Showing 1-30 of 30 results for "

107-39-1

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Yosuke Doi et al.
Cancer science, 101(6), 1529-1535 (2010-04-07)
Vascular endothelial growth factor receptors (VEGFRs) are mainly expressed by endothelial cells, but they are also expressed by some cancer cells, including pancreatic cancer. The objective of this study was to evaluate the significance of VEGFRs expression in pancreatic cancer...
Beth N Peshkin et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 11(10 Pt 1), 1115-1118 (2002-10-12)
We conducted a prospective, observational study to determine breast cancer screening practices among self-referred high-risk women who pursued genetic testing for BRCA1 and BRCA2 mutations. Of the 107 unaffected women included in this study, 41 were BRCA1/2 carriers and 66...
Iara Jose Messias Reason et al.
Human immunology, 67(12), 991-998 (2006-12-19)
Mannan-binding lectin (MBL) is an innate pattern recognition molecule known to play a key role in pathogen clearance. As MBL2 gene polymorphism is associated to an increased susceptibility to infection, we aimed to determine genetic variations in the MBL2 gene...
N D Forsberg et al.
Xenobiotica; the fate of foreign compounds in biological systems, 41(5), 422-429 (2011-03-31)
Levels of urinary dialkylphosphates (DAPs) are currently used as a biomarker of human exposure to organophosphorus insecticides (OPs). It is known that OPs degrade on food commodities to DAPs at levels that approach or exceed those of the parent OP....
Kenjiro Sawada et al.
Cancer research, 68(7), 2329-2339 (2008-04-03)
E-cadherin loss is frequently associated with ovarian cancer metastasis. Given that adhesion to the abdominal peritoneum is the first step in ovarian cancer dissemination, we reasoned that down-regulation of E-cadherin would affect expression of cell matrix adhesion receptors. We show...
S Banerjee et al.
Health technology assessment (Winchester, England), 17(7), 1-166 (2013-02-27)
Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression...
Xiao-wei Zhang et al.
Cancer immunology, immunotherapy : CII, 62(3), 563-570 (2012-10-24)
Expression of monocyte chemoattractant protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) and its significance has been demonstrated in some cancer cells in recent clinical studies. However, the role of tumor MCP-1 and CCR2 expression in non-small cell lung cancer...
C J Falzone et al.
Biochemistry, 35(21), 6519-6526 (1996-05-28)
In order to characterize the structural and dynamic factors that determine the assembly in b hemoproteins, the solution structure of the 98-residue protein apocytochrome b5 was determined by NMR methods. Over 800 experimental restraints derived from a series of two-...
Ruth J F Loos et al.
Obesity (Silver Spring, Md.), 15(11), 2723-2732 (2007-12-12)
To examine the importance of lipin 1 (LPIN1) gene variation in energy and glucose metabolism. Transgenic animal models have shown that lipin, a protein encoded by the LPIN1 gene, promotes fat synthesis and storage in adipose tissue while decreasing energy...
Theodore Spilker et al.
Journal of clinical microbiology, 50(9), 3010-3015 (2012-07-13)
The genus Achromobacter currently is comprised of seven species, including Achromobacter xylosoxidans, an opportunistic and nosocomial pathogen that displays broad-spectrum antimicrobial resistance and is recognized as causing chronic respiratory tract infection in persons with cystic fibrosis (CF). To enable strain...
A Ollerstam et al.
Acta physiologica Scandinavica, 173(4), 351-358 (2002-03-21)
Nitric oxide (NO) produced by neuronal NO-synthase (nNOS) in macula densa cells may be involved in the control of renin release. 7-Nitro indazole (7-NI) inhibits nNOS, and we investigated the effect of short- (4 days) and long-term (4 weeks) 7-NI...
Kyoichi Kaira et al.
American journal of translational research, 7(6), 1161-1171 (2015-08-19)
Amino acid transporters are essential for the growth, progression and the pathogenesis of various cancers. However, it remains obscure about the clinicopathological significance of L-type amino acid transporter 1 (LAT1) and system ASC amino acid transporter 2 (ASCT2) for patients...
A Colige et al.
The Journal of biological chemistry, 270(28), 16724-16730 (1995-07-14)
Procollagen I N-proteinase (EC 3.4.24.14), the enzyme that specifically processes type I and type II procollagens to collagen, was isolated from extracts of fetal calf skin. After two chromatographic steps on concanavalin A-Sepharose and heparin-Sepharose, the semi-purified preparation was used...
J H Bassett et al.
Clinical endocrinology, 50(1), 69-75 (1999-05-26)
Mutations of the DAX1 gene (Dosage-sensitive sex reversal-Adrenal hypoplasia congenita critical region on the X chromosome gene 1), which encodes a novel orphan nuclear receptor, have been identified in patients with X-linked adrenal hypoplasia congenita (AHC) and hypogonadotrophic hypogonadism (HHG)....
Ningwu Huang et al.
Molecular endocrinology (Baltimore, Md.), 19(8), 2020-2034 (2005-04-16)
Sex steroid synthesis requires the 17,20 lyase activity of P450c17, which is enhanced by cytochrome b5, acting as an allosteric factor to promote association of P450c17 with its electron donor, P450 oxidoreductase. Cytochrome b5 is preferentially expressed in the fetal...
