB ligand (Rankl) is a TNF-like factor that induces the formation of osteoclasts responsible for bone resorption. Although T cell activation up-regulates this gene, the molecular mechanism of its transcriptional control remains unknown. We used ChIP-chip analysis
Michael Bordonaro et al.
Experimental cell research, 313(8), 1652-1666 (2007-03-16)
Most colorectal carcinomas (CRCs) exhibit constitutively active Wnt signaling. We have reported that (a) the histone deacetylase inhibitor (HDACi)(2) sodium butyrate (NaB) modulates the canonical Wnt transcriptional activity of CRC cells in vitro and (b) a linear relationship exists between
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