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J L Concepción Curbelo et al.
International microbiology : the official journal of the Spanish Society for Microbiology, 3(4), 239-245 (2001-05-04)
Bacteriocins have been isolated both as simple proteins and as proteins in association with carbohydrates, lipids, etc. Colicins are commonly inducible and extracellular. Their molecular masses range from 30 to 90 kDa. Pure colicin S8 was obtained in three steps
Yuhui Lin et al.
Bioconjugate chemistry, 13(3), 605-610 (2002-05-16)
Recently, near-infrared (NIR) fluorescence light has been applied to image various biological events in vivo, because it penetrates tissue more efficiently than light in the visible spectrum. Compounds exhibiting fluorescent properties in the NIR range are key elements for this
Anouk M Rijs et al.
The journal of physical chemistry. A, 115(34), 9669-9675 (2011-04-29)
High-resolution IR spectroscopy has been employed to study isolated, switchable [2]rotaxanes. IR absorption spectra of two-station rotaxanes, their separate thread, and macrocycle components, as well as those of the individual stations incorporated into the thread, have been measured in the
Ana Silvia Arias et al.
Toxicon : official journal of the International Society on Toxinology, 132, 40-49 (2017-04-13)
The ability of two peptidomimetic hydroxamate metalloproteinase inhibitors, Batimastat and Marimastat, to abrogate toxic and proteinase activities of the venom of Echis ocellatus from Cameroon and Ghana was assessed. Since this venom largely relies for its toxicity on the action
Kuo-Liang Su et al.
Bioorganic & medicinal chemistry, 17(15), 5414-5419 (2009-07-15)
Fumarate, a four-carbon trans dicarboxylic acid, is the allosteric activator of the human mitochondrial NAD(P)(+)-dependent malic enzyme (m-NAD(P)-ME). In this paper, we discuss the effects of the structural analogues of fumarate on human m-NAD(P)-ME. Succinate, a dicarboxylic acid with a
[Derivatives of succinic acid. II. Synthesis and hypoglycemic properties of various derivatives of N-(benzenesulfonyl)succinamide].
Z Brzozowski et al.
Acta poloniae pharmaceutica, 42(3), 244-250 (1985-01-01)
V V Marysheva et al.
Eksperimental'naia i klinicheskaia farmakologiia, 68(1), 67-70 (2005-03-25)
The antihypoxic activity of a series of 2-aminothiazole homologs and the related N-syccinamic acids was studied on four hypoxia models. All 2-aminothiazoles possess antihypoxant properties, which increase with the complexity of the molecular structure. The attachment of a succinic acid
Rustum S Boyce et al.
Current opinion in investigational drugs (London, England : 2000), 5(10), 1063-1071 (2004-11-13)
The identification of a highly efficacious anti-obesity agent remains an illusive goal. While many avenues of investigation have been pursued, none of the existing compounds claim much more than a 10% reduction in weight in humans (over a one year
C A Téllez Soto et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71(3), 1140-1145 (2008-07-08)
The infrared and Raman spectra of UO(2)(NH(3))(2)(NO(3))(2) with (14)NH(3)/(15)NH(3) isotopic substitution were measured. The structure was optimized and the vibrational spectrum was calculated by DFT (B3LYP/6-31G(d)) methodology using relativistic effective core potential for U atom. The results for force constant
Chao Xu et al.
Materials science & engineering. C, Materials for biological applications, 84, 32-43 (2018-03-10)
Electroconductive hydrogels with excellent electromechanical properties have become crucial for biomedical applications. In this study, we developed a conductive composite hydrogel via in-situ chemical polymerization based on carboxymethyl chitosan (CMCS), as a biodegradable base macromolecular network, and poly(3,4-ethylenedioxythiophene) (PEDOT), as
Dengfeng Wu et al.
Microbiological research, 166(3), 155-160 (2010-07-16)
Strain BJ-L was isolated from the a water sample taken from Xiao Yue River in Beijing and identified as Acinetobacter sp. BJ-L based on the study of its morphology, physiology, biochemistry and 16S rRNA gene sequence. A new antimicrobial substance
Elisabeth Garanger et al.
Bioconjugate chemistry, 20(1), 170-173 (2008-12-17)
The biotin/avidin system is one of the most widely used affinity detection and affinity capture systems in biology. However, the determination of the exact number of biotin tags attached onto a substrate is complicated by the fact that biotin does
Huey-Sheng Shieh et al.
Protein science : a publication of the Protein Society, 20(4), 735-744 (2011-03-04)
A ((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl) succinamide derivative (here referred to as Compound 12) shows significant activity toward many matrix metalloproteinases (MMPs), including MMP-2, MMP-8, MMP-9, and MMP-13. Modeling studies had predicted that this compound would not bind to ADAMTS-5 (a disintegrin and metalloproteinase
Hideki Onagi et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 9(24), 5978-5988 (2003-12-18)
Eight new [2]rotaxanes have been prepared, incorporating an alpha-cyclodextrin as the rotor, a stilbene as the axle, and trinitrophenyl substituents as capping groups. Strategies have been devised to elaborate these by linking the rotor to the axle, to produce two
Arnab K Chatterjee et al.
Bioorganic & medicinal chemistry letters, 17(10), 2899-2903 (2007-03-27)
Peptidic, non-covalent inhibitors of lysosomal cysteine protease cathepsin S (1 and 2) were investigated due to low oral bioavailability, leading to an improved series of peptidomimetic inhibitors. Utilizing phenyl succinamides as the P2 residue increased the oral exposure of this
M C Pirrung et al.
