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Sonia Lefnaoui et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 23(6), 698-711 (2015-12-25)
A pregelatinized starch (PGS) was derivatized with sodium chloroacetate (SCA) in alcoholic medium under alkaline condition to produce carboxymethyl pregelatinized starch (CMPGS) with various degrees of substitution (DS). Influence of the molar ratio of SCA to the glucopyranose units (SCA/GU)
Ruben Magni et al.
Journal of translational medicine, 13, 346-346 (2015-11-06)
Prompt antibiotic treatment of early stage Lyme borreliosis (LB) prevents progression to severe multisystem disease. There is a clinical need to improve the diagnostic specificity of early stage Lyme assays in the period prior to the mounting of a robust
Yann S Gallot et al.
Cancer research, 74(24), 7344-7356 (2014-10-23)
Cachexia is a muscle-wasting syndrome that contributes significantly to morbidity and mortality of many patients with advanced cancers. However, little is understood about how the severe loss of skeletal muscle characterizing this condition occurs. In the current study, we tested
Jonathan G Crowston et al.
Experimental eye research, 141, 3-8 (2015-03-11)
We describe a model of acute intraocular pressure (IOP) elevation in the mouse eye that induces reversible loss of inner retinal function associated with oxidative stress, glial cell activation and minimal loss of retinal ganglion cell (RGC) number. Young healthy
Shuichi Mori et al.
Bioorganic & medicinal chemistry, 23(4), 803-809 (2015-01-17)
Nonsteroidal progesterone receptor (PR) full antagonists are needed as tools for elucidating the physiological functions of PR and as candidates for treatment of various diseases. We designed and synthesized 1,3-diphenyladamantane derivatives, and investigated their PR-antagonistic activity in comparison with our
Koji Y Arai et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 22(6), 701-711 (2014-09-17)
Epidermal-dermal interaction plays important roles in physiological events such as wound healing. In this study, we examined a double paracrine mechanism between keratinocytes and fibroblasts through interleukin-1 (IL-1) and an IL-1-induced inflammatory mediator prostaglandin E₂ (PGE₂) using the skin equivalent.
Shicheng Su et al.
Nature communications, 6, 8523-8523 (2015-10-06)
Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators of immune cell functions, but their roles in macrophage's fibrogenesis have not been characterized. Here we show that
Paul Thellmann et al.
Environmental science and pollution research international, 22(21), 16405-16416 (2014-11-14)
In order to evaluate surface water and the sediment quality of rivers connected to wastewater treatment plants (WWTPs) with different treatment technologies, fish embryo tests (FET) with Danio rerio were conducted using native water and sediment samples collected upstream and
Yingqi Cai et al.
The Plant cell, 27(9), 2616-2636 (2015-09-13)
The lipodystrophy protein SEIPIN is important for lipid droplet (LD) biogenesis in human and yeast cells. In contrast with the single SEIPIN genes in humans and yeast, there are three SEIPIN homologs in Arabidopsis thaliana, designated SEIPIN1, SEIPIN2, and SEIPIN3.
Sonam Dilwali et al.
Cancer biology & therapy, 16(1), 170-175 (2015-02-19)
Vestibular schwannoma (VS), the fourth most common intracranial tumor, arises from the Schwann cells of the vestibular nerve. Although several pathways have been independently implicated in VS pathobiology, interactions among these pathways have not been explored in depth. We have
Takako Tabata et al.
Journal of virology, 89(9), 5134-5147 (2015-03-06)
Human cytomegalovirus (HCMV) is a major cause of birth defects that include severe neurological deficits, hearing and vision loss, and intrauterine growth restriction. Viral infection of the placenta leads to development of avascular villi, edema, and hypoxia associated with symptomatic
Di Xu et al.
Journal of environmental sciences (China), 25(4), 637-644 (2013-08-09)
Organic phosphorus (nonreactive P, NRP) is a major component of P in sediments, but information about its chemical forms and dynamic transformation is limited. The chemical forms and dynamic behaviors of NRP in a sediment profile from Lake Taihu, a
Michael Knösel et al.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 144(1), 86-96 (2013-07-03)
White spot lesions that form during orthodontic treatment are a problem for patients and clinicians. Lesion infiltration with low-viscosity light-cured resin has been proposed as a treatment to inhibit further demineralization. The purpose of this study was to assess the
Jan Lukas et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(3), 456-464 (2014-11-21)
Lysosomal storage disorders (LSD) are a group of heterogeneous diseases caused by compromised enzyme function leading to multiple organ failure. Therapeutic approaches involve enzyme replacement (ERT), which is effective for a substantial fraction of patients. However, there are still concerns
Priscilla B Pail et al.
Neurotoxicology, 50, 71-80 (2015-08-10)
Mephedrone and methedrone are cathinone-related compounds, which act as non-selective substrates for monoamine transporters, facilitating a neurotransmitter release. We compared the acute pharmacological effects of mephedrone and methedrone, attempting to further evaluate the action mechanisms of methedrone by responsibly and
Qian Zhang et al.
