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Showing 1-30 of 82 results for "07-354" within Papers
Angelina S Gross et al.
The Journal of biological chemistry, 294(32), 12020-12039 (2019-06-19)
Autophagy, a membrane-dependent catabolic process, ensures survival of aging cells and depends on the cellular energetic status. Acetyl-CoA carboxylase 1 (Acc1) connects central energy metabolism to lipid biosynthesis and is rate-limiting for the de novo synthesis of lipids. However, it
Regulation of TCR V?2 gene rearrangement by the helix-loop-helix protein, E2A.
Nozaki, M; Wakae, K; Tamaki, N; Sakamoto, S; Ohnishi, K; Uejima, T; Minato, N; Yanagihara et al.
International Immunology null
Abril Marcela Herrera-Solorio et al.
EMBO reports, 20(4) (2019-03-06)
Post-translational modifications of histone H3 N-terminal tails are key epigenetic regulators of virulence gene expression and sexual commitment in the human malaria parasite Plasmodium falciparum Here, we identify proteolytic clipping of the N-terminal tail of nucleosome-associated histone H3 at amino
Godfried W van der Heijden et al.
Mechanisms of development, 122(9), 1008-1022 (2005-06-01)
In mammalian fertilization, the paternal genome is delivered to the secondary oocyte by sperm with protamine compacted DNA, while the maternal genome is arrested in meiotic metaphase II. Thus, at the beginning of fertilization, the two gametic chromatin sets are
Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia and regenerative changes in the absence of "floxed" alleles.
Huh WJ, Mysorekar IU, Mills JC
American Journal of Physiology: Gastrointestinal and Liver Physiology null
S Sah et al.
Reproduction, fertility, and development, 32(5), 508-521 (2020-01-22)
Expression levels of 13 microRNAs (miRNAs) were compared between buffalo blastocysts produced by somatic cell nuclear transfer through hand-made cloning and IVF to improve cloning efficiency. Expression of miR-22, miR-145, miR-374a and miR-30c was higher, whereas that of miR-29b, miR-101
Hashem A Meriesh et al.
The Journal of biological chemistry, 295(19), 6561-6569 (2020-04-05)
Histone H2B monoubiquitylation (H2Bub1) has central functions in multiple DNA-templated processes, including gene transcription, DNA repair, and replication. H2Bub1 also is required for the trans-histone regulation of H3K4 and H3K79 methylation. Although previous studies have elucidated the basic mechanisms that
Mass spectrometry analysis of the variants of histone H3 and H4 of soybean and their post-translational modifications.
Wu, T; Yuan, T; Tsai, SN; Wang, C; Sun, SM; Lam, HM; Ngai, SM
BMC plant biology null
Thomas Rauen et al.
The Journal of biological chemistry, 286(50), 43437-43446 (2011-10-26)
IL-17A is a proinflammatory cytokine that is produced by specialized T helper cells and contributes to the development of several autoimmune diseases such as systemic lupus erythematosus (SLE). Transcription factor cAMP-responsive element modulator (CREM)α displays increased expression levels in T
Sushil Kumar Mohapatra et al.
PloS one, 10(6), e0129235-e0129235 (2015-06-09)
Despite being successfully used to produce live offspring in many species, somatic cell nuclear transfer (NT) has had a limited applicability due to very low (>1%) live birth rate because of a high incidence of pregnancy failure, which is mainly
Ling-Jun Zhao et al.
Genes & cancer, 7(3-4), 98-109 (2016-07-07)
Human cancers frequently arise from increased expression of proto-oncogenes, such as MYC and HER2. Understanding the cellular pathways regulating the transcription and expression of proto-oncogenes is important for targeted therapies for cancer treatment. Adenoviral (Ad) E1A 243R (243 aa residues)
Charles T Foster et al.
Molecular and cellular biology, 30(20), 4851-4863 (2010-08-18)
Lysine-specific demethylase 1 (LSD1), which demethylates mono- and dimethylated histone H3-Lys4 as part of a complex including CoREST and histone deacetylases (HDACs), is essential for embryonic development in the mouse beyond embryonic day 6.5 (e6.5). To determine the role of
Francesca Martinato et al.
PloS one, 3(11), e3650-e3650 (2008-11-06)
The c-myc proto-oncogene is induced by mitogens and is a central regulator of cell growth and differentiation. The c-myc product, Myc, is a transcription factor that binds a multitude of genomic sites, estimated to be over 10-15% of all promoter
Qianwen Wang et al.
Nucleic acids research, 49(17), 9755-9767 (2021-08-18)
Pericentromeric DNA, consisting of high-copy-number tandem repeats and transposable elements, is normally silenced through DNA methylation and histone modifications to maintain chromosomal integrity and stability. Although histone deacetylase 6 (HDA6) has been known to participate in pericentromeric silencing, the mechanism is
Coactivator function defines the active estrogen receptor alpha cistrome.
