Showing 1-17 of 17 results for "

112-43-6

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Yuji Mizuno et al.
Journal of the neurological sciences, 315(1-2), 20-25 (2012-01-20)
TDP-43 has been identified as a major component of the pathological inclusions in most forms of frontotemporal lobar degeneration with ubiquitin-positive inclusions and in amyotrophic lateral sclerosis (ALS). In the present study, paraffin sections of the midbrain in 112 patients...
Boryana Konstantinova Popivanova et al.
Cancer science, 98(3), 321-328 (2007-02-03)
We previously observed that Pim-3 with serine/threonine kinase activity, was aberrantly expressed in malignant lesions of endoderm-derived organs, liver and pancreas. Because Pim-3 protein was not detected in normal colon mucosal tissues, we evaluated Pim-3 expression in malignant lesions of...
Luigi Boiardi et al.
The Journal of rheumatology, 33(4), 703-708 (2006-04-04)
To assess the role of -174 G/C promoter polymorphism of interleukin 6 (IL-6) in the susceptibility to polymyalgia rheumatica (PMR). We also investigated whether this polymorphism modulates the circulating level of IL-6 and the risk of relapse/recurrence in a series...
D S Alberts et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 14(2), 224-228 (2004-04-17)
This report provides follow-up progression-free survival (PFS) and median survival data for women who achieved clinical complete remission (cCR) from stage III ovarian cancer after first-line therapy and were treated with altretamine consolidation therapy. Patients who enrolled in the SWOG...
B Ballantyne et al.
Toxicology and industrial health, 5(1), 45-54 (1989-01-01)
The acute handling hazards of tris(dimethylamino)silane [TDMAS] were investigated. The acute male rat peroral LD50 (with 95% confidence limits) was 0.71 (0.51-0.97) ml/kg, and the acute male rabbit percutaneous LD50 was 0.57 (0.35-0.92) ml/kg. The liquid was severely irritating to...
G Matthijs et al.
American journal of human genetics, 62(3), 542-550 (1998-04-29)
Carbohydrate-deficient-glycoprotein syndrome type 1 (CDG1; also known as "Jaeken syndrome") is an autosomal recessive disorder characterized by defective glycosylation. Most patients show a deficiency of phosphomannomutase (PMM), the enzyme that converts mannose 6-phosphate to mannose 1-phosphate in the synthesis of...
D Tschoepe et al.
Diabetologia, 46(7), 984-989 (2003-06-27)
The gene encoding the beta(3)-subunit (GPIIIa) of the platelet alpha(2)beta(3)-integrin (fibrinogen receptor) shows a polymorphism PlA1/A2 with the A2 allele putatively associated with an increased risk of acute ischaemic events. This study investigated whether Type 2 diabetes as a particular...
Eric Raymond et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26(28), 4659-4665 (2008-10-01)
To evaluate the safety and the efficacy of imatinib in recurrent malignant gliomas. This was a single-arm, phase II study. Eligible patients had recurrent glioma after prior radiotherapy with an enhancing lesion on magnetic resonance imaging. Three different histologic groups...
Hiroyuki Matsubayashi et al.
Cancer biology & therapy, 2(6), 652-655 (2003-12-23)
Long standing chronic pancreatitis is a risk factor for developing pancreatic cancer. Inheritance of polymorphisms in SPINK1 and CFTR are associated with an increased risk of developing pancreatitis. The aim of this study was to determine if patients who carry...
Ai-hua Zhang et al.
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 45(5), 393-398 (2011-07-16)
To explore the influence of arsenic pollution caused by coal-burning on methylation (promoter and exon 5) and mutation (exon 5) of human p53 gene, and to analyze the relationship between methylation, mutation and arsenism. According to the diagnostic criteria of...
Yi Li et al.
SpringerPlus, 4, 637-637 (2015-11-07)
CYP3A5 and ABCB1 polymorphisms have been shown to influence tacrolimus blood concentrations and dose requirements, but the conclusion in the current reports were inconformity. Sirolimus are also metabolized by CYP3A subfamily and are substrates of the P-gp. The aim was...
Lidia Ziółkowska et al.
Kardiologia polska, 73(6), 419-428 (2015-01-08)
Cardiovascular magnetic resonance (CMR) imaging is a clinically proven and reliable diagnostic method for the assessment of morphology, function, and characteristics of myocardial tissue in patients with myocardial diseases. The use of gadolinium contrast agents has created new diagnostic possibilities...
Richard J Caselli et al.
Archives of neurology, 64(9), 1306-1311 (2007-09-12)
Memory declines more rapidly with age in apolipoprotein E (APOE) epsilon4 carriers than in APOE epsilon4 noncarriers, and APOE epsilon4 homozygotes' cognitive performances correlate with stressors. These changes could represent presymptomatic disease in some, despite their youth. To show that...
Ilya R Bederman et al.
Journal of applied physiology (Bethesda, Md. : 1985), 119(1), 16-26 (2015-05-02)
We previously showed that a single bolus of "doubly-labeled" water ((2)H2 (18)O) can be used to simultaneously determine energy expenditure and turnover rates (synthesis and degradation) of tissue-specific lipids and proteins by modeling labeling patterns of protein-bound alanine and triglyceride-bound...
D Nicholas Bateman et al.
Lancet (London, England), 383(9918), 697-704 (2013-12-03)
Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated with frequent adverse effects related to concentration, which can cause treatment interruption. We aimed to ascertain whether adverse effects could be...
Qiong Wu et al.
Epilepsy research, 148, 8-16 (2018-10-15)
To investigate the spatiotemporal expression of cannabinoid receptor type 2 (CB2R) in the hippocampus of pilocarpine-treated rats experiencing a status epilepticus (SE). A total of 112 male Sprague-Dawley rats at three weeks of age, weighing 43 g-68.5 g, were used for this...
Claudia Trenkwalder et al.
The Lancet. Neurology, 12(12), 1141-1150 (2013-10-22)
Opioids are a potential new treatment for severe restless legs syndrome. We investigated the efficacy and safety of a fixed-dose combination of prolonged release oxycodone-naloxone for patients with severe restless legs syndrome inadequately controlled by previous, mainly dopaminergic, treatment. This...