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Showing 1-30 of 148 results for "1265515" within Papers
Suresh Gadde et al.
Advanced healthcare materials, 3(9), 1448-1456 (2014-03-25)
Liver X receptors (LXRs) attenuate inflammation by modulating the expression of key inflammatory genes, making LXRs and their ligands particularly attractive candidates for therapeutic intervention in cardiovascular, metabolic, and/or inflammatory diseases. Herein, enhanced proresolving activity of polymeric nanoparticles (NPs) containing
M Argun et al.
Eye (London, England), 28(6), 752-760 (2014-03-08)
Under conditions of oxidative stress, cell apoptosis is triggered through the mitochondrial intrinsic pathway. Increased levels of reactive oxygen species (ROS) are linked to excess cell loss and mediate the initiation of apoptosis in a diverse range of cell types.
Baozhang Li et al.
Sensors (Basel, Switzerland), 14(6), 9889-9899 (2014-06-06)
We have developed a highly sensitive flexible pressure sensor based on a piezopolymer and silver nanowires (AgNWs) composite. The composite nanofiber webs are made by electrospinning mixed solutions of poly(inylidene fluoride) (PVDF) and Ag NWs in a cosolvent mixture of
Lili Huang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16309-16319 (2014-12-05)
The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth hormone (GH) secretion;
H Craig Heller et al.
Neurobiology of learning and memory, 116, 162-171 (2014-12-03)
Down syndrome (DS) has an incidence of about 1/700 births, and is therefore the most common cause of cognitive and behavioral impairments in children. Recent studies on mouse models of DS indicate that a number of pharmacotherapies could be beneficial
Dmitry Shvartsman et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(7), 1243-1253 (2014-04-29)
Tissue reinnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal muscle innervation after ischemic injury by promoting both maintenance
Positive propylene glycol result in a patient with ethylene glycol poisoning.
Zengliu Su et al.
Clinical chemistry, 60(4), 697-698 (2014-04-01)
Inas H Hafez et al.
Scientific reports, 4, 6295-6295 (2014-09-16)
Cost reduction and improved durability are the two major targets for accelerating the commercialization of polymer electrolyte membrane fuel cells (PEFCs). To achieve these goals, the development of a novel method to fabricate platinum (Pt)-based electrocatalysts with a high mass
Yang Yu et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(4), 593-606 (2014-08-13)
Sporadic Alzheimer's disease (AD) is a multifactorial metabolic brain disorder characterized by progressive neurodegeneration. Decreased brain energy and glucose metabolism occurs before the appearance of AD symptoms and worsens while the disease progresses. Deregulated brain insulin signaling has also been
Nandi J Reddy et al.
Clinical toxicology (Philadelphia, Pa.), 48(10), 967-973 (2011-01-05)
Ethylene glycol, diethylene glycol and methanol are widely available chemicals and are found in a variety of common household products including antifreeze, windshield washer fluid, brake fluid and lubricants. Following ingestion of these glycols and methanol, patients frequently develop an
Qiang Shi et al.
Colloids and surfaces. B, Biointerfaces, 125, 28-33 (2014-12-02)
There is an urgent need to develop blood-contacting biomaterials with long-term anti-hemolytic capability. To obtain such biomaterials, we coaxially electrospin [ascorbic acid (AA) and lecithin]/poly (ethylene oxide) (PEO) core-shell nanofibers onto the surface of styrene-b-(ethylene-co-butylene)-b-styrene elastomer (SEBS) that has been
James A Kruse
Critical care clinics, 28(4), 661-711 (2012-09-25)
Accidental or intentional ingestion of substances containing methanol and ethylene glycol can result in death, and some survivors are left with blindness, renal dysfunction, and chronic brain injury. However, even in large ingestions, a favorable outcome is possible if the
Mark R Battig et al.
Biomaterials, 35(27), 8040-8048 (2014-06-24)
While the discovery of highly potent biologics has led to the development of promising therapies for various human diseases, biologics can cause severe toxicity if delivered inappropriately. Thus, great efforts have been made to synthesize polymeric systems for safe and
Sandra Flessau et al.
Physical chemistry chemical physics : PCCP, 16(22), 10444-10455 (2014-05-03)
The optical properties of single colloidal semiconductor nanoparticles (NPs) are considerably influenced by the direct environment of the NPs. Here, the influence of different liquid and solid glycol matrices on CdSe-based NPs is investigated. Since the fluorescence of individual NPs
Rungusa Pantan et al.
Life sciences, 116(1), 31-36 (2014-08-26)
The aim of this study is to investigate the vasorelaxant effect of 16-O-acetyldihydroisosteviol (ADIS) and its underlying mechanisms in isolated rat aorta. Rat aortic rings were isolated, suspended in organ baths containing Kreb's solution, maintained at 37°C, and mounted on
Yang Zhang et al.
Journal of the American Chemical Society, 137(14), 4709-4719 (2015-03-21)
Self-assembling nanoparticles of amphiphilic polymers can transport hydrophobic molecules across hydrophilic media and, as a result, can be valuable delivery vehicles for a diversity of biomedical applications. Strategies to monitor their dynamics noninvasively and in real time are, therefore, essential
Sinan Cemgil Sultan et al.
