Showing 1-30 of 38 results for "118-75-2"
Lisa Polzien et al.
The Journal of biological chemistry, 284(41), 28004-28020 (2009-08-12)
BAD is a proapoptotic member of the Bcl-2 protein family that is regulated by phosphorylation in response to survival factors. Although much attention has been devoted to the identification of phosphorylation sites in murine BAD, little data are available with...
Reyhan Bayrak et al.
Diagnostic pathology, 7, 9-9 (2012-01-25)
Metastatic adenocarcinoma from an unknown primary site is a common clinical problem. Determining the cytokeratin (CK) 7/CK20 pattern of tumors is one of the most helpful procedures for this purpose since the CK7-/CK20+ pattern is typical of colorectal adenocarcinomas. CDX2...
M Schmelz et al.
Neuroscience letters, 290(1), 57-60 (2000-08-05)
The effect of topically applied acetyl salicylic acid (ASA) and dipyrone on capsaicin-evoked protein extravasation was investigated by dermal microdialysis in rat. After a baseline of 75 min, capsaicin (1%) was applied epicutaneously under occlusion for 75 min above the...
Heiner Adams et al.
Expert opinion on therapeutic targets, 14(6), 577-584 (2010-04-27)
HDAC inhibitors (HDI) are anti-neoplastic drugs with preliminary successful clinical applications in Hodgkin's lymphoma (HL). Systematic investigations of HDAC expression in HL, based on histology and immunohistochemistry are yet rare. We investigated the expression of HDAC1, 2 and 3 in...
Zhe Li et al.
Zhonghua zhong liu za zhi [Chinese journal of oncology], 33(9), 666-670 (2012-02-22)
The purpose of this study was to investigate the correlation between gene mutation and gene copy number and their association with the clinical profiles and pathological features in Chinese patients with non-small cell lung cancer (NSCLC). Surgical specimens of cancer...
Chang-Su Park et al.
Biotechnology letters, 32(12), 1947-1953 (2010-09-03)
A putative L-rhamnose isomerase (RhaA) from Thermotoga maritima was purified with a specific activity of 55 U/mg by His-Trap affinity chromatography. The native enzyme was estimated as a 46 kDa tetramer by gel filtration chromatography. The half-lives of the enzyme...
Hans Ragnar Norli et al.
Journal of chromatography. A, 1218(41), 7234-7241 (2011-09-09)
The QuEChERS method developed for 22 organochlorine pesticides (OCPs) and 7-polychlorinated biphenyls (PCBs) in fish tissue involves a simple and efficient freezing technique for removal of lipids. The equipment developed consists of disposable syringes and a freezing block constructed from...
Mohamed A Bedaiwy et al.
Obstetrics and gynecology, 108(1), 162-168 (2006-07-04)
Although most women experience retrograde menses during their reproductive life, endometriosis develops only in a small percentage. We hypothesized that persistence of a fibrin matrix in peritoneal pockets, as a result of hypofibrinolysis, could allow menstrually deposited endometrial fragments to...
James M Mathews et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(12), 1213-1224 (2012-06-26)
The disposition of 2-Methoxy-4-nitroaniline (MNA) was investigated in male and female Harlan Sprague Dawley rats and B6C3F(1)/N mice following oral, intravenous, and dermal exposure to [(14)C]MNA at 2, 15, or 150 mg/kg. Clearance of MNA was investigated in male and...
M Inzinger et al.
The British journal of dermatology, 165(3), 640-645 (2011-05-14)
Few studies have directly compared the clinical efficacy of psoralen plus ultraviolet A (PUVA) vs. biologics in the treatment of psoriasis. To compare the clinical efficacy of PUVA and biologic therapies for psoriasis under daily life conditions. Data from a...
Yin-Bo Chen et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 15(5), 340-342 (2013-05-17)
To investigate the clinical efficacy and safety of oxcarbazepine (OXC) suspension in children with focal epilepsy. A total of 118 children aged 2-14 years, who were newly diagnosed with focal epilepsy between October 2009 and December 2011, were randomly divided...
Hyunjung Kim et al.
Platelets, 26(2), 148-153 (2014-03-13)
The purpose of this study was to evaluate associations between INNOVANCE PFA P2Y (PFA P2Y) test results and CYP2C19 genotypes and provide baseline data for PFA P2Y testing to establish a therapeutic monitoring strategy for clopidogrel. A total of 75...
J L Bartoe et al.
Journal of neurochemistry, 74(5), 2021-2032 (2000-05-09)
The neurally active cytokine leukemia inhibitory factor (LIF) signals through a bipartite receptor complex composed of LIF receptor alpha (LIFR) and gp130. gp130 and LIFR contain consensus binding motifs for the protein tyrosine phosphatase SHP-2 surrounding tyrosines 118 and 115...
Olga K Weinberg et al.
The Journal of molecular diagnostics : JMD, 9(4), 530-537 (2007-07-27)
Follicular lymphomas are frequently associated with the t(14;18)(q32;q21). This translocation can be detected by karyotype, polymerase chain reaction (PCR), and fluorescence in situ hybridization (FISH). In addition to the breakpoints currently used for diagnosis located in the major breakpoint region...
Gustavs Latkovskis et al.
Medicina (Kaunas, Lithuania), 50(1), 19-27 (2014-07-26)
Additional loading doses and higher maintenance doses (MDs) have been used to overcome hyporesponsiveness of clopidogrel. We aimed to investigate whether genetic polymorphisms of two cytochromes (CYP2C19 and CYP2C9) and ABCB1 modify effect of such dose-adjustment strategy. We enrolled 118...