Journal of dairy science, 98(12), 8698-8709 (2015-09-28)
Elevated needs for glucose in lactating dairy cows are met through a combination of increased capacity for gluconeogenesis and increased supply of gluconeogenic precursors, primarily propionate. This study evaluated the effects of propionate on mRNA expression of cytosolic phosphoenolpyruvate carboxykinase
Masaru Kurosawa et al.
Human molecular genetics, 24(4), 1092-1105 (2014-10-12)
Huntington's disease (HD) is a dominantly inherited genetic disease caused by mutant huntingtin (htt) protein with expanded polyglutamine (polyQ) tracts. A neuropathological hallmark of HD is the presence of neuronal inclusions of mutant htt. p62 is an important regulatory protein
Ludmila Müllerová et al.
Journal of chromatography. A, 1384, 147-154 (2015-02-11)
Interactions among analyte forms that undergo simultaneous dissociation/protonation and complexation with multiple selectors take the shape of a highly interconnected multi-equilibrium scheme. This makes it difficult to express the effective mobility of the analyte in these systems, which are often
Stefanie J Pottgiesser et al.
Anticancer research, 35(11), 5927-5943 (2015-10-28)
Intercellular apoptosis-inducing HOCl signaling is discussed as a control step during oncogenesis. It is defined as a sophisticated interplay between transformed target cells and non-transformed or transformed effector cells. In this study, transformed target cells were seeded as clumps of
Rui Gusmão et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(46), 16474-16478 (2015-10-08)
Fluorographane (C1 Hx F1-x+δ )n is a new member of the graphene family that exhibits hydrophobicity and a large band gap that is tunable based on the level of fluorination. Herein, sensing and energy applications of fluorographane are reported. The
Tomomi Hatanaka et al.
Pharmaceutical research, 32(12), 3965-3974 (2015-07-22)
To develop an in silico method based on Fick's law of diffusion to estimate the skin concentration following dermal exposure to chemicals with a wide range of lipophilicity. Permeation experiments of various chemicals were performed through rat and porcine skin.
Kyung Min Jeong et al.
Archives of pharmacal research, 38(12), 2143-2152 (2015-11-05)
Deep eutectic solvents (DESs) were investigated as tunable, environmentally benign, yet superior extraction media to enhance the extraction of anthocyanins from grape skin, which is usually discarded as waste. Ten DESs containing choline chloride as hydrogen bond acceptor combined with
Dorit Rennspiess et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 10(2), 360-366 (2014-12-20)
Although the molecular genetics possibly underlying the pathogenesis of human thymoma have been extensively studied, its etiology remains poorly understood. Because murine polyomavirus consistently induces thymomas in mice, we assessed the presence of the novel human polyomavirus 7 (HPyV7) in
Georg Wultsch et al.
Mutagenesis, 30(5), 701-709 (2015-05-11)
Wood dust was classified by the IARC as a human carcinogen which causes sinonasal tumours. However, the exposure in different industries varies strongly and the risks of workers depend on the specific situation which can be assessed by the use
Shan Lu et al.
Molecular pharmaceutics, 12(2), 621-629 (2015-01-16)
In this study, we formulated polyplexes with different compositions for codelivery of DNA and small-interfering RNA (siRNA). Since DNA and siRNA have distinctive and complementary morphological characteristics (DNA is long and winding and siRNA is short and rigid), we hypothesized
Seshadri Reddy Ankireddy et al.
International journal of nanomedicine, 10 Spec Iss, 113-119 (2015-09-09)
Dopamine is a neurotransmitter of the catecholamine family and has many important roles, especially in human brain. Several diseases of the nervous system, such as Parkinson's disease, attention deficit hyperactivity disorder, restless legs syndrome, are believed to be related to
Jamie P Adams et al.
Veterinary journal (London, England : 1997), 202(3), 436-442 (2014-12-03)
Virtually all diabetic dogs require exogenous insulin therapy to control their hyperglycaemia. In the UK, the only licensed insulin product currently available is a purified porcine insulin preparation. Recombinant insulin is somewhat problematic in terms of its manufacture, since the
Yanru Bu et al.
International journal of nanomedicine, 10 Spec Iss, 47-54 (2015-09-09)
AgcoreAushell nanoparticles (NPs) are a promising surface-enhanced Raman scattering (SERS) substrate, which can offer a high enhancement factor through the combined effect of the high SERS activity of the Ag core and the biocompatibility of the Au shell. In this
Dominique Talabot-Ayer et al.
Journal of immunology (Baltimore, Md. : 1950), 194(2), 750-760 (2014-12-17)
IL-33 is a cytokine of the IL-1 family, which signals through the ST2 receptor. Previous studies emphasized a role for IL-33 in shaping innate and adaptive immune responses. IL-33 was also reported to modulate myelopoiesis and myeloid cell activity. In
Kibaek Choe et al.
The Journal of clinical investigation, 125(11), 4042-4052 (2015-10-06)
Lacteals are lymphatic vessels located at the center of each intestinal villus and provide essential transport routes for lipids and other lipophilic molecules. However, it is unclear how absorbed molecules are transported through the lacteal. Here, we used reporter mice
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