Lupien, M; Eeckhoute, J; Meyer, CA; Krum, SA; Rhodes, DR; Liu, XS; Brown, M
Molecular and cellular biology null
Kezhi Yan et al.
Science advances, 6(4), eaax0021-eaax0021 (2020-02-06)
Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23). We report that these complexes also catalyze H3K23 propionylation in vitro and
Luis F Duarte et al.
Nature communications, 5, 5210-5210 (2014-11-15)
The process of cellular senescence generates a repressive chromatin environment, however, the role of histone variants and histone proteolytic cleavage in senescence remains unclear. Here, using models of oncogene-induced and replicative senescence, we report novel histone H3 tail cleavage events
Harsimran Kaur Garcha et al.
Pharmaceuticals (Basel, Switzerland), 15(11) (2022-11-11)
NK/T-cell lymphoma (NKTCL) and γδ T-cell non-Hodgkin lymphomas (γδ T-NHL) are highly aggressive lymphomas that lack rationally designed therapies and rely on repurposed chemotherapeutics from other hematological cancers. Histone deacetylases (HDACs) have been targeted in a range of malignancies, including
Rafal Donczew et al.
eLife, 9 (2020-01-09)
Deletions within genes coding for subunits of the transcription coactivator SAGA caused strong genome-wide defects in transcription and SAGA-mediated chromatin modifications. In contrast, rapid SAGA depletion produced only modest transcription defects at 13% of protein-coding genes - genes that are
Nucleosome competition reveals processive acetylation by the SAGA HAT module.
Ringel, AE; Cieniewicz, AM; Taverna, SD; Wolberger, C
Proceedings of the National Academy of Sciences of the USA null
Alec M Desimone et al.
Molecular and cellular biology, 30(13), 3342-3356 (2010-05-05)
Switching between alternate states of gene transcription is fundamental to a multitude of cellular regulatory pathways, including those that govern differentiation. In spite of the progress in our understanding of such transitions in gene activity, a major unanswered question is
Ana Carolina Pinheiro Campos et al.
Cellular and molecular neurobiology, 40(6), 939-954 (2020-01-16)
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapeutic strategy for motor symptoms of Parkinson's disease (PD) when L-DOPA therapy induces disabling side effects. Classical inflammatory activation of glial cells is well established in PD, contributing
Danqi Chen et al.
Environmental and molecular mutagenesis, 59(5), 375-385 (2018-03-24)
As the primary metabolite of alcohol and the most abundant carcinogen in tobacco smoke, acetaldehyde is linked to a number of human diseases associated with chronic alcohol consumption and smoking including cancers. In addition to direct DNA damage as a
Mingxuan Wu et al.
eLife, 7 (2018-06-06)
The core CoREST complex (LHC) contains histone deacetylase HDAC1 and histone demethylase LSD1 held together by the scaffold protein CoREST. Here, we analyze the purified LHC with modified peptide and reconstituted semisynthetic mononucleosome substrates. LHC demethylase activity toward methyl-Lys4 in
Developmental and environmental signals induce distinct histone acetylation profiles on distal and proximal promoter elements of the C4-Pepc gene in maize.
Offermann, S; Dreesen, B; Horst, I; Danker, T; Jaskiewicz, M; Peterhansel, C
Genetics null
Hideaki Ogiwara et al.
PloS one, 7(12), e52810-e52810 (2013-01-04)
Histone acetylation at DNA double-strand break (DSB) sites by CBP and p300 histone acetyltransferases (HATs) is critical for the recruitment of DSB repair proteins to chromatin. Here, we show that CBP and p300 HATs also function in DSB repair by
Guochun Zhu et al.
International journal of biological sciences, 18(14), 5522-5538 (2022-09-24)
Cathepsins play a role in regulation of cell function through their presence in the cell nucleus. However, the role of Cathepsin K (Ctsk) as an epigenetic regulator in osteoclasts remains unknown. Our data demonstrated that Ctsk-/-Mmp9-/- mice have a striking
The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3.
Cieniewicz, AM; Moreland, L; Ringel, AE; Mackintosh, SG; Raman, A; Gilbert, TM; Wolberger et al.
Molecular and Cellular Proteomics null
Krimo Toutah et al.
Journal of medicinal chemistry, 64(12), 8486-8509 (2021-06-09)
Epigenetic targeting has emerged as an efficacious therapy for hematological cancers. The rare and incurable T-cell prolymphocytic leukemia (T-PLL) is known for its aggressive clinical course. Current epigenetic agents such as histone deacetylase (HDAC) inhibitors are increasingly used for targeted
Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance.
Lupien, M; Meyer, CA; Bailey, ST; Eeckhoute, J; Cook, J; Westerling, T; Zhang, X; Carroll et al.
Genes & Development null
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