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Yu-Jin Guo et al.
Die Pharmazie, 69(4), 306-310 (2014-05-06)
Myricetin is one of the main ingredients of Chinese bayberry, which is used as a traditional medicine. The purpose of this study was to find out whether myricetin influences the rat cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C9 and CYP3A4) by
Janneke Jentink et al.
BMJ (Clinical research ed.), 341, c6581-c6581 (2010-12-04)
To identify specific major congenital malformations associated with use of carbamazepine in the first trimester of pregnancy. A review of all published cohort studies to identify key indications and a population based case-control study to test these indications. Review of
Sylwia Magiera et al.
Journal of AOAC International, 97(6), 1526-1537 (2015-01-30)
A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs were extracted from urine samples and then separated on a Zorbax Rapid Resolution
R Barrons et al.
Journal of clinical pharmacy and therapeutics, 35(2), 153-167 (2010-05-12)
The goal of this review is to evaluate the efficacy and safety of carbamazepine and oxcarbazepine in treatment of alcohol withdrawal syndrome (AWS) and determine the role in therapy of both agents. Relevant literature was identified through a search of
Sang Yoon Lee et al.
Toxicology letters, 229(1), 33-40 (2014-06-10)
Although cytochrome P450 inhibition is the major drug-drug interaction (DDI) mechanism in clinical pharmacotherapy, DDI of a number of well-established drugs have not been investigated. Rifampicin, isoniazid, pyrazinamide and ethambutol combination therapy inhibits clearance of theophylline in patients with tuberculosis.
Ganna Fedorova et al.
Chemosphere, 111, 55-60 (2014-07-07)
In this study, the stability of 124 target analytes in influent and effluent wastewater samples during short-term (4°C) and long-term (-18°C) storage was assessed. The most common storage scenario was considered, in which samples were frozen immediately after sampling without
Zhengwei Zhou et al.
Journal of pharmaceutical and biomedical analysis, 106, 37-45 (2014-07-27)
The performance of ferrate(VI) in treating sulfamethoxazole (SMX), diclofenac (DCF), carbamazepine (CBZ) and bezafibrate (BZF) in test solutions containing the four compounds was investigated. A series of jar-test experiments was performed on a bench-scale at pH 6-9 and at a
Chen-Hsu Wang et al.
Pharmaceutical biology, 52(11), 1451-1459 (2014-07-16)
Abstract Background: Carbamazepine, which was developed primarily for the treatment of epilepsy, is now also useful for the treatment of non-epileptic disorders and inflammatory hyperalgesia. However, the mechanism of its anti-neuroinflammatory action remains poorly understood. This study elucidates the anti-neuroinflammatory
Xiangjun Qiu et al.
Journal of chromatographic science, 53(1), 85-89 (2014-04-29)
In this study, a simple, rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry method is described for the determination of glipizide in human plasma samples using carbamazepine as the internal standard (IS) from bioequivalence assays. Sample preparation was accomplished
Zhican Wang et al.
Endocrinology, 155(6), 2052-2063 (2014-03-20)
25-Hydroxyvitamin D3 (25OHD3) is used as a clinical biomarker for assessment of vitamin D status. Blood levels of 25OHD3 represent a balance between its formation rate and clearance by several oxidative and conjugative processes. In the present study, the identity
Jacek Wójcikowski et al.
Pharmacological reports : PR, 66(6), 1122-1126 (2014-12-03)
Joint administration of phenothiazine neuroleptics and an antidepressant or carbamazepine is applied in the therapy of many complex psychiatric disorders. The aim of the present study was to investigate possible effects of the tricyclic antidepressant drug amitriptyline and the anticonvulsant
Ji-Yoon Lee et al.
Chemico-biological interactions, 229, 109-118 (2015-01-28)
We investigated to compare species differences in amitriptyline (AMI) metabolism among mouse, rat, dog, and human liver microsomes. We developed a method for simultaneous determination of metabolic stability and metabolite profiling using predictive multiple reaction monitoring information-dependent acquisition-enhanced product ion
Fouad F Al-Qaim et al.
Journal of chromatography. A, 1345, 139-153 (2014-04-29)
An analytical method that facilitated the analysis of 11 pharmaceuticals residue (caffeine, prazosin, enalapril, carbamazepine, nifedipine, levonorgestrel, simvastatin, hydrochlorothiazide, gliclazide, diclofenac-Na, and mefenamic acid) with a single pre-treatment protocol was developed. The proposed method included an isolation and concentration procedure
Zhe Wang et al.
Biomedical chromatography : BMC, 29(2), 188-193 (2014-06-14)
A sensitive and rapid ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed to determine voriconazole in human plasma. Sample preparation was accomplished through a simple one-step protein precipitation with methanol. Chromatographic separation was carried out on an
Clara Boix et al.
Food chemistry, 160, 313-320 (2014-05-07)
Veterinarian and human pharmaceuticals may be intentionally added to animal feed to enhance animal production. Monitoring these substances is necessary for protecting the consumers. In this work, a screening method covering 116 human and veterinary drugs has been developed and
Andrew J Chetwynd et al.
