Search Within
Applied Filters:
Keyword:'109290'
Showing 1-30 of 57 results for "

109290

" within Papers
Xiaole Qi et al.
The Journal of pharmacy and pharmacology, 67(4), 493-500 (2014-12-17)
The aim of this study was to prepare a disintegrating gastric floating tablet composed of floating pellets coated with acrylic resin to prolong the gastric residence time and increase the oral bioavailability of famotidine. The gastric floating pellets containing famotidine...
Katarzyna Pietrzak et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 380-387 (2015-08-19)
The advances in personalised medicine increased the demand for a fast, accurate and reliable production method of tablets that can be digitally controlled by healthcare staff. A flexible dose tablet system is presented in this study that proved to be...
Gavin P Andrews et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 69(1), 264-273 (2008-01-01)
The aim of this highly novel study was to use hot-melt extrusion technology as an alternative process to enteric coating. In so doing, oral dosage forms displaying enteric properties may be produced in a continuous, rapid process, providing significant advantages...
Emilia Entcheva et al.
IEEE transactions on bio-medical engineering, 51(2), 333-341 (2004-02-10)
Tracking spatial and temporal determinants of cardiac arrhythmogenesis at the cellular level presents challenges to the optical mapping techniques employed. In this paper, we describe a compact system combining two nontraditional low-cost solutions for excitation light sources and emission filters...
Kakuyou Ogawa et al.
Biological & pharmaceutical bulletin, 37(9), 1559-1563 (2014-09-02)
Zerumbone 1 is an 11-membered cyclic sesquiterpene obtained from the rhizomes of Zingiber zerumbet SMITH (Zingiberaceae). In this study, we investigated the structure-activity relationship of 1, α-humulene (2), tetrahydrozerumbone stereoisomers (3-5), and tetrahydrozerumbone derivatives (6-9). The oxygen-containing functional groups and...
Vivek S Dave et al.
Drug development and industrial pharmacy, 38(10), 1240-1253 (2012-01-20)
The influence of plasticizer level, roll pressure and sintering temperature was investigated on the granule properties, tablet breaking force and theophylline release from tablets. Nine formulations using theophylline as a model drug, Eudragit(®) RL PO, Eudragit(®) RS PO, or both...
Nilesh Saindane et al.
Journal of pharmaceutical sciences, 101(9), 3169-3179 (2012-03-16)
The aim of the present investigation was to develop controlled porosity osmotic system for poorly water-soluble drug based on drug in polymer-surfactant layer technology. A poorly water-soluble drug, glipizide (GZ), was selected as the model drug. The technology involved core...
Makoto Ishida et al.
Drug development and industrial pharmacy, 40(8), 1054-1064 (2013-06-21)
Abstract The applicability of porous spherical silica (PSS) was evaluated as core particles for pharmaceutical products by comparing it with commercial core particles such as mannitol (NP-108), sucrose and microcrystalline cellulose spheres. We investigated the physical properties of core particles...
Sushmita Bhattacharjya et al.
AAPS PharmSciTech, 9(2), 449-457 (2008-04-24)
The purpose of the present investigation was to elucidate the influence of curing on different physical properties of Eudragit NE and RS coating systems. Increased curing times resulted in decreased drug release rates from Eudragit NE-coated beads. However, an increase...
S Monfort et al.
International journal of food microbiology, 145(2-3), 476-482 (2011-02-19)
This paper is an evaluation of the lethal effectiveness of a successive application of pulsed electric fields (PEFs) and heat treatment in liquid whole egg (LWE) in the presence of different additives on the population of Salmonella serovar Enteritidis. Synergistic...
Hamdy Abdelkader et al.
International journal of pharmaceutics, 477(1-2), 631-642 (2014-12-03)
Naltrexone hydrochloride (NTX) is an innovative drug used in ophthalmology for treatment of ocular surface diseases such as impaired corneal wound healing and severe dry eye. Poor chemical stability has been a major limitation for development of NTX in solution...
Manjeet B Pimparade et al.
International journal of pharmaceutics, 487(1-2), 167-176 (2015-04-19)
The objective of this study was to develop caffeine citrate orally disintegrating tablet (ODT) formulations utilizing hot-melt extrusion technology and evaluate the ability of the formulation composition to mask the unpleasant bitter taste of the drug using in vitro and...
Grega Hudovornik et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 75, 160-168 (2015-05-03)
Special populations including paediatric and elderly patients often need advanced approaches in treatment, such as one-a-day dosing, which is achieved with modified release formulations or alternative routes of applications such as nasogastric route. Pellets are a dosage form that is...
Soravoot Rujivipat et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(1), 223-229 (2012-01-25)
Enteric polymers such as cellulose esters (cellulose acetate phthalate, hydroxypropylmethylcellulose acetate succinate) and methacrylic acid-acrylate copolymers (Eudragit® L100-55 and S100) are quite brittle in the dry state and thus not suitable as pellet coatings for compression into tablets. The objective...
Caroline Désirée Kablitz et al.
