Showing 1-8 of 8 results for "128937"
Synthesis and structure-activity relationships of a class of sodium iodide symporter function inhibitors.
Fanny Waltz et al.
ChemMedChem, 6(10), 1775-1777 (2011-07-14)
M Ulgen et al.
Xenobiotica; the fate of foreign compounds in biological systems, 24(8), 735-748 (1994-08-01)
1. The in vitro hepatic microsomal metabolism of certain substituted N-benzylanilines was studied in the male hamster to establish the mechanism(s) and process(es) involved in the formation of the corresponding amides. 2. N-Benzyl-2,4,6-trihalogeno, N-benzyl-4-cyano- and N-benzyl-4-nitroanilines were only metabolized by...
Masaharu Uno et al.
Organic & biomolecular chemistry, 6(6), 979-981 (2008-03-11)
N-Benzylanilines were designed and synthesized as vascular endothelial growth factor (VEGF)-2 inhibitors using de novo drug design systems based on the X-ray structure of VEGFR-2 kinase domain. Among compounds synthesized, compound showed the most potent inhibitory activity toward VEGFR-2 (KDR)...
Weiqiang Zhan et al.
Journal of medicinal chemistry, 50(23), 5655-5664 (2007-10-26)
In light of a proposed molecular mechanism for the C-X-C chemokine receptor type 4 (CXCR4) antagonist 1 (AMD3100), a template with the general structure 2 was designed, and 15 was identified as a lead by means of an affinity binding...
Identification of a new metabolite after incubation of N-benzylaniline with rabbit liver microsomes.
H M Ali et al.
Journal of chromatography, 202(2), 287-293 (1980-12-19)
Sun-Young Han et al.
Journal of enzyme inhibition and medicinal chemistry, 18(3), 279-283 (2003-09-26)
Lignostilbene-alpha,beta-dioxygenase (LSD, EC 1.13.11.43) is involved in oxidative cleavage of the central double bond of lignostilbene to form the corresponding aldehydes by a mechanism similar to those of 9-cis-epoxycarotenoid dioxygenase and beta-carotene 15,15'-dioxygenase, key enzymes in abscisic acid biosynthesis and...
J W Gorrod et al.
Xenobiotica; the fate of foreign compounds in biological systems, 15(12), 1021-1031 (1985-12-01)
Using direct specific analytical techniques microsomal metabolism of N-benzyl-4-substituted anilines has been investigated and found to include both N- and C-oxidation. N-Debenzylation was observed with all substrates and species examined. N-Oxidation usually yielded aryl nitrones, although the N-hydroxy derivative of...
Yung-Hung Chang et al.
Dalton transactions (Cambridge, England : 2003), (5)(5), 861-867 (2009-01-22)
Both saturated and unsaturated N-benzyl substituted heterocyclic carbene (NHC) iridum(i) complexes were synthesized. The unsaturated carbene complex [(un-NHC-Bn)Ir(CO)(2)Cl] in the cis form was prepared via the carbene transfer from the corresponding silver complex to [Ir(COD)(2)Cl](2) followed by ligand substitution with...

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