Showing 1-30 of 64 results for "105-50-0"
A Ito et al.
Journal of the National Cancer Institute, 77(1), 277-281 (1986-07-01)
The tumorigenicity of 9-3',4',5',6'-tetrachloro-o-carboxy phenyl-6-hydroxy-2,4,5,7-tetraiodo-3-isoxanthone sodium (CAS: 632-68-8) [also called Food Red 105 (FR 105) or Rose Bengal B], which is widely used for food or cosmetic coloring in Japan, was examined in (C57BL/6N X C3H/N)F1 mice. Animals were divided...
Edmondo Falleti et al.
Human immunology, 71(10), 999-1004 (2010-07-27)
Genetic polymorphisms of interleukin-6 (IL-6) (-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C) may affect the outcomes of several diseases. This study was aimed to verify the role of these polymorphisms on the disease progression of patients with hepatitis C virus (HCV) infection...
Filip Janku et al.
Cancer research, 73(1), 276-284 (2012-10-16)
PIK3CA mutations may predict response to PI3K/AKT/mTOR inhibitors in patients with advanced cancers, but the relevance of mutation subtype has not been investigated. Patients with diverse cancers referred to the Clinical Center for Targeted Therapy were analyzed for PIK3CA and...
Z J Liu et al.
Neoplasma, 64(5), 795-802 (2017-06-09)
Hepatocarcinogenesis, a multistep process, involves not only genetic mutations but also epigenetic alterations. Widespread of global DNA hypomethylation is accompanied with specific regional hypermethylation especially at tumor suppressor genes' promoters. The aim of this study is to determine the efficacy...
B Chaigne et al.
Clinical and experimental immunology, 176(2), 172-179 (2013-12-07)
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) treatment strategy is based on immunosuppressive agents. Little information is available concerning mycophenolic acid (MPA) and the area under the curve (AUC) in patients treated for AAV. We evaluated the variations in pharmacokinetics for MPA...
Gustavo H Dayan et al.
Human vaccines & immunotherapeutics, 10(10), 2853-2863 (2014-12-09)
Several ChimeriVax-Dengue (CYD)-based vaccination strategies were investigated as potential alternatives to vaccination with tetravalent CYD vaccine (CYD-TDV) in this phase IIa trial conducted in 2008-9 in 150 healthy adults. Participants were randomized and vaccinated on D0 and D105 (± 15...
Stephen Z Levine et al.
Schizophrenia research, 145(1-3), 125-127 (2013-02-12)
The treatment and measurement of negative symptoms are currently at issue in schizophrenia, but the clinical meaning of symptom severity and change is unclear. To offer a clinically meaningful interpretation of severity and change scores on the Scale for the...
Xiu Li Wei et al.
Journal of basic microbiology, 55(10), 1212-1218 (2015-07-28)
A Gram-positive, facultative anaerobic, rod-shaped, and endospore-forming strain, designated 53-2(T) was isolated from the root nodule of Oxytropis ochrocephala Bunge growing on Qilian mountain, China. The strain can grow at pH 7.0-8.0, 10-50 °C and tolerate up to 11% NaCl. Optimal...
Malcolm A Lyons et al.
Physiological genomics, 17(2), 114-121 (2004-02-12)
To determine the genetic contribution to variation among lipoprotein cholesterol levels, we performed quantitative trait locus (QTL) analyses on an intercross between mouse strains RIIIS/J and 129S1/SvImJ. Male mice of the parental strains and the reciprocal F1 and F2 populations...
Riika Merivirta et al.
Journal of pain research, 8, 39-45 (2015-02-06)
Quality of life is decreased in patients with hallux valgus deformity, mainly because of pain. Significant improvement is usually achieved by surgery. However, postoperative pain can be moderate to severe for 2-3 days. The aim of the present study was...
I Chu et al.
Journal of applied toxicology : JAT, 18(4), 285-292 (1998-08-27)
The toxicity of 2,3,3',4,4'-pentachlorobiphenyl (PCB 105) was investigated in Sprague-Dawley rats following dietary exposure to this substance at levels of 0, 0.05, 0.5, 5 or 50 ppm for 13 weeks. Growth rate and food consumption were not affected and no...
Lena Löfberg et al.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 8(7), 549-557 (2006-06-27)
To compare the electrophysiological and antiarrhythmic effects of AZD7009, azimilide, and AVE0118 in the acutely dilated rabbit atria in vitro. In the isolated Langendorf-perfused rabbit heart, the atrial effective refractory period (AERP) and the inducibility of atrial fibrillation (AF) were...
T W Rosanske et al.
Journal of pharmaceutical sciences, 69(5), 564-567 (1980-05-01)
The solubility, spectral, and kinetic methods were used to study complexing between alpha-cyclodextrin (ligand, L) and 3,5-dimethoxycinnamic acid, benzalacetone, and methyl cinnamate (substrates, S). In aqueous solution at 25 degrees and with an ionic strength of 0.01 M, the following...
Yao-Yuan Hsieh et al.
Fertility and sterility, 87(4), 886-895 (2007-01-16)
To investigate whether certain polymorphisms are correlated with leiomyoma susceptibility, i.e., interleukin (IL)-1, IL-2, IL-4, IL-8, IL-12, and IL-18, which are all immunomodulatory cytokines that play important roles in host immune responses against cancers. Departments of gynecology and genetics in...
Sara Thønnings et al.
BMC infectious diseases, 12, 153-153 (2012-07-11)
Optimal antibiotic treatment strategies of Haemophilus infections are still needed. Therefore, 30-day case fatality rate (CFR) of Haemophilus bacteremia and efficacy of various antibiotic treatment regimes were studied. All episodes of Haemophilus bacteremia in the former Copenhagen County during the...
