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Showing 1-30 of 153 results for "07-448" within Papers
Constance Alabert et al.
Nature cell biology, 16(3), 281-293 (2014-02-25)
To maintain genome function and stability, DNA sequence and its organization into chromatin must be duplicated during cell division. Understanding how entire chromosomes are copied remains a major challenge. Here, we use nascent chromatin capture (NCC) to profile chromatin proteome
Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome.
Putiri, EL; Tiedemann, RL; Liu, C; Choi, JH; Robertson, KD
Oncotarget null
Zsolt Toth et al.
PLoS pathogens, 6(7), e1001013-e1001013 (2010-07-28)
Epigenetic modifications of the herpesviral genome play a key role in the transcriptional control of latent and lytic genes during a productive viral lifecycle. In this study, we describe for the first time a comprehensive genome-wide ChIP-on-Chip analysis of the
Yi-Zhe Zhang et al.
Nature communications, 11(1), 6212-6212 (2020-12-06)
Histone 3 Lys 27 trimethylation (H3K27me3)-mediated epigenetic silencing plays a critical role in multiple biological processes. However, the H3K27me3 recognition and transcriptional repression mechanisms are only partially understood. Here, we report a mechanism for H3K27me3 recognition and transcriptional repression. Our
Profile of histone lysine methylation across transcribed mammalian chromatin.
Vakoc, CR; Sachdeva, MM; Wang, H; Blobel, GA
Molecular and cellular biology null
Steven Z DeLuca et al.
eLife, 9 (2020-08-11)
Polycomb silencing represses gene expression and provides a molecular memory of chromatin state that is essential for animal development. We show that Drosophila female germline stem cells (GSCs) provide a powerful system for studying Polycomb silencing. GSCs have a non-canonical
Qingtian Li et al.
PLoS genetics, 10(7), e1004524-e1004524 (2014-08-01)
Histone demethylases have emerged as important players in developmental processes. Jumonji domain containing-3 (Jmjd3) has been identified as a key histone demethylase that plays a critical role in the regulation of gene expression; however, the in vivo function of Jmjd3
Patterns of histone H3 lysine 27 monomethylation and erythroid cell type-specific gene expression.
Steiner, LA; Schulz, VP; Maksimova, Y; Wong, C; Gallagher, PG
The Journal of Biological Chemistry null
Pierre Bourguet et al.
Genome biology, 21(1), 283-283 (2020-11-26)
Chromatin organizes DNA and regulates its transcriptional activity through epigenetic modifications. Heterochromatic regions of the genome are generally transcriptionally silent, while euchromatin is more prone to transcription. During DNA replication, both genetic information and chromatin modifications must be faithfully passed
Theresa Baker et al.
Oncotarget, 6(32), 32646-32655 (2015-09-12)
Although targeted therapies have revolutionized cancer treatment, overcoming acquired resistance remains a major clinical challenge. EZH2 inhibitors (EZH2i), EPZ-6438 and GSK126, are currently in the early stages of clinical evaluation and the first encouraging signs of efficacy have recently emerged
Granulocyte heterochromatin: defining the epigenome.
Olins, DE; Olins, AL
BMC Cell Biology null
RNA-directed DNA methylation induces transcriptional activation in plants.
Kenichi Shibuya, Setsuko Fukushima, Hiroshi Takatsuji, Kenichi Shibuya, Setsuko Fukushima et al.
Proceedings of the National Academy of Sciences of the USA null
Shuai-Kun Su et al.
Journal of cell science, 129(12), 2343-2353 (2016-04-30)
Unlike other members of the polycomb group protein family, EZH1 has been shown to positively associate with active transcription on a genome-wide scale. However, the underlying mechanism for this behavior still remains elusive. Here, we report that EZH1 physically interacts
Xinjie Zhao et al.
Journal of integrative plant biology, 65(1), 203-222 (2022-12-22)
Minichromosome Maintenance protein 10 (MCM10) is essential for DNA replication initiation and DNA elongation in yeasts and animals. Although the functions of MCM10 in DNA replication and repair have been well documented, the detailed mechanisms for MCM10 in these processes
Shigeki Iwase et al.
