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Keyword:'12010'
Showing 1-3 of 3 results for "

12010

" within Genes
B2M
beta-2-microglobulin
Species:
Human B2M (567), Mouse B2m (12010), Rat B2m (24223), naked mole-rat B2m (101702715), domestic guinea pig B2m (100379556), sheep B2M (443295), Zebrafish b2m (30400), cow B2M (280729), Horse B2M (100034203), domestic cat B2M (494145), dog B2M (100855741), dog B2M (478284), chicken B2M (414830)
Summary:
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009
Products:
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
Synonyms:
LRRC65, MASL1
Species:
Human MFHAS1 (9258), Mouse Mfhas1 (52065), Rat Mfhas1 (306508), Zebrafish mfhas1 (797005), dog MFHAS1 (475604), cow MFHAS1 (782395), domestic cat MFHAS1 (101092431), chicken MFHAS1 (422628), sheep MFHAS1 (101102369), naked mole-rat Mfhas1 (101716242), domestic guinea pig Mfhas1 (100732163)
Summary:
Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH. [provided by RefSeq, Jul 2008
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TPM1
tropomyosin 1 (alpha)
Synonyms:
C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA
Species:
Human TPM1 (7168), Mouse Tpm1 (22003), Rat Tpm1 (24851), Zebrafish tpm1 (393908), domestic cat TPM1 (101091450), dog TPM1 (478332), chicken TPM1 (396366), cow TPM1 (281544), sheep TPM1 (100145865), domestic guinea pig Tpm1 (100717160), naked mole-rat Tpm1 (101714552)
Summary:
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008
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