Showing 1-29 of 29 results for "127-20-8"
Mohammed K Khuthaila et al.
American journal of ophthalmology, 155(4), 757-763 (2013-01-16)
To report the frequency of postoperative vitreous hemorrhage (VH) in eyes that underwent primary 23-gauge pars plana vitrectomy (PPV) for nonclearing VH resulting from proliferative diabetic retinopathy, as well as associated risk factors. Retrospective, consecutive, interventional case series. Institutional (Retina...
Jens Mollerup et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 20(1-4), 143-156 (2007-06-28)
Murine leukotriene B(4) (LTB(4)) receptor (mBLT1) cDNA was identified by searching the EST database using human LTB(4) receptor as the query sequence. Expression of functional mBLT1 after injection of in vitro transcribed cRNA into Xenopus laevis oocytes was demonstrated as...
T Saetre et al.
Shock (Augusta, Ga.), 9(2), 109-115 (1998-03-06)
The role of nitric oxide (NO) in hepatic oxygen transport is unclear. We investigated the effects of aminoethyl-isothiourea (AE-ITU), a selective inhibitor of iNOS activity, on liver blood flow and oxygen consumption (VO2H) in the pig. Endotoxin (lipopolysaccharide, LPS) was...
Jelle W G van den Berg et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 150(1), 16-21 (2013-11-19)
To assess the effectiveness of nasal saline irrigation in adult patients with chronic rhinosinusitis. PubMed, EMBASE, the Cochrane Library. A comprehensive search was performed, and 2 authors independently screened publications. The design of selected studies was assessed on directness of...
Marina Miller et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(41), 16648-16653 (2012-09-27)
Orosomucoid like 3 (ORMDL3) has been strongly linked with asthma in genetic association studies, but its function in asthma is unknown. We demonstrate that in mice ORMDL3 is an allergen and cytokine (IL-4 or IL-13) inducible endoplasmic reticulum (ER) gene...
Rana Abu-Huwaij et al.
Drug development and industrial pharmacy, 33(4), 437-448 (2007-05-25)
The aim of this study was to develop a controlled release buccal mucoadhesive delivery system for systemic delivery of lidocaine hydrochloride as a model drug. In vitro release and buccal permeation as well as in vivo permeation of LDHCL patches...
Naoki Tamasawa et al.
Diabetes research and clinical practice, 72(1), 6-11 (2005-11-01)
Elevations in plasma triglyceride (TG) and free fatty acid (FFA) concentrations are generally thought to play a role in the pathogenesis of insulin-resistant diabetes. The objective of this study was to investigate the relationship between hypertriglyceridemia and glucose-stimulated insulin responsiveness...
B Charleston et al.
Gene, 137(2), 327-331 (1993-12-31)
We have cloned a 2.4-kb cDNA containing the complete coding sequence of ovine Mx from a lambda ZAP library constructed using RNA from the endometrium of a normal sheep on day 16 of pregnancy. Ovine Mx shows 80% similarity to...
Javier Ruiz-Ederra et al.
Investigative ophthalmology & visual science, 50(5), 2132-2138 (2009-01-13)
Tear film composition depends on water and ion transport across ocular surface epithelia and on fluid secretion by lacrimal glands. The purpose of this study was to establish in situ fluorescence methods to measure tear film ionic concentrations and pH...
Pedro Cabrales et al.
Free radical biology & medicine, 39(9), 1229-1237 (2005-10-11)
Nitric oxide (NO) is an important signaling molecule modulating diverse processes such as vasodilation, neurotransmission, long-term potentiation, and immune responses. The endothelium contributes a significant fraction of NO from endothelial NO synthase (eNOS). The objective of this work was to...
Udo Kraushaar et al.
Pflugers Archiv : European journal of physiology, 445(2), 279-288 (2002-11-29)
GABA(A) receptors (GABA(A)Rs) and glycine receptors (GlyRs) expressed in developing neurons (P3-8) of the rat inferior colliculus (IC) were investigated using fast application of transmitters on nucleated patches and whole-cell patch-clamp recordings. At a holding potential of -60 mV and...
Jason L Hornick et al.
The American journal of surgical pathology, 33(4), 542-550 (2008-11-27)
INI1 (hSNF5/SMARCB1), a member of the SWI/SNF chromatin remodeling complex located on chromosome 22q11.2, is deleted or/or mutated in strictly defined malignant rhabdoid tumors (MRT) of infancy. Recent studies suggest that some epithelioid sarcomas (ES) also show inactivation of INI1....
Victoria E Shaw et al.
Molecular cancer, 13, 114-114 (2014-06-03)
We investigated whether combinations of serum cytokines, used with logistic disease predictor models, could facilitate the detection of pancreatic ductal adenocarcinoma (PDAC). The serum levels of 27 cytokines were measured in 241 subjects, 127 with PDAC, 49 with chronic pancreatitis...
C Zoja et al.
Kidney international, 53(3), 726-734 (1998-03-21)
As an alternative to classical immunosuppressants in experimental lupus nephritis, we looked at bindarit, 2-methyl-2-[[1-phenylmethyl)-1H-indazol-3-y1]methoxy]propanoic acid, a novel molecule devoid of immunosuppressive effects, which selectively reduces chronic inflammation in rat adjuvant arthritis. Two groups of NZB/W mice (N = 55...
Fiona Simpkins et al.
