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Knoevenagel Condensation Reaction
Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.
A Comparison of Solid Phase Extraction (SPE) Products Used to Purify Peanut Paste Extract for Aflatoxin Analysis
Supel Tox AflaZea SPE produced exceptional analyte recoveries with good reproducibility for all aflatoxins while requiring less than half the sample volume required by competing products.HPLC analysis of all spiked samples after SPE cleanup showed that all compared SPE cartridges...
Proton Exchange Membrane (PEM) Fuel Cells
Proton exchange membrane (PEM) fuel cells operate at relatively low temperatures and are composed of two electrodes and a conductive elecrolyte.
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Analysis of Pesticide Residues in Pistachios Using QuEChERS Extraction and Cleanup with Supel™ QuE Z-Sep+
Pistachios contain approximately 45% fat, which can result in a significant amount of coextracted matrix in the acetonitrile extract generated using the QuEChERS procedure. A zirconia based adsorbent significantly reduces coextracted matrix prior to LC-MS or GC-MS.
Glycosyltransferases were initially considered to be specific for a single glycosyl donor and acceptor, which led to the one enzyme-one linkage concept. Subsequent observations have refuted the theory of absolute enzymatic specificity by describing the transfer of analogs of some...
Sol-Gel Science for Ceramic Materials
Research involving reactive silicone chemistry has focused on the production of pure silicon and hybrid materials, hydrosilylation, ring-opening and atom transfer polymerizations, polymerizations with controlled stereochemistry, and condensation reactions.
MRI/MRS: Use of Isotopes in Hyperpolarization presents an article concerning MRI/MRS and the use of isotopes in hyperpolarization.
Nanostructured Olivine-based Cathode Materials for Lithium-ion Batteries
Due to the adverse impact of the continued use of fossil fuels on the earth’s environment and climate, researchers have been asked to develop new approaches for producing power using renewable sources like wind and solar energy
Building Blocks for Introducing Post-translational Modified Amino Acids
We provide an overview of our available reagents, together with recommendations and details of their use for synthesis of peptides containing post-translationally modified amino acids.
Carcinogenesis and Epigenetics
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D
Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D
Lithography Nanopatterning Tutorial
Tutorial Lithography Nanopatterning at Sigma-Aldrich. Lithography, based on traditional ink-printing techniques, is a process for patterning various layers, such as conductors, semiconductors, or dielectrics, on a surface.
Use of PEPscreen® Peptides to Investigate Protein Farnesyltransferase Substrate Specificity
Prenylation is an essential post-translational modification for the proper localization and function of many proteins and is catalyzed by protein farnesyltransferase (FTase) and protein geranylgeranyltransferase type I (GGTase-I). To identify potential novel prenylated proteins, we used a PEPscreen peptide library...
Delivery of Nucleic Acids Using Polymers
Delivery of Nucleic Acids Using Polymers
Glycosyltransferases: Tools for Synthesis and Modification of Glycans
The presence of multiple functional groups and stereocenters in complex carbohydrates makes them challenging targets for the organic chemist.
Isotopic Labeling for NMR Spectroscopy of Biological Solids
Isotopic Labeling for NMR Spectroscopy of Biological Solids;
Perovskite-Type Oxide Materials
Thermoelectric Performance of Perovskite-type Oxide Materials
TRC Library Citations
TRC 1.5 human and mouse shRNA libraries