Showing 1-23 of 23 results for "107-49-3"
Laura M Castellano et al.
Biology open, 4(9), 1206-1212 (2015-09-01)
Semen harbors amyloid fibrils formed by proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) that potently enhance HIV infectivity. Amyloid but not soluble forms of these peptides enhance HIV infection. Thus, agents that remodel...
Luca Gianni et al.
The Lancet. Oncology, 13(1), 25-32 (2011-12-14)
Studies with pertuzumab, a novel anti-HER2 antibody, show improved efficacy when combined with the established HER2-directed antibody trastuzumab in breast cancer therapy. We investigated the combination of pertuzumab or trastuzumab, or both, with docetaxel and the combination of pertuzumab and...
Yu-Ching Weng et al.
Annals of clinical and laboratory science, 35(3), 259-264 (2005-08-06)
Graves' disease (GD) is an autoimmune disease but the underlying etiology has not been completely elucidated. Genetic susceptibility has been believed to play a major role. Recent studies showed that the CT60 single nucleotide polymorphism (SNP), which is in the...
Ponnusamy Vinay et al.
Journal of molecular neuroscience : MN, 71(1), 28-41 (2020-06-23)
This study was designed to test whether the Cronobacter sakazakii infection-impaired contextual learning and memory are mediated by the activation of the complement system; subsequent activation of inflammatory signals leads to alternations in serotonin transporter (SERT). To test this, rat...
Asta Dvaranauskaite et al.
Journal of agricultural and food chemistry, 56(9), 3279-3286 (2008-04-17)
Currently essential oil from black currant ( Ribes nigrum L.) buds is mainly used as a valuable perfumery ingredient. This study reports more comprehensive characterization of dormant buds of various black currant ( Ribes nigrum L.) cultivars which are grown...
Janna M Schurer et al.
The American journal of tropical medicine and hygiene, 90(6), 1184-1190 (2014-03-19)
Residents of remote and Indigenous communities might experience higher exposure to some zoonotic parasites than the general North American population. Human sero-surveillance conducted in two Saulteaux communities found 113 volunteers exposed as follows: Trichinella (2.7%), Toxocara canis (4.4%), Echinococcus (4.4%)...
Melih O Babaoglu et al.
Clinical pharmacology and therapeutics, 78(6), 619-626 (2005-12-13)
Resistance to antiemetic treatment with 5-hydroxytryptamine type 3 (5-HT(3)) receptor antagonists is still a major problem resulting in patient discomfort and poor compliance to chemotherapy. We hypothesized that clinical resistance to 5-HT(3) antagonists is associated with the single-nucleotide polymorphism (3435C>T)...
Heiner K Berthold et al.
Scandinavian cardiovascular journal. Supplement, 47(1), 20-27 (2012-09-28)
Statins decrease cardiovascular events mainly by lowering cholesterol but anti-inflammatory effects also play a role. The effects of the cholesterol absorption inhibitor ezetimibe on markers of inflammation remain unclear. We performed an exploratory post-hoc analysis whether these drugs influence the...
Jan Tkadlec et al.
Microbial drug resistance (Larchmont, N.Y.), 21(4), 416-423 (2015-04-01)
Staphylococcus aureus is one of the most frequent pathogens infecting the respiratory tract of patients with cystic fibrosis (CF). This study was the first to examine S. aureus isolates from CF patients in the Czech Republic. Among 100 S. aureus...
Rita Teek et al.
International journal of pediatric otorhinolaryngology, 74(9), 1007-1012 (2010-08-17)
The purpose of this study was to determine the prevalence of c.35delG and p.M34T mutations in the GJB2 gene among children with early onset hearing loss and within a general population of Estonia. Using an arrayed primer extension assay, we...
Raffaele Serra et al.
Surgery, 157(1), 155-162 (2014-12-03)
An association between arterial aneurysms and matrix metalloproteinases (MMPs) has been described previously. MMPs regulate extracellular structural proteins and tissue remodeling. Neutrophil gelatinase-associated lipocalin (NGAL) is involved in the regulation of MMP activity. The aim of this work was to...