Hong-Hu Zhu et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(33), 4215-4221 (2013-10-16)
This randomized, multicenter, phase III noninferiority trial was designed to test the efficacy and safety of an oral tetra-arsenic tetra-sulfide (As4S4) -containing formula named the Realgar-Indigo naturalis formula (RIF) compared with intravenous arsenic trioxide (ATO) as both induction and maintenance...
Hisham M Darwish et al.
Hemoglobin, 29(2), 119-132 (2005-06-01)
beta-Thalassemia (thal) is an autosomal recessive disorder that results in hypochromic hemolytic anemia in affected patients. In the West Bank area of Palestine, the prevalence of beta-thal trait is approximately 3.5% among the population, with an estimated 120,000 carriers. Seventeen...
Asta Dvaranauskaite et al.
Journal of agricultural and food chemistry, 56(9), 3279-3286 (2008-04-17)
Currently essential oil from black currant ( Ribes nigrum L.) buds is mainly used as a valuable perfumery ingredient. This study reports more comprehensive characterization of dormant buds of various black currant ( Ribes nigrum L.) cultivars which are grown...
Rong-Li Piao et al.
World journal of gastroenterology, 18(18), 2280-2286 (2012-05-23)
To determine the utility of connective tissue growth factor (CCN2/CTGF) for assessing hepatic fibrosis in hepatitis B virus (HBV)-induced chronic liver diseases (CLD-B). Enzyme-linked immunosorbent assay was used to measure CCN2 in sera from 107 patients with chronic hepatitis B...
Carol L Shields et al.
Cornea, 34(1), 42-48 (2014-10-25)
To describe the clinical features, treatment, and outcome of patients with iris metastasis. Retrospective case series of 160 tumors in 107 eyes of 104 patients with iris metastasis from systemic cancer. The median age at presentation with iris metastasis was...
Vanderson Rocha et al.
Blood, 100(12), 3908-3918 (2002-10-24)
We made the hypothesis that donor and recipient gene polymorphisms that drive the host response to microorganisms could be associated with infections after bone marrow transplantation (BMT). HLA-identical BMT was performed for patients with acute (n = 39) or chronic...
J E Leysen et al.
Molecular pharmacology, 27(6), 600-611 (1985-06-01)
In vitro and in vivo receptor-binding properties of the new serotonin antagonist, ritanserin, are reported. In in vitro binding assays, ritanserin shows high affinity binding to serotonin-S2 sites in rat frontal cortex tissue: IC50 = 0.9 nM without drug preincubation...
Maximilian Schöniger-Hekele et al.
Journal of gastroenterology and hepatology, 21(9), 1466-1469 (2006-08-17)
Epithelial tissues of the gastrointestinal tract and the liver express predominantly cytokeratin 8 and cytokeratin 18. In vitro experiments and animal studies have demonstrated a protective influence of keratin 8 and keratin 18 against toxic damage of hepatocytes. A specific...
R C Smallridge et al.
Endocrinology, 131(4), 1883-1888 (1992-10-01)
TRH increases cytosolic-free calcium ([Ca2+]i) by activating phospholipase C(PL-C), which induces phosphoinositol hydrolysis, leading to Ca2+ mobilization from inositol trisphosphate (IP3) sensitive stores, and by increasing Ca2+ influx. Increases in [Ca2+]i stimulate PRL secretion. We investigated the effects of U-73122...
Wieneke A Buikhuisen et al.
The Lancet. Oncology, 14(6), 543-551 (2013-04-16)
Standard chemotherapy does not lead to long-term survival in patients with malignant pleural mesothelioma. Malignant pleural mesothelioma is strongly dependent on vasculature with high vessel counts and high concentrations of serum vascular growth factors. Thalidomide has shown antiangiogenic activity, and...
Angela M Summers et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 20(11), 2427-2432 (2005-07-28)
Changes in renal vasculature, with vascular and interstitial fibrosis, are hallmarks of progression to chronic kidney disease (CKD) stage 5. Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor. Transforming growth factor-beta1 (TGF-beta1) plays a critical...
A Fanelli et al.
Archives des maladies du coeur et des vaisseaux, 95(7-8), 701-708 (2002-10-09)
Polymorphisms of the -106 mutation and z - 2 or z + 2 microsatellites (-2.1 kb) of the Aldose Reductase (AR) gene have been associated to microangiopathic complications of the diabetes mellitus. The study aimed to establish a relation between...
Dane Salazar et al.
Clinical orthopaedics and related research, 472(7), 2269-2275 (2014-04-09)
Heterotopic ossification is the most common extrinsic cause of elbow contracture and may lead to clinically important stiffness, and rarely, complete bony ankylosis. Surgery sometimes is performed to treat this problem, and published reports differ regarding the factors that are...
Gunter von Minckwitz et al.
The Lancet. Oncology, 15(7), 747-756 (2014-05-06)
Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, trastuzumab, and a platinum salt for HER2-positive breast cancer. We therefore aimed to assess the efficacy...
Emilie Sbidian et al.
The Cochrane database of systematic reviews, 1, CD011535-CD011535 (2020-01-10)
Psoriasis is an immune-mediated disease for which some people have a genetic predisposition. The condition manifests in inflammatory effects on either the skin or joints, or both, and it has a major impact on quality of life. Although there is...