Showing 1-30 of 233 results for "128910"
A Hynowska et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(8), 1569-1579 (2014-12-24)
The microstructure, mechanical behaviour, and biocompatibility (cell culture, morphology, and cell adhesion) of nanostructured Ti45 Zr15 Pd35- x Si5 Nbx with x = 0, 5 (at. %) alloys, synthesized by arc melting and subsequent Cu mould suction casting, in the form of...
Michael John Robert Previte et al.
Nature communications, 6, 5936-5936 (2015-01-24)
Next-generation sequencing (NGS) has transformed genomic research by decreasing the cost of sequencing. However, whole-genome sequencing is still costly and complex for diagnostics purposes. In the clinical space, targeted sequencing has the advantage of allowing researchers to focus on specific...
Yelko Rodríguez-Carrasco et al.
Toxins, 7(3), 705-718 (2015-02-28)
A duplicate diet study was designed to explore the occurrence of 15 Fusarium mycotoxins in the 24 h-diet consumed by one volunteer as well as the levels of mycotoxins in his 24 h-collected urine. The employed methodology involved solvent extraction...
Naeem Khan et al.
Clinical and vaccine immunology : CVI, 22(1), 99-107 (2014-11-21)
The shortcomings of the licensed polysaccharide-based pneumococcal vaccine are driving efforts toward development of a protein-based vaccine that is serotype independent and effective in all age groups. An opsonophagocytic killing assay (OPKA) is used to evaluate the antibody response against...
Margaux Monot et al.
Journal of virology, 89(16), 8462-8473 (2015-06-05)
Ovine pulmonary adenocarcinoma is a naturally occurring lung cancer in sheep induced by the Jaagsiekte sheep retrovirus (JSRV). Its envelope glycoprotein (Env) carries oncogenic properties, and its expression is sufficient to induce in vitro cell transformation and in vivo lung...
Migaku Kawaguchi et al.
Analytical and bioanalytical chemistry, 388(2), 391-398 (2007-03-16)
A novel method, stir-bar-sorptive extraction (SBSE), with in-situ deconjugation and thermal desorption (TD) with in-tube silylation, followed by gas chromatography-mass spectrometry (GC-MS), for determination of trace amounts of 4-nonylphenol glucuronide (NP-G) and 4-tert-octylphenol glucuronide (OP-G) in human urine, is described....
Lauren K Woolley et al.
Vaccine, 32(34), 4333-4341 (2014-06-17)
Pig responses to recombinant subunit vaccines containing fragments of eight multifunctional adhesins of the Mycoplasma hyopneumoniae (Mhp) P97/P102 paralog family formulated with Alhydrogel(®) or Montanide™ Gel01 were compared with a commercial bacterin following experimental challenge. Pigs, vaccinated intramuscularly at 9...
Abdelbasset Amara et al.
Iranian journal of public health, 44(3), 396-403 (2015-04-24)
HNF4A-p.I463Vvariant, reported previously in two distinct families suspected of MODY-1, is assessed in this report to determine whether it is a mutation or a polymorphism (frequency >1%). 200 Tunisian healthy people were screened for the presence of HNF4A-p.I463V variant, using...
Jie-Ren Li et al.
ACS nano, 9(7), 6738-6746 (2015-06-10)
A recent finding reports that co-stimulation of the high-affinity immunoglobulin E (IgE) receptor (FcεRI) and the chemokine receptor 1 (CCR1) triggered formation of membrane nanotubes among bone-marrow-derived mast cells. The co-stimulation was attained using corresponding ligands: IgE binding antigen and...
Meizi Zhang et al.
PloS one, 10(7), e0133788-e0133788 (2015-07-29)
FTO (fat mass and obesity associated gene) was genetically identified to be associated with body mass index (BMI), presumably through functional regulation of energy homeostasis. However, the cellular and molecular mechanisms by which FTO functions remain largely unknown. Using 3T3-L1...
Chad J Roy et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(12), 3782-3787 (2015-03-17)
Ricin toxin (RT) is the second most lethal toxin known; it has been designated by the CDC as a select agent. RT is made by the castor bean plant; an estimated 50,000 tons of RT are produced annually as a...
Gerald B W Wertheim et al.
Clinical chemistry, 61(1), 249-258 (2014-10-29)
Epigenetic dysregulation involving alterations in DNA methylation is a hallmark of various types of cancer, including acute myeloid leukemia (AML). Although specific cancer types and clinical aggressiveness of tumors can be determined by DNA methylation status, the assessment of DNA...
Susana S Santos et al.
Journal of microbiological methods, 115, 13-19 (2015-05-15)
The use of molecular methods to investigate protist communities in soil is in rapid development this decade. Molecular analysis of soil protist communities is usually dependant on direct genomic DNA extraction from soil and inefficient or differential DNA extraction of...
Vikash Verma et al.
PloS one, 10(9), e0137125-e0137125 (2015-09-09)
DNA origami provides a versatile platform for conducting 'architecture-function' analysis to determine how the nanoscale organization of multiple copies of a protein component within a multi-protein machine affects its overall function. Such analysis requires that the copy number of protein...
Mohammad Saraji et al.
Journal of separation science, 29(9), 1223-1229 (2006-07-13)
A simple analytical procedure based on single-drop microextraction combined with in-syringe derivatization and GC-MS was developed for determination of some phenolic acids in fruits and fruit juices. Cinnamic acid, o-coumaric acid, caffeic acid, and p-hydroxybenzoic acid were used as model...
