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Masanori Matsuoka et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(7), 629-634 (2015-07-15)
This paper for the first time reports on novel and non-enzymatic method for studying the free radical-scavenging properties of phenolic compounds against superoxide anion radicals (O2·(-)) by using the cathodic electrochemiluminescence (ECL) of lucigenin (Luc(2+)). The ECL of Luc(2+) at
Lawrence Green et al.
Journal of drugs in dermatology : JDD, 12(2), 180-185 (2013-02-05)
Acne vulgaris is a common dermatologic disease that most frequently affects adolescents and young adults. Over-the-counter (OTC) acne treatment regimens are increasingly being used by individuals with acne. To compare the efficacy, user satisfaction, and tolerability of the OTC regimens
Matthew Di Rago et al.
Forensic science international, 243, 35-43 (2014-05-06)
The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction technique with simple automated data processing.
Kyle W Bender et al.
The Biochemical journal, 457(1), 127-136 (2013-10-10)
Many signalling pathways in plants are regulated by the second messenger calcium (Ca(2+)). In the standard model, Ca(2+)-sensor proteins, such as CaM (calmodulin), detect Ca(2+) signals and subsequently regulate downstream targets to advance the signal transduction cascade. In addition to
Shunping Yan et al.
Molecular cell, 52(4), 602-610 (2013-11-12)
DNA damage is normally detrimental to living organisms. Here we show that it can also serve as a signal to promote immune responses in plants. We found that the plant immune hormone salicylic acid (SA) can trigger DNA damage in
Magdalena Kotzé et al.
AAPS PharmSciTech, 16(4), 835-845 (2015-01-13)
Oil-in-water (o/w) emulsions are commonly converted into solid-like powders in order to improve their physical and chemical stabilities. The aim of this study was to investigate whether whey protein/polysaccharide-stabilized o/w emulsions could be converted into stable oil powders by means
Michelle A Ouimet et al.
Macromolecular bioscience, 15(3), 342-350 (2014-10-22)
Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In
Jinyoung Kwak et al.
Langmuir : the ACS journal of surfaces and colloids, 29(14), 4477-4484 (2013-03-20)
Photoluminescent spherical nanostructures were prepared through the self-assembly of a tyrosine-containing bolaamphiphilic molecule, and their antenna effect was examined. The photoluminescent spherical nanostructures were simply prepared by self-assembly of bolaamphiphile molecules in an aqueous solution in which water-soluble photosensitizers and
Suneela S Dhaneshwar et al.
European journal of medicinal chemistry, 44(10), 3922-3929 (2009-05-16)
Colon-specific mutual azo prodrugs of 5-aminosalicylic acid with essential amino acids were synthesized for the management of inflammatory bowel disease. The structures were confirmed by elemental and spectral analyses. 85-88% release of 5-aminosalicylic acid was achieved in rat fecal matter
A Corina Vlot et al.
Annual review of phytopathology, 47, 177-206 (2009-04-30)
For more than 200 years, the plant hormone salicylic acid (SA) has been studied for its medicinal use in humans. However, its extensive signaling role in plants, particularly in defense against pathogens, has only become evident during the past 20
Jose Pedro Fonseca et al.
PloS one, 9(12), e114119-e114119 (2014-12-02)
Nudix hydrolases comprise a large gene family of twenty nine members in Arabidopsis, each containing a conserved motif capable of hydrolyzing specific substrates like ADP-glucose and NADH. Until now only two members of this family, AtNUDX6 and AtNUDX7, have been
Carola M Wassvik et al.
Journal of medicinal chemistry, 51(10), 3035-3039 (2008-04-10)
Solubility and solid-state characteristics were determined and multivariate data analysis was used to deduce structural features important for solid-state limited solubility of marketed drugs. Molecules with extended ring structures and large conjugated systems were less soluble, indicating that structural features
Guozhang Kang et al.
Molecular genetics and genomics : MGG, 288(11), 591-599 (2013-08-15)
Basic transcription factor 3 (BTF3), the β-subunit of the nascent polypeptide-associated complex, is responsible for the transcriptional initiation of RNA polymerase II and is also involved in cell apoptosis, translation initiation regulation, growth, development, and other functions. Here, we report
Thorsten E Fisher et al.
Bioorganic & medicinal chemistry letters, 17(23), 6511-6515 (2007-10-13)
A series of potent novel 8-hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors was identified. These compounds inhibited the strand transfer process of HIV-1 integrase and viral replication in cells. Compound 12 is active against replication of HIV-1 in cell culture with a CIC(95)
Themba T Ndovi et al.
Clinical pharmacology and therapeutics, 80(2), 146-158 (2006-08-08)
The male genital tract is a complex collection of anatomically and biochemically distinct compartments that contribute to the ejaculate. Understanding the pharmacokinetics in these compartments should inform rational therapeutics involving these glands. Nineteen men were administered a single dose of
[10-year-old boy with blackish brown skin alterations].
