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111-13-7

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Francesca Molinari et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(14), 4901-4914 (2011-06-03)
KRAS mutations represent the main cause of resistance to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs) in metastatic colorectal cancer (mCRC). We evaluated whether highly sensitive methods for KRAS investigation improve the accuracy of predictions of anti-EGFR MoAbs efficacy....
Ola Nilsson et al.
Annals of the New York Academy of Sciences, 1014, 275-279 (2004-05-22)
Malignant carcinoid tumors express high numbers of somatostatin receptors. Radiation therapy using labeled somatostatin analogs is a novel treatment modality for these tumors. We have analyzed the biokinetics and therapeutic effect of radiolabeled somatostatin analog on a human midgut carcinoid...
Gustavo Pimentel Dutra et al.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 32(3), 275-278 (2010-04-24)
Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine...
M E Martínez et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 12(5), 778-785 (1997-05-01)
Parathyroid hormone-related protein (PTHrP) is synthesized by osteoblasts, although its local role in bone is not completely understood. The C-terminal (107-111) region of PTHrP seems to be a potent inhibitor of osteoblastic bone resorption. We studied the effect of this...
Issan Yee San Tam et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(5), 1647-1653 (2006-03-15)
This study evaluated the mutational profile of epidermal growth factor receptor (EGFR) and KRAS in non-small cell lung cancers in Hong Kong and determined their relation with smoking history and other clinicopathologic features. Mutational profile of exons 18 to 21...
Kai Zhou et al.
Research in microbiology, 163(5), 316-322 (2012-06-05)
An intragenic tandem repeat (TR) region has been previously reported in the tolA gene of Escherichia coli. In silico analysis of 123 E. coli tolA sequences from Genbank and PCR analysis of the tolA TR region from 111 additional E....
Gerhard Binder et al.
Clinical endocrinology, 82(1), 100-105 (2014-09-11)
The distinction between constitutional delay of growth and puberty (CDGP) and isolated hypogonadotropic hypogonadism (IHH) in males with delayed puberty is difficult but important for timely treatment. We assessed the accuracy of the GnRH agonist test (triptorelin 0·1 mg) in...
Richard C Ho et al.
Cytokine, 30(1), 14-21 (2005-03-24)
Mexican Americans (MA) exhibit high risk for the insulin resistance syndrome characterized by subclinical inflammation and greater risk for type 2 diabetes compared with non-Hispanic white (NHW) adults. The reasons for this phenomenon remain obscure. Because the inflammatory cytokine, tumor...
Roberta W Scherer et al.
JAMA otolaryngology-- head & neck surgery, 145(7), 597-608 (2019-05-24)
Tinnitus retraining therapy (TRT) is an internationally recognized, but controversial, protocol of uncertain efficacy that uses tinnitus-specific educational counseling (TC) and sound therapy (ST) to reduce the patient's tinnitus-evoked negative reaction to, and awareness of, tinnitus. To compare the efficacy...
Richard C Bell et al.
The Journal of chemical physics, 127(2), 024704-024704 (2007-07-21)
An ion soft-landing approach was applied to study the motion of hydronium (D(3)O(+)) and cesium (Cs(+)) ions from 84 to 104 K in glassy 3-methyl-pentane (3MP) films vapor deposited on Pt(111). Both ions were found to have very similar mobilities...
Noriko Kimura et al.
Endocrine-related cancer, 21(3), 405-414 (2014-02-14)
Phaeochromocytomas (PHEO) and paragangliomas are rare catecholamine-producing tumours. Although 10-30% of these tumours metastasise, histopathological criteria to discriminate malignant from benign tumours have not been established; therefore, reliable histopathological markers predicting metastasis are urgently required. A total of 163 tumours...
M L Katz et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 10(11), 1050-1053 (1999-11-11)
Late-infantile ceroid-lipofuscinosis (CLN2) is an autosomal recessively inherited, neurodegenerative disease in humans. The CLN2 locus has been mapped to Chromosome (Chr) 11p15, and its sequence and genomic organization have recently been reported. In the present study, the cDNA sequence, exon/intron...
Chisato Shimizu et al.
Journal of human genetics, 55(12), 779-784 (2010-09-10)
Aneurysms of the vascular wall represent a final common pathway for a number of inflammatory processes, including atherosclerosis and idiopathic vasculitis syndromes. Kawasaki disease (KD) is an acute, self-limited vasculitis in children and the leading cause of acquired coronary artery...
S Banerjee et al.
Health technology assessment (Winchester, England), 17(7), 1-166 (2013-02-27)
Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression...
Guri Hagberg et al.
BMC neurology, 20(1), 174-174 (2020-05-10)
Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI is unclear. We hypothesize that amyloid deposition, measured with Flutemetamol (18F-Flut) positron emission tomography (PET), is common in seven-year...
L Ay et al.
