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Thomas B Nicholson et al.
PloS one, 8(4), e60913-e60913 (2013-05-03)
Lysine-specific demethylase 1 (Lsd1/Aof2/Kdm1a), the first enzyme with specific lysine demethylase activity to be described, demethylates histone and non-histone proteins and is essential for mouse embryogenesis. Lsd1 interacts with numerous proteins through several different domains, most notably the tower domain
Mikko P Turunen et al.
Circulation research, 105(6), 604-609 (2009-08-22)
We studied a possibility that shRNAs can lead to transcriptional gene activation at the promoter level via epigenetic mechanism. The purpose of this study was to test the effects on vascular endothelial growth factor (VEGF-A) expression by promoter targeted small
A designed curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver.
Fukunaga S, Kanda G, Tanase J, Harashima H, Ohyama T, Kamiya H
Gene Therapy null
Junjun Cheng et al.
Journal of virology, 94(17) (2020-06-26)
Covalently closed circular DNA (cccDNA) of hepadnaviruses exists as an episomal minichromosome in the nucleus of an infected hepatocyte and serves as the template for the transcription of viral mRNAs. It had been demonstrated by others and us that interferon
Koshiki Mino et al.
Bioscience, biotechnology, and biochemistry, 78(6), 1010-1017 (2014-07-19)
Tissue factor pathway inhibitor-2 (TFPI-2) is a major inhibitor of extracellular matrix degradation. Decreases in TFPI-2 contribute to malignant tumor cell production, and TFPI-2 is a presumed tumor suppressor. TFPI-2 gene transcription is regulated by two epigenetic mechanisms: DNA methylation
Francisco Gimeno-Valiente et al.
Scientific reports, 9(1), 9339-9339 (2019-06-30)
Most of colorectal cancer CRC-related death is due to metastasis and the finding of markers for prognosis of invasiveness, constitutes an appealing challenge. Here, after analysing cDNA array containing 43 tumour and 5 normal mucosa samples, we report that the
Alexey S Revenko et al.
Molecular and cellular biology, 30(22), 5260-5272 (2010-09-22)
Histone modifications are regarded as the carrier of epigenetic memory through cell divisions. How the marks facilitate cell cycle-dependent gene expression is poorly understood. The evolutionarily conserved AAA ATPase ANCCA (AAA nuclear coregulator cancer-associated protein)/ATAD2 was identified as a direct
Sherri A Rennoll et al.
Biochemical and biophysical research communications, 443(1), 217-222 (2013-12-05)
The β-catenin transcriptional coactivator is the key mediator of the canonical Wnt signaling pathway. In the absence of Wnt, β-catenin associates with a cytosolic and multi-protein destruction complex where it is phosphorylated and targeted for proteasomal degradation. In the presence
Marion Clavel et al.
BMC plant biology, 15, 70-70 (2015-04-08)
In plants and animals, a large number of double-stranded RNA binding proteins (DRBs) have been shown to act as non-catalytic cofactors of DICERs and to participate in the biogenesis of small RNAs involved in RNA silencing. We have previously shown
Dynamic histone H3 acetylation and methylation at human cytomegalovirus promoters during replication in fibroblasts.
Cuevas-Bennett, C; Shenk, T
Journal of virology null
FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors.
Schroeder, et al.
Neuroscience Letters, 550, 119-124 (2020)
Fang Lu et al.
Journal of virology, 91(20) (2017-08-11)
Epstein-Barr virus (EBV) latency and its associated carcinogenesis are regulated by dynamic changes in DNA methylation of both virus and host genomes. We show here that the ten-eleven translocation 2 (TET2) gene, implicated in hydroxymethylation and active DNA demethylation, is
Minerva S Trejo-Arellano et al.
The Plant journal : for cell and molecular biology, 90(2), 293-303 (2017-02-10)
Amino-terminal tails of histones are targets for diverse post-translational modifications whose combinatorial action may constitute a code that will be read and interpreted by cellular proteins to define particular transcriptional states. Here, we describe monomethylation of histone H3 lysine 23
Mi-Sun Kang et al.
Cell reports, 29(13), 4632-4645 (2019-12-26)
Proliferating cell nuclear antigen (PCNA) is a DNA clamp essential for DNA replication. During DNA synthesis, PCNA is continuously loaded onto and unloaded from DNA. PCNA recruits various proteins to nascent DNA to facilitate chromosome duplication. Therefore, timely PCNA unloading
miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target.