G Beaty et al.
Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia, 36(3), 217-232 (1986-01-01)
We have studied the inhibitory effects of several cations (OG+, Mg2+, Ca2+, Sr2+, Ba2+, Mn2+, La3+) on the uniport and exchange pathways for Na+ and K+ of rat liver mitochondria. Swelling of mitochondria suspended in sodium or potassium acetates indicates...
Frank J Quayle et al.
Surgery, 142(6), 800-805 (2007-12-08)
The occurrence of pheochromocytoma in multiple endocrine neoplasia type 2A (MEN 2A) carriers varies greatly. This study aims to determine PC expression for specific MEN 2A RET mutations. Charts of MEN 2A patients enrolled in our multiple endocrine neoplasia program...
Yoshiro Tani et al.
Toxicologic pathology, 33(3), 313-319 (2005-04-09)
Two-year mouse and rat bioassay studies of 2-methylimidazole (2-MI) conducted by the National Toxicology Program revealed that epididymal sperm granuloma(SG)s occurred only in male B6C3F1 mice in a dose-related manner. The present study characterized 2-MI-induced SGs in these epididymides. Groups...
Annamaria Ruzzo et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24(12), 1883-1891 (2006-04-20)
To investigate whether polymorphisms with putative influence on fluorouracil/cisplatin activity are associated with clinical outcomes of patients with advanced gastric cancer (AGC). Peripheral blood samples from 175 prospectively enrolled AGC patients treated with fluorouracil/cisplatin palliative chemotherapy were used for genotyping...
Mariela Bernabe-García et al.
Nutrients, 13(2) (2021-03-07)
Necrotizing enterocolitis (NEC) is an inflammatory bowel disease and a leading cause of morbidity and mortality in preterm infants. In this study, a randomized double-blind parallel-group (1:1) trial was carried out in two neonatal intensive care units of two tertiary...
National Toxicology Program technical report series, (497)(497), 1-225 (2002-01-24)
Methacrylonitrile is an unsaturated aliphatic nitrile. It is widely used in the preparation of homopolymers and copolymers, elastomers, and plastics and as a chemical intermediate in the preparation of acids, amides, amines, esters, and other nitriles. Methacrylonitrile is also used...
R S Chhabra et al.
Toxicological sciences : an official journal of the Society of Toxicology, 60(1), 28-37 (2001-02-27)
p,p'-Dichlorodiphenyl sulfone (DDS) is used as a starting material in the production of polysulfones and polyethersufones, a family of thermoplastics. DDS was studied because of its high production volume and use. In toxicology studies, 10 Fischer 344 rats and 10...
Sureewan Bumrungthai et al.
Journal of translational medicine, 13, 244-244 (2015-07-26)
Cervical squamous cell carcinoma (CSCC) is a major cause of female mortality worldwide. This study has examined epidermal growth factor receptor (EGFR) pathway markers that represent actionable pharmacological targets. HPV16 positive CSCCs (n = 105 patients) from Madhya Pradesh, India...
Yasunori Sato et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 6(1), 132-138 (2010-11-17)
Our goal was to identify candidate polymorphisms that could influence overall survival (OS) in advanced non-small cell lung cancer (NSCLC) patients treated with carboplatin (CBDCA) and paclitaxel (PTX). Chemotherapy-naïve stage IIIB or IV NSCLC patients treated with CBDCA (area under...
David Hong et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 34(15), 1764-1771 (2016-04-06)
The primary objective was to determine safety, toxicity, and a recommended phase II dose regimen of LY2606368, an inhibitor of checkpoint kinase 1, as monotherapy. This phase I, nonrandomized, open-label, dose-escalation trial used a 3 + 3 dose-escalation scheme and...
M Yat Tse et al.
BMC research notes, 4, 565-565 (2011-12-30)
The methylation of DNA is recognized as a key mechanism in the regulation of genomic stability and evidence for its role in the development of cancer is accumulating. LINE-1 methylation status represents a surrogate measure of genome-wide methylation. Using high...
A Helldén et al.
European journal of clinical pharmacology, 68(9), 1281-1286 (2012-03-09)
The influence of the cytochrome P450 enzyme CYP2D6 in the metabolism of the novel dopaminergic stabilizer pridopidine was investigated in healthy Swedish Caucasians. Six extensive metabolizers (EM) and six poor metabolizers (PM) of debrisoquine were given a single oral dose...
Harini Jogiraju et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 963, 83-89 (2014-06-21)
NGP1-01 (8-benzylamino-8,11-oxapentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane) is a heterocyclic cage compound with multifunctional calcium channel blocking activity that has been demonstrated to be neuroprotective in several neurodegenerative models. A sensitive internal standard LC-MS/MS method was developed and validated to quantify NGP1-01 in mouse serum....
National Toxicology Program technical report series, 477, 1-264 (2003-02-07)
1-Chloro-2-propanol and its positional isomer, 2-chloro-1-propanol, are used as chemical intermediates for the manufacture of propylene oxide, a starting material for production of polyurethane polyols and propylene glycol. The National Cancer Institute nominated 1-chloro-2-propanol for study because of potential for...
National Toxicology Program technical report series, 487, 1-230 (2003-02-04)
Isobutene is produced during the fractionation of refinery gases or through the catalytic cracking of methyl-t-butyl ether. Isobutene is primarily used to produce diisobutylene, trimers, butyl rubber, and other polymers. In addition, it is used in the production of isooctane...

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