Journal of mass spectrometry : JMS, 49(10), 1063-1069 (2014-10-11)
Mass spectrometry (MS) profiling techniques are used for analysing metabolites and xenobiotics in biofluids; however, detection of low abundance compounds using conventional MS techniques is poor. To counter this, nanoflow ultra-high-pressure liquid chromatography-nanoelectrospray ionization-time-of-flight MS (nUHPLC-nESI-TOFMS), which has been used
V L Yip et al.
Clinical pharmacology and therapeutics, 92(6), 757-765 (2012-11-08)
Carbamazepine (CBZ) therapy is associated with cutaneous adverse reactions in up to 10% of patients. Predisposition to these hypersensitivity reactions has been linked to the human leukocyte antigen (HLA) genotype. This systematic review determines the strength of these associations and
M Muz et al.
Environmental technology, 35(9-12), 1055-1063 (2014-04-08)
The fate and removal of six selected endocrine disrupting compounds in a lab-scale anaerobic/aerobic (A/O) sequencing batch reactor (SBR), operating at 5 days, solids retention time (SRT) were investigated. A carbamazepine (CBZ), acetaminophen (ATP), diltiazem (DTZ), butyl benzyl phthalate (BBP)
Yousheng Xiao et al.
The Cochrane database of systematic reviews, 1, CD008781-CD008781 (2012-01-20)
The efficacy and safety of vigabatrin (VGB) as an add-on therapy for refractory epilepsy has been well established. However, this needs to be weighed against the risk of the development of visual field defects. Whether VGB monotherapy is an effective
Sidy Ba et al.
Journal of hazardous materials, 280, 662-670 (2014-09-15)
Widespread detection of numerous micropollutants including aromatic pharmaceuticals in effluents of wastewater treatment plants has prompted much research aimed at efficiently eliminating these contaminants of environmental concerns. In the present work, a novel hybrid bioreactor (HBR) of cross-linked enzymes aggregates
Question 2 Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant?
Subramanian Ganesan et al.
Archives of disease in childhood, 96(1), 104-106 (2010-12-21)
Paul M Bradley et al.
Environmental pollution (Barking, Essex : 1987), 193, 173-180 (2014-07-20)
Pharmaceutical contamination of shallow groundwater is a substantial concern in effluent-dominated streams, due to high aqueous mobility, designed bioactivity, and effluent-driven hydraulic gradients. In October and December 2012, effluent contributed approximately 99% and 71%, respectively, to downstream flow in Fourmile
Yasuhiro Horita et al.
Antimicrobial agents and chemotherapy, 58(6), 3168-3176 (2014-03-26)
Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS coinfection cases. We evaluated
Tae Hwan Kim et al.
Epilepsia, 56(1), e6-e9 (2014-12-10)
Oxcarbazepine (OXC), widely used to treat focal epilepsy, is reported to exacerbate seizures in patients with generalized epilepsy. OXC is metabolized to monohydroxy derivatives in two enantiomeric forms: (R)-licarbazepine and (S)-licarbazepine. Eslicarbazepine acetate is a recently approved antiepileptic drug that
Giuseppe Gangarossa et al.
Hippocampus, 24(12), 1466-1481 (2014-07-22)
The acute activation of the dopamine D1-like receptors (D1R) is involved in a plethora of functions ranging from increased locomotor activity to the facilitation of consolidation, storage, and retrieval of memories. Although much less characterized, epileptiform activities, usually triggered by
Dong-Lou Liang et al.
Die Pharmazie, 69(4), 301-305 (2014-05-06)
The purpose of this study was to find out whether icaritin influences the effect on rat cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C9, CYP2E1 and CYP3A4) using cocktail probe drugs in vivo. A cocktail solution at a dose of 5 mL/kg
Mladen Milović et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 226-232 (2014-08-16)
We report the application of diatom as a solid carrier for water insoluble drugs applied in oral drug delivery system based on the self-emulsifying drug delivery system (SEDDS) caprylocaproyl macrogol-8 glycerides/lecithin/propylene glycol/caprylic/capric triglyceride. Diatoms are fossilized skeletons of photosynthetic algae
Rita Celano et al.
Journal of chromatography. A, 1355, 26-35 (2014-06-19)
Pharmaceutical and personal care products (PPCPs) are one of the most important classes of emerging contaminants. The potential of ecological and environmental impacts associated with PPCPs are of particular concern because they continually penetrate the aquatic environment. This work describes
Huihui Chen et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 1-8 (2014-06-22)
Carbamazepine (CBZ), an anticonvulsant and mood-stabilizing pharmaceutical, is a widespread contaminant in aquatic environments. In this study, the effects of chronic exposure to environmentally relevant CBZ concentrations were investigated in freshwater clams Corbicula fluminea. Adult C. fluminea were exposed to
Claudia Kasserra et al.
Journal of clinical pharmacology, 55(2), 168-178 (2014-08-28)
Pomalidomide offers an alternative for patients with relapsed/refractory multiple myeloma who have exhausted treatment options with lenalidomide and bortezomib. Little is known about pomalidomide's potential for drug-drug interactions (DDIs); as pomalidomide clearance includes hydrolysis and cytochrome P450 (CYP450)-mediated hydroxylation, possible
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