Showing 1-30 of 204 results for "11175025910"
Takashi Koyama et al.
Current biology : CB, 29(11), 1901-1909 (2019-05-28)
Vertebrate sex development consists largely of two processes: "sex determination," the initial bifurcation of sexual identity, and "sex differentiation," which subsequently facilitates maleness or femaleness according to the sex determination signal. Steroid hormones promote multiple types of sexual dimorphism in...
Anand Venkataraman et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 13(3), 531-540 (2014-01-11)
Grp1-associated scaffold protein (Grasp), the product of a retinoic acid-induced gene in P19 embryonal carcinoma cells, is expressed primarily in brain, heart, and lung of the mouse. We report herein that Grasp transcripts are also found in mouse skin in...
Manush Saydmohammed et al.
Nature communications, 9(1), 3381-3381 (2018-08-25)
Establishing left-right asymmetry is a fundamental process essential for arrangement of visceral organs during development. In vertebrates, motile cilia-driven fluid flow in the left-right organizer (LRO) is essential for initiating symmetry breaking event. Here, we report that myosin 1d (myo1d)...
János Györi et al.
Scientific reports, 11(1), 5478-5478 (2021-03-23)
ATP and its ionotropic P2X receptors are components of the most ancient signaling system. However, little is known about the distribution and function of purinergic transmission in invertebrates. Here, we cloned, expressed, and pharmacologically characterized the P2X receptors in the...
Pamela C Powell et al.
Heliyon, 5(4), e01397-e01397 (2019-04-19)
Volume overload (VO) of isolated mitral regurgitation (MR) or aortocaval fistula (ACF) is associated with extracellular matrix degradation and cardiomyocyte myofibrillar and desmin breakdown. Left ventricular (LV) chymase activity is increased in VO and recent studies demonstrate chymase presence within...
Ana Cecilia Aliaga Fandino et al.
Biology open, 8(3) (2019-02-23)
Cambium contains a stem cell population that produces xylem and phloem tissues in a radial direction during the secondary growth stage. The growth of many storage roots, including in the radish, Raphanus sativus L., also depends on cambium. Interestingly, we...
Víctor Velecela et al.
Development (Cambridge, England), 146(20) (2019-10-19)
The epicardium plays a crucial role in embryonic heart development and adult heart repair; however, the molecular events underlying its maturation remain unknown. Wt1, one of the main markers of the embryonic epicardium, is essential for epicardial development and function....
Meade Haller et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(8), E1849-E1858 (2018-02-13)
Genitourinary (GU) birth defects are among the most common yet least studied congenital malformations. Congenital anomalies of the kidney and urinary tract (CAKUTs) have high morbidity and mortality rates and account for ∼30% of structural birth defects. Copy number variation...
Debanjan Dhar et al.
Cancer cell, 33(6), 1061-1077 (2018-06-13)
How fully differentiated cells that experience carcinogenic insults become proliferative cancer progenitors that acquire multiple initiating mutations is not clear. This question is of particular relevance to hepatocellular carcinoma (HCC), which arises from differentiated hepatocytes. Here we show that one...
Yansen Ma et al.
FEBS letters, 587(10), 1489-1495 (2013-03-29)
One of the major challenges in stem cell research is to decipher the controlling mechanisms/genes of stem cell homeostasis. Through an RNAi mediated genetic screen of living animals, we identified an evolutionarily conserved histone acetyltransferase Atac2 as a novel regulator...
Barbara Dupret et al.
PloS one, 11(7), e0158700-e0158700 (2016-07-22)
Polycomb Repressive Complex (PRC) 1 regulates the control of gene expression programs via chromatin structure reorganization. Through mutual exclusion, different PCGF members generate a variety of PRC1 complexes with potentially distinct cellular functions. In this context, the molecular function of...
Guang Chen et al.
Plant, cell & environment, 38(12), 2747-2765 (2015-06-06)
Potassium (K) absorption and translocation in plants rely upon multiple K transporters for adapting varied K supply and saline conditions. Here, we report the expression patterns and physiological roles of OsHAK1, a member belonging to the KT/KUP/HAK gene family in...
Michael S Fleming et al.
eLife, 4, e06828-e06828 (2015-04-04)
RET can be activated in cis or trans by its co-receptors and ligands in vitro, but the physiological roles of trans signaling are unclear. Rapidly adapting (RA) mechanoreceptors in dorsal root ganglia (DRGs) express Ret and the co-receptor Gfrα2 and...
Tadasuke Tsukiyama et al.
Nature communications, 11(1), 4586-4586 (2020-09-17)
Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity...
Inbal Shainer et al.
Current biology : CB, 29(12), 2009-2019 (2019-06-11)
Agouti-related protein (AgRP) is a hypothalamic regulator of food consumption in mammals. However, AgRP has also been detected in circulation, but a possible endocrine role has not been examined. Zebrafish possess two agrp genes: hypothalamically expressed agrp1, considered functionally equivalent...
Eyal Maori et al.
