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Junmou Hong et al.
Oncotarget, 5(14), 5602-5614 (2014-07-02)
Esophageal quamous cell carcinoma (ESCC) is the predominant histological type of esophageal carcinoma in Asian populations. To date, few biomarkers have been identified for ESCC. In present study, we found a tumor suppressor, NUMB isoform 1 (NUMB-1), as a promising
A L Benjamin et al.
Journal of dairy science, 98(3), 1836-1850 (2015-01-20)
Staphylococcus aureus is a common cause of chronic mammary gland infections in dairy cattle. However, the inflammatory response and duration of infection following pathogen exposure is variable between individual animals. To investigate interanimal differences in immune response, dermal fibroblast cultures
Xin Chen et al.
PloS one, 9(12), e115652-e115652 (2014-12-23)
Maduramicin, a polyether ionophore antibiotic derived from the bacterium Actinomadura yumaensis, is currently used as a feed additive against coccidiosis in poultry worldwide. It has been clinically observed that maduramicin can cause skeletal muscle and heart cell damage, resulting in
Ida Aronchik et al.
Molecular cancer research : MCR, 12(11), 1621-1634 (2014-07-11)
Human melanoma cells displaying distinct PTEN genotypes were used to assess the cellular role of this important tumor-suppressor protein in the antiproliferative response induced by the chemopreventative agent indole-3-carbinol (I3C), a natural indolecarbinol compound derived from the breakdown of glucobrassicin
Wai-Hang Leung et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2930-2941 (2015-02-18)
Many malignant cells release the NKG2D ligand ULBP2 from their cell surface to evade immunosurveillance by NK cells and CD8 T cells. Although the shedding mechanism remains unclear, various inhibitors of matrix metalloproteinases have been shown to efficiently block the
Hiroyuki Kimura et al.
Journal of labelled compounds & radiopharmaceuticals, 57(12), 680-686 (2014-10-09)
Microwave technology has been successfully applied to enhance the effectiveness of radiolabeling reactions. The use of a microwave as a source of heat energy can allow chemical reactions to proceed over much shorter reaction times and in higher yields than
Victoria L Luchenko et al.
Molecular oncology, 8(8), 1379-1392 (2014-06-24)
Romidepsin and vorinostat are histone deacetylase inhibitors (HDACis) that have activity in T-cell lymphomas, but have not gained traction in solid tumors. To gain deeper insight into mechanisms of HDACi efficacy, we systematically surveyed 19 cell lines with different molecular
Kristin Zscharnack et al.
Analytica chimica acta, 854, 145-152 (2014-12-07)
H2O2 is a widely occurring molecule which is also a byproduct of a number of enzymatic reactions. It can therefore be used to quantify the corresponding enzymatic substrates. In this study, the time-resolved fluorescence emission of a previously described complex
André Richters et al.
ACS chemical biology, 10(1), 289-298 (2014-12-30)
The cytosolic Ser/Thr kinase TBK1 was discovered to be an essential element in the mediation of signals that lead to tumor migration and progression. These findings meet the need for the identification of novel tool compounds and potential therapeutics to
Viswanath Das et al.
Journal of neuroscience research, 92(9), 1155-1166 (2014-05-03)
An important aspect of synaptic plasticity in the brain is axonal transport of essential components such as mitochondria from the soma to the synapse. For uninterrupted transport of cellular cargo down the axon, functional microtubules are required. Altered microtubule dynamics
Praveen K Mandapalli et al.
Drug delivery, 21(8), 605-614 (2013-12-18)
The objective of this study is to investigate the influence of charge of model small molecules on their encapsulation and release behavior in layer-by-layer microcapsules (LbL-MC). Poly(styrene sulfonate) and poly(ethylene imine) were sequentially adsorbed on calcium carbonate sacrificial templates to
Tyler L Harris et al.
ACS chemical neuroscience, 5(8), 632-636 (2014-07-08)
Botulinum neurotoxicity is characterized by peripheral neuromuscular blockade/flaccid paralysis that can lead to respiratory failure and ultimately death. Current therapeutic options provide relief in a pre-exposure scenario, but there are no clinically approved postexposure medical countermeasures. Here, we introduce a
Jun Liu et al.
International journal of biological macromolecules, 69, 1-4 (2014-05-17)
A neutral polysaccharide fraction (CGPP) was extracted from Gynostemma pentaphyllum by water extraction and ethanol precipitation. Gas chromatography (GC) analysis showed that the CGPP was mainly composed of mannose, glucose, arabinose, rhamnose, galactose and glucuronic acid in molar ratios of
Tianxing Gong et al.
Journal of biomedical materials research. Part A, 102(7), 2295-2304 (2013-08-16)
Injectable bone cements have been well characterized and studied in non-load bearing bone fixation and bone screw augmentation applications. Current calcium phosphate cement or poly(methyl methacrylate) cement have drawbacks like low mechanical strength and in situ exothermic properties. This leads
Kimberly Cornish Carmony et al.
Chembiochem : a European journal of chemical biology, 16(2), 284-292 (2014-12-06)
In addition to two well-recognized proteasome subtypes-constitutive proteasomes and immunoproteasomes-mounting evidence also suggests the existence of intermediate proteasome subtypes containing unconventional mixtures of catalytic subunits. Although they appear to play unique biological roles, the lack of practical methods for detecting
G Mangan et al.
