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X-Q Yang et al.
Bulletin of entomological research, 105(3), 316-325 (2015-03-18)
The codling moth Cydia pomonella (L.) is an economically important fruit pest and it has been directly targeted by insecticides worldwide. Serious resistance to insecticides has been reported in many countries. As one of the most serious invasive pest, the
Snežana D Marković et al.
General physiology and biophysics, 33(4), 393-401 (2014-08-26)
The effects of nitroglycerin (glyceryl trinitrate - GTN) are mediated by liberated nitric oxide (NO) and formed reactive nitrogen species, which induces oxidative stress during biotransformation in red blood cells (RBCs). The aim of this study was to evaluate effects
Camila R Murussi et al.
Archives of environmental contamination and toxicology, 68(4), 646-654 (2015-03-18)
Clomazone is considered a potential contaminant of groundwater and is persistent in the environment. To verify the effects of clomazone in Cyprinus carpio and Rhamdia quelen, a method that combines biomarker responses into an index of "integrated biomarker response" (IBR)
Flavia Bieczynski et al.
Aquatic toxicology (Amsterdam, Netherlands), 154, 97-106 (2014-05-29)
We studied Abcc mediated-transport in middle and posterior intestine of the rainbow trout, Oncorhynchus mykiss. Luminal and serosal transport were evaluated in everted and non-everted intestinal sacs, respectively, incubated with 1-chloro-2,4-dinitrobenzene (CDNB; 200 μM). CDNB enters the cells and is
Jae Ho Choi et al.
Environmental toxicology and pharmacology, 33(3), 446-452 (2012-03-13)
Platycodi Radix has been used to treat chronic diseases, such as bronchitis, asthma, and hyperlipidemia. In this study, we examined the effect of an aqueous extract, Changkil (CK), from the root of Platycodi Radix on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like
Eun-Hyeong Shim et al.
The Journal of pharmacy and pharmacology, 66(9), 1303-1316 (2014-06-26)
We aimed to investigate the inhibitory efficacy of Solanum tuberosum L. var. Vitelotte (SV) extract on atopic dermatitis (AD)-like skin lesions induced by the topical application of 2,4-dinitrochlorobenzene in NC/Nga mice. SV extract was administered orally to NC/Nga mice at the
Qi Yin et al.
Journal of biomedical nanotechnology, 11(10), 1764-1775 (2015-10-28)
The clinical success of anthracyclines-containing chemotherapy for breast cancer is mainly restricted by cardiac damage and the development of multidrug resistance (MDR). For efficient reversal of drug resistance, doxorubicin (DOX) loaded multifunctional bioreducible micelles were constructed from a new amphiphilic
Nelson Leonel Martínez-Rodríguez et al.
Toxicology in vitro : an international journal published in association with BIBRA, 57, 54-61 (2019-02-17)
Ferrite nanoparticles (NPs) have gained attention in biomedicine due to their many potential applications, such as targeted drug delivery, their use as contrast agents for magnetic resonance imaging and oncological treatments. The information about the risk effects of ferrite NPs
Felix C Weber et al.
The Journal of experimental medicine, 212(1), 15-22 (2014-12-17)
Allergic contact dermatitis and its animal model, contact hypersensitivity (CHS), are T cell-mediated inflammatory skin diseases induced by contact allergens. Though numerous cellular and molecular players are known, the mechanism of chemical-induced sensitization remains poorly understood. Here, we identify neutrophils
Rachana D Sharma et al.
Journal of pineal research, 59(2), 240-254 (2015-06-24)
Oxidative stress-induced methemoglobinemia remained an untouched area in venom pharmacology till date. This study for the first time explored the potential of animal venoms to oxidize hemoglobin to methemoglobin. In in vitro whole-blood assay, methemoglobin forming ability of venoms varied
Gabsik Yang et al.
Immunopharmacology and immunotoxicology, 34(3), 413-418 (2012-05-09)
The flower of Chrysanthemum boreale has traditionally been used for treatment of various inflammatory disease including atopic dermatitis (AD). However, its action on AD is unclear. Therefore, we investigated the effect of CB on AD using NC/Nga mice as an
Shaojuan Song et al.
PloS one, 9(9), e107685-e107685 (2014-09-23)
Antioxidant enzymes play a major role in defending against oxidative damage by copper. However, few studies have been performed to determine which antioxidant enzymes respond to and are necessary for copper detoxification. In this study, we examined both the activities
Raffaele Fabrini et al.
PloS one, 9(11), e112797-e112797 (2014-11-14)
Glutathione transferases (GSTs) are a superfamily of detoxifying enzymes over-expressed in tumor tissues and tentatively proposed as biomarkers for localizing and monitoring injury of specific tissues. Only scarce and contradictory reports exist about the presence and the level of these
Zhaoguo Liu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 82, 12-18 (2015-05-10)
Inflammation and oxidative stress have been implicated in various pathological processes including skin tumorigenesis. Skin cancer is the most common form of cancer responsible for considerable morbidity and mortality, the treatment progress of which remains slow though. Therefore, chemoprevention and
Ritika Nagar et al.
European journal of drug metabolism and pharmacokinetics, 40(1), 45-51 (2014-01-30)
Glutathione S-transferases (GSTs) play an important role in the biotransformation of endogenous compounds and xenobiotics as well as in the metabolic inactivation of pharmacologically active substances, including anticancer drugs. Using cisplatin as the prototype drug, we investigated if any correlation
Francine R Ianiski et al.
