Showing 1-30 of 37 results for "102-70-5"
T Doi et al.
British journal of cancer, 107(3), 429-434 (2012-06-28)
TAS-102 consists of α, α, α-trifluorothymidine (TFT) and an inhibitor of thymidine phosphorylase (TPI). We conducted a dose-escalation phase I study in Japanese patients with advanced solid tumours. TAS-102 was administered twice daily on days 1-5 and days 8-12 in...
H G Hwu et al.
American journal of medical genetics, 96(6), 797-800 (2000-12-20)
This study investigated the association between T/C polymorphism, at position 102, of the 5-hydroxytryptamine 2A receptor gene and alcoholism with and without behavior problems. Eighty-five subjects (45 men, 40 women) with alcohol abuse, 75 subjects (51 men, 24 women) with...
Carine Vergne-Vaxelaire et al.
Applied microbiology and biotechnology, 102(13), 5569-5583 (2018-05-08)
Most of the "repressor, open reading frame, kinase" (ROK) proteins already characterized so far, and exhibiting a kinase activity, take restrictedly D-glucose as substrate. By exploring the sequenced bacterial diversity, 61 ATP-dependent kinases belonging to the ROK family have been...
Joel Shapiro et al.
Annals of surgery, 258(5), 678-688 (2013-10-08)
To gain insight into the exact location of residual esophageal cancer in the esophageal wall and regional lymph nodes after neoadjuvant chemoradiotherapy (nCRT) and to determine the pattern of regression. Data from the recently published chemoradiotherapy for oesophageal cancer followed...
Satoshi Narumi et al.
The Journal of clinical endocrinology and metabolism, 94(4), 1317-1323 (2009-01-23)
The prevalence of congenital hypothyroidism (CH) associated with mutations in the TSH receptor gene (TSHR) has not been established. We examined the frequency of TSHR mutations among patients with permanent primary CH and in the general population in Japan. We...
J Pineda et al.
Naunyn-Schmiedeberg's archives of pharmacology, 348(2), 134-140 (1993-08-01)
Clonidine and related drugs not only interact with alpha 2-adrenoceptors but also recognise non-adrenoceptor sites in the brain. The involvement of these imidazoline-preferring receptors in the regulation of the activity of locus coeruleus noradrenergic neurones (NA-LC) was investigated after inactivation...
Kazuhiko Nakamura et al.
The international journal of neuropsychopharmacology, 11(8), 1073-1084 (2008-07-03)
Autism is a pervasive developmental disorder diagnosed in early childhood. Abnormalities of serotonergic neurotransmission have been reported in autism. Serotonin transporter (5-HTT), which modulates serotonin levels, is a major therapeutic target in autism. Therefore, factors that regulate 5-HTT expression might...
E L Schiffrin et al.
The Journal of clinical endocrinology and metabolism, 72(2), 484-491 (1991-02-01)
We have previously demonstrated the presence of binding sites for atrial natriuretic peptide (ANP) in human platelets. These sites have pharmacological characteristics similar to those of rat vascular smooth muscle. They are subject to regulation by circulating levels of ANP...
H H Hansen et al.
Seminars in oncology, 19(2 Suppl 6), 65-68 (1992-04-01)
The epipodophyllotoxin derivatives teniposide and etoposide have been under clinical investigation for over 15 years. Although etoposide has been established as one of the most active compounds in the treatment of small cell lung cancer (SCLC), teniposide has received little...
Anna Mitchell et al.
Clinical pharmacology and therapeutics, 74(5), 499-504 (2003-10-31)
The ultimate mode of action by which nitroglycerin elicits vasodilation remains elusive. Animal studies point to an involvement of pertussis toxin-sensitive G proteins. The 825T allele of the GNB3 C825T polymorphism in the gene encoding the G protein beta3 subunit...
Yumiko Hayashi et al.
Animal science journal = Nihon chikusan Gakkaiho, 89(5), 825-832 (2018-02-21)
T cell-mediated cellular immunity and humoral immunity are equally important for the prevention of diseases. To assess activation of human and mouse cellular immunity, early activation markers of lymphocytes are often used in flow cytometry targeting expression of CD69 molecules....
Kathryn C Racine et al.
Journal of chromatography. A, 1594, 54-64 (2019-03-13)
Cocoa flavanols (catechins and procyanidins) can exist in various polymerization states and are commonly classified by their degree of polymerization (DP). There is increasing evidence that flavanols of distinct DP possess different biological activities, but separation and quantification of the...
Pascal M Groenen et al.
American journal of obstetrics and gynecology, 189(6), 1713-1719 (2004-01-08)
The purpose of this study was to investigate the maternal and children's myo-inositol, glucose, and zinc status in association with spina bifida risk. Sixty-three mothers and 70 children with spina bifida and 102 control mothers and 85 control children were...
P Goyette et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 9(8), 652-656 (1998-07-29)
Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. A human cDNA for MTHFR, 2.2 kb in length, has been expressed and shown to result in a catalytically active enzyme of approximately...
Jaqueline Renovato et al.
Applied biochemistry and biotechnology, 165(1), 382-395 (2011-04-20)
Significant differences on structure, stability, and catalytic properties of tannase were found when this enzyme was produced under solid-state and submerged fermentations (SSF and SmF) by Aspergillus niger. The specific activity was 5.5 times higher on SSF than in SmF....
Rozanna Avagyan et al.
