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101-29-1

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Kelsie L Thu et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 6(9), 1594-1598 (2011-08-19)
MicroRNA-101 (miR-101) is frequently downregulated in cancer and exhibits antitumorigenic properties, suggesting that miR-101 is a putative tumor suppressor. miR-101 is encoded at two loci in the human genome: 1p31.3 (miR-101-1) and 9p24.1 (miR-101-2). We sought to investigate miR-101 locus-specific...
Gitit Tomer et al.
The American journal of gastroenterology, 98(11), 2479-2484 (2003-11-26)
NOD2/CARD15 variants have recently been shown to be associated with Crohn's disease (CD). No analysis of NOD2/CARD15 gene variants has so far been reported in pediatric patients. Therefore, our aim was to analyze NOD2/CARD15 gene variants in children with CD...
N Yamada et al.
American journal of human genetics, 66(1), 187-195 (2000-01-13)
Cigarette smoke, containing reactive oxygen species, is the most important risk factor for chronic pulmonary emphysema (CPE). Heme oxygenase-1 (HO-1) plays a protective role as an antioxidant in the lung. A (GT)n dinucleotide repeat in the 5'-flanking region of human...
Matthew J Farrer et al.
Parkinsonism & related disorders, 15(6), 414-416 (2008-10-03)
It has been proposed that there is an increased frequency of glucosidase-beta mutations in Lewy body disorders. Our comprehensive DNA sequencing approach found a small number of glucosidase-beta mutations in 101 neuropathologically defined Lewy body disease cases (3%) compared to...
Serap Hastürk et al.
Cancer, 94(4), 1023-1031 (2002-03-29)
Cyclooxygenase (Cox) is the main target enzyme for the nonsteroidal antiinflammatory drugs that have been shown to suppress carcinogenesis in both experimental models and epidemiologic studies. To evaluate its utility as an intermediate biomarker in bronchial chemoprevention trials, the authors...
J Fernández-Alba et al.
Journal of chemotherapy (Florence, Italy), 16(2), 179-186 (2004-06-26)
Because of its potential as a low cost first-line monotherapy for the most common vulvovaginal infections, we evaluated fenticonazole nitrate in a prospective, open-label, multicenter pilot study with 101 sexually active women (per-protocol; 16 to 61 years of age) with...
Martin F Fromm et al.
Pharmacogenetics and genomics, 15(10), 737-741 (2005-09-06)
The present study aimed to determine whether a polymorphism in CYP3A5, encoding the major CYP3A enzyme in the human kidney, is associated with blood pressure in Caucasians. A homogenous group of 115 young, white male students with normal or mildly...
W Shen et al.
Human & experimental toxicology, 15(5), 428-434 (1996-05-01)
1. Nitrofurantoin is an antimicrobial agent which produces hepatotoxicity caused by the redox cycling of the nitro group and its radical anion. This futile cycling triggers a complex series of events known collectively as oxidative stress. 2. Our goal was...
Suk Kyeong Kim et al.
Thyroid : official journal of the American Thyroid Association, 19(2), 137-141 (2008-11-19)
It has been reported that patients with papillary thyroid carcinoma (PTC) have a high incidence of background Hashimoto thyroiditis (HT); however, the linkage of HT to PTC is controversial. Recent studies have shown that the prevalence of activating point mutations...
Cheol-Min Yook et al.
Journal of labelled compounds & radiopharmaceuticals, 58(8), 317-326 (2015-06-03)
New [(18) F]fluorinated 1,2,3-triazolyl amino acid derivatives were efficiently prepared from Huisgen 1,3-dipolar cycloaddition reactions, well known as click reaction. We developed two simultaneous click reactions in one-pot with a simple solid-phase extraction (SPE) purification method. [(18) F]fluoro-1-propyne was obtained...
Simone Mader et al.
PloS one, 5(5), e10455-e10455 (2010-05-14)
Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a long...
Guoan Chen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(4), 817-826 (2010-12-21)
The active form of vitamin D, 1α,25-dihydroxyvitamin D(3) (1,25-D(3)), exerts antiproliferative effects in cancers, including lung adenocarcinoma (AC). CYP24A1 is overexpressed in many cancers and encodes the enzyme that catabolizes 1,25-D(3). The purpose of our study was to assess CYP24A1...
A Kogan et al.
American journal of medical genetics, 102(3), 272-276 (2001-08-03)
Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterized by recurrent attacks of fever and inflammation of serosal membranes and gradual development of nephropathic amyloidosis. The recent cloning of the FMF gene (MEFV) and identification of disease-associated mutations in...
T Fujita et al.
Biochimica et biophysica acta, 1308(1), 49-57 (1996-07-31)
We isolated and characterized genomic and cDNA clones encoding mouse senescence marker protein-30 (SMP30), the protein amounts of which are known to decrease with aging in the livers of rats. This decrease in the expression of SMP30 is independent of...
Jingzhong Ding et al.
American heart journal, 152(6), 1109-1115 (2006-12-13)
The 4G allele in the promoter region of the plasminogen activator inhibitor type 1 (PAI-1) gene is associated with higher plasma PAI-1 levels and activity, but its association with cardiovascular diseases is unclear. We investigated the association of polymorphisms and...
Abdulbaki Kumbasar et al.
Journal of nephrology, 25(5), 825-832 (2012-02-07)
Although intravenous iron (IVI) is thought to have potential inflammatory and atherogenic effects, there are not enough studies comparing these effects in chronic hemodialysis (HD) patients. In this study, different doses and types of IVI were examined for effects on...