Cell, 128(6), 1077-1088 (2007-02-27)
Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3). We show that the X-linked mental
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
Chen, S; Ma, J; Wu, F; Xiong, LJ; Ma, H; Xu, W; Lv, R; Li, X; Villen, J; Gygi, SP; Liu, XS; Shi, Y
Genes & Development null
Ziqi Zhu et al.
Cell research, 20(7), 794-801 (2010-06-10)
Dimethylation of histone H3 lysine 9 (H3K9me2) is an important epigenetic mark associated with transcription repression. Here, we identified PHF8, a JmjC-domain-containing protein, as a histone demethylase specific for this repressing mark. Recombinant full-length wild type protein could remove methylation
Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2) in human oral cancer cell line.
Yamamoto, D; Shima, K; Matsuo, K; Nishioka, T; Chen, CY; Hu, GF; Sasaki, A; Tsuji, T
Testing null
Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36.
Jung, HR; Pasini, D; Helin, K; Jensen, ON
Molecular and Cellular Proteomics null
A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells.
Ohno, R; Nakayama, M; Naruse, C; Okashita, N; Takano, O; Tachibana, M; Asano, M; Saitou, M; Seki, Y
Development null
Chengyang Huang et al.
Cell research, 20(2), 154-165 (2010-01-20)
Dimethylations of histone H3 lysine 9 and lysine 27 are important epigenetic marks associated with transcription repression. Here, we identified KIAA1718 (KDM7A) as a novel histone demethylase specific for these two repressing marks. Using mouse embryonic stem cells, we demonstrated
Angèle Santenard et al.
Nature cell biology, 12(9), 853-862 (2010-08-03)
In mammals, oocyte fertilization by sperm initiates development. This is followed by epigenetic reprogramming of both parental genomes, which involves the de novo establishment of chromatin domains. In the mouse embryo, methylation of histone H3 establishes an epigenetic asymmetry and
Alina Rabinovich et al.
Genome research, 18(11), 1763-1777 (2008-10-07)
We have previously shown that most sites bound by E2F family members in vivo do not contain E2F consensus motifs. However, differences between in vivo target sites that contain or lack a consensus E2F motif have not been explored. To
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.
Tan, J; Yang, X; Zhuang, L; Jiang, X; Chen, W; Lee, PL; Karuturi, RK; Tan, PB; Liu, ET; Yu, Q
Genes & Development null
Mary T Scott et al.
Cancer discovery, 6(11), 1248-1257 (2016-11-04)
A major obstacle to curing chronic myeloid leukemia (CML) is residual disease maintained by tyrosine kinase inhibitor (TKI)-persistent leukemic stem cells (LSC). These are BCR-ABL1 kinase independent, refractory to apoptosis, and serve as a reservoir to drive relapse or TKI
Heterochromatic genes undergo epigenetic changes and escape silencing in immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome.
Brun, ME; Lana, E; Rivals, I; Lefranc, G; Sarda, P; Claustres, M; Megarbane, A; De Sario, A
Testing null
Edwin R Smith et al.
Molecular and cellular biology, 28(3), 1041-1046 (2007-11-28)
Histone H3 methylation at Lys27 (H3K27 methylation) is a hallmark of silent chromatin, while H3K4 methylation is associated with active chromatin regions. Here we report that a Drosophila JmjC family member, dUTX, specifically demethylates di- and trimethylated but not monomethylated
Autocatalytic differentiation of epigenetic modifications within the Arabidopsis genome.
Inagaki, S; Miura-Kamio, A; Nakamura, Y; Lu, F; Cui, X; Cao, X; Kimura, H; Saze, H; Kakutani, T
The Embo Journal null
Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases.
Jacob, Y; Stroud, H; Leblanc, C; Feng, S; Zhuo, L; Caro, E; Hassel, C; Gutierrez et al.
Nature null
G9a selectively represses a class of late-replicating genes at the nuclear periphery.
Yokochi, T; Poduch, K; Ryba, T; Lu, J; Hiratani, I; Tachibana, M; Shinkai, Y; Gilbert, DM
Proceedings of the National Academy of Sciences of the USA null
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