Bioorganic & medicinal chemistry letters, 10(18), 2115-2118 (2000-09-22)
A method for encoding solid-phase split/mix combinatorial libraries using the chemical shift of synthetic fluoroarenes ('F-codes') has been developed. They have wide chemical shift dispersion and are detectable at the sub-micromol level. 19F NMR is used for decoding. Nine fluoroarenes
Xiaobin Zhang et al.
Drug delivery, 11(5), 301-309 (2005-03-04)
To investigate the effect of RMP-7 and its derivative on drug transport across blood brain barrier (BBB), RMP-7 and DSPE-PEG-NHS [1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-n-[poly(ethyleneglycol)]-hydroxy succinamide, PEG M 3400] were conjugated under mild conditions and the reaction ratio was determined using MALDI-TOF-MS (matrix-assisted laser
T Watanabe et al.
Chemical & pharmaceutical bulletin, 45(9), 1458-1469 (1997-10-23)
A series of succinamide derivatives containing the 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one skeleton (6a-z) was prepared and evaluated for binding affinity to muscarinic receptors in vitro and for antagonism of bradycardia and salivation in vivo in comparison with AF-DX 116 (1a). Structure-activity relationships (SAR)
Olaf F A Larsen et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(38), 13378-13382 (2005-09-10)
Femtosecond 2D-IR spectroscopy has been used to study the structure of a [2]rotaxane composed of a benzylic amide macrocycle that is mechanically interlocked onto a succinamide-based thread. Both the macrocycle and the thread contain carbonyl groups, and by determining the
Rajib Ahmed et al.
Advanced materials (Deerfield Beach, Fla.), 32(19), e1907160-e1907160 (2020-03-24)
Metasurfaces are engineered nanostructured interfaces that extend the photonic behavior of natural materials, and they spur many breakthroughs in multiple fields, including quantum optics, optoelectronics, and biosensing. Recent advances in metasurface nanofabrication enable precise manipulation of light-matter interactions at subwavelength
Ning Xi et al.
Bioorganic & medicinal chemistry letters, 14(2), 377-381 (2003-12-31)
A novel series of piperazines appended to a succinamide backbone were synthesized and found to have a high affinity for the melanocortin-4 receptor (IC(50)s ranging from <0.1 to 200 nM). Both agonists and antagonists of MC4R were prepared by modifying
Petras P Dzeja et al.
American journal of physiology. Heart and circulatory physiology, 284(4), H1048-H1056 (2003-04-02)
Modulation of mitochondrial respiratory chain, dehydrogenase, and nucleotide-metabolizing enzyme activities is fundamental to cellular protection. Here, we demonstrate that the potassium channel opener diazoxide, within its cardioprotective concentration range, modulated the activity of flavin adenine dinucleotide-dependent succinate dehydrogenase with an
Marco Pompei et al.
Bioorganic & medicinal chemistry letters, 20(1), 168-174 (2009-11-26)
Hepatitis C represents a serious worldwide health-care problem. Recently, we have disclosed a novel class of P2-P4 macrocyclic inhibitors of NS3/4A protease containing a carbamate functionality as capping group at the P3 N-terminus. Herein we report our work aimed at
Birgit T Priest et al.
Biochemistry, 43(30), 9866-9876 (2004-07-28)
Sodium channel blockers are used clinically to treat a number of neuropathic pain conditions, but more potent and selective agents should improve on the therapeutic index of currently used drugs. In a high-throughput functional assay, a novel sodium channel (Na(V))
T Watanabe et al.
Chemical & pharmaceutical bulletin, 45(6), 996-1007 (1997-06-01)
A series of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one derivatives containing the succinamide skeleton has been synthesized and evaluated for M1, M2 and M3 muscarinic receptor binding affinities (in vitro) and M2 and M3 muscarinic receptor antagonistic activities (in vivo). Some of them showed higher
Ozra Tabasi et al.
Colloids and surfaces. B, Biointerfaces, 98, 18-25 (2012-06-02)
The present work concerns a preliminary step in the production of anticancer drug loaded porous silicon (PSi) for targeted-drug-delivery applications. A successful procedure for the covalent attachment of folic acid, polyethylene glycol (PEG) and doxorubicin to hydrophilic mesoporous silicon layers
Stephan M Cameron et al.
ACS catalysis, 2011(1), 1075-1082 (2011-09-08)
Biuret is an intermediate in the bacterial metabolism of s-triazine ring compounds and is occasionally used as a ruminant feed supplement. We used bioinformatics to identify a biuret hydrolase, an enzyme that has previously resisted efforts to stabilize, purify and
Further studies on the utilization of aspartic acid, succinamide, and asparagine by green algae.
Algeeus S.
Physiologia Plantarum, 3(4), 370-375 (1950)
Gavin J Miller et al.
Organic letters, 12(22), 5262-5265 (2010-10-22)
A modular approach to the synthesis of trivalent C-glycosidic carbohydrates is described. The approach is illustrated employing carboxylate-terminated C-glycosidic d-mannose, d-glucose, and d-galactose derivatives with different length C1-linked spacer units and also core units with different length linker units attached.
Sytze J Buwalda et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 139, 232-239 (2019-04-08)
Fast in situ forming, chemically crosslinked hydrogels were prepared by the amidation reaction between N-succinimidyl ester end groups of multi-armed poly(ethylene glycol) (PEG) and amino surface groups of poly(amido amine) (PAMAM) dendrimer generation 2.0. To control the properties of the
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