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Hector Magaña et al.
International journal of pharmaceutics, 511(1), 579-585 (2016-07-28)
Medical devices decorated with salicylic acid-based polymer chains (polymeric prodrug) that slowly release this anti-inflammatory and anti-biofilm drug at the implantation site were designed. A "grafting from" method was implemented to directly grow chains of a polymerizable derivative of salicylic
Sonita A P Siboro et al.
Materials (Basel, Switzerland), 13(12) (2020-07-08)
In this article, a drug delivery system with a near-infrared (NIR) light-responsive feature was successfully prepared using a block copolymer poly(ethylene oxide)-b-poly(glycidyl methacrylate)-azide (PEO-b-PGMA-N3) and a cross-linker containing a Se-Se bond through "click" chemistry. Doxorubicin (DOX) was loaded into the
Chun-Hua Wang et al.
International journal of biological macromolecules, 84, 418-427 (2015-12-30)
Five water-soluble O-quaternary ammonium salt-chitosans (QAS-CS) bearing N-methyl-N-R-N, N-bis(2-hydroxyethyl) ammonium bromides (R=-benzyl (chloride, BNQAS-CS), -dodecyl (C12QAS-CS), -tetradecyl (C14QAS-CS), -hexadecyl (C16QAS-CS), -octadecyl (C18QAS-CS)) were prepared, respectively. They were characterized by FTIR, (1)H NMR and elemental analysis. Through chemical modification of O-quaternized
Dong Youl Yoon et al.
Journal of biomaterials science. Polymer edition, 28(6), 505-518 (2017-01-14)
Nanogel composed of rhodamine B isothiocyanate-labeled cinnamoyl polymeric β cyclodextrin and cinnamoyl Pluronic F127 was prepared by taking advantage of their self-assembling property in aqueous phase. The in vivo lifetime of the nanogel in the blood circulation system of hairless
Suzanne M D'Addio et al.
Molecular pharmaceutics, 12(5), 1554-1563 (2015-03-27)
Tuberculosis (TB) remains a major global health concern, and new therapies are needed to overcome the problems associated with dosing frequency, patient compliance, and drug resistance. To reduce side effects associated with systemic drug distribution and improve drug concentration at
Martien A Würdemann et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 26(36), 8090-8100 (2020-03-28)
Pyrazines are an underreported class of N-heterocycles available from nitrogen-rich biomass presenting an interesting functional alternative for current aromatics. In this work, access to pyrazines obtained from amino acids by using the 90 year old Dakin-West reaction was explored. After
Nadrajan Jawahar et al.
Drug development research, 81(3), 305-314 (2019-11-30)
Breast cancer is one of the leading causes of mortality specifically for the women. The existing therapy is not sufficient due to the lack of target specificity and drug resistance. Carbon nanotubes (CNTs) are one of the promising formulation approaches
Sonia Trombino et al.
The Journal of pharmacy and pharmacology, 68(2), 275-281 (2016-02-03)
This study concerns the preparation and characterization of microspheres based on a mixture of triterpene saponins, from Physospermum verticillatum (Waldst & Kit), as a carrier for the specific release of gemcitabine. Triterpene saponins were derivatized with acrylic acid. The obtained
Wenping Wang et al.
Artificial cells, nanomedicine, and biotechnology, 45(1), 69-75 (2016-01-13)
Hydrophobic modification of Bletilla striata polysaccharide (BSP) was performed by grafting fatty acids to BSP backbone and then characterized on their physicochemical properties. All neutral derivatives were able to self-assemble into spherical particles within the size range of 250-400 nm, their
Huapan Fang et al.
ACS applied materials & interfaces, 11(51), 47785-47797 (2019-11-28)
Constructing an efficient in vivo gene delivery system has always been extremely challenging. Herein, a highly efficient H2O2-responsive in vivo polycationic gene delivery system is developed for the first time. The efficient vector PLL-RT (i.e., polylysine grafted with p-tosyl-l-arginine) is
Amit Alexander et al.
Drug development and industrial pharmacy, 41(12), 1954-1961 (2015-02-14)
Although the melphalan (ML) used extensively for the management of breast cancer, its clinical application is limited due to significant hemolytic activity. In the present work, a comparative analysis of two distinct in situ-based thermogelling polymers of PEGylated ML was
Dhanya Dhanyalayam et al.
International journal of pharmaceutics, 517(1-2), 395-402 (2016-12-23)
Microbial infections still remain one of the main issues for human health. The rapid development of resistance towards the most common antimicrobial drugs in bacteria represents today a challenge in the infections management. In the present work we have investigated
Mariano Walter Pertino et al.
Molecules (Basel, Switzerland), 20(5), 8666-8686 (2015-05-27)
Abietane diterpenes exhibit an array of interesting biological activities, which have generated significant interest among the pharmacological community. Starting from the abietane diterpenes carnosic acid and carnosol, twenty four new triazole derivatives were synthesized using click chemistry. The compounds differ
Moira C Vyner et al.
Acta biomaterialia, 31, 89-98 (2015-11-27)
Tissue cells are known to respond to the stiffness of the polymer substrate on which they are grown. It has been suggested that material stiffness influences the composition of the protein layer that adsorbs to the material surface, which affects
Shogo Sasaki et al.
