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110175

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GGCT
gamma-glutamylcyclotransferase
Synonyms:
C7orf24, CRF21, GCTG, GGC
Species:
Human GGCT (79017), Mouse Ggct (110175), Rat Ggct (362368), chicken GGCT (420676), dog GGCT (611603), domestic cat GGCT (101087219), cow GGCT (533374), sheep GGCT (101102474), domestic guinea pig Ggct (100723170), naked mole-rat Ggct (101723887)
Summary:
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010
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