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Showing 1-30 of 48 results for "115-18-4" within Papers
Alex J Eustace et al.
Journal of proteomics, 74(4), 490-501 (2011-01-18)
Current therapeutic regimes for metastatic melanoma have failed to provide robust clinical responses. Dasatinib has shown anti-proliferative and anti-invasive effects in vitro; however, not all melanoma cells tested were sensitive to dasatinib. We used 2D-DIGE analysis of phospho-enriched fractions to
Shengxi Chen et al.
Journal of the American Chemical Society, 135(35), 12924-12927 (2013-08-15)
Two fluorescent amino acids, including the novel fluorescent species 4-biphenyl-l-phenylalanine (1), have been incorporated at positions 17 and 115 of dihydrofolate reductase (DHFR) to enable a study of conformational changes associated with inhibitor binding. Unlike most studies involving fluorescently labeled
S Taylor et al.
DNA sequence : the journal of DNA sequencing and mapping, 10(6), 387-394 (2000-05-29)
Caspases are cysteine proteases which have important roles in the activation of cytokines and in apoptosis. The ICE subfamily of caspases comprise peptides closely related to caspase-1, or interleukin-1beta (IL-1beta) converting enzyme (ICE), which promotes maturation of interleukin IL-1beta and
Dorothe Burggraf et al.
Thrombosis and haemostasis, 89(6), 1072-1080 (2003-06-05)
While recombinant tissue plasminogen activator (rt-PA) is successfully used in human ischemic stroke, it may also cause hemorrhagic complications. Animal experiments have shown that hemorrhages are related to microvascular basal lamina damage. We investigated the effects of different doses of
T Hemdan et al.
British journal of cancer, 111(6), 1180-1187 (2014-07-30)
The oncoprotein-18/stathmin 1 (STMN1), involved in cell progression and migration, is associated with clinical outcome in breast cancer. Here we aim to investigate its clinical significance in urinary bladder cancer and its possibilities as a therapeutic target. Immunohistochemical analyses of
Yasuo Kobayashi et al.
Masui. The Japanese journal of anesthesiology, 55(5), 595-599 (2006-05-24)
High concentration of isoflurane often induces not only tachycardia but also hypertension during induction of anesthesia and causes further hyperdynamic changes after tracheal intubation. Forty patients, ASA physical status I, were randomly assigned to receive 4% or 2.5% isoflurane. Anesthesia
Margaret I Davis et al.
The Journal of biological chemistry, 278(49), 48973-48980 (2003-10-01)
Cannabinoids activate several members of the mitogen-activated protein kinase superfamily including p44 and p42 extracellular signal-regulated kinase (ERK). We used N1E-115 neuroblastoma cells and the cannabinoid receptor agonist WIN 55,212-2 (WIN) to examine the signal transduction pathways leading to the
Jing Zhao et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 40(10), 671-674 (2012-02-11)
To investigate the detection technology and its clinical significance of the EGFR gene mutation in non-small cell lung cancer. DNA direct sequencing methods by PCR amplification were used to detect EGFR gene exons 18-21 mutation and to analyze its clinical
Issan Yee San Tam et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(5), 1647-1653 (2006-03-15)
This study evaluated the mutational profile of epidermal growth factor receptor (EGFR) and KRAS in non-small cell lung cancers in Hong Kong and determined their relation with smoking history and other clinicopathologic features. Mutational profile of exons 18 to 21
Pauline Puylaert et al.
Biomedicines, 10(5) (2022-05-29)
Gasdermin D (GSDMD) is the key executor of pyroptotic cell death. Recent studies suggest that GSDMD-mediated pyroptosis is involved in atherosclerotic plaque destabilization. We report that cleaved GSDMD is expressed in macrophage- and smooth muscle cell-rich areas of human plaques.
Konstantinos J Dabos et al.
Liver international : official journal of the International Association for the Study of the Liver, 31(5), 707-711 (2011-04-05)
Little is known about the metabolism of acetoacetate and β-hydroxybutyrate in patients with cirrhosis and encephalopathy. We investigated the fate of ketone bodies in these conditions. We studied 18 cirrhotic patients with encephalopathy and 17 cirrhotics without. At the time
Antonio Piga et al.
British journal of haematology, 168(6), 882-890 (2014-11-18)
Some patients with β thalassaemia experience non-progressive creatinine increases with deferasirox, mostly within normal limits; the mechanisms involved are not fully elucidated. The effects of deferasirox on renal haemodynamics, including glomerular filtration rate (GFR) and renal plasma flow (RPF), were
K Sayama et al.
Laboratory animals, 28(1), 44-49 (1994-01-01)
Mammary tumours developed in 110 (95.7%) of 115 DDD/1-Mtv-2/Mtv-2 (DDD/1-Mtv-2) and 24 (47.1%) of 51 DDD/1fDDD/1-Mtv-2 (DDD/1fMtv-2) force-bred female mice during a one-year period. The mean tumour age +/- SE was 220 +/- 7 and 269 +/- 7 days, respectively.
A Edlund et al.
Clinical science (London, England : 1979), 87(2), 143-149 (1994-08-01)
1. The effects of local intra-arterial infusion of adenosine on renal blood flow, glomerular filtration and renin release in eight healthy awake subjects have been examined. 2. Renal blood flow and glomerular filtration rate were measured as the clearances of
J Ishikawa et al.
Diabetes research and clinical practice, 39(1), 3-9 (1998-05-23)
Metabolic and cardiovascular effects of 6-cyclohexyl-2'-O-methyl-adenosine (SDZ WAG 994), a selective and orally-active adenosine A1 receptor agonist, were examined in spontaneously hypertensive rats (SHR) with hyperglycemia (SHR-DM). This model was made by the administration of streptozotocin (STZ; 60 mg/kg s.c.)