Journal of thrombosis and haemostasis : JTH, 8(4), 759-765 (2010-01-28)
Patients with morbid obesity (MO; body mass index > 40 kg m(-2)) suffer from an increased risk of cardiovascular disease, stroke, venous thromboembolism and all-cause mortality. Because weight loss by bariatric surgery reduces cardiovascular and all-cause mortality, we hypothesized that...
Jenica H Kakadia et al.
American journal of physiology. Endocrinology and metabolism, 319(3), E614-E628 (2020-08-04)
In cultured fetal liver cells, insulin-like growth factor (IGF) binding protein (IGFBP)-1 hyperphosphorylation in response to hypoxia and amino acid deprivation is mediated by inhibition of mechanistic target of rapamycin (mTOR) and activation of amino acid response (AAR) signaling and...
Antoine Kimmoun et al.
Annals of intensive care, 5(1), 35-35 (2015-11-06)
Data are sparse regarding the effects of prolonged prone positioning (PP) during VV-ECMO. Previous studies, using short sessions (<12 h), failed to find any effects on respiratory system compliance. In the present analysis, the effects of prolonged PP sessions (24 h) were...
Louis Guillou et al.
The American journal of surgical pathology, 31(9), 1387-1402 (2007-08-28)
Low-grade fibromyxoid sarcomas (LGFMS) bear either the t(7,16) (q32-34;p11) or t(11,16) (p11;p11) translocations, resulting in FUS-CREB3L2 or FUS-CREB3L1 fusions, respectively. Heretofore, fusion transcripts were mainly detected in frozen tissues, using reverse transcription-polymerase chain reaction. In this study, we aimed to...
Eva Potura et al.
Anesthesia and analgesia, 120(1), 123-129 (2014-09-05)
Recent studies have shown a decline in glomerular filtration rate and increased renal vasoconstriction after administration of normal saline when compared with IV solutions with less chloride. In this study, we investigated the impact of normal saline versus a chloride-reduced...
Takako Kawasaki et al.
BMC cancer, 8, 33-33 (2008-01-31)
Cyclooxygenase-2 (COX-2, PTGS2) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Evidence suggests that MSI/CIMP+ colorectal cancer may arise through the serrated...
Jonathan Draher et al.
Rapid communications in mass spectrometry : RCM, 30(11), 1265-1272 (2016-05-14)
Milk-derived ingredients are widely used around the world in the manufacturing of nutritional products. They are prone to economically motivated adulteration with nitrogenous compounds such as melamine and its analogs in order to increase the nitrogen content of these ingredients....
Yael Hacohen et al.
Journal of neurology, neurosurgery, and psychiatry, 84(7), 748-755 (2012-11-24)
To report the clinical and investigative features of children with a clinical diagnosis of probable autoimmune encephalopathy, both with and without antibodies to central nervous system antigens. Patients with encephalopathy plus one or more of neuropsychiatric symptoms, seizures, movement disorder...
Aurel C Allabi et al.
British journal of clinical pharmacology, 56(6), 653-657 (2003-11-18)
To investigate the distribution of cytochrome P450 2C9 (CYP2C9) and 2C19 (CYP2C19) genotype frequencies in the Beninese and Belgian Caucasian populations. Beninese (n = 111) and Belgian (n = 121) were genotyped for CYP2C9*2, *3, *4, *5, and *11 as...
Nina-Sophie Schmidt-Hegemann et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 60(7), 963-970 (2018-12-16)
68Ga-prostate-specific membrane antigen PET/CT (68Ga-PSMA PET/CT) offers unprecedented accuracy for staging of primary, persistent, or recurrent prostate cancer. Thus, we hypothesized that 68Ga-PSMA PET/CT before radiotherapy significantly affects the radiotherapeutic approach in comparison to the current standard, a CT-based approach....
Blake R Hopiavuori et al.
Molecular neurobiology, 55(2), 1795-1813 (2017-11-24)
Lipids are essential components of the nervous system. However, the functions of very long-chain fatty acids (VLC-FA; ≥ 28 carbons) in the brain are unknown. The enzyme ELOngation of Very Long-chain fatty acids-4 (ELOVL4) catalyzes the rate-limiting step in the biosynthesis...
R Marcucci et al.
Journal of thrombosis and haemostasis : JTH, 3(5), 929-934 (2005-05-05)
In recent years there has been a significant increase in the diagnosis of sudden sensorineural hearing loss (SSHL) in western, countries with an incidence of 20 of 100,000 people affected every year. No clear causes for this disease have been...
Ping Jin et al.
Zhonghua fu chan ke za zhi, 46(5), 329-332 (2011-07-08)
To investigate the effect of Interleukin (IL)-18, IL-12 and tumor necrosis factor-α (TNF-α) in hepatic injury in intrahepatic cholestasis of pregnancy (ICP). Sixty-two cases of ICP patients (ICP group), 30 cases of normal pregnant women (control group) and 30 cases...