Showing 1-15 of 15 results for "115-21-9"
S L Harbeson et al.
Journal of medicinal chemistry, 35(21), 3949-3955 (1992-10-16)
Analogues of [Leu10]NKA4-10 were synthesized in which each of the amide bonds was sequentially replaced with the reduced amide psi (CH2NH) bond to determine the effect of this structural modification on the antagonism of NKA binding to the HUB NK2...
Caroline O'Shea et al.
International journal of cancer, 105(6), 754-761 (2003-05-27)
The ADAMs (a disintegrin and metalloprotease) are membrane proteins containing both protease and adhesion domains and thus may be potentially important in cancer invasion and metastasis. The aim of our study was to investigate the distribution and potential clinical significance...
Tsutomu Ishihara et al.
The Journal of pharmacology and experimental therapeutics, 329(2), 412-417 (2009-02-27)
We examined the therapeutic activity of betamethasone disodium 21-phosphate (BP) encapsulated in biocompatible and biodegradable blended nanoparticles of poly (D,L-lactic/glycolic acid) (PLGA)/poly(D,L-lactic acid) (PLA) homopolymers and polyethylene glycol (PEG)-block-PLGA/PLA copolymers (stealth nanosteroid) in experimental arthritis models. Various stealth nanosteroids with...
N Fiotti et al.
Archives of gerontology and geriatrics, 49 Suppl 1, 83-94 (2009-10-27)
Remodeling of skeletal muscles is regulated by matrix metalloproteinases (MMPs). Functional genetic polymorphism (PM), modulating the expression of some MMPs, might be associated to different body composition and muscular strength improvement after exercise. Genetic PM of MMP-1 (G+/- at -1607)...
Kwong-Ming Kee et al.
Digestive diseases and sciences, 58(2), 556-561 (2012-09-25)
The long-term trend of platelet count in chronic hepatitis C virus patients with sustained virological response (SVR) has rarely been investigated. To elucidate changes of thrombocytopenia after SVR, trajectory patterns of platelet count over time and their associated factors. From...
Yi-Sheng Huang et al.
Chinese medical journal, 124(16), 2457-2460 (2011-09-22)
Epidermal growth factor receptor (EGFR) mutations in lung carcinomas can make the disease more responsive to the treatment with tyrosine kinase inhibitors. We aimed to evaluate the prevalence of EGFR mutations in a large series of lung carcinomas. We examined...
X Li et al.
Oncogene, 31(48), 4979-4986 (2012-01-31)
Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely reported to display strong efficacy for cancer chemoprevention, although their mechanism of action is poorly understood. The most well-documented effects of NSAIDs include inhibition of tumor cell proliferation and induction of apoptosis, but...
Rolf Symons et al.
Radiology, 274(1), 93-102 (2014-09-11)
To evaluate the relationship between myocardial infarction ( MI myocardial infarction ) severity at magnetic resonance (MR) imaging and regional and global postinfarction left ventricular ( LV left ventricular ) remodeling. This HIPAA-compliant study was institutional review board approved. In...
G Millat et al.
American journal of human genetics, 65(5), 1321-1329 (1999-10-16)
Niemann-Pick type C (NPC) disease is an autosomal recessive lipid-storage disorder usually characterized by hepatosplenomegaly and severe progressive neurological dysfunction, resulting from mutations affecting either the NPC1 gene (in 95% of the patients) or the yet-to-be-identified NPC2 gene. Our initial...
Rinath Jeselsohn et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(7), 1757-1767 (2014-01-09)
We undertook this study to determine the prevalence of estrogen receptor (ER) α (ESR1) mutations throughout the natural history of hormone-dependent breast cancer and to delineate the functional roles of the most commonly detected alterations. We studied a total of...
Anurag N Malani et al.
JAMA, 309(23), 2465-2472 (2013-06-20)
Injection of contaminated methylprednisolone has resulted in an unprecedented nationwide outbreak of Exserohilum rostratum fungal infections, manifested initially as meningitis and/or basilar stroke. Insidious onset of spinal or paraspinal infection at the injection site has been increasingly reported and is...
Seung Ho Hong et al.
Circulation research, 93(10), 1006-1012 (2003-10-25)
Recent studies have implicated mutations in the ATP-binding cassette transporter A1, ABCA1, as a cause of Tangier disease (TD) and familial hypoalphalipoproteinemia (FHA). We investigated a proband with very low levels of high-density lipoprotein cholesterol (HDL-C, 6 mg/dL) and a...
E Emsen et al.
Animal reproduction science, 126(1-2), 57-60 (2011-05-17)
A total of 415 fat tailed ewes were randomly assigned to two groups to assess the effect of duration of melengestrol acetate (MGA) (9 versus 12d) administration on reproductive parameters associated with laparoscopic artificial insemination. At the end of MGA...
Stěpán Zezulka et al.
Aquatic toxicology (Amsterdam, Netherlands), 140-141, 37-47 (2013-06-12)
Polycyclic aromatic hydrocarbons (PAHs) represent one of the major groups of organic contaminants in the aquatic environment. Duckweed (Lemna minor L.) is a common aquatic plant widely used in phytotoxicity tests for xenobiotic substances. The goal of this study was...
Mei-rong Zang et al.
Zhonghua yi xue za zhi, 92(16), 1100-1103 (2012-07-12)
To explore the effects and mechanism of bone marrow stromal cells (BMSCs) on the drug resistance of multiple myeloma (MM). Fresh untreated MM patient (5 samples) and health donor (5 samples) bone marrow samples were collected from May 2011 to...

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