Gynecologic oncology, 136(2), 240-245 (2014-12-09)
To evaluate the effect of adding bevacizumab to adjuvant paclitaxel and carboplatin and as maintenance on progression-free survival (PFS) in advanced or recurrent endometrial carcinoma (EMCA). A phase II trial was conducted in patients with measurable disease. Paclitaxel (175mg/m(2)/3h), carboplatin...
Ilham El-Khattabi et al.
American journal of physiology. Endocrinology and metabolism, 285(5), E991-E1000 (2003-08-07)
We investigated the effect of an isocaloric maternal low-protein diet during pregnancy in rats on the proliferative capacity of cultured fetal hepatocytes. The potential roles of these changes on the IGF-IGF-binding protein (IGFBP) axis, and the role of insulin and...
Edmondo Falleti et al.
Cytokine, 44(2), 256-261 (2008-09-24)
This study aimed to verify whether specific single nucleotide polymorphisms (SNPs) of the transforming growth factor-beta1 (TGF-beta1) may predispose to end-stage liver disease and/or hepatocellular carcinoma (HCC). One hundred eighty-eight consecutive patients transplanted for liver cirrhosis (HBV N=21, HCV N=68...
P B Mehta et al.
Oncogene, 22(9), 1381-1389 (2003-03-06)
The novel mitogen/extracellular-signal-regulated kinase kinase 5/extracellular signal-regulated kinase-5 (MEK5/ERK5) pathway has been implicated in the regulation of cellular proliferation. MEK5 expression has been detected in prostate cancer cells, although the significance of the MEK5/ERK5 pathway in human prostate cancer has...
Valérie Pelletier et al.
Human mutation, 28(1), 81-91 (2006-09-14)
X-linked forms of retinitis pigmentosa (RP) (XLRP) account for 10 to 20% of families with RP and are mainly accounted for by mutations in the RP2 or RP GTPase regulator (RPGR) genes. We report the screening of these genes in...
Iva Karacić et al.
Molecular genetics and metabolism, 97(3), 165-171 (2009-04-28)
Specific mutations in the gene encoding phenylalanine hydroxylase (PAH), located on chromosome 12q22-24.1, are linked to tetrahydrobiopterin (BH4; sapropterin)-responsive phenylketonuria (PKU). Diagnosis is usually done through the newborn screening for PKU, followed by a BH4 loading test. So far, more...
Akihide Konishi et al.
International journal of cardiology, 179, 476-483 (2014-12-04)
The contribution of clopidogrel response due to cytochrome P450 (CYP) 2C19 loss-of-function polymorphism after drug-eluting stent (DES) implantation is unclear. A total of 196 patients who had undergone optical coherence tomography (OCT) at 8 months following first-generation DES (120 lesions)...
Pinar Nalcacioglu-Yüksekkaya et al.
European journal of ophthalmology, 24(1), 14-20 (2013-07-03)
To describe the clinical features, visual outcome, medical treatment, and complications of presumed herpetic anterior uveitis. We retrospectively analyzed the clinical data related to 79 eyes of 77 patients with presumed herpetic anterior uveitis seen at the Uveitis Unit of...
Bin Liu et al.
Cancer cell international, 18, 38-38 (2018-03-24)
Esophageal squamous cell carcinoma (ESCC) is one of the prevalent and deadly cancers worldwide, especially in China. Considering the poor prognosis of ESCC, the aim of this study is to dissect the effects of long non-coding RNA (lncRNA) AK001796 on...
Joseph M Zmuda et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 24(3), 437-447 (2008-11-20)
Wnts comprise a family of secreted growth factors that regulate the development and maintenance of many organs. Recently, Wnt10b was shown to stimulate osteoblastogenesis and bone formation in mice. To evaluate further the role of Wnt10b in bone health in...
Tilman T Zittel et al.
Diseases of the colon and rectum, 56(6), 761-767 (2013-05-09)
Cyclo-oxygenase 2 inhibitors can be used for pain treatment after colorectal surgery. The aim of this study was to investigate whether the use of etoricoxib has negative effects on the perioperative outcome in colorectal surgery. Complication data from an advanced...
Tonghai Xing et al.
Die Pharmazie, 68(10), 821-826 (2013-11-28)
To investigate the acute cellular rejection rate of liver transplant recipients taking or not taking calcitriol in a prospective, randomized, controlled clinical study. Primary liver transplant patients were randomized to receive the placebo (arm A), calcium gluconate (arm B) or...
Luis Paz-Ares et al.
The Lancet. Oncology, 16(3), 328-337 (2015-02-24)
Necitumumab is a second-generation recombinant human immunoglobulin G1 EGFR monoclonal antibody that competitively inhibits ligand binding. We aimed to compare necitumumab plus pemetrexed and cisplatin with pemetrexed and cisplatin alone in patients with previously untreated, stage IV, non-squamous non-small-cell lung...
Silke Wiedmann et al.
Diabetes, 57(1), 209-217 (2007-10-18)
Lipin, a novel molecular protein expressed by adipocytes, has marked effects on adipose tissue mass, insulin sensitivity, and glucose homeostasis. Thus, we hypothesized that genetic variants within LPIN1 are associated with traits of the metabolic syndrome. A total of 15...
Farid E Ahmed et al.
Cancer genomics & proteomics, 10(3), 93-113 (2013-06-07)
To present proof-of-principle application for employing micro(mi)RNAs as diagnostic markers for colon cancer, we carried out global microarray expression studies on stool samples obtained from fifteen individuals (three controls, and three each with TNM stage 0-1, stage 2, stage 3...

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