Acta physiologica (Oxford, England), 212(1), 75-85 (2014-05-28)
The purpose of this study was to determine whether 17β-estradiol (E2) enhances the activation, proliferation and differentiation of muscle satellite cells (SC) following eccentric exercise either via insulin-like growth factor-1 (IGF-1) or through phosphatidylinositol 3-kinase (PI3K) signalling. This study used
Line Rørbæk Olsen et al.
Analytical and bioanalytical chemistry, 407(8), 2149-2158 (2014-11-19)
Desorption electrospray ionization (DESI) mass spectrometry (MS) imaging was used to image locusts dosed with the antihistamine drug terfenadine. The study was conducted in order to elucidate a relatively high elimination rate of terfenadine from the locust hemolymph. In this
Paulo Michel Pinheiro Ferreira et al.
Anais da Academia Brasileira de Ciencias, 87(1), 313-330 (2015-02-05)
Eleven phthalimide derivatives were evaluated with regards to their antiproliferative activity on tumor and normal cells and possible toxic effects. Cytotoxic analyses were performed against murine tumors (Sarcoma 180 and B-16/F-10 cells) and peripheral blood mononuclear cells (PBMC) using MTT
Carolina Castilla et al.
Molecular cancer therapeutics, 13(10), 2372-2383 (2014-08-15)
PTTG1 protein, the human securin, has a central role in sister chromatid separation during mitosis, and its altered expression has been reported in many tumor types. Paclitaxel is a widely used chemotherapeutic drug, whose mechanism of action is related to
Mohammad I K Hamad et al.
Journal of neuroscience methods, 240, 48-60 (2014-12-03)
Calcium imaging has unraveled the calcium-dependent mechanisms underlying neuronal function. Acetoxymethyl ester (AM) dyes are widely employed for calcium imaging. Pluronic F127 (PF127) as a surfactant and dimethyl sulfoxide (DMSO) as a solvent are used to dissolve the dyes, but
Joseph C Murray et al.
Cancer immunology research, 2(12), 1186-1198 (2014-10-11)
Monoclonal antibodies (mAb) can modulate cancer cell signal transduction and recruit antitumor immune effector mechanisms-including antibody-dependent cellular cytotoxicity (ADCC). Although several clinically effective antibodies can promote ADCC, therapeutic resistance is common. We hypothesized that oncogenic signaling networks within tumor cells
Madhu Cholenahalli Lingaraju et al.
Pharmaceutical biology, 52(8), 1069-1078 (2014-07-16)
Eugenia jambolana Lam. (Myrtaceae) is a medicinal plant used in folk medicine for the treatment of diabetes, inflammation, and pain. We investigated the antinociceptive effect of kaempferol-7-O-α-l-rhamnopyranoside]- 4'-O-4'-[kaempferol-7-O-α-l-rhamnopyranoside (EJ-01), isolated from the E. jambolana leaves. EJ-01 (3, 10, and 30 mg kg(-1)
Lawrence M Kauvar et al.
Antimicrobial agents and chemotherapy, 59(3), 1558-1568 (2014-12-24)
Human cytomegalovirus (HCMV) is the most common infection causing poor outcomes among transplant recipients. Maternal infection and transplacental transmission are major causes of permanent birth defects. Although no active vaccines to prevent HCMV infection have been approved, passive immunization with
Pablo B Martínez de Morentin et al.
Endocrinology, 156(3), 947-960 (2014-12-24)
During gestation, hyperphagia is necessary to cope with the metabolic demands of embryonic development. There were three main aims of this study: Firstly, to investigate the effect of pregnancy on hypothalamic fatty acid metabolism, a key pathway for the regulation
Sonja Endres et al.
PloS one, 9(6), e99228-e99228 (2014-06-19)
Marine bacteria are the main consumers of freshly produced organic matter. Many enzymatic processes involved in the bacterial digestion of organic compounds were shown to be pH sensitive in previous studies. Due to the continuous rise in atmospheric CO2 concentration
Jin-Ping Li et al.
Drug design, development and therapy, 9, 1627-1652 (2015-04-04)
Alisertib (ALS) is an investigational potent Aurora A kinase inhibitor currently undergoing clinical trials for the treatment of hematological and non-hematological malignancies. However, its antitumor activity has not been tested in human breast cancer. This study aimed to investigate the
Natalia Machado Tavares et al.
The Journal of infectious diseases, 210(4), 656-666 (2014-03-19)
Neutrophils are rapidly recruited to the site of Leishmania infection and play an active role in capturing and killing parasites. They are the main source of leukotriene B4 (LTB4), a potent proinflammatory lipid mediator. However, the role of LTB4 in
Daqiang Zhu et al.
Anti-cancer drugs, 26(1), 64-73 (2014-08-15)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mainly induces apoptosis through the extrinsic death receptor-induced pathway by ligation with death receptor 4 (DR4) and death receptor 5 (DR5). On the basis of the antitumor activity to cancer cells and no cytotoxity
Akhilesh Rawat et al.
Cellular oncology (Dordrecht), 37(6), 409-419 (2014-10-23)
We and others show that SOSTDC1 is down-regulated in breast cancer tissues compared to matched normal tissues. Previously, we found that epigenetic mechanisms underlie the down-regulation of SOSTDC1 in gastric cancer cells. The aim of this study was to assess
Ling E Ling et al.
Journal of biomedical materials research. Part A, 103(5), 1732-1745 (2014-08-19)
The objective of this study is to compare the effects of the two calcium phosphate composite scaffolds on the attachment, proliferation, and osteogenic differentiation of rabbit dental pulp stem cells (DPSCs). One nano-hydroxyapatite/collagen/poly (l-lactide) (nHAC/PLA), imitating the composition and the
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