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Christelle de Renty et al.
PloS one, 9(5), e97434-e97434 (2014-05-23)
Proliferating trophoblast stem cells (TSCs) can differentiate into nonproliferating but viable trophoblast giant cells (TGCs) that are resistant to DNA damage induced apoptosis. Differentiation is associated with selective up-regulation of the Cip/Kip cyclin-dependent kinase inhibitors p57 and p21; expression of
M Jesús Gómez-Lamarca et al.
Journal of cell science, 127(Pt 21), 4667-4678 (2014-09-03)
Coordinating exit from the cell cycle with differentiation is crucial for proper development and tissue homeostasis. Failure to do so can lead to aberrant organogenesis and tumorigenesis. However, little is known about the developmental signals that regulate the switch from
Roberta Quaranta et al.
Cell death & disease, 8(7), e2942-e2942 (2017-07-21)
Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule cell progenitors (GCPs) and its misregulation is linked to various disorders, including cerebellar cancer medulloblastoma. The effects of Shh pathway are mediated by the Gli family of transcription factors
Chengming Fan et al.
JCI insight, 5(12) (2020-05-27)
The mortality of patients suffering from acute myocardial infarction is linearly related to the infarct size. As regeneration of cardiomyocytes from cardiac progenitor cells is minimal in the mammalian adult heart, we have explored a new therapeutic approach, which leverages
Martinho Soto-Ribeiro et al.
Journal of cell science, 132(8) (2019-03-21)
Heterodimeric integrin receptors control cell adhesion, migration and extracellular matrix assembly. While the α integrin subunit determines extracellular ligand specificity, the β integrin chain binds to an acidic residue of the ligand, and cytoplasmic adapter protein families such as talins
Bin Lin et al.
Frontiers in endocrinology, 8, 253-253 (2017-10-27)
With recent advances in stem cell technology, it is becoming efficient to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes, which can subsequently be used for myriad purposes, ranging from interrogating mechanisms of cardiovascular disease, developing novel cellular therapeutic approaches
Esmaeil H Shiri et al.
The International journal of developmental biology, 53(4), 579-584 (2009-04-21)
To establish whether dehydroepiandrosterone (DHEA) as a neurosteroid could enhance the rate of neuronal differentiation in neuronal-competent bone marrow mesenchymal stem cells (BM-MSCs), we added DHEA before and after plating the neurosphere-like aggregates. Flow cytometric analysis of Tubulin-III and Tau
Samuel J Rodgers et al.
Nature communications, 12(1), 3140-3140 (2021-05-27)
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to PI3K regulation is unclear. We
Prachi N Ghule et al.
Cell cycle (Georgetown, Tex.), 14(15), 2501-2508 (2015-06-02)
Histone Nuclear Factor P (HINFP) is essential for expression of histone H4 genes. Ablation of Hinfp and consequential depletion of histones alter nucleosome spacing and cause stalled replication and DNA damage that ultimately result in genomic instability. Faithful replication and
Yuanyuan Xue et al.
Developmental cell, 42(4), 349-362 (2017-08-15)
In mammals, hematopoietic stem and progenitor cells (HSPCs) rapidly expand in the fetal liver (FL), but the underlying mechanism remains unclear. Here, we characterize zebrafish caudal hematopoietic tissue (CHT) and identify an important cellular and molecular mechanism of HSPC expansion.
Boaz Kigel et al.
Blood, 118(15), 4285-4296 (2011-08-13)
Plexin-A4 is a receptor for sema6A and sema6B and associates with neuropilins to transduce signals of class-3 semaphorins. We observed that plexin-A1 and plexin-A4 are required simultaneously for transduction of inhibitory sema3A signals and that they form complexes. Unexpectedly, inhibition
Turgay Saritas et al.
Cell reports, 25(10), 2668-2675 (2018-12-06)
Distal nephron remodeling contributes to the pathophysiology of many clinically relevant scenarios, including diuretic resistance and certain Mendelian disorders of blood pressure. However, constitutive genetic disruptions are likely to have substantial developmental effects in this segment, and whether tubule remodeling
R Santoro et al.
Oncogene, 31(24), 2931-2942 (2011-10-18)
Several epidemiological studies have shown that high levels of melatonin, an indolic hormone secreted mainly by the pineal gland, reduce the risks of developing cancer, thus suggesting that melatonin triggers the activation of tumor-suppressor pathways that lead to the prevention
Sophie Vasseur et al.
Oncogene, 21(11), 1685-1694 (2002-03-16)
p8 is a stress-induced DNA-binding protein, biochemically related to the architectural chromatin binding HMG protein family and whose function is presently unknown. We obtained fibroblast from mice lacking p8 and found that p8 is involved in cell growth regulation and
Nitin Sabherwal et al.
Development (Cambridge, England), 136(16), 2767-2777 (2009-07-28)
During neurogenesis in Xenopus, apicobasally polarised superficial and non-polar deep cells take up different fates: deep cells become primary neurons while superficial cells stay as progenitors. It is not known whether the proteins that affect cell polarity also affect cell
Karen Crasta et al.