Aguado-Fraile, E; Ramos, E; Saenz-Morales, D; Conde, E; Blanco-Sanchez, I; Stamatakis et al.
Testing null
Dominique Pontier et al.
Life science alliance, 2(3) (2019-05-31)
Global, segmental, and gene duplication-related processes are driving genome size and complexity in plants. Despite their evolutionary potentials, those processes can also have adverse effects on genome regulation, thus implying the existence of specialized corrective mechanisms. Here, we report that
(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.
Reddy, MV; Akula, B; Cosenza, SC; Lee, CM; Mallireddigari, MR; Pallela, VR; Subbaiah et al.
Journal of medicinal chemistry null
Fabio Stossi et al.
Molecular and cellular biology, 29(7), 1749-1759 (2009-02-04)
The regulation of gene expression by nuclear receptors controls the phenotypic properties and diverse biologies of target cells. In breast cancer cells, estrogen receptor alpha (ERalpha) is a master regulator of transcriptional stimulation and repression, yet the mechanisms by which
Robert M Yarrington et al.
Genetics, 215(2), 407-420 (2020-04-25)
Mediator is an essential, multisubunit complex that functions as a transcriptional coactivator in yeast and other eukaryotic organisms. Mediator has four conserved modules, Head, Middle, Tail, and Kinase, and has been implicated in nearly all aspects of gene regulation. The
Poly(ADP-ribosyl)ation is required to modulate chromatin changes at c-MYC promoter during emergence from quiescence.
Mostocotto, C; Carbone, M; Battistelli, C; Ciotti, A; Amati, P; Maione, R
Testing null
John C Newman et al.
Cell metabolism, 26(3), 547-557 (2017-09-07)
Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance on fatty acid metabolism and production of ketone bodies. We investigated whether an isoprotein ketogenic diet (KD) might, like dietary restriction, affect longevity and healthspan in C57BL/6 male mice.
Naoki Sakane et al.
PLoS pathogens, 7(8), e1002184-e1002184 (2011-08-31)
The essential transactivator function of the HIV Tat protein is regulated by multiple posttranslational modifications. Although individual modifications are well characterized, their crosstalk and dynamics of occurrence during the HIV transcription cycle remain unclear.We examine interactions between two critical modifications
Ulrike Göbel et al.
Genome biology and evolution, 10(6), 1403-1415 (2018-05-23)
The merging of two divergent genomes in a hybrid is believed to trigger a "genomic shock", disrupting gene regulation and transposable element (TE) silencing. Here, we tested this expectation by comparing the pattern of expression of transposable elements in their
Gretchen Poortinga et al.
Nucleic acids research, 39(8), 3267-3281 (2010-12-24)
Loss of c-MYC is required for downregulation of ribosomal RNA (rRNA) gene (rDNA) transcription by RNA Polymerase I (Pol I) during granulocyte differentiation. Here, we demonstrate a robust reduction of Pol I loading onto rDNA that along with a depletion
Laure Ferry et al.
Molecular cell, 67(4), 550-565 (2017-08-15)
DNA methylation is an essential epigenetic mark in mammals that has to be re-established after each round of DNA replication. The protein UHRF1 is essential for this process; it has been proposed that the protein targets newly replicated DNA by
Danhua Jiang et al.
PLoS genetics, 7(3), e1001330-e1001330 (2011-03-23)
Histone H3 lysine-4 (H3K4) methylation is associated with transcribed genes in eukaryotes. In Drosophila and mammals, both di- and tri-methylation of H3K4 are associated with gene activation. In contrast to animals, in Arabidopsis H3K4 trimethylation, but not mono- or di-methylation
Jonathan M Palmer et al.
Eukaryotic cell, 7(12), 2052-2060 (2008-10-14)
In most species, chromatin remodeling mediates critical biological processes ranging from development to disease states. In fungi within the genus Aspergillus, chromatin remodeling may regulate expression of metabolic gene clusters, but other processes regulated by chromatin structure remain to be
Shuichi Watanabe et al.
International journal of cancer, 145(1), 192-205 (2018-12-18)
Although genomic analysis have recently discovered the malignant subtype of human pancreatic ductal adenocarcinoma (PDAC) characterized by frequent mutations of histone demethylase KDM6A, the biological and molecular roles still remain obscure. We herein elucidated the clinical and biological impacts of
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