C Guarneri et al.
Deutsche medizinische Wochenschrift (1946), 139(50), 2585-2586 (2014-12-04)
A Kunkel et al.
Archiv der Pharmazie, 332(5), 175-178 (1999-06-15)
Capillary electrophoresis (CE) is often regarded as a separation technique of choice because of its high selectivity and its cost advantages compared to LC.RSD% of 0.5% have become standard for quality control assays. Using CE, sample pretreatment can often be
Ashish Ranjan et al.
Functional & integrative genomics, 15(3), 363-373 (2014-12-17)
Xanthomonas oryzae pv. oryzae, the causal agent of bacterial blight of rice, secretes several cell wall degrading enzymes including cellulase (ClsA) and lipase/esterase (LipA). Prior treatment of rice leaves with purified cell wall degrading enzymes such as LipA can confer
Jukrapun Komaikul et al.
Natural product communications, 10(7), 1253-1256 (2015-09-29)
Morus alba L. has been used in Asian traditional medicine as an anti-inflammatory, anti-asthmatic, anthelmintic and as a whitening agent in cosmetic products. Mulberroside A is the major active compound from M. alba root bark. In this study, cell suspension
Vijayata Singh et al.
Molecular plant-microbe interactions : MPMI, 26(9), 1079-1088 (2013-06-12)
Localized infection in plants often induces systemic acquired resistance (SAR), which provides long-term protection against subsequent infections. A signal originating in the SAR-inducing organ is transported to the distal organs, where it stimulates salicylic acid (SA) accumulation and priming, a
Ganesan Karthikeyan et al.
British journal of haematology, 146(2), 142-149 (2009-05-15)
Guidelines differ on whether acetyl salicylic acid (ASA, aspirin) should be used for prophylaxis in patients at high-risk of venous thromboembolism (VTE), principally because of differences in perceptions of its efficacy. ASA is an attractive therapeutic option because it is
Artem O Surov et al.
Molecular pharmaceutics, 12(11), 4154-4165 (2015-10-20)
Salts of the antiviral drug Arbidol (umifenovir) with pharmaceutically relevant benzoate and salicylate anions were obtained, and their crystal structures were described. For Arbidol salicylate, an unstable solvate with acetonitrile was also found and characterized. Analysis of the conformational preferences
Andrés Olivares-Morales et al.
The AAPS journal, 17(5), 1177-1192 (2015-05-20)
Regional intestinal effective permeability (P(eff)) values are key for the understanding of drug absorption along the whole length of the human gastrointestinal (GI) tract. The distal regions of the GI tract (i.e. ileum, ascending-transverse colon) represent the main sites for
Rajeev Kumar Kapoor et al.
Bioresource technology, 189, 99-106 (2015-04-16)
Laccases have wide range of substrate specificity and find applications from pulp industry to waste water remediation. Laccases have also been used in combined pretreatment of biomass hydrolyzates to remove enzymatic and fermentation inhibitors. In this study, laccase production by
Sylwia Magiera et al.
Journal of AOAC International, 97(6), 1526-1537 (2015-01-30)
A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs were extracted from urine samples and then separated on a Zorbax Rapid Resolution
Michael Groszmann et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(46), E6397-E6406 (2015-11-04)
Plant hybrids are extensively used in agriculture to deliver increases in yields, yet the molecular basis of their superior performance (heterosis) is not well understood. Our transcriptome analysis of a number of Arabidopsis F1 hybrids identified changes to defense and
Alexander S Hahn et al.
Journal of virology, 88(16), 8724-8734 (2014-06-06)
The ephrin receptor tyrosine kinase A2 (EphA2) is an entry receptor for Kaposi's sarcoma-associated herpesvirus (KSHV) that is engaged by the virus through its gH/gL glycoprotein complex. We describe here that natural ephrin ligands inhibit the gH/gL-EphA2 interaction. The effects
Tomonori Kawano et al.
Plant cell reports, 32(7), 1125-1138 (2013-05-22)
It is well recognized that salicylic acid (SA) acts as a natural signaling molecule involved in both local and systemic plant defense responses upon attacks by pathogens. Recently, cellular SA receptors and a number of SA-related phloem-mobile signals were identified.
Amanda Dahl et al.
Journal of drugs in dermatology : JDD, 12(1), 52-58 (2013-02-05)
Hydroquinone (HQ) is the benchmark prescription agent for skin lightening. However, HQ use is recently banned in Europe and in parts of Asia because of potential long-term consequences, including carcinogenesis when orally consumed. This has resulted in development of alternative
Mina Heidarian Höckerfelt et al.
International journal of pharmaceutics, 477(1-2), 326-333 (2014-12-03)
The purpose of the research was to investigate the effect of moisture content of cellulose on the degradation of a drug in binary mixtures with cellulose. Physical mixtures of acetylsalicylic acid and two forms of cellulose, either microcrystalline cellulose or
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