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Showing 1-30 of 39 results for "11483188001" within Papers
Jinhua Ma et al.
Cancer management and research, 13, 2773-2783 (2021-04-02)
MicroRNAs (miRNAs) are key players in the progression of human cancers. While several miRNAs have been reported to regulate the development of tumors, the molecular mechanisms and roles of miR-149-5p in prostate carcinoma (PCa) remain unclear. Our aim was to
Serge Haan et al.
JAK-STAT, 4(1), e1062596-e1062596 (2015-09-29)
Aberrant activation of oncogenic kinases is frequently observed in human cancers, but the underlying mechanism and resulting effects on global signaling are incompletely understood. Here, we demonstrate that the oncogenic FIP1L1-PDGFRα kinase exhibits a significantly different signaling pattern compared to
Nooreen S Dabbish et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(44), 15932-15943 (2011-11-04)
Approximately one-fourth of the neurons in Caenorhabditis elegans adults are born during larval development, indicating tremendous plasticity in larval nervous system structure. Larval development shows cyclical expression of sleep-like quiescent behavior during lethargus periods, which occur at larval stage transitions.
Sandra Cortijo et al.
Molecular systems biology, 15(1), e8591-e8591 (2019-01-27)
A fundamental question in biology is how gene expression is regulated to give rise to a phenotype. However, transcriptional variability is rarely considered although it could influence the relationship between genotype and phenotype. It is known in unicellular organisms that
Deniz Kanliada et al.
International journal of molecular and cellular medicine, 1(4), 217-224 (2012-10-01)
The aim of this study is to determine whether there is a role of podoplanin and glutathione S-transferases T1 (GST-T1) expression in laryngeal squamous cell carcinoma. The study was completed with 33 patients and gene expression analysis was performed by qRT-PCR.
Fa-Xiu Chen et al.
American journal of translational research, 12(9), 5064-5079 (2020-10-13)
Sarcopenia is an age-associated disorder that results in skeletal muscle loss. Apoptosis and inflammation are the two major contributors to sarcopenia. Emerging evidence has shown that long-chain fatty acids (LCFAs) are implicated in the muscles of sarcopenic animal models. However
Siddharth De et al.
Cell reports, 30(7), 2083-2093 (2020-02-23)
Cell-autonomous changes in p53 expression govern the duration and outcome of cell-cycle arrest at the G2 checkpoint for DNA damage. Here, we report that mitogen-activated protein kinase (MAPK) signaling integrates extracellular cues with p53 dynamics to determine cell fate at
Sheng Chen et al.
Gastroenterology research and practice, 2022, 6972331-6972331 (2022-05-27)
BHLHE41 has been shown to be a marker of tumorigenesis. Colon cancer (CC) is a common malignant tumor of colonic mucosa. This study mainly explored the mechanism of BHLHE41 in alleviating malignant behavior of hypoxia-induced CC cells. The levels of
Chung-Yang Kao et al.
PLoS genetics, 16(6), e1008868-e1008868 (2020-06-25)
Parkinson's disease (PD) is a neurodegenerative disorder featuring progressive loss of midbrain dopaminergic (DA) neurons that leads to motor symptoms. The etiology and pathogenesis of PD are not clear. We found that expression of COUP-TFII, an orphan nuclear receptor, in
Aysegul Bayrak et al.
Asian Pacific journal of cancer prevention : APJCP, 18(1), 201-205 (2017-02-28)
Background:The process of development of bladder cancer features alteration of normal biological conditions caused by changes in molecular pathways. Removing control over regulation of these pathways could lead to changes in signal transduction and abnormal regulation of genes. During tumor
Yan Xing et al.
PloS one, 14(6), e0218278-e0218278 (2019-06-14)
Children born small for gestational age (SGA) generally have a catch-up growth and rapid weight gain in the first years of life, which is a high risk of insulin resistance and cardiovascular diseases later in life. It was reported that
Yan Xing et al.
PloS one, 14(5), e0216665-e0216665 (2019-05-10)
Individuals with intrauterine growth retardation (IUGR) are prone to insulin resistance, whereas the underlying molecular mechanisms remain unclear. In this study, we investigated if the PI3K/Akt signaling pathway in skeletal muscle tissues involves insulin resistance in IUGR offsprings, particularly ones
Screening of Selected Soil and Endophytic Fungi for Lovostatin
Biosynthetic Genes lovE and lovF
Biosynthetic Genes lovE and lovF
Bhargavi SD
Microbial Biotechnology (2015)
Jian Han et al.
Molecular medicine reports, 18(1), 1058-1066 (2018-05-31)
Atorvastatin is a member of the statin class of drugs, which competitively inhibit the activity of 5‑hydroxy‑3‑methylglutaryl‑coenzyme A reductase. The aim of the present study was to assess whether atorvastatin may protect BV‑2 microglia and hippocampal neurons against oxygen‑glucose deprivation
Jianwen Liu et al.
Cell cycle (Georgetown, Tex.), 20(12), 1134-1146 (2021-06-08)
Hepatocellular carcinoma (HCC) is generally known as one of the most common cancers in the world. Nowadays, interventional therapies such as transcatheter arterial chemoembolization (TACE) have emerged as an efficient therapy for HCC patients. Accumulating evidence has unveiled that long
Bita Nickkholgh et al.