The Journal of pharmacy and pharmacology, 66(12), 1747-1754 (2014-08-19)
In this study, the antioxidant action of ((4-tert-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide, a novel unsymmetrical divinyl sulfide, against oxidative damage induced by sodium nitroprusside (SNP) in brains of mice was investigated. Mice received SNP (0.335 μmol/site, intracerebroventricular) 30 min after administration of sulfide
Gabriela Chaufan et al.
Chemical research in toxicology, 32(4), 745-752 (2019-02-01)
The fungicide agents are a key component in the fruits and vegetables production. The Iprodione residues are one of the pesticide more frequently found in food products. The available data about the cytotoxicity of iprodione and its metabolites are scarce
Noomi Asker et al.
Environmental toxicology and chemistry, 34(7), 1511-1523 (2015-02-11)
A broad biomarker approach was applied to study the effects of marine pollution along the Swedish west coast using the teleost eelpout (Zoarces viviparus) as the sentinel species. Measurements were performed on different biological levels, from the molecular to the
Nora L Krutz et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 515-523 (2015-07-18)
The monoterpene ascaridole, a fairly stable endoperoxide found in essential oils such as tea tree oil can provoke allergic contact dermatitis which has been evidenced under patch test conditions. However, concomitantly we observed irritative skin reactions that demand further data
Hyun Yang et al.
Molecular medicine reports, 12(1), 345-350 (2015-03-12)
Aromatherapy has been suggested as an alternative therapeutic method for the treatment of atopic dermatitis (AD), eczema and other skin diseases. In the current study, the anti-atopic properties of the volatile organic compounds of Chamaecyparis obtusa (VOCCo) were examined to
Bo-Kyung Park et al.
Journal of ethnopharmacology, 165, 54-60 (2015-02-28)
Gamisasangja-tang (GST) is a traditional herbal formula prescribed for patients with intractable pruritus in association with various inflammatory skin diseases. To evaluate the effects of GST on pruritic skin inflammation and investigate its cellular and molecular mechanisms. We orally administered
Denis Benito et al.
The Science of the total environment, 689, 1087-1103 (2019-08-31)
For reliable mussel monitoring programmes based on biomarkers, regionally relevant reference values and their natural variability need to be known. The Baltic Sea exhibits high inter-regional and seasonal variability in physical factors such as salinity, temperature and primary production. The
Jin Kyeong Choi et al.
Toxicology and applied pharmacology, 269(1), 72-80 (2013-03-19)
Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are common allergic and inflammatory skin diseases caused by a combination of eczema, scratching, pruritus, and cutaneous sensitization with allergens. This paper examines whether oleanolic acid acetate (OAA) modulates AD and ACD
Le Son Tran et al.
Journal of innate immunity, 7(4), 392-404 (2015-02-28)
Human papillomaviruses (HPVs) have evoked numerous mechanisms to subvert host innate immunity and establish a local immunosuppressive environment to facilitate persistent virus infection. Topical application of 2,4-dinitrochlorobenzene (DNCB) was speculated to overcome this immunosuppressive environment and was employed in the
Mahboobeh Sharifi et al.
Insect science, 22(5), 639-650 (2014-07-06)
Insecticidal effects of 4-hexylresorcinol, a phenoloxidase (PO) inhibitor, were determined on Hyphantria cunea (Drury) under laboratory conditions. The LC50 for the 15-d-old larvae was estimated to be 2.95 g/L after 96 h exposure. The activities of glutathione S-transferase (GST) and
Anne-Sophie Bergot et al.
Immunology and cell biology, 93(6), 540-547 (2015-01-21)
Atopic dermatitis is a common pruritic and inflammatory skin disorder with unknown etiology. Most commonly occurring during early childhood, atopic dermatitis is associated with eczematous lesions and lichenification, in which the epidermis becomes hypertrophied resulting in thickening of the skin.
E O Farombi et al.
Andrologia, 46(8), 893-901 (2013-10-02)
The indiscriminate use, abuse and patients' noncompliance to normal prescription of artemisinin and its derivatives are a common practice during the treatment for drug-resistant malaria parasites in most developing countries. This study investigated the influence of artemisinin on the testicular
Davorka K Hackenberger et al.
Chemosphere, 224, 572-579 (2019-03-06)
Organisms in soil are often exposed to different mixtures of contaminants. These contaminants may interact with each other and, consequently, may have a different effect on organisms than each of them alone. We wanted to investigate possible effects of ZnO
Augustine Arukwe et al.
PloS one, 10(6), e0130002-e0130002 (2015-06-19)
In the present study, the biotransformation and oxidative stress responses in relation to chemical burden in the liver of male and female Nile crocodiles--Crocodylus niloticus--from a commercial crocodile farm passively exposed to various anthropogenic aquatic pollutants was investigated. In general
Iva Boušová et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(9), 872-879 (2012-03-31)
Flavonoids are known to modulate catalytic activity and expression of various enzymes. Glutathione S-transferases (GSTs) are the important biotransformation enzymes defending cells against potentially toxic xenobiotics. Therefore, the modulation of GST activity may influence detoxification of xenobiotics. The aim of
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