Analytical and bioanalytical chemistry, 407(16), 4523-4534 (2015-05-04)
A simple and fast method for analysis of hydroxylated polycyclic aromatic hydrocarbons using pressurized liquid extraction and high performance liquid chromatography utilizing photoionization tandem mass spectrometry was developed. Simultaneous separation and determination of nine hydroxylated polycyclic aromatic hydrocarbons and two...
Pablo Gago-Ferrero et al.
Chemosphere, 84(8), 1158-1165 (2011-05-03)
Many substances related to human activities end up in wastewater and accumulate in sewage sludge. So far, there is only one extensive survey on the occurrence of UV filter residues in sewage sludge. However, more data are required to draw...
W Langseth et al.
Mycopathologia, 147(3), 157-165 (2000-10-21)
A total of 449 grain samples, 102 barley, 169 wheat and 178 oat samples were collected from different regions of Norway from 1996-1998 crops, mainly from grain loads and silos. The samples were analysed for type A and B trichothecenes...
Qiu-Ning Liu et al.
Fish & shellfish immunology, 60, 247-254 (2016-11-07)
Hepcidin is a small, cysteine-rich antimicrobial peptide with a highly conserved β-sheet structure that plays a vital role in innate host immunity against pathogenic organisms. In this study, a hepcidin gene was identified in Pelteobagrus fulvidraco, an economically important freshwater...
V Hofman et al.
Cytopathology : official journal of the British Society for Clinical Cytology, 23(1), 30-38 (2011-01-08)
Recurrence rates after surgery for non-small cell lung cancer (NSCLC) range from 25 to 50% and 5-year survival is only 60-70%. Because no biomarkers are predictive of recurrence or the onset of metastasis, pathological TNM (pTNM) staging is currently the...
Stanisław Walorczyk
Talanta, 120, 106-113 (2014-01-29)
A triple quadrupole GC-QqQ-MS/MS method was optimized for multiresidue analysis of over 180 pesticides in blackcurrants. The samples were prepared by using a modified quick, easy, cheap, effective, rugged and safe (QuEChERS) analytical protocol. To reduce matrix co-extractives in the...
A Abdi-Ali et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 16(3), 521-528 (2014-01-28)
IgA nephropathy is associated with increased cardiovascular risk, though whether this is due to loss of kidney function or proteinuria is unclear. For this study 10 normotensive IgA nephropathy subjects with early kidney disease (41±5 yrs, glomerular filtration rate (GFR)...
Mohamed M Hefnawy et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 856(1-2), 328-336 (2007-08-08)
A sensitive and selective high-performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination of bufuralol enantiomers in plasma and pharmaceutical formulations. Enantiomeric resolution was achieved on a vancomycin macrocyclic antibiotic chiral stationary phase (CSP) known as Chirobiotic...
Jidong Shan et al.
International journal of pediatric otorhinolaryngology, 74(6), 611-618 (2010-04-13)
The purpose of the study is to determine whether Caribbean Hispanic and African admixture populations have a paucity of mutations in GJB2, encoding connexin 26. We reported the paucity of mutations in GJB2 and deletions in GJB6 in Caribbean Hispanic...
Ashraf Mohamadkhani et al.
Archives of Iranian medicine, 16(4), 208-212 (2013-03-19)
Northern Iran (Ardabil) is characterized by a high gastric cancer (GC) rate, whereas Southern Iran (Kerman and Yazd) has a low GC rate. The aim of this study is to verify the potential for pepsinogen I and II to detect...
Chawalit Lertbutsayanukul et al.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 194(5), 375-385 (2018-01-06)
This study was performed to compare the acute and late toxicities between sequential (SEQ) and simultaneous integrated boost (SIB) intensity-modulated radiotherapy (IMRT) in nasopharyngeal carcinoma (NPC). Stage I-IVB NPC patients were randomized to receive SEQ-IMRT or SIB-IMRT. SEQ-IMRT consisted of two...
Qaiser Bashir et al.
The Lancet. Haematology, 6(5), e266-e275 (2019-03-27)
Retrospective studies suggest that conditioning therapy with busulfan plus melphalan could result in longer progression-free survival compared with melphalan alone in patients with multiple myeloma undergoing autologous haemopoietic cell transplantation (auto-HCT). We aimed to test this hypothesis in a randomised...
Niels C Kyvsgaard et al.
Veterinary parasitology, 181(2-4), 248-254 (2011-05-17)
Horses, mules and donkeys are indispensable farming and working animals in many developing countries, and their health status is important to the farmers. Strongyle parasites are ubiquitous in grazing horses world-wide and are known to constitute a threat to equine...
Andrea M Haqq et al.
The Journal of clinical endocrinology and metabolism, 88(1), 174-178 (2003-01-10)
Ghrelin, an endogenous ligand of the GH secretagogue receptor, stimulates appetite and causes obesity in animal models and in humans when given in pharmacologic doses. Prader-Willi Syndrome (PWS) is a genetic obesity syndrome characterized by GH deficiency and the onset...
M Nakamuta et al.
The Journal of biological chemistry, 270(22), 13042-13056 (1995-06-02)
Apolipoprotein (apo) B mRNA editing consists of a C-->U conversion involving the first base of the codon CAA, encoding Gln 2153, to UAA, a stop codon. Editing occurs in the intestine only in most mammals, and in both the liver...

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