P Sabbatini et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 17(3), 589-594 (2007-02-16)
The objective of this study was to analyze retrospective populations with recurrent ovarian cancer to assess differences in CA-125 patterns during chemotherapy. The populations included all patients treated between January 1994 and January 2004, who received liposomal doxorubicin and topotecan...
Anna Jouppila-Mättö et al.
Histology and histopathology, 26(4), 443-449 (2011-03-02)
Snail1, a key regulator of epithelial-mesenchymal transition (EMT), plays an important role in tumour progression. Previous studies of snail1 have mainly focused on the epithelial tumour cells. The objective of this study was to evaluate the expression of snail1 protein...
Marije N van Doorn-van Atten et al.
The British journal of nutrition, 119(10), 1185-1194 (2018-05-16)
This study aimed to evaluate the effects of an intervention including nutritional telemonitoring, nutrition education, and follow-up by a nurse on nutritional status, diet quality, appetite, physical functioning and quality of life of Dutch community-dwelling elderly. We used a parallel...
Yusmin Mohd-Yusuf et al.
Immunology letters, 139(1-2), 68-72 (2011-06-11)
We investigated the association of the HLA genes in Malaysian patients with systemic lupus erythematosus (SLE) and their associations with the clinical manifestations in 160 SLE patients (99 Chinese and 61 Malays) and 107 healthy control individuals (58 Chinese and...
A Gödecke et al.
Circulation research, 82(2), 186-194 (1998-02-19)
For the specific analysis of endothelial NO synthase (eNOS) function in the coronary vasculature, we generated a mouse homozygous for a defective eNOS gene (eNOS-/-). Western blot as well as immunohistochemical staining revealed the absence of eNOS protein in eNOS-/-...
A Ollerstam et al.
Acta physiologica Scandinavica, 173(4), 351-358 (2002-03-21)
Nitric oxide (NO) produced by neuronal NO-synthase (nNOS) in macula densa cells may be involved in the control of renin release. 7-Nitro indazole (7-NI) inhibits nNOS, and we investigated the effect of short- (4 days) and long-term (4 weeks) 7-NI...
Philipp M Kazmierczak et al.
PloS one, 13(10), e0204930-e0204930 (2018-10-04)
To investigate αvβ3-integrin-targeted optoacoustic imaging and MRI for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma. Human BRAF V600E-positive melanoma xenograft (A375)-bearing Balb/c nude mice (n = 10) were imaged before (day 0) and after...
Richard Brans et al.
Toxicology, 212(2-3), 148-154 (2005-06-14)
Dyes such as para-phenylene diamine (PPD) or related para-compounds are very common contact sensitizers in man. The corresponding contact dermatitis in sensitized individuals is a complex and common illness associated with considerable morbidity and social cost. It has been found...
S Bevan et al.
British journal of pharmacology, 107(2), 544-552 (1992-10-01)
1. Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin. The present study shows the capsazepine acts as a competitive antagonist of capsaicin. 2. Capsazepine (10 microM) reversibly reduced or abolished the current response to capsaicin (500 nM)...
Zhao-Hui Yin et al.
World journal of gastroenterology, 11(8), 1232-1236 (2005-03-09)
To investigate the expression of tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial growth factor (VEGF) in the development of esophageal varices in portal hypertensive rats. Thirty male Sprague-Dawley (SD) rats in the model group in which a two-stage ligation of...
Roberta W Scherer et al.
JAMA otolaryngology-- head & neck surgery, 145(7), 597-608 (2019-05-24)
Tinnitus retraining therapy (TRT) is an internationally recognized, but controversial, protocol of uncertain efficacy that uses tinnitus-specific educational counseling (TC) and sound therapy (ST) to reduce the patient's tinnitus-evoked negative reaction to, and awareness of, tinnitus. To compare the efficacy...
Gunter von Minckwitz et al.
The Lancet. Oncology, 15(7), 747-756 (2014-05-06)
Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, trastuzumab, and a platinum salt for HER2-positive breast cancer. We therefore aimed to assess the efficacy...

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