Fertility and sterility, 102(2), 558-565 (2014-05-28)
To evaluate the degree of enrichment of spermatogonial stem cells (SSCs) from human testicular cell cultures by ITGA6+, HLA-/ITGA6+, GPR125+, and HLA-/GPR125+ magnetic-assisted cell sorting (MACS). Experimental basic science study. Reproductive biology laboratory. Multiple samples of cryopreserved human testicular cells
Roles of Signal Transducer Pathways in Investigation of Biopsies from Patients with Bladder Tumors
Aysegul Bayrak
Asian Pacific Journal of Cancer Prevention (2017)
Deniz Kanliada et al.
Journal of clinical laboratory analysis, 28(3), 186-190 (2014-01-08)
The aim of the study is to determine whether there is a role of podoplanin and glutathione S-transferases T1 (GST-T1) expression in laryngeal squamous cell carcinoma. In this study, 33 patients were enrolled and gene expression analysis was performed by
Yarong Dai et al.
Stem cells international, 2021, 5512153-5512153 (2021-11-02)
Limbal stem cells are essential for continuous corneal regeneration and injury repair. METTL3-catalyzed N6-methyladenosine (m6A) mRNA modifications are involved in many biological processes and play a specific role in stem cell regeneration, while the role of m6A modifications in corneal
Kazuya Ono et al.
PLoS genetics, 10(1), e1004118-e1004118 (2014-01-28)
Inner ear mechanosensory hair cells transduce sound and balance information. Auditory hair cells emerge from a Sox2-positive sensory patch in the inner ear epithelium, which is progressively restricted during development. This restriction depends on the action of signaling molecules. Fibroblast
Relationship of Podoplanin and Glutathione S-transferases T1 Expression with Laryngeal Cancer
Deniz K
International journal of molecular and cellular medicine (2012)
Yuyuan Zhang et al.
Evidence-based complementary and alternative medicine : eCAM, 2021, 8810414-8810414 (2021-02-11)
The abnormal neurites have long been regarded as the main player contributing to the poor outcome of patients with subarachnoid hemorrhage (SAH). (-)-Eigallocatechin-3-gallate (EGCG), the major biological component of tea catechin, exhibited strong neuroprotective effects against central nervous system diseases;
Attila Sachslehner et al.
Scientific reports, 11(1), 18030-18030 (2021-09-11)
The mesoderm is considered the youngest of the three germ layers. Although its morphogenesis has been studied in some metazoans, the molecular components underlying this process remain obscure for numerous phyla including the highly diverse Mollusca. Here, expression of Hairy
Zsolt Szilagyi et al.
Molecular and cellular biology, 32(11), 2099-2109 (2012-03-28)
Temporal changes in transcription programs are coupled to control of cell growth and division. We here report that Mediator, a conserved coregulator of eukaryotic transcription, is part of a regulatory pathway that controls mitotic entry in fission yeast. The Mediator
Weiwei Liu et al.
Oncology letters, 17(1), 348-354 (2019-01-19)
This study investigated the inhibitory effects of miR-124 and miR-152 on the growth of human ovarian cancer (OC) SKOV3 cell line subcutaneous xenografts in nude mice. Twenty-eight healthy nude mice were selected and divided into the experimental group 1 (n=4)
María Sánchez-Campillo et al.
Annals of nutrition & metabolism, 78(2), 80-90 (2021-11-18)
Dietary exposure and drug treatments influence gut cellular pathways and hence growth and potentially even the gut-brain-microbiome axis. Since eukaryotic mRNA presents poly-A sequence that distinguishes them from the prokaryotes mRNA, we could analyze the gene expression of human gut
Lingjie Meng et al.
Turkish neurosurgery (2022-04-14)
To explore the extent to which LNC01296 inhibits the miRNA-29c expansion genes Birc2 and Bak1 from causing damage induced by brain expansion and reimplantation. A total of 120 adult male experimental rats were divided to verify the effects of miRNA-29c
Lukas Horvath et al.
Audiology & neuro-otology, 20(1), 51-61 (2014-11-28)
Activin, a member of the TGF-F superfamily, was found to play an important role in the development, repair and apoptosis of different tissues and organs. Accordingly, activin signaling is involved in the development of the cochlea. Activin binds to its
Yu Y Li et al.
Laboratory investigation; a journal of technical methods and pathology, 93(3), 322-333 (2013-02-06)
P38/Mk2 (mitogen-activated protein kinase (MAPK)-activated protein kinase-2, also known as MAKAP kinase-2) is a member of the mitogen-activated protein kinases (MAPKs) family, and participates in inflammatory responses directly or indirectly. WIN55, 212-2 (WIN55) is a synthetic non-selective agonist of cannabinoid
Regina Teo et al.
Molecular biology of the cell, 21(15), 2788-2796 (2010-06-11)
Glycogen synthase kinase-3 (GSK3) is a highly conserved protein kinase that is involved in several important cell signaling pathways and is associated with a range of medical conditions. Previous studies indicated a major role of the Dictyostelium homologue of GSK3
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