Showing 1-30 of 397 results for "109681"
Li Liu et al.
Scientific reports, 6, 21810-21810 (2016-02-26)
Protein arginine methyltransferase 1 (PRMT1) catalyzes methylation of histones and other cellular proteins, and thus regulates gene transcription and protein activity. In antigen-induced pulmonary inflammation (AIPI) PRMT1 was up-regulated in the epithelium, while in chronic AIPI, increased PRMT1 shifted to...
Adrián Plaza et al.
British journal of pharmacology, 176(15), 2678-2690 (2019-04-24)
A cholecystokinin (CCK) system has been identified in white adipose tissue (WAT). Nevertheless, the endocrine actions of CCK on WAT remain unknown. Our goal was to investigate the role of CCK in regulating the production of adiponectin, an adipokine expressed...
Stine Hole et al.
Breast cancer research and treatment, 149(3), 715-726 (2015-02-11)
Aromatase inhibitors (AIs) are used for treatment of estrogen receptor α (ER)-positive breast cancer; however, resistance is a major obstacle for optimal outcome. This preclinical study aimed at identifying potential new treatment targets in AI-resistant breast cancer cells. Parental MCF-7...
Natasha L Tilston-Lunel et al.
Journal of virology, 90(5), 2616-2627 (2015-12-25)
Oropouche virus (OROV) is a midge-borne human pathogen with a geographic distribution in South America. OROV was first isolated in 1955, and since then, it has been known to cause recurring outbreaks of a dengue-like illness in the Amazonian regions...
Ryuta Uraki et al.
The Journal of infectious diseases, 212(12), 1939-1948 (2015-07-01)
Secondary bacterial infections after influenza can be a serious problem, especially in young children and the elderly, yet the efficacy of current vaccines is limited. Earlier work demonstrated that a replication-incompetent PB2-knockout (PB2-KO) influenza virus possessing a foreign gene in...
Andrea R McWhorter et al.
The Journal of general virology, 96(Pt 5), 1127-1137 (2015-01-13)
Infection with multiple genetically distinct strains of pathogen is common and can lead to positive (complementation) or negative (competitive) within-host interactions. These interactions can alter aspects of the disease process and help shape pathogen evolution. Infection of the host with...
Agnieszka Blitek et al.
Theriogenology, 84(6), 969-982 (2015-07-04)
The prostacyclin (PGI2) signaling pathway plays an important role during early pregnancy in rodents and ruminants. Abundant concentrations of PGI2 were also found in the endometrium and uterine lumen of gilts during the period of implantation. The present study was...
Daniela Kramer et al.
Cell death and differentiation, 24(2), 300-316 (2016-11-12)
All current regimens for treating ovarian cancer center around carboplatin as standard first line. The HSP90 inhibitor ganetespib is currently being assessed in advanced clinical oncology trials. Thus, we tested the combined effects of ganetespib and carboplatin on a panel...
Beatriz Perdiguero et al.
Frontiers in immunology, 10, 2941-2941 (2020-01-11)
The generation of a vaccine against HIV-1 able to induce durable protective immunity continues a major challenge. The modest efficacy (31.2%) of the phase III RV144 clinical trial provided the first demonstration that a prophylactic HIV/AIDS vaccine is achievable but...
Francisco Bosch-Reig et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 181, 7-12 (2017-03-18)
A method for quantifying the individual components of mineral samples based on attenuated total reflectance - Fourier transform infrared spectroscopy (ATR-FTIR) is described, extending the constant ratio (CR) method to analytes absorbing in a common range of wavenumbers. Absorbance values...
Dev Nathani et al.
Muscle & nerve, 59(6), 643-649 (2019-02-01)
To improve diagnostic accuracy, in this study we compared prebiopsy clinical parameters with subsequent pathological confirmation of peripheral nerve vasculitis. Clinical, laboratory, and neurophysiological parameters were analyzed for consecutive patients referred for nerve biopsy with suspected vasculitis. Patients were assigned...
Masako Dannoura et al.
Tree physiology, 39(2), 201-210 (2018-06-23)
Phloem failure has recently been recognized as one of the mechanisms causing tree mortality under drought, though direct evidence is still lacking. We combined 13C pulse-labelling of 8-year-old beech trees (Fagus sylvatica L.) growing outdoors in a nursery with an...
Omar A Abdul-Rahman et al.
Birth defects research. Part A, Clinical and molecular teratology, 106(1), 47-54 (2015-09-27)
The National Children's Study (NCS) Vanguard Study began enrollment in January 2009 as an initial pilot study for a planned large-scale, longitudinal U.S. cohort study of the effect of environmental influences on child health and development, with biological and environmental...
Shafiq M Syed et al.
Cell stem cell, 26(1), 64-80 (2019-12-31)
The remarkable regenerative capacity of the endometrium (the inner lining of the uterus) is essential for the sustenance of mammalian life. Over the years, the role of stem cells in endometrial functions and their pathologies has been suggested; however, the...
Paige S Katz et al.
Alcohol (Fayetteville, N.Y.), 49(8), 759-765 (2015-11-26)
Activated CD8+ T-cells correlate with viral load and may foretell antiretroviral therapy (ART) failure. HIV infection has been suggested to accelerate immunosenescence through chronic persistent inflammation. Alcohol-use disorders (AUD) are prevalent in persons living with HIV/AIDS (PLWHA). We tested the...
Emmanuelle Saint-Germain et al.
