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Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion
He?elbach K, et al.
Epigenetics, 1-14 (2017)
Lysozyme and penicillin inhibit the growth of anaerobic ammonium-oxidizing planctomycetes.
Hu Z, et al.
Applied and Environmental Microbiology, 79(24), 7763-7769 (2013)
Krishnan MohanKumar et al.
American journal of physiology. Gastrointestinal and liver physiology, 318(4), G705-G716 (2020-02-25)
Anemia is a frequent diagnosis in critically ill infants, but the clinical implications of severe anemia in these patients remain unclear. In this study, we examined preweaned mice to investigate the effects of severe anemia during early infancy on gut
Ali Can Sahillioglu et al.
Cancer immunology research, 9(9), 999-1007 (2021-07-02)
Adoptive transfer of genetically modified or donor-derived T cells can efficiently eradicate human tumors but is also frequently associated with major toxicity. There are several switches that can be used to kill the infused cell pool in the case of
Seyhan Turk et al.
PloS one, 15(11), e0242497-e0242497 (2020-11-26)
Despite the availability of various treatment protocols, response to therapy in patients with Acute Myeloid Leukemia (AML) remains largely unpredictable. Transcriptomic profiling studies have thus far revealed the presence of molecular subtypes of AML that are not accounted for by
Irene Iscla et al.
Nature communications, 5, 4891-4891 (2014-09-11)
The antibiotic streptomycin is widely used in the treatment of microbial infections. The primary mechanism of action is inhibition of translation by binding to the ribosome, but how it enters the bacterial cell is unclear. Early in the study of
Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma
Hooijkaas A, et al.
Oncoimmunology, 1(5), 609-617 (2012)
Marten Szibor et al.
The Journal of biological chemistry, 295(14), 4383-4397 (2020-02-26)
Mitochondrial oxidative phosphorylation (OXPHOS) and cellular workload are tightly balanced by the key cellular regulator, calcium (Ca2+). Current models assume that cytosolic Ca2+ regulates workload and that mitochondrial Ca2+ uptake precedes activation of matrix dehydrogenases, thereby matching OXPHOS substrate supply
Matteo Zurlo et al.
International journal of oncology, 59(2) (2021-07-20)
In the development of novel and more effective anticancer approaches, combined treatments appear to be of great interest, based on the possibility of obtaining relevant biological or therapeutic effects using lower concentrations of single drugs. Combination therapy may prove to
Daniela Hirsch et al.
Scientific reports, 10(1), 17895-17895 (2020-10-23)
Human cancer cell lines are frequently used as model systems to study molecular mechanisms and genetic changes in cancer. However, the model is repeatedly criticized for its lack of proximity to original patient tumors. Therefore, understanding to what extent cell
Treatment with 7% and 10% CO2 enhanced expression of IL-1β, TNF-α, and IL-6 in hypoxic cultures of human whole blood.
Hongguang Ding et al.
The Journal of international medical research, 48(4), 300060520912105-300060520912105 (2020-04-09)
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