Jeffrey O Bush et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(18), 7022-7027 (2004-05-01)
Cleft lip and palate (CL/P) is a common disfiguring birth defect with complex, poorly understood etiology. Mice carrying a spontaneous mutation, Dancer (Dc), exhibit CL/P in homozygotes and show significantly increased susceptibility to CL/P in heterozygotes [Deol, M. S. &...
Seiji Suzuki et al.
Journal of gastroenterology and hepatology, 18(10), 1139-1143 (2003-09-17)
Transforming growth factor beta-1 (TGF-beta1) is one of the most dominant fibrogenic cytokines in hepatic fibrosis. The aim of the present study was to examine the effects of TGF-beta1 polymorphisms in Japanese patients with chronic hepatitis C virus (HCV) infection...
Wanee Plengpanich et al.
Molecular genetics and metabolism reports, 23, 100576-100576 (2020-03-20)
Severe hypertriglyceridemia (HTG) due to chylomicronemia is associated with acute pancreatitis and is related to genetic disturbances in several proteins involved in triglyceride (TG) metabolism. Lipase maturation factor 1 (LMF1) is a protein essential for the maturation of lipoprotein lipase...
Ruben Lopez-Benitez et al.
Cardiovascular and interventional radiology, 40(8), 1246-1254 (2017-03-21)
In vitro and in vivo evaluation of fast- and slow-release gemcitabine-eluting hydrogel (GEH) devices. For in vitro elution, the GEH devices were placed in phosphate-buffered saline at 37 °C. Periodically, the solution was analyzed for gemcitabine. The devices consisting of fast...
Chun-Sung Sung et al.
CNS neuroscience & therapeutics, 23(7), 580-589 (2017-05-26)
We previously demonstrated that intrathecal IL-1β upregulated phosphorylation of p38 mitogen-activated protein kinase (P-p38 MAPK) and inducible nitric oxide synthase (iNOS) in microglia and astrocytes in spinal cord, increased nitric oxide (NO) release into cerebrospinal fluid, and induced thermal hyperalgesia...
A Pulkkinen et al.
Metabolism: clinical and experimental, 48(7), 853-856 (1999-07-27)
Hyperinsulinemia has been shown to predict coronary heart disease (CHD) events in both nondiabetic subjects and patients with non-insulin-dependent diabetes mellitus (NIDDM). Therefore, defects in genes that regulate insulin action could be responsible for an increased risk of CHD. The...
J E Craig et al.
The British journal of ophthalmology, 90(11), 1420-1424 (2006-08-04)
To investigate the role of the common OPTN Met98Lys variant as a risk allele in open-angle glaucoma (OAG), autosomal dominant optic atrophy (ADOA) and Leber's hereditary optic neuropathy (LHON). The presence of the Met98Lys variant was determined in a total...
E P Leumann et al.
Pediatric nephrology (Berlin, Germany), 4(5), 493-497 (1990-09-01)
The molar ratios of oxalate and glycolate over creatinine were determined in single urine samples of 26 infants and 27 children aged 1-5 years. In 135 children aged 5-16 years, two urine specimens were collected, one before breakfast and one...
Marta Fontal et al.
Journal of chromatography. A, 1404, 28-38 (2015-06-10)
A method for the quantitative analysis of organic compounds on submicron particulate matter (PM1) collected on quartz filters was developed. The compounds analyzed encompassed C22-C35 alkanes, polycyclic aromatic hydrocarbons (PAHs), quinones, levoglucosan, cis-pinonic acid and short chain dicarboxylic acids such...
C Lenzner et al.
Blood, 89(5), 1793-1799 (1997-03-01)
We investigated the DNA of 29 unrelated pyruvate kinase (PK) deficiency (PKD) patients from Central Europe with hereditary nonspherocytic hemolytic anemia for mutations in the PK-L/R gene. Among 58 potentially affected alleles, 53 mutations were identified, of which 17 were...
Jeffrey I Mechanick et al.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 16(2), 175-247 (2020-01-10)
The development of these updated clinical practice guidelines (CPG) was commissioned by the American Association of Clinical Endocrinologists, The Obesity Society, the American Society of Metabolic and Bariatric Surgery, the Obesity Medicine Association, and the American Society of Anesthesiologists boards...
Wojciech Zareba et al.
Journal of cardiovascular electrophysiology, 14(11), 1149-1153 (2003-12-18)
Recent data showed that long QT syndrome (LQTS) patients with mutations in the pore region of the HERG (LQT2) gene have significantly higher risk of cardiac events than subjects with mutations in the non-pore region. The aim of this study...
Dong Feng et al.
Acta pharmacologica Sinica, 36(12), 1462-1472 (2015-11-26)
Xuezhikang (XZK), an extract of red yeast rice, has been widely used in traditional Chinese medicine to treat cardiovascular disease. Three fractions F1, F2 and F3 (primarily containing isoflavones, monacolins or phytosterols, respectively) are extracted from Xuezhikang capsules. In this...
Afolabi Adisa et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 50(8), 552-559 (2015-06-13)
Twenty-eight different tea samples sold in the United States were evaluated using high-performance liquid chromatography (HPLC) with fluorescence detection (FLD) for their contamination with polycyclic aromatic hydrocarbons (PAHs). Many PAHs exhibit carcinogenic, mutagenic, and teratogenic properties and have been related...
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