Talanta, 129, 523-528 (2014-08-17)
Glassy carbon paste electrode (GCPE) was modified with graphene platinum hybrid nanoparticle (Gr-Pt hybrid NP) and used as a transducer for label and indicator free electrochemical genosensor. 22 mer oligonucleotides representing Escherichia coli bacteria were used as a model case.
Hao Wu et al.
Journal of agricultural and food chemistry, 62(31), 7682-7689 (2014-07-17)
A novel and easy two-step microextraction technique combining anionic surfactant coacervation phase (CAP) extraction and dispersive microsolid-phase extraction (D-μ-SPE) was developed for the high-performance liquid chromatography-ultraviolet detection to determination of phthalate esters (PEs) in water samples. The method started with
Rifat J Hussain et al.
Physiology & behavior, 138, 113-117 (2014-12-03)
Our laboratory has previously shown that antidepressants regulate glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC). To determine if PFC GR are involved in antidepressant effects on behavior or hypothalamic-pituitary-adrenocortical (HPA) axis activity, we treated floxed GR male mice
Jaspreet Singh Kochhar et al.
Pharmaceutical research, 31(7), 1724-1734 (2014-01-23)
To fabricate microneedle arrays directly off a photomask using a simple photolithographical approach and evaluate their potential for delivering collagen. A simple photolithographical approach was developed by using photomask consisting of embedded micro-lenses that govern microneedle geometry in a mould
Chun-ling Dai et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(4), 607-617 (2014-09-23)
Intraneuronal accumulation of abnormally hyperphosphorylated tau in the brain is a histopathological hallmark of Alzheimer's disease and a family of related neurodegenerative disorders collectively called tauopathies. At present there is no effective treatment available for these progressive neurodegenerative diseases which
V K Kolli et al.
Human & experimental toxicology, 33(10), 1051-1065 (2013-12-19)
The efficacy of methotrexate (MTX), a widely used chemotherapeutic drug, is limited by its gastrointestinal toxicity and the mechanism of which is not clear. The present study investigates the possible role of mitochondrial damage in MTX-induced enteritis. Small intestinal injury
Rossana Canavesi et al.
Journal of pharmaceutical and biomedical analysis, 97, 141-150 (2014-05-28)
Pantethine (d-bis-(N-pantothenyl-β-aminoethyl)-disulfide, PAN), the stable disulfide form of pantetheine, has beneficial effects in vascular diseases being able to decrease the hyperlipidaemia, moderate the platelet function and prevent the lipid peroxidation. Furthermore, recent studies suggested that PAN may be an effective
Giuseppe Gangarossa et al.
Hippocampus, 24(12), 1466-1481 (2014-07-22)
The acute activation of the dopamine D1-like receptors (D1R) is involved in a plethora of functions ranging from increased locomotor activity to the facilitation of consolidation, storage, and retrieval of memories. Although much less characterized, epileptiform activities, usually triggered by
Yun Kyung Hahn et al.
Current HIV research, 13(1), 10-20 (2015-03-12)
The NeuN antibody has been widely used to identify and quantify neurons in normal and disease situations based on binding to a nuclear epitope in most types of neurons. This epitope was recently identified as the RNA-binding, feminizing locus on
Moritz Beck-Broichsitter et al.
Journal of pharmaceutical sciences, 103(8), 2585-2589 (2014-07-06)
Nebulization of active pharmaceutical ingredient (API) solutions is a well-established means to achieve pulmonary drug deposition. The current study identified the impact of formulation variables on the aerosolization performance of the eFlow(®) rapid with special respect to optimized lung application.
Mark D Swartzlander et al.
Biomaterials, 41, 79-88 (2014-12-20)
The implantation of non-biological materials, including scaffolds for tissue engineering, ubiquitously leads to a foreign body response (FBR). We recently reported that this response negatively impacts fibroblasts encapsulated within a synthetic hydrogel and in turn leads to a more severe
Wen Jen Lin et al.
Carbohydrate polymers, 120, 7-14 (2015-02-11)
The aim of this study was to develop hepatocyte-targeting non-viral polymeric nono-carriers for gene delivery. Chitosan was selected as the main polymer. An asialoglycoprotein receptor recognized sugar, galactose, was introduced. The methoxy poly(ethylene glycol) (mPEG) or short chain poly(ethylene glycol)
Münire Nalan Tüzmen et al.
Toxicology mechanisms and methods, 25(2), 120-127 (2014-12-17)
Exposure to aluminum (Al) and lead (Pb) can cause brain damage. Also, Pb and Al exposure alters N-methyl-d-aspartate receptor (NMDAR) subunit expression. Polyphenols such as tannic acid and curcumin are very efficient chelator for metals. The effects of curcumin and
Yuan Zhang et al.
ACS nano, 9(3), 3097-3108 (2015-02-26)
Viewing angle characteristics of displays and performance of electro-optic devices are often compromised by the quality of dichroic thin-film polarizers, while dichroic optical filters usually lack tunability and cannot work beyond the visible part of optical spectrum. We demonstrate that
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