Christian Anderwald et al.
Diabetes, 52(7), 1792-1798 (2003-06-28)
The gastric peptide ghrelin augments and the adipocyte-derived hormone leptin reduces appetite and food intake. In the central nervous system, insulin directly decreases hunger sensation but could also act indirectly by modulating ghrelin and leptin secretion. This study examines dose-dependent
Michelle M Kittleson et al.
International journal of cardiology, 102(2), 333-340 (2005-06-29)
Giant cell myocarditis is a rapidly progressive and often fatal condition without a clear etiology or treatment. A better understanding of giant cell myocarditis pathogenesis is critical to developing treatments to prevent progression and reverse damage. We compared the gene
Rolf Symons et al.
Radiology, 274(1), 93-102 (2014-09-11)
To evaluate the relationship between myocardial infarction ( MI myocardial infarction ) severity at magnetic resonance (MR) imaging and regional and global postinfarction left ventricular ( LV left ventricular ) remodeling. This HIPAA-compliant study was institutional review board approved. In
T L Moser et al.
The Journal of biological chemistry, 268(25), 18917-18923 (1993-09-05)
This study describes the binding of plasminogen and tissue-type plasminogen activator (t-PA) to the extracellular matrix proteins fibronectin and laminin. Plasminogen bound specifically and saturably to both fibronectin and laminin immobilized on microtiter wells, with Kd(app) values of 115 and
M A Misdaq et al.
Health physics, 96(1), 27-36 (2008-12-11)
Uranium (238U) and thorium (232Th) concentrations as well as radon (222Rn) and thoron (220Rn) alpha activities per unit volume have been measured inside 18 medical drugs (4 liquid and 14 solid materials), widely prescribed by doctors to the Moroccan adult
Marcelo F Montenegro et al.
Clinica chimica acta; international journal of clinical chemistry, 367(1-2), 192-195 (2006-02-01)
delta-Aminolevulinic acid dehydratase (ALAD) catalyzes the second step of heme synthesis. The ALAD gene shows a polymorphism (G-to-C transversion at position 177) leading to 2 alleles (ALAD1 and ALAD2) and 3 phenotypes (ALAD 1-1, ALAD 1-2 and ALAD 2-2). This
J F Hare et al.
Biochemistry, 28(2), 574-580 (1989-01-24)
The turnover of proteins on the surface of cultured mammalian cells was measured by a new approach. Reactive free amino or sulfhydryl groups on surface-accessible proteins were derivatized with biotinyl reagents and the proteins solubilized from culture dishes with detergent.
Maria Santacana et al.
Human pathology, 45(12), 2394-2403 (2014-10-06)
Histologic typing may be difficult in a subset of endometrial carcinoma (EC) cases. In these cases, interobserver agreement improves when immunohistochemistry (IHC) is used. A series of endometrioid type (EEC) grades 1, 2, and 3 and serous type (SC) were
Bo Yang et al.
Zhongguo shi yan xue ye xue za zhi, 17(4), 857-860 (2009-08-25)
This study was purposed to investigate lrp16 gene expression in leukemia cell lines and bone marrow cells of leukemia patients and explore the relationship between lrp16 gene expression and development of leukemia. Reverse transcriptase-polymerase chain reaction (RT-PCR) was employed to
Aseem Arif Shaikh et al.
Clinical orthopaedics and related research, 472(7), 2201-2207 (2014-03-07)
The treatment of knee arthritis with coexistent bone or joint sepsis is challenging. Despite the condition causing considerable morbidity, there is no generally agreed-upon approach to its treatment. We used aggressive débridement of the knee and implantation of intraoperatively molded
P Szentesi et al.
The Journal of physiology, 505 ( Pt 2), 371-384 (1998-01-10)
1. Single muscle fibres were dissociated enzymatically from the extensor digitorum longus and communis muscles of rats and guinea-pigs. The fibres were mounted into a double Vaseline gap experimental chamber and the events in excitation-contraction coupling were studied under voltage
Shabih U Hasan et al.
JAMA pediatrics, 171(11), 1081-1089 (2017-10-04)
Bronchopulmonary dysplasia (BPD) occurs in approximately 40% of infants born at younger than 30 weeks' gestation and is associated with adverse pulmonary and neurodevelopmental outcomes. To test whether administration of inhaled nitric oxide to preterm infants requiring positive pressure respiratory
Yong-ning Zhai et al.
Zhonghua fu chan ke za zhi, 45(9), 682-685 (2010-11-26)
To evaluate the effect of exogenous wild PTEN gene stable transfected into human ovarian cancer cell line HO-8910 on phosphatidyl inositol 3-kinase (PI3K)/protein kinase B (Akt) signal pathway and cells proliferation. Wild-type PTEN recombinant eukaryotic expression plasmid was constructed and
Wai W Cheung et al.
American journal of physiology. Renal physiology, 303(9), F1315-F1324 (2012-08-24)
Aberrant melanocortin signaling has been implicated in the pathogenesis of wasting in chronic kidney disease (CKD). Previously, we demonstrated that agouti-related peptide (AgRP), a melenocortin-4 receptor antagonist, reduced CKD-associated cachexia in CKD mice. Our previous studies with AgRP utilized dual
Sarah B Fisher et al.
Journal of surgical oncology, 117(4), 685-691 (2017-12-02)
Elevated BNP is associated with adverse cardiac outcomes after noncardiac surgery. We assessed BNP values as markers of perioperative fluid status and their correlation with major/cardiopulmonary (CP) complications following CRS + HIPEC. Fluid balance, BNP levels, and morbidity data were collected for
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