Peggy Scholtysek et al.
Soft matter, 11(30), 6106-6117 (2015-07-03)
Cholesterol (Ch) linked to a linear-hyperbranched block copolymer composed of poly(ethylene glycol) (PEG) and poly(glycerol) (hbPG) was investigated for its membrane anchoring properties. Two polyether-based linear-hyperbranched block copolymers with and without a covalently attached rhodamine fluorescence label (Rho) were employed...
Doory Kim et al.
PloS one, 10(4), e0124581-e0124581 (2015-04-16)
Correlative fluorescence light microscopy and electron microscopy allows the imaging of spatial distributions of specific biomolecules in the context of cellular ultrastructure. Recent development of super-resolution fluorescence microscopy allows the location of molecules to be determined with nanometer-scale spatial resolution....
Carsten Tischbirek et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(36), 11377-11382 (2015-08-26)
In vivo Ca2+ imaging of neuronal populations in deep cortical layers has remained a major challenge, as the recording depth of two-photon microscopy is limited because of the scattering and absorption of photons in brain tissue. A possible strategy to...
Elena Pascual et al.
Journal of virology, 89(5), 2563-2574 (2014-12-19)
Bioengineering of viruses and virus-like particles (VLPs) is a well-established approach in the development of new and improved vaccines against viral and bacterial pathogens. We report here that the capsid of a major avian pathogen, infectious bursal disease virus (IBDV)...
Maria Q Gaunsbaek et al.
ORL; journal for oto-rhino-laryngology and its related specialties, 76(5), 288-301 (2014-12-17)
To investigate the presence of surfactant protein (SP) A, B, C and D in nasal airways and to determine whether the proteins exert their main functions in nasal secretions or in the deeper layers of the nasal mucosa. Volunteers were...
Jie He et al.
Analytical chemistry, 87(22), 11407-11414 (2015-10-24)
For applications ranging from medical diagnostics and drug screening to chemical and biological warfare detection, inexpensive, rapid-readout, portable devices are required. Localized surface plasmon resonance (LSPR) technologies show substantial promise toward meeting these goals, but the generation of portable, multiplexed...
Peng Zhai et al.
Materials science & engineering. C, Materials for biological applications, 56, 251-259 (2015-08-08)
Poly(lactic-co-glycolic acid) (PLGA) microspheres and PLGA/alginate composite microspheres were prepared by a novel double emulsion and solvent evaporation technique and loaded with bovine serum albumin (BSA) or rabbit anti-laminin antibody protein. The addition of alginate and the use of a...
Osiris Marroquin Belaunzaran et al.
PloS one, 10(6), e0130811-e0130811 (2015-07-01)
HLA-B27 is a common genetic risk factor for the development of Spondyloarthritides (SpA). HLA-B27 can misfold to form cell-surface heavy chain homodimers (B272) and induce pro-inflammatory responses that may lead to SpA pathogenesis. The presence of B272 can be detected...
Lorena S Ver et al.
Journal of virology, 89(19), 10023-10030 (2015-07-24)
Transcription and replication of influenza A virus are carried out in the nuclei of infected cells in the context of viral ribonucleoproteins (RNPs). The viral polymerase responsible for these processes is a protein complex composed of the PB1, PB2, and...
Anne Burtey et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4695-4712 (2015-07-30)
Intercellular communication between cancer cells, especially between cancer and stromal cells, plays an important role in disease progression. We examined the intercellular transfer of organelles and proteins in vitro and in vivo and the role of tunneling nanotubes (TNTs) in...
Christoph Schell et al.
PloS one, 10(6), e0129424-e0129424 (2015-06-16)
The coxsackie- and adenovirus receptor (CXADR) is a member of the immunoglobulin protein superfamily, present in various epithelial cells including glomerular epithelial cells. Beside its known function as a virus receptor, it also constitutes an integral part of cell-junctions. Previous...
Ying Zhang et al.
Biomaterials, 64, 88-97 (2015-07-01)
Autologous stem cells are a promising cell source for cartilage regeneration; however, cell replicative senescence and joint posttraumatic inflammation provide challenges in bringing this treatment modality to fruition. In this study, we hypothesized that preconditioning with p38 MAPK inhibitor (sb203580)...
Clara Sciorati et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(3), 809-822 (2014-12-17)
Muscle regeneration is a hallmark of the idiopathic inflammatory myopathies (IIMs), a group of autoimmune disorders that are characterized by leukocyte infiltration and dysfunction of the skeletal muscle. Despite detailed studies describing the clinical and histopathologic features of IIMs, the...
Jessica Mayeux et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 1955-1963 (2015-07-26)
Tight control of B cell differentiation into plasma cells (PCs) is critical for proper immune responses and the prevention of autoimmunity. The Ets1 transcription factor acts in B cells to prevent PC differentiation. Ets1(-/-) mice accumulate PCs and produce autoantibodies....
Yuzhen Guo et al.
Lab on a chip, 15(7), 1759-1764 (2015-02-17)
A simple method to fabricate microchannels is demonstrated based on an inkjet printing liquid template. The morphology of the liquid template can be well controlled by using ink with viscosity sensitive to temperature. The as-prepared Y-shape microchannel is used as...

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