Journal of bioscience and bioengineering, 119(2), 200-205 (2014-07-26)
We demonstrated the synthesis of molecularly imprinted polymers (MIPs) with binding affinity toward a target protein, ribonuclease A (RNase) by atom transfer radical polymerization (ATRP) of acrylic acid, acrylamide, and N,N'-methylenebisacrylamide in the presence of RNase. The binding activity of
Sagarika Samantray et al.
Nature communications, 11(1), 880-880 (2020-02-16)
A self-assembled coordination cage usually possesses one well-defined three-dimensional (3D) cavity whereas infinite number of 3D-cavities are crafted in a designer metal-organic framework. Construction of a discrete coordination cage possessing multiple number of 3D-cavities is a challenging task. Here we
Manon Le Gars et al.
Carbohydrate polymers, 234, 115899-115899 (2020-02-20)
Cellulose nanocrystals (CNCs) are used to design nanocomposites because of their high aspect ratio and their outstanding mechanical and barrier properties. However, the low compatibility of hydrophilic CNCs with hydrophobic polymers remains a barrier to their use in the nanocomposite
Shallu Kutlehria et al.
AAPS PharmSciTech, 19(2), 792-802 (2017-10-12)
Triple-negative breast cancer (TNBC) is the leading cancer in women. Chemotherapeutic agents used for TNBC are mainly associated with dose-dependent toxicities and development of resistance. Hence, novel strategies to overcome resistance and to offer dose reduction are warranted. In this
Manisha Singh et al.
Biomedical chromatography : BMC, 29(9), 1330-1337 (2015-02-03)
In the present studies formation of diastereomers of (RS)-etodolac was confirmed using LC-MS when [M + H](+) or [M](+) were recorded for the diastereomers. The lowest energy optimized structures of two diastereomers were drawn, which confirmed the three-dimensional geometry of the diastereomers.
Hong-Mei Liu et al.
International journal of nanomedicine, 12, 1065-1083 (2017-02-23)
Here, we report the hypoxia-responsive ionizable liposomes to deliver small interference RNA (siRNA) anticancer drugs, which can selectively enhance cellular uptake of the siRNA under hypoxic and low-pH conditions to cure glioma. For this purpose, malate dehydrogenase lipid molecules were
Uyen T Phan et al.
Anti-cancer agents in medicinal chemistry, 16(10), 1281-1287 (2013-11-24)
Nanoparticles for a specific delivery are likely to be designed for cancer therapeutic effectiveness and improvement. In this study, a fucoidan-oleic acid conjugate was prepared and investigated in terms of loading capacity for poorly water-soluble anti-cancer drugs to maximize effectiveness
Baolin Guo et al.
Acta biomaterialia, 84, 180-193 (2018-12-12)
Injectable conductive hydrogels have great potential as tissue engineering scaffolds and delivery vehicles for electrical signal sensitive cell therapy. In this work, we present the synthesis of a series of injectable electroactive degradable hydrogels with rapid self-healing ability and their
Njemuwa Nwaji et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 204, 629-639 (2018-07-07)
The synthesis of asymmetric benzothiazole substituted phthalocyanines (complexes 3 to 5) and their covalent attachment to glutathione (GSH) functionalized quantum dots (QDs) are reported in this work. Additionally, their photophysical and nonlinear optical properties were investigated. A decrease in the
Rongrong Zhang et al.
Drug design, development and therapy, 11, 2631-2642 (2017-09-19)
Cisplatin plus gemcitabine (GEM) is a standard regimen for the first-line treatment of advanced non-small cell lung cancer. The aim of this study was to prepare biocompatible and biodegradable polymeric prodrugs and construct nanoparticles (NPs) with layer-by-layer (LbL) technique. Platinum
Eli Vlaisavljevich et al.
Ultrasound in medicine & biology, 42(4), 931-946 (2016-01-18)
Nanodroplet-mediated histotripsy (NMH) is a targeted ablation technique combining histotripsy with nanodroplets that can be selectively delivered to tumor cells. In two previous studies, polymer-encapsulated perfluoropentane nanodroplets were used to generate well-defined ablation similar to that obtained with histotripsy, but
Xiaoyu Lu et al.
Drug delivery and translational research, 10(1), 122-135 (2019-08-25)
PEGylated triacontanol (mPEG2k-b-TRIA) was developed as a dual-functional polymer with remarkable biocompatibility. The polymer could self-assemble to micelles with critical micelle concentration (CMC) 17.62 μg mL-1. Docetaxel-loaded mPEG2k-b-TRIA micelles (DTX PMs) were fabricated to evaluate the feasibility of mPEG2k-b-TRIA as drug delivery
Roberta Cassano et al.
Colloids and surfaces. B, Biointerfaces, 151, 128-133 (2016-12-19)
The main target of this study was the preparation, characterization and antioxidant activity evaluation of α-tocopheryl linolenate based solid lipid nanoparticles (SLNs-TL), able to incorporate omega-3 α-linolenic acid, useful for the treatment of melanoma, a type of skin cancer. In
Jonathan Cartmell et al.
Carbohydrate research, 403, 123-134 (2014-08-16)
Selective strategies for the construction of novel three component glycoconjugate vaccines presenting Candida albicans cell wall glycan (β-1,2 mannoside) and polypeptide fragments on a tetanus toxoid carrier are described. The first of two conjugation strategies employed peptides bearing an N-terminal
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