Nature, 482(7383), 53-58 (2012-01-20)
The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of debate, in large part because of the lack of insight into underlying mechanisms. Here we identify a mechanism by which errors in mitotic chromosome segregation generate DNA breaks via
Elina Järvinen et al.
International journal of stem cells, 3(1), 46-53 (2010-05-01)
Neural stem cells contribute to mammalian brain tissue turnover in specific locations throughout life. Differentiation of stem cells is associated with terminal mitosis and cell cycle exit, but it is unclear how the timing and signaling of these are interlinked.
Yuanyuan Xue et al.
Cell reports, 27(5), 1567-1578 (2019-05-03)
In vertebrates, hematopoiesis occurring in different niches is orchestrated by intrinsic and extrinsic regulators. Previous studies have revealed numerous linear and planar regulatory mechanisms. However, a multi-dimensional transcriptomic atlas of any given hematopoietic organ has not yet been established. Here
Mona Abdelhamid et al.
Journal of Alzheimer's disease : JAD, 85(4), 1555-1571 (2021-12-28)
Probiotic supplementation reestablishes microbiome diversity and improves brain function in Alzheimer's disease (AD); their molecular mechanisms, however, have not yet been fully illustrated. We investigated the effects of orally supplemented Bifidobacterium breve MCC1274 on cognitive function and AD-like pathologies in
Christopher D Wiley et al.
Cell reports, 28(13), 3329-3337 (2019-09-26)
Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senescence-associated secretory phenotype (SASP) that participates in several age-related diseases. Using stable isotope labeling with amino acids (SILACs) and cultured cells, we identify 343 SASP proteins that senescent human fibroblasts
Sandra Bauer et al.
The Journal of clinical endocrinology and metabolism, 89(2), 812-822 (2004-02-07)
We have tested the hypothesis that elevated concentrations of TNF alpha could impair trophoblast invasion. Using first-trimester placental explant cultures, we have demonstrated that the cytokine inhibits in vitro migration of extravillous trophoblasts (EVT) on collagen I, and invasion through
Aliesha González-Arenas et al.
Endocrinology, 156(3), 1010-1022 (2014-12-17)
Progesterone regulates cancer cell proliferation and invasion through its receptors (PR-A and PR-B), whose phosphorylation modifies their transcriptional activity and induce their degradation. We identified by in silico analysis a putative residue (Ser400) in PR that might be phosphorylated by
Juan Manuel González-Rosa et al.
Developmental cell, 44(4), 433-446 (2018-02-28)
Correlative evidence suggests that polyploidization of heart muscle, which occurs naturally in post-natal mammals, creates a barrier to heart regeneration. Here, we move beyond a correlation by demonstrating that experimental polyploidization of zebrafish cardiomyocytes is sufficient to suppress their proliferative
Arpita Baisantry et al.
Cell cycle (Georgetown, Tex.), 15(21), 2973-2979 (2016-11-02)
Autophagy and senescence are 2 distinct pathways that are importantly involved in acute kidney injury and renal repair. Recent data indicate that the 2 processes might be interrelated. To investigate the potential link between autophagy and senescence in the kidney
Che-Pei Kung et al.
Cancer biology & therapy, 18(7), 484-491 (2017-05-06)
The TP53 gene is distinguished as the most frequently mutated gene in cancer. Unlike most cancer-relevant genes, the TP53 gene is also distinguished by the existence of coding region polymorphisms that alter p53 sequence, and in some cases, also alter
Christoph Mück et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 65(11), 1165-1180 (2010-08-03)
Tumor necrosis factor-like cytokine 1A (TL1A) is expressed in endothelial cells and contributes to T-cell activation, via an extracellular fragment TL1A(L72-L251), generated by ectodomain shedding. Fragments of TL1A, referred to as vascular endothelial growth inhibitor, were found to induce growth
Wuqiang Zhu et al.
Circulation research, 122(1), 88-96 (2017-10-12)
The effectiveness of transplanted, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for treatment of ischemic myocardial injury is limited by the exceptionally low engraftment rate. To determine whether overexpression of the cell cycle activator CCND2 (cyclin D2) in hiPSC-CMs can
Alexia Vite et al.
Development (Cambridge, England), 145(5) (2018-02-23)
Shortly after birth, muscle cells of the mammalian heart lose their ability to divide. At the same time, the N-cadherin/catenin cell adhesion complex accumulates at the cell termini, creating a specialized type of cell-cell contact called the intercalated disc (ICD).
F Fausti et al.
Cell death and differentiation, 20(11), 1498-1509 (2013-08-13)
Werner syndrome (WS) results from dysfunction of the WRN protein, and is associated with premature aging and early death. Here we report that loss of WRN function elicits accumulation of the Yes-associated protein (YAP protein), a major effector of the
Lenka Stixová et al.
Epigenetics & chromatin, 7(1), 39-39 (2015-01-15)
The repair of spontaneous and induced DNA lesions is a multistep process. Depending on the type of injury, damaged DNA is recognized by many proteins specifically involved in distinct DNA repair pathways. We analyzed the DNA-damage response after ultraviolet A
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