R Waurick et al.
Naunyn-Schmiedeberg's archives of pharmacology, 359(6), 484-492 (1999-08-04)
The aim of the study was to investigate the effects of the putative protein phosphatase (PP) activator 2,3-butanedione monoxime (BDM) in vascular smooth muscle. BDM concentration-dependently increased PP activity in homogenates of bovine coronary arteries and led to dephosphorylation of...
M K Duncan et al.
Biochimica et biophysica acta, 1261(1), 68-76 (1995-03-14)
The complete sequence was determined for the chicken beta B1-crystallin gene and 2.2 kbp of its 5' flanking region; the chicken gene was then compared to its rat ortholog. Although both have a 5' non-coding exon followed by 5 protein...
Volker Maus et al.
Cerebrovascular diseases (Basel, Switzerland), 46(1-2), 59-65 (2018-08-10)
One endovascular treatment option of acute ischemic stroke due to tandem occlusion (TO) comprises intracranial thrombectomy and acute extracranial carotid artery stenting (CAS). In this setting, the order of treatment may impact the clinical outcome in this stroke subtype. Retrospective...
Ingrid I L Berk-Planken et al.
Diabetes care, 26(2), 427-432 (2003-01-28)
Hepatic lipase (HL) is involved in the metabolism of several lipoproteins and may contribute to the atherogenic lipid profile in type 2 diabetes. Little is known about the effect of cholesterol synthesis inhibitors on HL activity in relation to sex...
Ai-Rong Chen et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 33(5), E290-E297 (2010-10-12)
Metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) are complex diseases affected by both dietary intake and genetic background. Whether N-5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, high-sensitivity C-reactive protein (hs-CRP) and dietary components folate and vitamin B12 are...
Geoffrey H Tofler et al.
The American journal of cardiology, 111(12), 1755-1758 (2013-04-09)
Heavy physical exertion, emotional stress, heavy meals, and respiratory infection transiently increase the risk of myocardial infarction, sudden cardiac death, and stroke; however, it remains uncertain how to use this information for disease prevention. We determined whether it was feasible...
N Koyanagi et al.
Cancer research, 54(7), 1702-1706 (1994-04-01)
The search for compounds active against solid tumors has led us to the discovery of a novel sulfonamide, E7010 (N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4- methoxybenzenesulfonamide), which inhibits tubulin polymerization. When administered orally, E7010 showed good antitumor activity against various rodent tumors and human tumor...
H Yilmaz et al.
Journal of endocrinological investigation, 38(5), 527-533 (2014-12-17)
Galectin-3 (Gal-3) is a marker of cardiac fibrosis and predicts incident heart failure. Gal-3-deficient mice are resistant to multiple low-dose streptozotocin-induced diabetes. Recent experimental studies suggested an important role for Gal-3 in the regulation of adiposity, metaflammation and type 2...
James J H Chong et al.
Journal of the American Heart Association, 8(1), e011028-e011028 (2019-01-01)
Background Neutrophil gelatinase-associated lipocalin ( NGAL ) or lipocalin 2 may promote atherosclerosis and plaque instability leading to increased risk of cardiac events. We investigated the relationships between plasma NGAL , cardiovascular disease biomarkers, and long-term cardiac events. Methods and...
Anne J Stokka et al.
The Biochemical journal, 369(Pt 3), 509-518 (2002-10-16)
The optical biosensor technique, based on the surface plasmon resonance (SPR) phenomenon, was used for real-time measurements of the slow conformational transition (isomerization) which occurs in human phenylalanine hydroxylase (hPAH) on the binding/dissociation of L-phenylalanine (L-Phe). The binding to immobilized...
Alexandros G Asimakopoulos et al.
Journal of chromatography. A, 1324, 141-148 (2013-12-10)
A liquid-liquid extraction (LLE; ethyl acetate) protocol, followed by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) methodology, was developed for the determination of 19 compounds, including bisphenol A diglycidyl ethers (BADGEs; industrial ethers), benzophenone-type UV filters (BP-UV filters; precursors and...
J Maylie et al.
The Journal of physiology, 442, 551-567 (1991-10-01)
1. The effects of 2,3-butanedione monoxime (BDM) on the optical retardation and myoplasmic Ca2+ signal were studied in twitch fibres of Rana temporaria. The myoplasmic Ca2+ transient in response to action potential stimulation was monitored in cut fibres containing Antipyrylazo...
Robert Hudek et al.
Journal of shoulder and elbow surgery, 23(12), 1763-1771 (2014-09-03)
Propionibacterium acnes has been linked to chronic infections in shoulder surgery. Whether the bacterium is a contaminant or commensal of the deep tissue is unclear. We aimed to assess P. acnes in intraoperative samples of different tissue layers in patients...
Ophir Bar-On et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 14(1), 53-62 (2014-06-12)
Nontuberculous mycobacteria (NTM) are emerging infections in the CF population. To assess NTM infection prevalence and associated features in our CF clinic population. Patient records, 2002-2011, were reviewed for NTM infection. FEV1, pancreatic function, sputum microbiology, and serum cytokines were...
Justin A Bishop et al.
Human pathology, 41(1), 20-25 (2009-09-11)
Recent advances in the treatment of pulmonary adenocarcinoma have increased the need for accurate typing of non-small cell carcinomas. Immunohistochemistry for thyroid transcription factor-1 is widely used in the diagnosis of pulmonary adenocarcinomas because it marks approximately 75% of lung...

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