Cell reports, 27(7), 1949-1959 (2019-05-06)
Systemic RNAi, initiated by double-stranded RNA (dsRNA) ingestion, has been reported in diverse invertebrates, including honey bees, demonstrating environmental RNA uptake that undermines homologous gene expression. However, the question why any organism would take up RNA from the environment has...
Alysha A Rauhauser et al.
American journal of physiology. Renal physiology, 309(9), F770-F778 (2015-08-21)
Hedgehog (Hh) is an evolutionary conserved signaling pathway that has important functions in kidney morphogenesis and adult organ maintenance. Recent work has shown that Hh signaling is reactivated in the kidney after injury and is an important mediator of progressive...
Uma M Neelathi et al.
Development (Cambridge, England), 145(14) (2018-06-28)
The zebrafish posterior lateral line primordium migrates along a path defined by the chemokine Cxcl12a, periodically depositing neuromasts, to pioneer formation of the zebrafish posterior lateral line system. snail1b, known for its role in promoting cell migration, is expressed in...
Surendra Singh Patel et al.
The Journal of experimental biology, 223(Pt 8) (2020-02-27)
Eisenia fetida, the common vermicomposting earthworm, shows robust regeneration of posterior segments removed by amputation. During the period of regeneration, the newly formed tissue initially contains only undifferentiated cells but subsequently differentiates into a variety of cell types including muscle...
Mritunjay Pandey et al.
Pain, 158(5), 931-944 (2017-01-31)
Itch is a protective sensation producing a desire to scratch. Pathologic itch can be a chronic symptom of illnesses such as uremia, cholestatic liver disease, neuropathies and dermatitis, however current therapeutic options are limited. Many types of cell surface receptors...
Ludivine Raby et al.
Genes, 11(4) (2020-04-02)
The Polycomb Repressive Complex 1 (PRC1) is a chromatin-associated protein complex involved in transcriptional repression of hundreds of genes controlling development and differentiation processes, but also involved in cancer and stem cell biology. Within the canonical PRC1, members of Pc/CBX...
Marcin Andrzej Lipiec et al.
Development (Cambridge, England), 147(16) (2020-07-18)
Neuronal phenotypes are controlled by terminal selector transcription factors in invertebrates, but only a few examples of such regulators have been provided in vertebrates. We hypothesised that TCF7L2 regulates different stages of postmitotic differentiation in the thalamus, and functions as...
Weiyue Chen et al.
Nature communications, 10(1), 4164-4164 (2019-09-15)
BES1 and BZR1 were originally identified as two key transcription factors specifically regulating brassinosteroid (BR)-mediated gene expression. They belong to a family consisting of six members, BES1, BZR1, BEH1, BEH2, BEH3, and BEH4. bes1 and bzr1 single mutants do not...
Shijia Chen et al.
Neuron, 95(1), 153-168 (2017-06-27)
Light affects sleep and wake behaviors by providing an indirect cue that entrains circadian rhythms and also by inducing a direct and rapid regulation of behavior. While circadian entrainment by light is well characterized at the molecular level, mechanisms that...
Peng Xia et al.
Molecular therapy. Nucleic acids, 19, 1470-1481 (2020-03-13)
Osteosarcoma (OS) is the most common primary bone malignancy derived from primitive bone-forming mesenchymal cells. Long noncoding RNA (lncRNA) expression profiles have been intensively studied for their involvement in OS. Herein, we clarify whether lncRNA CEBPA-AS1 is a regulator of...
Shuyu Guo et al.
Theranostics, 11(9), 4316-4334 (2021-03-24)
Trio is a unique member of the Rho-GEF family that has three catalytic domains and is vital for various cellular processes in both physiological and developmental settings. TRIO mutations in humans are involved in craniofacial abnormalities, in which patients present...
Chulin Yu et al.
Reproduction (Cambridge, England) (2016-11-01)
The corticotropin-releasing hormone (CRH) signaling system is involved in numbers of stress-related physiological and pathological responses,including its inhibiting effects on estradiol (E2) synthesis and follicular development in the ovary. In addition, there are reports that microRNAs (miRNAs) can control the...
Arthur Marivin et al.
The Journal of cell biology, 218(5), 1743-1763 (2019-04-06)
Heterotrimeric G proteins are signaling switches that control organismal morphogenesis across metazoans. In invertebrates, specific GPCRs instruct G proteins to promote collective apical cell constriction in the context of epithelial tissue morphogenesis. In contrast, tissue-specific factors that instruct G proteins...
Jing Liu et al.
Cell stem cell, 21(5), 635-649 (2017-10-17)
Human brain evolution is associated with expansion and folding of the neocortex. Increased diversity in neural progenitor (NP) populations (such as basally located radial glia [RG], which reside in an enlarged outer subventricular zone [OSVZ]) likely contributes to this evolutionary...
Xudong Wu et al.
Nature communications, 10(1), 3801-3801 (2019-08-25)
The bundle of stereocilia on inner ear hair cells responds to subnanometer deflections produced by sound or head movement. Stereocilia are interconnected by a variety of links and also carry an electron-dense surface coat. The coat may contribute to stereocilia...

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