Cancer research, 79(13), 3306-3319 (2019-05-19)
Expression of the suppressor of cytokine signaling-1 (SOCS1) is inactivated in hematopoietic and solid cancers by promoter methylation, miRNA-mediated silencing, and mutations. Paradoxically, SOCS1 is also overexpressed in many human cancers. We report here that the ability of SOCS1 to...
Masako Yaoita et al.
Human genetics, 135(2), 209-222 (2015-12-31)
RASopathies are autosomal dominant disorders caused by mutations in more than 10 known genes that regulate the RAS/MAPK pathway. Noonan syndrome (NS) is a RASopathy characterized by a distinctive facial appearance, musculoskeletal abnormalities, and congenital heart defects. We have recently...
Prasanna Kumar Athyala et al.
Biochemical and biophysical research communications, 469(2), 257-262 (2015-12-09)
Neocarzinostatin (NCS) a potent DNA-damaging, anti-tumor toxin extracted from Streptomyces carzinostaticus that recognizes double-stranded DNA bulge and induces DNA damage. 2 Fluoro (2F) Modified EpCAM RNA aptamer is a 23-mer that targets EpCAM protein, expressed on the surface of epithelial...
Ahmad Khoramabadi-zad et al.
Molecular diversity, 14(4), 829-832 (2009-11-10)
Two N-chloro reagents (chloramine-T and N-chlorosuccinimide) were used as effective oxidizing agents for the oxidation of bisnaphthols to the corresponding Abel's ketones under mild and convenient conditions at room temperature with good to excellent yields.
Katarzyna Skrypnik et al.
Food & function, 10(8), 5228-5238 (2019-08-07)
Obesity leads to detrimental abnormalities of iron (Fe) metabolism. So far, studies have shown that single-strain probiotic supplementation ameliorates the gut microbiota quality disrupted in the obese and improves Fe homeostasis. The effect of multistrain probiotic supplementation and its dose-dependence...
Tayita Suttirojpattana et al.
Theriogenology, 85(3), 509-518 (2015-10-21)
The aim of the present study was to optimize the temperature for the temporal storage of matured bovine oocytes. In vitro-matured bovine oocytes were preserved in HEPES-buffered TCM199 medium supplemented with 10% newborn calf serum at different temperatures (4 °C...
Piotr Kaczynski et al.
Theriogenology, 142, 169-176 (2019-10-11)
Blood vessel formation is a critical process for successful pregnancy establishment and placenta formation. Angiogenic factors such as vascular endothelial growth factor (VEGF), angiopoietins (ANGPTs) or fibroblast growth factor 2 (FGF2) are known to be involved in angiogenesis. However, the...
Joanna Klubo-Gwiezdzinska et al.
Endocrine connections, 6(7), 469-478 (2017-08-10)
Amifostine is a potent scavenger of reactive oxygen species that is used for the salivary gland protection during therapy with radioactive iodine for thyroid cancer. There are no data on the potential effect of amifostine on thyroid cancer cells. We...
Ryan L Hanson et al.
The Journal of cell biology, 218(4), 1282-1297 (2019-02-13)
In response to DNA damage, the transcription factor p53 accumulates in a series of pulses. While p53 dynamics play a critical role in regulating stress responses, how p53 pulsing affects target protein expression is not well understood. Recently, we showed...
Diana K Bowen et al.
The Canadian journal of urology, 22(6), 8063-8068 (2015-12-22)
We designed a pilot study to measure preoperative sexual dysfunction risk counseling between sexual medicine experts (SME) and general urologists between monopolar/bipolar transuretheral resection of the prostate (TURP) and laser TURP (LT). An emailed electronic survey was distributed to members...
Ananya Nandy et al.
Infection and immunity, 86(6) (2018-04-11)
Mycobacterium tuberculosis, a successful human pathogen, utilizes multiple carbon sources from the host but adapts to a fatty-acid-rich environment in vivo We sought to delineate the physiologic response of M. tuberculosis to a lipid-rich environment by using differentiated adipocytes as...
Yu-ichi Noto et al.
Journal of neurology, neurosurgery, and psychiatry, 86(4), 378-384 (2014-08-06)
To elucidate the ultrasound (US) features of peripheral nerves including nerve roots in patients with different types of Charcot-Marie-Tooth disease (CMT), and the association between US findings, clinical features and parameters of nerve conduction studies (NCS) in CMT1A. US of...
David A Foley et al.
The Journal of organic chemistry, 76(23), 9630-9640 (2011-10-28)
On-flow ReactIR and (1)H NMR reaction monitoring, coupled with in situ intermediate characterization, was used to aid in the mechanistic elucidation of the N-chlorosuccinimide mediated transformation of an α-thioamide. Multiple intermediates in this reaction cascade are identified and characterized, and...
Natalia Molchanova et al.
ChemMedChem, 12(4), 312-318 (2017-01-05)
Multidrug-resistant bacteria pose a serious threat to public health worldwide. Previously, α-peptide/β-peptoid hybrid oligomers were found to display activity against Gram-negative multidrug-resistant bacteria. In the present work, the influence of hydrophobicity, fluorination, and distribution of cationic/hydrophobic residues on antimicrobial, hemolytic...
Reactivity of Pd(II) complexes with electrophilic chlorinating reagents: isolation of Pd(IV) products and observation of C-Cl bond-forming reductive elimination.
Salena R Whitfield et al.
Journal of the American Chemical Society, 129(49), 15142-15143 (2007-11-17)

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