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Showing 1-7 of 7 results for "09-814" within Papers
Olesya A Ulanovskaya et al.
Nature chemical biology, 9(5), 300-306 (2013-03-05)
Nicotinamide N-methyltransferase (NNMT) is overexpressed in a variety of human cancers, where it contributes to tumorigenesis by a mechanism that is still poorly understood. Here we show using metabolomics that NNMT impairs the methylation potential of cancer cells by consuming
Minghao Yang et al.
Cell death & disease, 13(9), 815-815 (2022-09-24)
Osteosarcoma (OS), the most common primary malignancy of the bone, has a poor prognosis due to its high mortality rate and high potential for metastasis. Thus, it is urgently necessary to explore functional molecular targets of therapeutic strategies for osteosarcoma.
Yongtai Bai et al.
Molecular cell, 75(6), 1299-1314 (2019-07-30)
MRE11 nuclease forms a trimeric complex (MRN) with RAD50 and NBS1 and plays a central role in preventing genomic instability. When DNA double-strand breaks (DSBs) occur, MRN is quickly recruited to the damage site and initiates DNA end resection; accordingly
Li-Ming Liu et al.
Life (Basel, Switzerland), 11(8) (2021-08-28)
The protein p53 is one of the most important tumor suppressors, responding to a variety of stress signals. Mutations in p53 occur in about half of human cancer cases, and dysregulation of the p53 function by epigenetic modifiers and modifications
Zhen-Yu Zuo et al.
Nucleic acids research, 50(4), 2005-2018 (2022-02-10)
The second cell fate decision in the early stage of mammalian embryonic development is pivotal; however, the underlying molecular mechanism is largely unexplored. Here, we report that Prmt1 acts as an important regulator in primitive endoderm (PrE) formation. First, Prmt1
Li-Ming Liu et al.
Cancer research, 79(11), 2865-2877 (2019-04-25)
C/EBPα is an essential transcription factor involved in regulating the expression or function of certain cell-cycle regulators, including in breast cancer cells. Although protein arginine methyltransferases have been shown to play oncogenic roles in a variety of cancers, little is
Gang Ren et al.
Scientific reports, 9(1), 6688-6688 (2019-05-02)
One third of newly diagnosed breast cancers in the US are early-stage lesions. The etiological understanding and treatment of these lesions have become major clinical challenges. Because breast cancer risk factors are often linked to aberrant nitric oxide (NO) production
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