Pharmaceutical development and technology, 18(1), 39-45 (2011-08-20)
A recent development of coating technology is dry coating, where polymer powder and liquid plasticizer are layered on the cores without using organic solvents or water. Several studies evaluating the process were introduced in literature, however, little information about the...
Kit Frederiksen et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 91, 9-15 (2015-01-18)
Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Their application convenience and cosmetic attributes, superior to conventional semi-solids, may offer...
M R Abbaspour et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 68(3), 747-759 (2007-11-06)
One challenge in tableting of sustained-release multiparticulates is maintaining the desired drug release after compaction. The aim of this study was to design sustained-release ibuprofen tablets which upon oral ingestion rapidly disintegrate into sustained-release pellets in which the integrity of...
Vesna Petrovska-Jovanovska et al.
International journal of pharmaceutics, 484(1-2), 75-84 (2015-02-25)
In this study, hybrid silica xerogel particles were developed as carriers of budesonide (BDS) for efficient local treatment of inflammatory bowel diseases (IBD). Organically modified silica particles (ORMOSILs) were prepared by co-condensation of 3-aminopropyltriethoxysilane (APTES) and tetraethyl orthosilicate (TEOS) by...
Sheng-Feng Hung et al.
PloS one, 9(6), e100321-e100321 (2014-06-27)
Effervescent multiple-unit floating drug delivery systems (muFDDSs) consisting of drug (lorsartan)- and effervescent (sodium bicarbonate)-containing pellets were characterized in this study. The mechanical properties (stress and strain at rupture, Young's modulus, and toughness) of these plasticized polymeric films of acrylic...
Ryan C Bennett et al.
Drug development and industrial pharmacy, 41(3), 382-397 (2013-12-18)
Acetyl-11-keto-β-boswellic acid (AKBA), a gum resin extract, possesses poor water-solubility that limits bioavailability and a high melting point making it difficult to successfully process into solid dispersions by fusion methods. The purpose of this study was to investigate solvent and...
Thermal and mechanical properties of poly (lactic acid)/starch/methylenediphenyl diisocyanate blending with triethyl citrate.
Ke T and Sun XS.
Journal of Applied Polymer Science, 88(13), 2947-2955 (2003)
Dorothea Sauer et al.
Drug development and industrial pharmacy, 35(6), 646-654 (2009-04-02)
Limited information on thermally cured dry-powder coatings used for solid dosage forms has been available in the literature. The aim of this study was to characterize the film formation process of Eudragit L 100-55 dry-powder coatings and to investigate the...
Felipe J O Varum et al.
International journal of pharmaceutics, 468(1-2), 172-177 (2014-04-15)
Despite rapid dissolution in compendial phosphate buffers, gastro resistant (enteric coated) products can take up to 2 h to disintegrate in the human small intestine, which clearly highlights the inadequacy of the in vitro test method to predict in vivo...
Lisa Claire du Toit et al.
Journal of pharmaceutical sciences, 97(6), 2176-2207 (2007-09-21)
The crux of this research was the pragmatic investigation into the formulation of a reconstitutable multiparticulate anti-tuberculosis drug delivery system for facilitated administration for the attainment of segregated gastrointestinal (GI) delivery of rifampicin (RIF) and isoniazid (INH) in order to...
Sandra U Schilling et al.
Journal of microencapsulation, 27(6), 521-532 (2010-06-26)
Matrix-type pellets with controlled-release properties may be prepared by hot-melt extrusion applying a single-step, continuous process. However, the manufacture of gastric-resistant pellets is challenging due to the high glass transition temperature of most enteric polymers and an unacceptably high, diffusion-controlled...
Friederike Folttmann et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 931-938 (2014-12-03)
A spatial filtering velocimetry (SFV) probe was applied to monitor the increase in particle size during pellet Wurster coating processes in-line. Accuracy of the in-line obtained pellet sizes was proven by at-line performed digital image analysis (DIA). Regarding particle growth...
A Charakida et al.
The British journal of dermatology, 157(3), 569-574 (2007-07-20)
Acne vulgaris is a major clinical problem; despite a vast array of treatment modalities available for acne, there is considerable dissatisfaction in acne treatment among patients and doctors. Rising antibiotic drug resistance consequent to the widespread use of topical antibiotics...
Claire Gendre et al.
International journal of pharmaceutics, 421(2), 237-243 (2011-10-11)
The aim of this work was to carry out real-time near infrared (NIR) predictions of drug release from sustained release coated tablets and to determine end point of coating operation. In-line measurements were ensured by implementation of a NIR probe...
Aleksandar Aleksovski et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 75, 114-122 (2015-04-08)
Mini-tablets are gaining great attention as systems capable of being formulated into multiple unit systems providing a specific drug release pattern. Within the presented research a combined, multiple-unit system, based on different coated matrix mini-tablets, has been developed in order...
Michael Drechsler et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 807-815 (2014-10-11)
The aim of the present study was to develop film-coated tablets which release a minor amount of the active pharmaceutical ingredient (API) into the stomach and small intestine, yet show a sharp increase of drug release in the colon. Tablets...
Page 1 of 2
Page 1 of 2